Clinical Study of Intradermal Block Treatment for Post-herpetic Neuralgia Using Different Dose of Compound Betamethasone_West China Medical Journal

Authors：

 FanWenjiang ¹ ,  LiuQing ²

1. Department of Pain Medicine, the First People’s Hospital of Neijiang, Neijiang, Sichuan 641000, P. R. China;
2. Department of Pain Medicine, the Affiliated Chinese Medical Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P. R. China;

Corresponding author：

LiuQing, Email: 1105859368@qq.com

Keywords：

Post-herpetic neuralgia; Intradermal block; Compound betamethasone; Visual analogue scale; Quality of sleep

DOI：

10.7507/1002-0179.201600191

Video：

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Objective To compare the effect of different doses of compound betamethasone intradermal block on post-herpetic neuralgia (PHN) in elderly patients. Methods Between June 2013 and December 2014, 96 elderly patients who matched the criteria of PHN were chosen and randomly divided into saline control group (group C), compound betamethasone 0.5 mL group (group B_0.5) and compound betamethasone 1.0 mL group (group B_1.0). For the control group, 20 mL analgesic saline liquid including 5 mL of 2% lidocaine was used. And 0.5 and 1.0 mL compound betamethasone was added into the solution of group C to get the solution for group B_0.5 and group B_1.0, respectively. The patients got intracutaneous injection once in the affected area on the day 1, 8, and 15 respectively, and patients in the same group were injected the same solution of analgesic liquid. All the patients took the same medicine during treatment. Their visual analog scale (VAS) scores, quality of sleep (QS) scores and adverse events before treatment (T₀), at discharging from the hospital (T₁), and three months after discharging (T₂) were carefully noted and analyzed. Results The VAS and QS scores of the three groups at T1 and T2 improved significantly compared with those at T0 (P < 0.05). The VAS and QS scores of group B_0.5 and group B_1.0 improved significantly more compared with group C (P < 0.05), and the difference of VAS and QS scores between group B_0.5 and group B_1.0 was not statistically insignificant (P > 0.05). Conclusions Adding 0.5 mL or 1 mL of compound betamethasone to the 20 mL analgesic liquid for intradermal block treatment on PHN can obviously release patients’ pain and improve their sleep quality. Compared with 1 mL, adding 0.5 mL compound betamethasone to the 20 mL analgesic liquid for intradermal block treatment on PHN is a more ideal dose.

Citation： FanWenjiang, LiuQing. Clinical Study of Intradermal Block Treatment for Post-herpetic Neuralgia Using Different Dose of Compound Betamethasone. West China Medical Journal, 2016, 31(4): 700-703. doi: 10.7507/1002-0179.201600191 Copy

1.	Neogi M, Basak S, Ghosh D, et al. A randomized double-blind placebo-controlled clinical study on the effects of gabapentin premedication on hemodynamic stability during laparoscopic cholecystectomy[J]. J Anaesthesiol Clin Pharmacol, 2012, 28(4): 456-459.
2.	Johnson RW, Mcelhaney J. Postherpetic neuralgia in the elderly[J]. Int J Clin Pract, 2009, 63(9): 1386-1391.
3.	Deniz MN, Sertoz N, Erhan E, et al. Effects of preoperative gabapentin on postoperative pain after radical retropubic prostatectomy[J]. J Int Med Res, 2012, 40(6): 2362-2369.
4.	魄伟, 吴惠俐, 秦立模. 三种糖皮质激素治疗带状疱疹神经痛的经济学评价[J]. 复旦学报: 医学版, 2004, 31(1): 78.
5.	庆俊. 应用糖皮质激素治疗带状疱疹神经痛的临床疗效[J]. 现代预防医学, 2011, 38(21): 4517-4518.
6.	王淑萍, 王静. 侧隐窝联合皮内给予复方倍他米松对老年人腰骶段带状疱疹后神经痛的疗效[J]. 郑州大学学报: 医学版, 2014, 49(2): 281-284.
7.	带状疱疹后神经痛诊疗共识编写专家组. 带状疱疹后神经痛诊疗中国专家共识(2016)[J]. 中国疼痛医学杂志, 2016, 22(3): 161-167.
8.	王家双, 陈军. 老年人顽固性疱疹后神经痛临床规范化诊疗[J]. 中华老年医学杂志, 2014, 33(8): 845-848.
9.	刘太华, 王骏, 王春梅. 不同方案治疗带状疱疹神经痛疗效比较[J]. 华西医学, 2015, 30(7): 1243-1245.
10.	王文珠, 王冉, 刘建, 等. 背根神经节脉冲射频刺激联合普瑞巴林治疗带状疱疹后遗神经痛的临床疗效[J]. 临床麻醉学杂志, 2014, 30(7): 663-665.
11.	陈彦青, 林莹, 戴双波. 改良椎旁神经阻滞治疗带状疱疹后遗神经痛[J]. 中国疼痛医学杂志, 2010, 16(1): 54-56.
12.	邵大清. 复方倍他米松不同给药途径对躯干疱疹后神经痛的效能评估[J]. 浙江实用医学, 2010, 15(3): 178-180.
13.	Amjad M, Mashhood AA. The efficacy of local infiltration of triamcinolone acetonide with lignocaine compared with lignocaine alone in the treatment of postherpetic neuralgia[J]. J Coll Physicians Surg Pak, 2005, 15(11): 683-685.
14.	章云海, 曾因明. 皮内注射治疗带状疱疹后神经痛的机制[J]. 中华麻醉学杂志, 2003, 23(2): 115-117.
15.	王雪笠, 冯连元, 贺银芳, 等. 伴有抑郁或焦虑症状的慢性失眠症患者多导睡眠图分析[J]. 中国行为医学科学, 2005, 14(3): 246.
16.	王淑萍, 王静. 侧隐窝联合皮内给予复方倍他米松对老年人腰骶段带状疱疹后神经痛的疗效[J]. 郑州大学学报: 医学版, 2014, 49(2): 281-283, 284.
17.	Kost RG, Straus SE. Postherpetic neuralgia-pathogenesis, treatment, and prevention[J]. N Engl J Med, 1996, 335(1): 32-42.

1. Neogi M, Basak S, Ghosh D, et al. A randomized double-blind placebo-controlled clinical study on the effects of gabapentin premedication on hemodynamic stability during laparoscopic cholecystectomy[J]. J Anaesthesiol Clin Pharmacol, 2012, 28(4): 456-459.
2. Johnson RW, Mcelhaney J. Postherpetic neuralgia in the elderly[J]. Int J Clin Pract, 2009, 63(9): 1386-1391.
3. Deniz MN, Sertoz N, Erhan E, et al. Effects of preoperative gabapentin on postoperative pain after radical retropubic prostatectomy[J]. J Int Med Res, 2012, 40(6): 2362-2369.
4. 魄伟, 吴惠俐, 秦立模. 三种糖皮质激素治疗带状疱疹神经痛的经济学评价[J]. 复旦学报: 医学版, 2004, 31(1): 78.
5. 庆俊. 应用糖皮质激素治疗带状疱疹神经痛的临床疗效[J]. 现代预防医学, 2011, 38(21): 4517-4518.
6. 王淑萍, 王静. 侧隐窝联合皮内给予复方倍他米松对老年人腰骶段带状疱疹后神经痛的疗效[J]. 郑州大学学报: 医学版, 2014, 49(2): 281-284.
7. 带状疱疹后神经痛诊疗共识编写专家组. 带状疱疹后神经痛诊疗中国专家共识(2016)[J]. 中国疼痛医学杂志, 2016, 22(3): 161-167.
8. 王家双, 陈军. 老年人顽固性疱疹后神经痛临床规范化诊疗[J]. 中华老年医学杂志, 2014, 33(8): 845-848.
9. 刘太华, 王骏, 王春梅. 不同方案治疗带状疱疹神经痛疗效比较[J]. 华西医学, 2015, 30(7): 1243-1245.
10. 王文珠, 王冉, 刘建, 等. 背根神经节脉冲射频刺激联合普瑞巴林治疗带状疱疹后遗神经痛的临床疗效[J]. 临床麻醉学杂志, 2014, 30(7): 663-665.
11. 陈彦青, 林莹, 戴双波. 改良椎旁神经阻滞治疗带状疱疹后遗神经痛[J]. 中国疼痛医学杂志, 2010, 16(1): 54-56.
12. 邵大清. 复方倍他米松不同给药途径对躯干疱疹后神经痛的效能评估[J]. 浙江实用医学, 2010, 15(3): 178-180.
13. Amjad M, Mashhood AA. The efficacy of local infiltration of triamcinolone acetonide with lignocaine compared with lignocaine alone in the treatment of postherpetic neuralgia[J]. J Coll Physicians Surg Pak, 2005, 15(11): 683-685.
14. 章云海, 曾因明. 皮内注射治疗带状疱疹后神经痛的机制[J]. 中华麻醉学杂志, 2003, 23(2): 115-117.
15. 王雪笠, 冯连元, 贺银芳, 等. 伴有抑郁或焦虑症状的慢性失眠症患者多导睡眠图分析[J]. 中国行为医学科学, 2005, 14(3): 246.
16. 王淑萍, 王静. 侧隐窝联合皮内给予复方倍他米松对老年人腰骶段带状疱疹后神经痛的疗效[J]. 郑州大学学报: 医学版, 2014, 49(2): 281-283, 284.
17. Kost RG, Straus SE. Postherpetic neuralgia-pathogenesis, treatment, and prevention[J]. N Engl J Med, 1996, 335(1): 32-42.

West China Medical Journal

Clinical Study of Intradermal Block Treatment for Post-herpetic Neuralgia Using Different Dose of Compound Betamethasone

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