Clinical Observation on the Treatment of Knee Osteoarthritis by Combined Traditional Chinese Medicine and Western Medicine_West China Medical Journal

Authors：

 HuangJian

Department of Acupuncture, Zigong Hospital of TCM, Zigong, Sichuan 643000, P. R. China;

Corresponding author：

Keywords：

Osteoarthritis, knee; Integrated traditional Chinese and Western medicine; Acupuncture; Specialized electromagnetic wave therapeutic apparatus; Glucosamine hydrochloride; Sodium hyaluronate

DOI：

10.7507/1002-0179.201600222

Video：

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Objective To observe the clinical effect of combined traditional Chinese and Western medicine in the treatment of knee osteoarthritis (KOA). Methods A total of 180 KOA patients treated between January 2012 and June 2015 were randomly assigned to 3 groups: Chinese medicine group (group A, n=60) with acupuncture and irradiation therapy of specific electromagnetic wave therapeutic apparatus , western medicine group (group B, n=60) with oral glucosamine hydrochloride tablets and knee joint cavity injection of sodium hyaluronate, and integrated traditional Chinese and Western medicine group (group C, n=60) with treatments combining those in both group A and B. The treatment course was 6 weeks. The Western Ontario & McMaster University (WOMAC) osteoarthritis index score and total effective rate were evaluated before treatment and 2 weeks after treatment, end of treatment and 5 months after treatment. Results After treatment, the average improvement of WOMAC scores in the three groups was significantly different (P ＜ 0.05) . The total effective rate was 78.33% in group A, 83.33% in group B, and 91.67% in group C. The difference of total effective rate between group C and A, and between group C and B was statistically significant (P＜0.05) ; and it was also statistically significant between group A and B (P ＜ 0.05) . There were two cases of adverse reactions in group A, two in group B, and two in group C, and the reactions were all relatively mild without any serious adverse events. Conclusions Chinese medicine and western medicine are both effective and safe for the treatment of KOA. When they are combined, the effect is further enhanced with no increase of adverse reactions.

Citation： HuangJian. Clinical Observation on the Treatment of Knee Osteoarthritis by Combined Traditional Chinese Medicine and Western Medicine. West China Medical Journal, 2016, 31(5): 811-815. doi: 10.7507/1002-0179.201600222 Copy

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19.	卢锋, 郭红卫. 盐酸氨基葡萄糖对骨关节炎作用机制的初步探讨[J]. 卫生研究, 2003, 32(6) : 594-597.
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1. 胥少汀, 葛宝丰, 徐印坎. 实用骨科学[M]. 北京：人民军医出版社, 2009: 1337.
2. 尹群党, 藏向博. 综合疗法治疗膝关节骨性关节炎临床分析[J]. 实用中医药杂志, 2013, 12(29) : 983-985.
3. 黄伟毅, 魏秋实, 曾健英, 等. 独活寄生汤配合玻璃酸钠对膝骨关节炎生活质量的影响[J]. 广东医学, 2014, 35(15) : 2247-2450.
4. 姬登高, 张国强, 张伟. 盐酸氨基葡萄糖联合独活寄生丸治疗膝骨性关节炎临床疗效观察[J]. 中外医学研究, 2014, 12(31) : 10-12.
5. 邓中甲. 方剂学[M]. 北京：中国中医药出版社, 2004: 316.
6. 张丽秀, 钟慧, 周兆德, 等. 独活寄生汤加针刺治疗膝骨关节炎疗效观察[J]. 云南中医中药杂志, 2014, 35(6) : 29-30.
7. 陈湘鄂, 陈四海, 韩东等. 综合康复治疗膝关节骨关节炎临床观察[J]. 中华物理医学与康复杂志, 2006, 28(3) : 213-214.
8. 李磊世, 陈俊伟, 周金龙, 等. 双醋瑞因联合美洛昔康治疗膝骨关节炎临床研究[J]. 中国药物与临床, 2010, 10(1) : 91-93.
9. 石楸鸣. 独活寄生汤的药理作用及临床应用[J]. 中国医院用药评价与分析, 2010, 10(6) : 575-576.
10. 朱粟才, 许能新. 基于中医骨正筋柔理论治疗膝关节骨关节炎的疗效研究[J]. 中外医学研究, 2013, 11(1) : 33-34.
11. 黄武君, 谈志龙, 白人骁. 细胞因子与骨关节炎软骨退变的研究[J]. 中国骨伤, 2006, 19(9) : 635.
12. 李卿, 陆俊鸿, 刘韦, 等. 软骨细胞的老化对软骨蛋白聚糖代谢的影响[J]. 中国临床康复, 2003(2) : 216-218.
13. Leslie M . Knee osteoarthritis management therapiea[J]. Pain Mang Nuts, 2000, 1(2) : 51-57.
14. McAlindon TE, Lavalley MP, Gulin IP, et al. Glucosamine and chondroitin for treatment of osteoarthritis a systematic quality assessment[J]. JAMA, 2000, 283(11) : 1469-1475.
15. 许志宇, 李敏, 刘娜. 盐酸氨基葡萄糖治疗膝关节半月板的临床研究[J]. 中国中医药科技, 2014, 7(21) : 216-217.
16. 陈洁, 兰申玉, 刘伟, 等. 盐酸氨基葡萄糖与双醋瑞因治疗软骨关节炎的临床对照研究[J]. 华西医学, 2014, 29(6) : 1111-1114.
17. 何忠斌, 朱海波. 盐酸氨基葡萄糖对膝骨关节炎患者血清IL-1b、MMP-9 和TNF-α表达的影响和临床疗效[J]. 医学理论与实践,2015, (28) : 1566-1570.
18. 张百挡, 梁祖建, 张还添, 等. 盐酸/硫酸氨基葡萄糖治疗膝骨关节炎的成本效果分析[J]. 中国组织工程研究, 2012, 16(52) : 9867-9872.
19. 卢锋, 郭红卫. 盐酸氨基葡萄糖对骨关节炎作用机制的初步探讨[J]. 卫生研究, 2003, 32(6) : 594-597.
20. Da Camara CC, Dowless GV. Glucosamine sulfate for osteoarthritis[J]. Ann Phammcother, 1998, 32(5) : 580-587.
21. O’Rourke M. Determining the efficacy of glucosamine and chondroitin for osteoarthritis[J]. Nurse Prac, 2001, 26(6) : 44-46, 49-52.
22. 原巧宁, 梁淑芬, 牛洁, 等. 独活寄生汤治疗大鼠膝骨性关节炎软骨病理学分析[J]. 山西中医, 2015, 31(4) : 51-53.
23. 何时华. 膝骨关节炎的针灸治疗与康复训练[J]. 医学美学美容,2014(7) : 466.

West China Medical Journal

Clinical Observation on the Treatment of Knee Osteoarthritis by Combined Traditional Chinese Medicine and Western Medicine

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