The Clinical Research on Combined Glucosamine and Ozone in the Treatment of Knee Osteoarthritis_West China Medical Journal

Authors：

 FanWenjiang ¹ ,  LiuQing ²

1. Department of Pain, The First People’s Hospital of Neijiang, Neijiang, Sichuan 641000, P. R. China;
2. Department of Pain, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P. R. China;

Corresponding author：

LiuQing, Email: 1105859368@qq.com

Keywords：

Ozone; Glucosamine; Osteoarthritis, knee

DOI：

10.7507/1002-0179.201600225

Video：

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Objective To discuss the efficacy and safety of the joint application of oral glucosamine hydrochloride tablets and knee joint cavity ozone injection in the treatment of knee osteoarthritis. Methods From January 2014 to January 2015, 72 patients who matched the criteria of moderate knee osteoarthritis were randomly divided into two groups according to the table of random number: oral glucosamine hydrochloride tablet and knee joint cavity ozone injection group (group G+O) and ozone group (group O). Patients of group G+O orally took glucosamine hydrochloride tablets (0.48 g, 3 times/day) for twelve weeks, and ozone was injected into the patients’ knee joint once a week for the first four weeks. The treatment for group O patients was the same with Group G+O, except that the glucosamine hydrochloride tablets were replaced by glucosamine hydrochloride placebo (2 tablets, 3 times/day, taking orally). We recorded the Visual Analogue Scale (VAS) score, Western Ontario & McMaster University (WOMAC) osteoarthritis index score and the adverse reactions before treatment and in the first, third and sixth month after treatment. Results Patients’ VAS scores and WOMAC scores of both the two groups in the first, third and sixth month after treatment were significantly different from those before the treatment (P ＜ 0.05) . In the first month after treatment, there were no significant difference in patients’ VAS scores and WOMAC scores between the two groups (P ＞ 0.05) . In the third and sixth month after treatment, there were significant differences in patients’ VAS scores and WOMAC scores between the two groups (P ＜ 0.05) . There was no obvious adverse reactions during the treatment. Conclusions The combined application of oral glucosamine hydrochloride tablets and knee joint cavity ozone injection and the ozone treatment for moderate knee osteoarthritis are both effective, without any adverse reaction. The combined treatment of oral glucosamine hydrochloride tablets and knee joint cavity ozone injection on moderate knee osteoarthritis has better long-term efficacy, and it is worth spreading.

Citation： FanWenjiang, LiuQing. The Clinical Research on Combined Glucosamine and Ozone in the Treatment of Knee Osteoarthritis. West China Medical Journal, 2016, 31(5): 823-826. doi: 10.7507/1002-0179.201600225 Copy

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19.	Moretti M. Effectiveness of Oxygen-Ozone and Hyaluronic Acid Injections in De Quervain’s Syndrome[J]. Intern J Ozone Ther, 2012, 11 (1) : 31-33.
20.	何晓峰. 臭氧治疗的临床应用[M]. 北京: 科学出版社, 2009: 99-103.
21.	Scott JL, Gabrielides C, Davidson RK, et al. Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease[J]. Ann Rheum Dis, 2010, 69(8) : 1502-1510.

1. 李宁华. 中老年人群骨关节炎的流行病学特征[J]. 中国临床康复, 2005, 9(38) : 133-135.
2. 陈明生, 张毅, 唐晓兰, 等. 盐酸氨基葡萄糖片联合玻璃酸钠治疗退行性骨性膝关节炎的临床观察[J]. 临床军医杂志, 2012, 40(5) : 1082-1084.
3. Laba TL, Brien JA, Fransen M, et al. Patient preferences for adherence to treatment for osteoarthritis: the MEdication Decisions in Osteoarthritis Study (MEDOS)[J]. BMC Musculoskelet Disord, 2013, 14(1) : 1-9.
4. 曾广南, 冯沃军, 胡永祥, 等. 膝关节退行性骨关节炎常见压痛点的临床观察[J]. 中国中医骨伤杂志, 2007, 15(11) : 18-20.
5. 何文革, 闫冬梅, 李瑞阳. 臭氧联合盐酸氨基葡萄糖用于膝关节股性关节炎治疗的疗效[J]. 中国康复医学杂志, 2014, 29(7) : 675-676.
6. 高越, 王飞, 范宇, 等. 臭氧治疗骨关节炎研究进展[J]. 中国疼痛医学杂志, 2014, 20(6) : 427-429.
7. 唐令. 不同药物治疗膝骨性关节炎综合症状的效果[J]. 中国医药导报, 2015, 12(15) : 132-135.
8. 李英. 盐酸氨基葡萄糖治疗骨关节炎的临床研究[J]. 医药, 2015 (1) : 71.
9. 余素君, 胡钰镔, 魏薇. 盐酸氨基葡萄糖治疗骨关节炎的疗效与安全性观察[J]. 医学信息, 2014, 27(9) : 228.
10. 向成浩, 蒋从斌, 杨万波, 等. 盐酸氨基葡萄糖治疗膝骨关节炎的临床研究[J]. 华西医学, 2012, 27(12) : 1796-1799.
11. 叶杨, 高晓梅, 杨南萍. 双盲双模拟药物治疗中重度膝骨关节炎的安全性和疗效分析评价[J]. 中国现代医学杂志, 2015, 25(13) : 73-77.
12. Kapur N, Kamel IR, HerlichA. Oral and craniofacil pain: diagnosis, pathophysiology, and treatment[J]. Int Anesthesiol Clin, 2003, 41(3) : 115-150.
13. Bellamy N, Buchanan WW, Goldsmith CH, et al. Validation study of WOMAC: a health status instrument for measuring clinically important patientrelevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee [J]. J Rheumatol 1988, 15(12) : 1833-1840.
14. 曾伟南, 周宗科, 李海, 等. 氨基葡萄糖联合布洛芬与单用布洛芬治疗髋关节骨关节炎前瞻性随机对照临床研究[J]. 华西医学, 2012, 27(12) : 1805-1808.
15. 陈洁, 兰由玉, 刘伟, 等. 盐酸氨基葡萄糖与双醋瑞因治疗骨关节炎的临床对照研究[J].华西医学, 2014, 29(6) : 1111-1114.
16. 陈瑶, 俞泳, 何成奇. 膝骨关节炎患者本体感觉、肌力及关节功能的相关性研究[J]. 四川大学学报: 医学版, 2015, 46(6) : 880-884.
17. Ruane R, Griffiths P. Glucosamine therapy compared to ibuprofen for joint pain[J]. Br J Community Nurs, 2002, 7(3) : 148-152.
18. 王大寿, 王林, 安裕文. 臭氧对兔膝骨性关节炎关节冲洗液中细胞因子含量影响的实验研究[J]. 中国疼痛医学杂志, 2011, 17(1) : 59-60.
19. Moretti M. Effectiveness of Oxygen-Ozone and Hyaluronic Acid Injections in De Quervain’s Syndrome[J]. Intern J Ozone Ther, 2012, 11 (1) : 31-33.
20. 何晓峰. 臭氧治疗的临床应用[M]. 北京: 科学出版社, 2009: 99-103.
21. Scott JL, Gabrielides C, Davidson RK, et al. Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease[J]. Ann Rheum Dis, 2010, 69(8) : 1502-1510.

West China Medical Journal

The Clinical Research on Combined Glucosamine and Ozone in the Treatment of Knee Osteoarthritis

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