• 1. Department of Social Medicine and Health Service Management, Academy of Military Preventive Medicine, the Third Military Medical University, Chongqing 400038, P. R. China;
  • 2. 2. Disease Control and Prevention Center of Yuzhong District, Chongqing 400042, P. R. China;
  • 3. Department of Medical Record Statistics, the Second Hospital Affiliated to Chongqing Medical University ,Chongqing 400010, R. R. China;
  • 4. Department of Healthcare, Chongqing Children’s Hospital Affiliated to Chongqing Medical University, Chongqing 400038, P. R. China;
HeJia, Email: hejiahj@126.com
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Objective To explore the risk factors associated with severe hand-food-mouth disease (HFMD) in Chongqing, in order to carry out intervention work in the future, provide reference for reducing the incidence and fatality rate of severe HFMD cases. Methods Ninety severe HFMD cases treated between 2011 and 2014 in Chongqing were enrolled as case group while another 90 mild HFMD cases were randomly selected as control group in the same period. All subjects’ parents or babysitters were asked to fill in a questionnaire which included demography, ways of babysitting, behavior and the like. All HFMD cases were diagnosed by both clinical symptoms and nuclear acid testing. Data were processed by EpiData 3.1 and analyzed by SPSS 13.0. Results Single-factor analysis showed that there were 14 risk factors of severe HFMD including virus type, registered residence type, current address type, cultural degree of their caregivers, season of the onset, existence of fever and rash, first hospital diagnosis type, and whether the first diagnosis was HFMD (P < 0.05) . Multifactor analysis showed the risk factors included the current rural residence type [OR=27.29, 95%CI (3.71, 200.72) ], misdiagnosis as disease other than HFMD in the first visit to the hospital [OR=141.03, 95%CI (12.43, 1 599.70) ], and virus type of EV71 [OR=244.32, 95%CI (18.99, 3 143.74) ]. Conclusions Active surveillance should be carried out on the risk factors of severe HFMD. At the same time, active and effective preventive measures, and timely treatment of patients with severe HFMD can help to reduce the incidence and case fatality rate.

Citation: ZhangKe, HeJia, ZhouXiaolan, ChenXiangang, YangHui, GuanLongzhi. A Case-control Study on the Risk Factors of Severe Hand-foot-mouth Disease in Chongqing City. West China Medical Journal, 2016, 31(5): 875-879. doi: 10.7507/1002-0179.201600238 Copy

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