Study on the Model to Predict Thymus Volume with Two-dimensional Section Diameters among Fetuses_West China Medical Journal

Authors：

 KangMin ¹ ,  QiYana ^2,3 , ShaoJianbo ⁴ , MaHuijing ⁴ , ZhengNannan ⁴

1. Department of Radiology, Women and Children's Hospital of Sichuan Province, Chengdu, Sichuan 610042, P. R. China;
2. West China School of Public Health;
3. Continuing Education Department, West China Hospital;Sichuan University, Chengdu, Sichuan 610041, P. R. China;
4. Women and Children Health Care Center of Wuhan City, Wuhan, Hubei 430016, P. R. China;

Corresponding author：

QiYana, Email: qiyana2012@163.com

Keywords：

Fetal thymus; Volume; Model; Magnetic resonance imaging

DOI：

10.7507/1002-0179.20160024

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To study the model to predict thymus volume with two-dimensional section diameters among fetuses. Methods From September 2010 to March 2012, 210 singleton pregnant women suspected with fetal abnormality by prenatal ultrasonic testing were confirmed using MRI technology. Three two-dimensional section diameters of thymus were measured and the volume was calculated. No abnormal fetuses regarded as the standard, theoretical normal volume of fetal thymus was calculated. Paired t-test was used to compare the actual thymus volume with its corresponding theoretical normal value, and thus the fetuses were divided into two groups of normal and dysplasia so as to establish predictive model respectively. With two-dimensional section diameters as independent variables and thymus volume as dependent variable, the linear regression model was established. According to the model, the thymus volume was predicted and the error rate was calculated by formula: error rate=(predicted value-actual value) /actual value×100%. The Pearson correlation coefficient of error rate and fetal gestational age was calculated. Results The models of normal and dysplasia groups to predict thymus volume were lnV=0.016d₁+0.030d₂+0.086d₃+5.707+ε (R₂=0.510) and lnV=0.048d₁+0.036d₂+0.016d₃+6.011+ε (R₂=0.447). The average absolute values of predicted error rate were 4.34% and 5.34% and decreased with fetal gestational age (normal r=-0.264, P=0.007; dysplasia r=-0.182, P=0.060). Conclusion The prediction effects of above models are not so good and the model accuracy increases with fetal gestational age. Normal fetuses' model of different gestational age should be established to predict thymus volume by conducting large sample size study in the future. The modeling approach has certain practicability and clinical value and can be applied in ultrasonic technique.

Citation： KangMin, QiYana, ShaoJianbo, MaHuijing, ZhengNannan. Study on the Model to Predict Thymus Volume with Two-dimensional Section Diameters among Fetuses. West China Medical Journal, 2016, 31(1): 94-97. doi: 10.7507/1002-0179.20160024 Copy

1.	Zalel Y, Gamzu R, Mashiach S, et al. The development of the fetal thymus:an in utero sonographic evaluation[J]. Prenat Diagn, 2002, 22(2):114-117.
2.	凌乐文, 吕国荣. 产前超声检测胎儿胸腺[J]. 中国介入影像与治疗学, 2012, 9(2):133-135.
3.	El-Haieg DO, Zidan AA, El-Nemr MM. The relationship between sonographic fetal thymus size and the components of the systemic fetal inflammatory response syndrome in women with preterm prelabour rupture of membranes[J]. BJOG, 2008, 115(7):836-841.
4.	Cromi A, Ghezzi F, Raffaelli R, et al. Ultrasonographic measurement of thymus size in IUGR fetuses:a marker of the fetal immunoendocrine response to malnutrition[J]. Ultrasound Obstet Gynecol, 2009, 33(4):421-426.
5.	纪伟英, 郑名芳, 陈常佩, 等. 胎儿胸腺发育的超声测量[J]. 中国医学影像学杂志, 2010, 18(1):80-81.
6.	李凌. 二维、三维超声检测胎儿胸腺及胎儿先心病与22q11微缺失关联性探讨[D]. 长沙:中南大学, 2010.
7.	李凌, 周启昌, 邹琳, 等. 二维、三维超声技术检测正常胎儿胸腺的研究[J]. 中华超声影像学杂志, 2011, 20(1):53-57.
8.	玄英华. 胎儿胸腺的超声研究[D]. 北京:北京协和医学院, 2012.
9.	郑建国, 景玉萍, 康照昌, 等. 几种先天畸形胎儿胸腺的解剖及组织观察[J]. 湖北职业技术学院学报, 2006, 9(2):82-84.
10.	杨文娟, 吴青青. 胎儿畸形与22q11微缺失相关性的研究进展[J]. 中国妇产科临床杂志, 2011, 12(2):151-153.
11.	吕国荣, 李伯义, 李丽雅, 等. 超声评估心脏畸形及感染胎儿的胸腺发育[J]. 中国超声医学杂志, 2011, 27(5):451-454.
12.	李建斌, 刘学敏, 李德明, 等. 胎儿胸腺的观察和测量[J]. 长治医学院学报, 2003, 17(3):163-164.
13.	杨瑞琦, 郭凤军, 刘学娟, 等. 二维和三维超声测量胎儿胸腺在胎儿宫内生长迟缓时的应用[J]. 中华医学杂志, 2014, 94(33): 2607-2609.
14.	陈静, 刘彩霞, 尹少尉. 磁共振成像在胎儿异常中的临床应用研究[J]. 中国医科大学学报, 2008, 37(5):670-672, 678.
15.	朱铭. 胎儿磁共振——磁共振检查的新领域[J]. 磁共振成像, 2011, 2(1):7-12.

1. Zalel Y, Gamzu R, Mashiach S, et al. The development of the fetal thymus:an in utero sonographic evaluation[J]. Prenat Diagn, 2002, 22(2):114-117.
2. 凌乐文, 吕国荣. 产前超声检测胎儿胸腺[J]. 中国介入影像与治疗学, 2012, 9(2):133-135.
3. El-Haieg DO, Zidan AA, El-Nemr MM. The relationship between sonographic fetal thymus size and the components of the systemic fetal inflammatory response syndrome in women with preterm prelabour rupture of membranes[J]. BJOG, 2008, 115(7):836-841.
4. Cromi A, Ghezzi F, Raffaelli R, et al. Ultrasonographic measurement of thymus size in IUGR fetuses:a marker of the fetal immunoendocrine response to malnutrition[J]. Ultrasound Obstet Gynecol, 2009, 33(4):421-426.
5. 纪伟英, 郑名芳, 陈常佩, 等. 胎儿胸腺发育的超声测量[J]. 中国医学影像学杂志, 2010, 18(1):80-81.
6. 李凌. 二维、三维超声检测胎儿胸腺及胎儿先心病与22q11微缺失关联性探讨[D]. 长沙:中南大学, 2010.
7. 李凌, 周启昌, 邹琳, 等. 二维、三维超声技术检测正常胎儿胸腺的研究[J]. 中华超声影像学杂志, 2011, 20(1):53-57.
8. 玄英华. 胎儿胸腺的超声研究[D]. 北京:北京协和医学院, 2012.
9. 郑建国, 景玉萍, 康照昌, 等. 几种先天畸形胎儿胸腺的解剖及组织观察[J]. 湖北职业技术学院学报, 2006, 9(2):82-84.
10. 杨文娟, 吴青青. 胎儿畸形与22q11微缺失相关性的研究进展[J]. 中国妇产科临床杂志, 2011, 12(2):151-153.
11. 吕国荣, 李伯义, 李丽雅, 等. 超声评估心脏畸形及感染胎儿的胸腺发育[J]. 中国超声医学杂志, 2011, 27(5):451-454.
12. 李建斌, 刘学敏, 李德明, 等. 胎儿胸腺的观察和测量[J]. 长治医学院学报, 2003, 17(3):163-164.
13. 杨瑞琦, 郭凤军, 刘学娟, 等. 二维和三维超声测量胎儿胸腺在胎儿宫内生长迟缓时的应用[J]. 中华医学杂志, 2014, 94(33): 2607-2609.
14. 陈静, 刘彩霞, 尹少尉. 磁共振成像在胎儿异常中的临床应用研究[J]. 中国医科大学学报, 2008, 37(5):670-672, 678.
15. 朱铭. 胎儿磁共振——磁共振检查的新领域[J]. 磁共振成像, 2011, 2(1):7-12.

West China Medical Journal

Study on the Model to Predict Thymus Volume with Two-dimensional Section Diameters among Fetuses

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content