Analysis of Risk Factors of Diabetic Retinopathy_West China Medical Journal

Authors：

 WangHan ,  WangHaoyue

Department of Ophthalmology, the People’s Hospital of Tengzhou, Tengzhou, Shandong 277500, P. R. China;

Corresponding author：

WangHaoyue, Email: whyyk@126.com

Keywords：

Diabetes mellitus; Retinopathy; Risk factors

DOI：

10.7507/1002-0179.201600241

Video：

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Objective To explore the risk factors of diabetic retinopathy. Methods We retrospectively analyzed the clinical data of 137 patients with diabetes mellitus (DM) from July 2012 to July 2015. According to the situation of retinopathy, the patients were divided into three groups. Forty-three patients without retinopathy were regarded as the control group, 46 non-proliferative retinopathy patients as the observation group, and 48 patients with proliferative retinopathy as the trial group. DM blood pressure, blood glucose, glycosylated hemoglobin, blood lipid, albumin creatinine ratio and other indicators were collected and analyzed, and multiple-factor non-conditional logistic regression analysis was carried out. Results Glycosylated hemoglobin, total cholesterol, triglyceride, low density lipoproteincholesterol, high density lipoprotein cholesterol, body mass index, postprandial 2-hour blood glucose and fasting blood glucose were not significantly different among the three groups (P ＞ 0.05) , but the duration of diabetes, vascular endothelial growth factor and urinary albumin creatinine ratio were significantly different (P ＜ 0.05) . The diabetic duration, glycosylated hemoglobin, systolic blood pressure, urinary albumin creatinine ratio and vascular endothelial growth factor were independently associated with diabetic retinopathy (P ＜ 0.05) . Conclusion The prolonged disease course of diabetic patients, unstable status of blood glucose and blood pressure, and the increase of blood vessel growth factor and vascular endothelial growth factor can cause the development of diabetic retinopathy.

Citation： WangHan, WangHaoyue. Analysis of Risk Factors of Diabetic Retinopathy. West China Medical Journal, 2016, 31(5): 889-892. doi: 10.7507/1002-0179.201600241 Copy

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14.	尤巧英, 朱麒钱, 斯徐伟. 等血管生成素及其Tie-2受体与不同分级的2型糖尿病视网膜病变的相关性研究[J]. 中华内分泌代谢杂志, 2011, 27(8) : 561-563.
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17.	王晓梅, 金成吉, 张弢, 等. 血管内皮生长因子基因多态性与糖尿病视网膜病变的相关性[J]. 中国糖尿病杂志,2008,16(8) :462-464.
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1. 罗洁, 赵菊莲, 游志鹏, 等. 糖尿病视网膜病变危险因素的研究现状[J]. 中国实用眼科杂志, 2011, 29(1) : 14-17.
2. 彭晓燕,张永鹏. 糖尿病视网膜病变的治疗趋势[J]. 眼科, 2011, 20(4) : 217-221.
3. 胡安娣娜. 李涛, 罗燕, 等. 增殖性糖尿病视网膜病变的危险因素分析[J]. 中国实用眼科杂志, 2011, 29(9) : 925-928.
4. 李丰, 游志鹏, 谢琳, 等. 糖尿病视网膜病变危险因素及基因多态性研究进展[J]. 中国实用眼科杂志, 2015, 33(1) : 6-8.
5. 钱荣立. 关于糖尿病新诊断标准与分型的意义[J]. 临床内科杂志, 2000, 17(3) : 133.
6. 于湄, 苏志燕, 刘向祎, 等. 2型糖尿病视网膜病变的相关因素分析 [J]. 中国实验诊断学, 2010, 14(9) : 1434-1436.
7. Wilkinson CP, Ferris FL 3rd, Klein RE, et al. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales[J]. Ophthalmology, 2003, 110(9) : 1677-1682.
8. Stratton IM, Kohner EM, Aldington SJ, et al. UKPDS 50: risk factors for incidence and progression of retinopathy in Type Ⅱ diabetes over 6 years from diagnosis[J]. Diabetologia, 2001, 44(2) : 156-163.
9. 王芳, 王春芳, 闫建林, 等. 45岁以上糖尿病患者中糖尿病视网膜病变的患病率调查及相关危险因素分析[J]. 中华实验眼科杂志, 2013, 31(8) : 783-787.
10. Hayes AJ, Leal J, Gray AM, et al. UKPDS outcomes model 2: a new version of a model to simulate lifetime health outcomes of patients with type 2 diabetes mellitus using data from the 30 year united kingdom prospective diabetes study: UKPDS 82[J]. Diabetologia, 2013, 56(9) : 1925-1933.
11. 胡利, 李东豪, 陈慧. 糖尿病患者血糖控制相关因素与糖尿病视网膜病变发生的关系[J]. 中华眼底病杂志, 2011, 27(3) : 210-213.
12. Sayin N, Kara N, Pekel G. Ocular complications of diabetes mellitus[J]. World J Diabetes, 2015, 6(1) : 92-108.
13. Janghorbani M, Amini M, Ghanbari H, et al. Incidence of and risk factors for diabetic retinopathy in Isfahan, Iran[J]. Ophthalmic Epidemiol, 2003, 10(2) : 81-95.
14. 尤巧英, 朱麒钱, 斯徐伟. 等血管生成素及其Tie-2受体与不同分级的2型糖尿病视网膜病变的相关性研究[J]. 中华内分泌代谢杂志, 2011, 27(8) : 561-563.
15. Pfister F, Wang Y, Schreiter K, et al. Retinal overexpression of angiopoietin-2 mimics diabetic retinopathy and enhances vascular damages in hyperglycemia[J]. Acta Diabetol, 2010, 47(1) : 59-64.
16. 张振华, 耿燕, 孙清秀, 等. 438名眼科医师糖尿病视网膜病变相关知识的认知度调查与影响因素分析[J]. 中国实用眼科杂志, 2011, 29(7) : 735-738.
17. 王晓梅, 金成吉, 张弢, 等. 血管内皮生长因子基因多态性与糖尿病视网膜病变的相关性[J]. 中国糖尿病杂志,2008,16(8) :462-464.
18. Feghhi M, Nikzamir A, Esteghamati A, et al. Relationship of vascular endothelial growth factor (VEGF) +405 G/C polymorphism and proliferative retinopathy in patients with type 2 diabetes[J]. Transl Res, 2011, 158(2) : 85-91.

West China Medical Journal

Analysis of Risk Factors of Diabetic Retinopathy

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