实时三维超声心动图评价缺血性二尖瓣反流的研究进展_West China Medical Journal

Authors：

 刘佳霓 , 白文娟 ,  唐红

四川大学华西医院心脏内科（成都 610041）;

Corresponding author：

唐红, Email: hxyyth@gmail.com

Keywords：

缺血性二尖瓣反流; 实时三维超声心动图; 研究进展

DOI：

10.7507/1002-0179.201600264

Video：

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缺血性二尖瓣反流（IMR）是冠状动脉粥样硬化性心脏病心肌梗死常见并发症之一，增加患者心力衰竭和死亡的发生率。IMR 的形成机制复杂，目前研究尚未达成共识，导致IMR 治疗措施不完善及标准。随着三维超声技术日趋成熟，实时三维超声心动图（RT3DE）将矩阵探头、三维空间定位和高通道的数据处理系统3 种先进技术结合，不依赖任何几何形态的假设，全面获得心脏三维立体结构及动态改变。RT3DE 对深入研究IMR 发病机制，探讨有效的临床治疗方法，评估病情进展、判断治疗效果、评价长期预后有重要临床价值，可作为临床评价IMR的首选方法。

Citation： 刘佳霓, 白文娟, 唐红. 实时三维超声心动图评价缺血性二尖瓣反流的研究进展. West China Medical Journal, 2016, 31(5): 978-981. doi: 10.7507/1002-0179.201600264 Copy

1.	Arenson D, Goldsher N, Zukermann R , et al. Ischemic mitral regurgitation and risk of heart failure after myocardial infarction[J]. Arch Intern Med, 2006, 166(21): 2362-2368.
2.	Boyd JH. Ischemic mitral regurgitation[J]. Circ J, 2013, 77(8): 1952- 1956.
3.	张炬倩, 李晨, 饶莉. 缺血性二尖瓣反流的机制、诊断和治疗研究进展[J]. 心血管病学进展, 2009, 30(6): 919-922．.
4.	黄国倩, 蒋字雯, 颜平, 等. 三维超声心动图定量评价二尖瓣反流患者的二尖瓣及瓣环几何构型[J]. 中国介入影像与治疗学, 2009, 6(4): 352-355．.
5.	Daimon M, Saracino G, Fukuda S, et al. Dynamic change of mitral annular geometry and motion in ischemic mitral regurgitation assessed by a computerized 3D echo method[J]. Echocardiography, 2010, 27(9): 1069-1077.
6.	Daimon M, Saracino G, Gillinov AM, et al. Local dysfunction and asymmetrical deformation of mitral annular geometry in ischemic mitral regurgitation: a novel computerized 3D echocardiographic analysis[J]. Echocardiography, 2008 , 25(4): 414-423.
7.	Song JM, Fukuda S, Kihara T, et al. Value of mitral valve tenting volume determined by real time three-dimensional echocardiography in patients with functional mitral regurgitation[J]. Am J Cardiol, 2006, 98(8): 1088-1093．.
8.	Watanabe N, Ognsawara Y, Yamaura Y, et al. Quantification of mitral valve tenting in ischemic mitral regurgitation by transthoracie real-time three-dimensional echocardiography[J].J Am Coil Cardiol, 2005, 45(5): 763-769．.
9.	Tibayan FA, Wilson A, Lai DT, et al. Tenting volume: threedimensional assessment of geometric perturbations in functional mitral regurgitation and implications for surgical repair[J]. J Heart Valve Dis, 2007, 16(1): 1-7.
10.	Veronesi F, Corsi C, Sugeng L, et al. Quantification of mitral apparatus dynamics in functional and ischemic mitral regurgitation using real-time 3-dimensional echocardiography[J]. J Am Soc Echocardiogr, 2008, 21(4): 347-354.
11.	王林林, 何怡华, 陈健, 等. 实时三维TEE评价犬二尖瓣对合程度与二尖瓣反流程度的关系[J]. 中国医学影像技术, 2012, 28(7): 1263-1267.
12.	贺林, 王新房, 谢明星, 等. 实时三维超声心动图对正常二尖瓣与功能性反流二尖瓣闭合线的对比研究[J]. 临床超声医学杂志, 2010, 12(10): 665-669.
13.	Matsumura Y, Fukuda S, Tran H, et al. Geometry of the proximal isovelocity surface area in mitral regurgitation by 3-dimensional color Doppler echocardiography: difference between functional mitral regurgitation and prolapse regurgitation[J]. Am Heart J 2008, 155(2): 231-238.
14.	Song JM, Kim MJ, Kim YJ. Three-dimensional characteristics of functional mitral regurgitation in patients with severe left ventricular dysfunction: a real-time three-dimensional color Doppler echocardiography study [J]. Heart , 2008, 94(5): 590-596.
15.	LittIe S, Igo SR, Pirant B, et al. In UitrovaIidation of real-time three dimensional color Doppler echocardiography for direct measurement of proximal isovelocity surface area in mitral regurgitation [J]. Am J CardiaoI, 2007, 99(10): 1440-1447.
16.	Grady L, Datta S, Kutter O, et al. Regurgitation quantification using 3D PISA in volume echocardiography[J]. Med Image Comput Assist Interv, 2011, 14(3): 512-519.
17.	Little SH, Pirat B, Kumar R, et al. Three-dimensional color Doppler echocardiography for direct measurement of vena contracta area in mitral regurgitation: in vitro validation and clinical experience[J]. JACC Cardiovasc Imaging, 2008, 1(6): 695-704.
18.	Hyodo E, Iwata S, Tugcu A, et al. Direct measurement of multiple vena contracta areas for assessing the severity of mitral regurgitation using 3D TEE[J]. JACC Cardiovasc Imaging, 2012, 5(7): 669-676.
19.	Yosefy C, Hung J, Chua S, et al. Direct measurement of vena contracta area by real-time 3-dimensional echocardiography for assessing severity of mitral regurgitation[J]. Am J Cardiol, 2009, 104(7): 978-983.
20.	Zeng X, Levine RA, Hua L, et al. Diagnostic value of vena contracta area in the quantification of mitral regurgitation severity by color Doppler 3D echocardiography[J]. Circ Cardiovasc Imaging, 2011, 4(5): 506-513.
21.	Chandra S, SalgoI S, Sugeng L, et al. A three-dimensional insight into the complexity of flow convergence in mitralregurgitation: adjunctive benefit of anatomic regurgitant orifice area[J]. Am J Physiol Heart Circ Physiol, 2011, 301(3): 1015-1024.
22.	Altiok E, Hamada S, van HallS, et al. Comparison of direct planimetry of mitral valve regurgitation orifice area by threedimensional transesophageal echocardiography to effective regurgitant orifice area obtained by proximal flow convergence method and vena contracta area determined by color Doppler echocardiography[J]. Am J Cardiol, 2011, 107(3): 452-458.
23.	Thavendiranathan P, Liu S, Datta S, et al. Automated quantification of mitral inflow and aortic outflow stroke volumes by threedimensional real-time volume color-flow Doppler transthoracic echocardiography: comparison with pulsed-wave Doppler and cardiac magnetic resonance imaging[J]. J Am Soc Echocardiogr, 2012, 25(1): 56-65.
24.	王吴刚, 林琼雯, 吴伟春, 等. 全身成像模式三维量化法评估二尖瓣反流体积与近端血流等速面法的对比研究[J]. 中国循环杂志, 2014, 29(1): 35-39.
25.	Abe Y, Imai T, Ohue K, et al. Relation between reduction in ischemic mitral regurgitation and improvement in regional left ventricular contractility during low dose dobutamine stress echocardiography[J]. Heart, 2005, 91(8): 1092-1093.
26.	文利, 高云华, 郑嘉荣, 等. 实时三维超声对慢性心肌缺血负荷前后左心室收缩同步性的实验研究[J]. 中华超声影像学杂志, 2010, 19(9): 806-810.

1. Arenson D, Goldsher N, Zukermann R , et al. Ischemic mitral regurgitation and risk of heart failure after myocardial infarction[J]. Arch Intern Med, 2006, 166(21): 2362-2368.
2. Boyd JH. Ischemic mitral regurgitation[J]. Circ J, 2013, 77(8): 1952- 1956.
3. 张炬倩, 李晨, 饶莉. 缺血性二尖瓣反流的机制、诊断和治疗研究进展[J]. 心血管病学进展, 2009, 30(6): 919-922．.
4. 黄国倩, 蒋字雯, 颜平, 等. 三维超声心动图定量评价二尖瓣反流患者的二尖瓣及瓣环几何构型[J]. 中国介入影像与治疗学, 2009, 6(4): 352-355．.
5. Daimon M, Saracino G, Fukuda S, et al. Dynamic change of mitral annular geometry and motion in ischemic mitral regurgitation assessed by a computerized 3D echo method[J]. Echocardiography, 2010, 27(9): 1069-1077.
6. Daimon M, Saracino G, Gillinov AM, et al. Local dysfunction and asymmetrical deformation of mitral annular geometry in ischemic mitral regurgitation: a novel computerized 3D echocardiographic analysis[J]. Echocardiography, 2008 , 25(4): 414-423.
7. Song JM, Fukuda S, Kihara T, et al. Value of mitral valve tenting volume determined by real time three-dimensional echocardiography in patients with functional mitral regurgitation[J]. Am J Cardiol, 2006, 98(8): 1088-1093．.
8. Watanabe N, Ognsawara Y, Yamaura Y, et al. Quantification of mitral valve tenting in ischemic mitral regurgitation by transthoracie real-time three-dimensional echocardiography[J].J Am Coil Cardiol, 2005, 45(5): 763-769．.
9. Tibayan FA, Wilson A, Lai DT, et al. Tenting volume: threedimensional assessment of geometric perturbations in functional mitral regurgitation and implications for surgical repair[J]. J Heart Valve Dis, 2007, 16(1): 1-7.
10. Veronesi F, Corsi C, Sugeng L, et al. Quantification of mitral apparatus dynamics in functional and ischemic mitral regurgitation using real-time 3-dimensional echocardiography[J]. J Am Soc Echocardiogr, 2008, 21(4): 347-354.
11. 王林林, 何怡华, 陈健, 等. 实时三维TEE评价犬二尖瓣对合程度与二尖瓣反流程度的关系[J]. 中国医学影像技术, 2012, 28(7): 1263-1267.
12. 贺林, 王新房, 谢明星, 等. 实时三维超声心动图对正常二尖瓣与功能性反流二尖瓣闭合线的对比研究[J]. 临床超声医学杂志, 2010, 12(10): 665-669.
13. Matsumura Y, Fukuda S, Tran H, et al. Geometry of the proximal isovelocity surface area in mitral regurgitation by 3-dimensional color Doppler echocardiography: difference between functional mitral regurgitation and prolapse regurgitation[J]. Am Heart J 2008, 155(2): 231-238.
14. Song JM, Kim MJ, Kim YJ. Three-dimensional characteristics of functional mitral regurgitation in patients with severe left ventricular dysfunction: a real-time three-dimensional color Doppler echocardiography study [J]. Heart , 2008, 94(5): 590-596.
15. LittIe S, Igo SR, Pirant B, et al. In UitrovaIidation of real-time three dimensional color Doppler echocardiography for direct measurement of proximal isovelocity surface area in mitral regurgitation [J]. Am J CardiaoI, 2007, 99(10): 1440-1447.
16. Grady L, Datta S, Kutter O, et al. Regurgitation quantification using 3D PISA in volume echocardiography[J]. Med Image Comput Assist Interv, 2011, 14(3): 512-519.
17. Little SH, Pirat B, Kumar R, et al. Three-dimensional color Doppler echocardiography for direct measurement of vena contracta area in mitral regurgitation: in vitro validation and clinical experience[J]. JACC Cardiovasc Imaging, 2008, 1(6): 695-704.
18. Hyodo E, Iwata S, Tugcu A, et al. Direct measurement of multiple vena contracta areas for assessing the severity of mitral regurgitation using 3D TEE[J]. JACC Cardiovasc Imaging, 2012, 5(7): 669-676.
19. Yosefy C, Hung J, Chua S, et al. Direct measurement of vena contracta area by real-time 3-dimensional echocardiography for assessing severity of mitral regurgitation[J]. Am J Cardiol, 2009, 104(7): 978-983.
20. Zeng X, Levine RA, Hua L, et al. Diagnostic value of vena contracta area in the quantification of mitral regurgitation severity by color Doppler 3D echocardiography[J]. Circ Cardiovasc Imaging, 2011, 4(5): 506-513.
21. Chandra S, SalgoI S, Sugeng L, et al. A three-dimensional insight into the complexity of flow convergence in mitralregurgitation: adjunctive benefit of anatomic regurgitant orifice area[J]. Am J Physiol Heart Circ Physiol, 2011, 301(3): 1015-1024.
22. Altiok E, Hamada S, van HallS, et al. Comparison of direct planimetry of mitral valve regurgitation orifice area by threedimensional transesophageal echocardiography to effective regurgitant orifice area obtained by proximal flow convergence method and vena contracta area determined by color Doppler echocardiography[J]. Am J Cardiol, 2011, 107(3): 452-458.
23. Thavendiranathan P, Liu S, Datta S, et al. Automated quantification of mitral inflow and aortic outflow stroke volumes by threedimensional real-time volume color-flow Doppler transthoracic echocardiography: comparison with pulsed-wave Doppler and cardiac magnetic resonance imaging[J]. J Am Soc Echocardiogr, 2012, 25(1): 56-65.
24. 王吴刚, 林琼雯, 吴伟春, 等. 全身成像模式三维量化法评估二尖瓣反流体积与近端血流等速面法的对比研究[J]. 中国循环杂志, 2014, 29(1): 35-39.
25. Abe Y, Imai T, Ohue K, et al. Relation between reduction in ischemic mitral regurgitation and improvement in regional left ventricular contractility during low dose dobutamine stress echocardiography[J]. Heart, 2005, 91(8): 1092-1093.
26. 文利, 高云华, 郑嘉荣, 等. 实时三维超声对慢性心肌缺血负荷前后左心室收缩同步性的实验研究[J]. 中华超声影像学杂志, 2010, 19(9): 806-810.

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West China Medical Journal

实时三维超声心动图评价缺血性二尖瓣反流的研究进展

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