• 1. Department of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
  • 2. Jinyang Community Health Services Center, Chengdu, Sichuan 610041, P. R. China;
ChenXiaoping, Email: chenxp13@aliyun.com
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Objective To investigate the correlation between lipid accumulation product (LAP) and risk of ischemic cardiovascular disease (ICVD). Methods This cross-sectional study was performed among community residents from an urban community in Chengdu area between September 2011 and June 2012. Questionnaire survey was carried out. Each individual underwent biochemistry analysis and physical examination. In addition, brachial-ankle pulse wave velocity (BaPWV) and augmentation index (AI) were detected. Pearson correlation analysis was performed to explore the relationship between LAP and each cardiovascular risk factor. Liner regression model was used to analyze the relationship between LAP and ICVD. Results A total of 780 individuals with complete data were included in the analysis. LAP was correlated with blood pressure, total cholesterol, high density lipoprotein cholesterol, fasting blood glucose, and BaPWV (P<0.05). LAP was associated with the risk of ICVD (r=0.253, P<0.001). After being adjusted with sex, age and other cardiovascular risk factors, LAP was also correlated with the risk of ICVD (r=0.050, P<0.001). Conclusions High LAP is associated with elevated cardiovascular risks and subclinical vascular damage. In addition, LAP is correlated with ICVD risk, thus it may be used to predict the incidence of ICVD to some extent. However, as the correlation is weak, our study does not support the direct use of this indicator to predict ICVD. Large-sample studies based on different races and ages are needed.

Citation: ZhaoWanyan, WangYong, ChenXiaoping. Research on the Correlation between Lipid Accumulation Product and the Risk of Ischemic Cardiovascular Disease in Middle-aged and Elderly People of Chengdu Area. West China Medical Journal, 2016, 31(6): 1053-1056. doi: 10.7507/1002-0179.201600283 Copy

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