Villoglandular Carcinoma of Cervix: A Clinicopathological Analysis_West China Medical Journal

Authors：

 ChenShigao , HuangLin , YangMingdong , LiuMingyan

Department of Pathology, the People's Hospital of Chengdu Tianfu New Area, Chengdu, Sichuan 610213, P. R. China;

Corresponding author：

Keywords：

Cervix neoplasms; Villoglandular carcinoma; Differential diagnosis; Clinicopathology

DOI：

10.7507/1002-0179.201600287

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Objective To investigate the clinicopathological features, diagnosis and differential diagnosis of villoglandular carcinoma of the uterine cervix. Methods The clinical data of a 34-year-old patient diagnosed with villoglandular carcinoma of cervix on April 6, 2010 was retrospectively analyzed. Surgical excision samples were analyzed by means of hematoxylin-eosin and immunohistochemical staining. Results The gross appearance of the tumor mass showed cauliflower-like pattern of growth. Histologically, it was similar to colorectal villoglandular adenoma, and was composed of branching papillae shaped like villous glandular tube structure, and the surface was coated with pseudostratified or stratified columnar cells which showed mild atypia and uncommon mitotic figures. Immunohistochemically, tumor cells were positive for carcinoma embryonic antigen, CK7 and CA125, and negative for estrogen receptor, progesterone receptor, P16, p53 and vimentin. This patient was subjected to a follow-up of 48 months, and was alive without recurrence or metastasis. Conclusions Villoglandular carcinoma of the uterine cervix is rare and has a favorable prognosis. The diagnosis of villoglandular carcinoma depends on pathological morphology, and meanwhile, it is necessary to distinguish villoglandular carcinoma from other benign and malignant tumors which exhibited papillary growth pattern.

Citation： ChenShigao, HuangLin, YangMingdong, LiuMingyan. Villoglandular Carcinoma of Cervix: A Clinicopathological Analysis. West China Medical Journal, 2016, 31(6): 1069-1072. doi: 10.7507/1002-0179.201600287 Copy

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4.	朱伦, 施雅, 郭庆, 等. 宫颈绒毛管状腺癌11例临床病理学特征及文献复习[J]. 临床与实验病理学杂志, 2013, 29(5): 506-510.
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6.	Korach J, Machtinger R, Perri T, et al. Villoglandular papillary adenocarcinoma of the uterine cervix: a diagnostic challenge[J]. Acta Obstet Gynecol Scand, 2009, 88(3): 355-358.
7.	Giordano G, D’Adda T, Gnetti L, et al. Villoglandular adenocarcinoma of the cervix two new cases with morphological and molecular study[J]. Int J Gynecol Pathol, 2007, 26(2): 199-204.
8.	Rubesa-Mihaljević R, Vrdoljak-Mozetic D, Ostojić DV, et al. Villoglandular papillary adenocarcinoma of the uterine cervix with aggressive clinical course-a case report[J]. Coll Antropol, 2010, 34(1): 291-294.
9.	Polat A, Düsmez D, Pata O, et al. Villoglandular papillary adenocarcinoma of the uterine cervix with immunohistochemical characteristics[J]. J Exp Clin Cancer Res, 2002, 21(3) : 425-427.
10.	Choi Y, Kim H, Choi H, et al. Liquid-based cytology of villoglandular adenocarcinoma of the cervix: a report of 3 cases[J]. Korean J Pathol, 2012, 46(2): 215-220.
11.	刘政操, 郑璐, 霍云龙, 等. 宫颈绒毛管状腺癌临床病理分析[J]. 中华病理学杂志, 2010, 39(5): 338-339.
12.	喻金梅, 安云婷, 邹美燕. 宫颈绒毛管状腺癌3例临床病理特点及文献复习[J]. 实用癌症杂志, 2015, 30(1): 151-152.
13.	Gurumurthy M, Lahiri R, Kennedy AM, et al. A case of villoglandular papillary adenocarcinoma of the cervix with vaginal skip metastasis[J]. Gynecol Oncol Case Rep, 2011, 1(1): 1-3.
14.	Takai N, Hayashita C, Nakamura S, et al. Villoglandular papillary adenocarcinoma of the uterine cervix diagnosed during pregnancy[J]. Eur J Gynaecol Oncol, 2010, 31(5): 573-574.
15.	Lavie O, Segev Y, Peer G, et al. Conservative management for villoglandular papillary adenocarcinoma of the cervix diagnosed during pregnancy followed by a successful term delivery: a case report and a review of the literature[J]. Eur J Surg Oncol, 2008, 34(5): 606-608.

1. Young RH, Scully RE. Villoglandular papillary adenocarcinoma of the uterine cervix, a clinicopathologic analysis of 13 cases[J]. Cancer, 1989, 63 (9): 1773-1779.
2. Lataifeh IM, Al-Hussaini M, Uzan C, et al. Villoglandular papillary adenocarcinoma of the cervix: a series of 28 cases including two with lymph node metastasis[J]. Int J Gynecol Cancer, 2013, 23(5): 900-905.
3. González-Bosquet E, Suñol M, Morante D, et al. Villoglandular papillary adenocarcinoma of the uterine cervix: a case report and literature review[J]. Eur J Gynaecol Oncol, 2009, 30(2): 211-213.
4. 朱伦, 施雅, 郭庆, 等. 宫颈绒毛管状腺癌11例临床病理学特征及文献复习[J]. 临床与实验病理学杂志, 2013, 29(5): 506-510.
5. Choi Y, Kim H, Choi H, et al. Liquid-based cytology of villoglandular adenocarcinoma of the cervix: a report of 3 cases[J]. Korean J Pathol, 2012, 46(2): 215-220.
6. Korach J, Machtinger R, Perri T, et al. Villoglandular papillary adenocarcinoma of the uterine cervix: a diagnostic challenge[J]. Acta Obstet Gynecol Scand, 2009, 88(3): 355-358.
7. Giordano G, D’Adda T, Gnetti L, et al. Villoglandular adenocarcinoma of the cervix two new cases with morphological and molecular study[J]. Int J Gynecol Pathol, 2007, 26(2): 199-204.
8. Rubesa-Mihaljević R, Vrdoljak-Mozetic D, Ostojić DV, et al. Villoglandular papillary adenocarcinoma of the uterine cervix with aggressive clinical course-a case report[J]. Coll Antropol, 2010, 34(1): 291-294.
9. Polat A, Düsmez D, Pata O, et al. Villoglandular papillary adenocarcinoma of the uterine cervix with immunohistochemical characteristics[J]. J Exp Clin Cancer Res, 2002, 21(3) : 425-427.
10. Choi Y, Kim H, Choi H, et al. Liquid-based cytology of villoglandular adenocarcinoma of the cervix: a report of 3 cases[J]. Korean J Pathol, 2012, 46(2): 215-220.
11. 刘政操, 郑璐, 霍云龙, 等. 宫颈绒毛管状腺癌临床病理分析[J]. 中华病理学杂志, 2010, 39(5): 338-339.
12. 喻金梅, 安云婷, 邹美燕. 宫颈绒毛管状腺癌3例临床病理特点及文献复习[J]. 实用癌症杂志, 2015, 30(1): 151-152.
13. Gurumurthy M, Lahiri R, Kennedy AM, et al. A case of villoglandular papillary adenocarcinoma of the cervix with vaginal skip metastasis[J]. Gynecol Oncol Case Rep, 2011, 1(1): 1-3.
14. Takai N, Hayashita C, Nakamura S, et al. Villoglandular papillary adenocarcinoma of the uterine cervix diagnosed during pregnancy[J]. Eur J Gynaecol Oncol, 2010, 31(5): 573-574.
15. Lavie O, Segev Y, Peer G, et al. Conservative management for villoglandular papillary adenocarcinoma of the cervix diagnosed during pregnancy followed by a successful term delivery: a case report and a review of the literature[J]. Eur J Surg Oncol, 2008, 34(5): 606-608.

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West China Medical Journal

Villoglandular Carcinoma of Cervix: A Clinicopathological Analysis

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