外用噻吗洛尔治疗婴幼儿血管瘤的临床研究_West China Medical Journal

Authors：

 杜继宇 , 郭军 , 董金容 , 张毅 ,  余静

绵阳市中心医院儿科, 四川绵阳 621000;

Corresponding author：

杜继宇, Email: 913293628@qq.com; 余静, Email: yujingjing62666@163.com

Keywords：

噻吗洛尔; 婴幼儿血管瘤; 治疗效果

DOI：

10.7507/1002-0179.201600295

Video：

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目的研究外用噻吗洛尔用于治疗婴幼儿血管瘤（IH）的临床效果。方法选择 2012 年 5 月-2014年 5 月共 90 例 IH 患儿治疗前行相关检查排除禁忌证，通过超声检查分为浅表型（n=40）、深部型（n=20）及混合性（n=30）3 组，均采用外用噻吗洛尔治疗，每月复查 1 次，通过用药前及用药后 3 个月进行疗效评价，采用 Achauer 疗效评定法进行分级评定。结果所有治疗患儿均无不良反应发生，浅表型 IH 治疗后Ⅲ级以上疗效率达 82.5%，深部型 IH 治疗后Ⅲ级以上疗效率为 20%，而混合型 IH 治疗后Ⅲ级以上疗效率为 50%，噻吗洛尔治疗浅表型 IH 疗效明显优于深部型 IH（P<0.05）。结论外用噻吗洛尔治疗浅表型 IH 安全有效。

Citation： 杜继宇, 郭军, 董金容, 张毅, 余静. 外用噻吗洛尔治疗婴幼儿血管瘤的临床研究. West China Medical Journal, 2016, 31(6): 1095-1096. doi: 10.7507/1002-0179.201600295 Copy

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1. Drolet B, Esterly NB, Frieden IJ. Hemangiomas in children[J]. N Engl J Med, 1999, 341(3) :173-181.
2. Metry D. Update on hemangiomas of infancy[J]. Curr Opin Pediatr, 2004, 16(4) :373-377.
3. Zimmermann AP, Wiegand S, Werner JA, et al. Propranolol therapy for infantile haemangiomas:review of the literature[J]. Int J Pediatr Otorhinolaryngol, 2010, 74(4) :338-342.
4. 池晨. 临床应用普萘洛尔的注意事项[J]. 中国药物与临床, 2004, 4(2) :139.
5. Waner M, Suen JY. A classification of congenital vascular lesions[M]//Waner M, Suen JY. Hemangiomas and vascular malformations of the head and neck. New York:Wiley-Liss,1999:1-12.
6. Achauer BM, Chang CJ, Vander Kam VM. Management of hemangioma of infancy:review of 245 patients[J]. Plast Reconstr Surg, 1997, 99(5) :1301-1308.
7. Léauté-Labrèze C, Dumas de la Roque E, Hubiche T, et al. Propranolol for severe hemangiomas of infancy[J]. N Engl J Med, 2008, 358(24) :2649-2651.
8. Guo S, Ni N. Topical treatment for capillary hemangioma of the eyelid using beta-blocker solution[J]. Arch Ophthalmol, 2010, 128(2) :255-256.
9. Semkova K, Kazandjieva J. Topical timolol maleate for treatment of infantile haemangiomas:preliminary results of a prospective study[J]. Clin Exp Dermatol, 2013, 38(2) :143-146.

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West China Medical Journal

外用噻吗洛尔治疗婴幼儿血管瘤的临床研究

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