Clinical Efficacy and Safety of Glucosamine Hydrochloride in the Treatment of Osteoarthritis_West China Medical Journal

Authors：

 CenYi ¹ , YanGuangjian ² ,  WangChuan'en ²

1. Emergency Department, Sport Hospital Attached to Chengdu Sport Institute, Chengdu, Sichuan 610041, P. R. China;
2. Department of Spinal Surgery, Sport Hospital Attached to Chengdu Sport Institute, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

WangChuan'en, Email: 420326301@qq.com

Keywords：

Osteoarthritis,knee; Glucosamine hydrochloride; Efficacy; Safety

DOI：

10.7507/1002-0179.201600317

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the efficacy and safety of glucosamine hydrochloride in the treatment of osteoarthritis. Methods A total of 150 patients with osteoarthritis treated between April 2014 and April 2015 were randomly divided into control group and trial group with 75 in each. Patients in the trial group accepted oral glucosamine hydrochloride, while those in the control group were given diclofenac sodium. Lequesne index, total effective rate and the incidence of adverse reactions of both groups were calculated before and 2, 4, 6 and 8 weeks after treatment, and 2 weeks after drug withdrawal. Results In both groups, Lequesne index started to decrease after 2 weeks of treatment (P<0.05), and reached the minimum value at treatment week eight (P<0.05). The Lequesne index 2 weeks after drug withdrawal was still obviously lower than that before treatment (P<0.05). There was no significant differences in the total effective rate at treatment week eight (83.1% for the control group and 80.9% for the trial group) or the total effective rate 2 weeks after drug withdrawal (80.0% for the control group and 79.4% for the trial group) between the control group and the trial group (P>0.05). The incidence of adverse reactions of the trial group (6.7%) was significantly lower than that of the control group (21.3%) (P<0.05). Conclusion Glucosamine hydrochloride is effective and safe in the treatment of osteoarthritis, which is suitable for long-term treatment.

Citation： CenYi, YanGuangjian, WangChuan'en. Clinical Efficacy and Safety of Glucosamine Hydrochloride in the Treatment of Osteoarthritis. West China Medical Journal, 2016, 31(7): 1164-1166. doi: 10.7507/1002-0179.201600317 Copy

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13.	唐进, 杨涛, 熊小江, 等. 盐酸氨基葡萄糖联合塞来昔布治疗不同程度膝关节骨性关节炎的临床研究[J]. 现代生物医学进展, 2015, 15(2):294-297.
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1. Valdes AM, Spector TD. The genetic epidemiology of osteoarthritis[J]. Curr Opin Rheumatol, 2010, 22(2):139-143.
2. Cushnaghan J, Dieppe P. Study of 500 patients with limb joint osteoarthritis. I. Analysis by age,sex,and distribution of symptomatic joint sites[J]. Ann Rheum Dis, 1991, 50(1):8-13.
3. 李玉飞. 湖南省中老年膝骨关节炎的流行病学调查研究[D]. 长沙:中南大学, 2013.
4. 谭静雅, 杨南萍. 骨关节炎的发病机制及其诊治的研究进展[J]. 华西医学, 2012, 27(12):1828-1832.
5. Recht MP, Kramer J, Marcelis S, et al. Abnormalities of articular cartilage in the knee:analysis of available MR techniques[J]. Radiology, 1993, 187(2):473-478.
6. Bliddal H, Christensen RD, Kristensen PK, et al. Glucosamine effectiveness in the treatment of knee osteoarthritis. Presentation of a Cochrane analysis with the perspective on the GAIT trial[J]. Ugeskr Laeger, 2006, 168(50):4405-4409.
7. Lequesne MG, Samson M. Indices of severity in osteoarthritis for weight bearing joints[J]. J Rheumatol Suppl, 1991, 27:16-18.
8. Behery O, Siston RA, Harris JD, et al. Treatment of cartilage defects of the knee:expanding on the existing algorithm[J]. Clin J Sport Med, 2014, 24(1):21-30.
9. Salazar J, Bello L, Chávez M, et al. Glucosamine for osteoarthritis:biological effects, clinical efficacy, and safety on glucose metabolism[J]. Arthritis, 2014, 2014:432463.
10. 石晓明, 于占革. 骨关节炎发病机制的研究进展[J]. 中华临床医师杂志:电子版, 2013, 12(24):11607-11610.
11. Permuy M, Guede D, López-Peña M, et al. Effects of glucosamine and risedronate alone or in combination in an experimental rabbit model of osteoarthritis[J]. BMC Vet Res, 2014, 10(1):97.
12. 闵华, 蒙珍. 双氯芬酸钠联合盐酸氨基葡萄糖治疗膝骨关节炎60例[J]. 中国药业, 2013, 22(9):31-32.
13. 唐进, 杨涛, 熊小江, 等. 盐酸氨基葡萄糖联合塞来昔布治疗不同程度膝关节骨性关节炎的临床研究[J]. 现代生物医学进展, 2015, 15(2):294-297.
14. Jordan KM, Arden NK, Doherty M, et al. EULAR recommendations 2003:an evidence based approach to the management of knee osteoarthritis:report of a task force of the Standing Committee for international clinical studies including therapeutic trials (ESCISIT)[J]. Ann Rheum Dis, 2003, 62(12):1145-1155.

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Clinical Efficacy and Safety of Glucosamine Hydrochloride in the Treatment of Osteoarthritis

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