Observation of the Clinical Curative Effect of Arthroscopic Debridement Combined with Glucosamine Hydrochloride Tablets in the Treatment of Knee Osteoarthritis_West China Medical Journal

Authors：

 MaoXianfa , ZhuLijun , LiHong , SongXiaoyan

Department of Orthopedics, People's Hospital of Wenjiang District, Chengdu, Sichuan 611130, P. R. China;

Corresponding author：

Keywords：

Osteoarthritis,knee; Arthroscopic debridement; Glucosamine hydrochloride

DOI：

10.7507/1002-0179.201600325

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Objective To investigate the effect of arthroscopic debridement combined with oral glucosamine hydrochloride tablets in the treatment of knee osteoarthritis. Methods Sixty-two patients with knee osteoarthritis treated between January 2013 and April 2015 were chosen to be our research subjects. They were randomly divided into trial group (n=31) and control group (n=31). The control group was treated with arthroscopic debridement, and the trial group was given glucosamine hydrochloride tablets for treatment, apart from arthroscopic debridement. We evaluated the clinical effects by visual analogue scale (VAS) score and Lysholm knee joint function score before, and 1 week, 4 weeks, 3 months and 6 months after surgery. Results One week after surgery, the VAS score and Lysholm knee joint function score were not significantly different between the two groups (P>0.05). Four weeks, 3 months and 6 months after surgery, the VAS score of the trial group was respectively 3.08±0.91, 2.46±0.87, and 1.45±0.66, and was 5.47±1.02, 3.55±1.20, and 2.37±0.53 in the control group; the Lysholm score of the trial group was 80.55±2.24, 85.35±1.79, and 89.74±4.58, respectively, and of the control group was 72.55±4.47, 74.68±2.94, and 76.69±5.63. The VAS score and the Lysholm score of the trial group were both better than those of the control group (P<0.05). Conclusion Arthroscopic debridement can alleviate the symptoms of knee osteoarthritis, and oral administration of glucosamine hydrochloride tablets after surgery has obvious effects.

Citation： MaoXianfa, ZhuLijun, LiHong, SongXiaoyan. Observation of the Clinical Curative Effect of Arthroscopic Debridement Combined with Glucosamine Hydrochloride Tablets in the Treatment of Knee Osteoarthritis. West China Medical Journal, 2016, 31(7): 1193-1195. doi: 10.7507/1002-0179.201600325 Copy

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9.	何文革, 闫冬梅, 李瑞阳, 等. 膝关节滑膜炎关节镜术后口服盐酸氨基葡萄糖的疗效[J]. 2015, 43(2):186-189.
10.	Wise BL, Niu J, Zhang Y. The association of parity with osteoarthritis and knee replacement in the multicenter osteoarthritis study[J]. Osteoarthritis Cartilage, 2013, 21(12):1849-1854.
11.	Lee YH, Woo JH, Choi SJ, et al. Effect of glucosamine or chondroitin sulfate on osteoarthritis progression:a meta-analysis[J]. Rheumatol Int, 2010, 30(3):357-363.
12.	苏江, 张晶, 吴侗, 等. 盐酸氨基葡萄糖治疗膝关节炎的随机对照研究[J]. 华西医学, 2012, 27(12):1776-1779.
13.	Towheed TE, Anastassiades TP, Shea B, et al. Glucosamine therapy for treating osteoarthritis[J]. Cochrane Database Syst Rev, 2001(1):CD002946.
14.	春洁, 贾源源, 张琦, 等. 盐酸氨基葡萄糖片联合玻璃酸钠治疗颞下颌关节骨关节炎的临床随机对照实验[J]. 华西口腔医学杂志, 2011, 29(6):632-639.

1. 柳学勇, 冉春风, 刘盼, 等. 低强度聚焦超声与普通超声治疗创伤性膝关节炎的疗效比较[J]. 中华物理医学与康复杂志, 2011, 33(12):927-929.
2. 何勇, 肖涟波, 翟伟韬, 等. 基于MRI滑膜测量的关节镜滑膜切除术治疗膝类风湿关节炎疗效分析[J]. 中国矫形外科杂志, 2014, 22(18):1651-1656.
3. Losina E, Burbine SA, Suter LG. Pharmacologic regimens for knee osteoarthritis prevention:can they be cost-effective?[J]. Osteoarthritis Cartilage, 2014, 22(3):415-430.
4. 谭静雅, 杨南萍. 骨关节炎的发病机制及诊治的研究进展[J]. 华西医学, 2012, 27(12):1828-1832.
5. 蒋礼源, 黄颂安. 关节镜下清理术联合玻璃酸钠治疗膝关节骨性关节炎55例[J]. 广西医学, 2012, 34(9):1220-1221.
6. Cooper MT, Miller MD.Primary articular cartilage procedures in the middle-aged Knee[J]. Sports Med Arthrosc Rev, 2003, 11(5):112-121.
7. Steadman JR, Briggs KK, Rodrigo JJ. Outcomes of microfracture for traumatic chondral of the knee:averge 11-year follow-up[J].Arthroscopy, 2003, 19(5):477-484.
8. Nakamura H, Shibakawa A, Tanaka M, et al. Effects of glucousamine hydrochloride on the production of prostaglandin E2, nitric oxide and metallogroteases by chondrocytes and synoviocytes in osteoarthritis[J]. Clin Exp Rheumatol, 2004, 22(3):293-299.
9. 何文革, 闫冬梅, 李瑞阳, 等. 膝关节滑膜炎关节镜术后口服盐酸氨基葡萄糖的疗效[J]. 2015, 43(2):186-189.
10. Wise BL, Niu J, Zhang Y. The association of parity with osteoarthritis and knee replacement in the multicenter osteoarthritis study[J]. Osteoarthritis Cartilage, 2013, 21(12):1849-1854.
11. Lee YH, Woo JH, Choi SJ, et al. Effect of glucosamine or chondroitin sulfate on osteoarthritis progression:a meta-analysis[J]. Rheumatol Int, 2010, 30(3):357-363.
12. 苏江, 张晶, 吴侗, 等. 盐酸氨基葡萄糖治疗膝关节炎的随机对照研究[J]. 华西医学, 2012, 27(12):1776-1779.
13. Towheed TE, Anastassiades TP, Shea B, et al. Glucosamine therapy for treating osteoarthritis[J]. Cochrane Database Syst Rev, 2001(1):CD002946.
14. 春洁, 贾源源, 张琦, 等. 盐酸氨基葡萄糖片联合玻璃酸钠治疗颞下颌关节骨关节炎的临床随机对照实验[J]. 华西口腔医学杂志, 2011, 29(6):632-639.

West China Medical Journal

Observation of the Clinical Curative Effect of Arthroscopic Debridement Combined with Glucosamine Hydrochloride Tablets in the Treatment of Knee Osteoarthritis

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