Ginkgo Leaf Extract and Dipyridamole Combined with Betahistine Injection for the Treatment of Vertebrobasilar Ischemia with Vertigo: A Meta-analysis_West China Medical Journal

Authors：

 DaiChengzhi , PengZhuyun , LiYuedan

Department of Neurology, Meishan People's Hospital, Meishan, Sichuan 620010, P. R. China;

Corresponding author：

Keywords：

Ginkgo leaf extract and dipyridamole injection; Betahistine injection; Vertebrobasilar ischemia with vertigo; Meta-analysis

DOI：

10.7507/1002-0179.201600332

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Objective To evaluate the effects and safety of ginkgo leaf extract and dipyridamole combined with betahistine injection for the treatment of vertebrobasilar ischemia with vertigo. Methods The Cochrane Library, Medline, Embase, Web of Science, China National Knowledge Infrastructure, VIP Database, Wanfang Database and China Biology Medicine Databases were searched from their establishment to September 2015. We used the method recommended by the Cochrane collaboration to perform a meta-analysis on randomized controlled trails. Results Six studies were included. The results of meta-analysis demonstrated that ginkgo leaf extract and dipyridamole combined with betahistine injection for the treatment of vertebrobasilar ischemia with vertigo was superior to either ginkgo leaf extract and dipyridamole or betahistine injection in total effective rate[RR=1.21, 95%CI (1.08, 1.35), P=0.000 7; RR=1.17, 95%CI (1.05, 1.31), P=0.006]. Conclusion Ginkgo leaf extract and dipyridamole combined with betahistine injection is effective for the treatment of vertebrobasilar ischemia with vertigo. However, due to the limited quantity and quality of the included studies, the results need to be further confirmed.

Citation： DaiChengzhi, PengZhuyun, LiYuedan. Ginkgo Leaf Extract and Dipyridamole Combined with Betahistine Injection for the Treatment of Vertebrobasilar Ischemia with Vertigo: A Meta-analysis. West China Medical Journal, 2016, 31(7): 1216-1219. doi: 10.7507/1002-0179.201600332 Copy

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1. 彭晓琴, 张兆辉, 何国厚. 依达拉奉联合银杏达莫治疗急性脑梗死的Meta分析[J]. 卒中与神经疾病, 2012, 19(3):159-163.
2. 陈新谦, 金有豫, 汤光. 新编药物学[M]. 17版. 北京:人民卫生出版社, 2011:306.
3. Higgins JPT, Altman DG. Cochrane handbook for systematic reviews of interventions Version 5.1.0 (updated March 2011)[EB/OL]. The Cochrane Collaboration, 2011[2013-04-01]. http://www.cochrane-handbook.org.
4. 毛小燕. 中西医结合治疗40例眩晕疗效观察[J]. 中国保健营养:中旬刊, 2013(2):447.
5. 张宇华. 倍他司汀联合银杏达莫对椎基底动脉供血不足性眩晕的治疗探讨[J]. 中国实用医药, 2012, 7(8):162-163.
6. 郑春成, 王延祥. 银杏达莫联合倍他司汀治疗椎基底动脉供血不足性眩晕[J]. 浙江中西医结合杂志, 2010, 20(7):437.
7. 赵春玉. 盐酸倍他司汀、银杏达莫注射液联合治疗椎基底动脉供血不足眩晕疗效观察[J]. 中外健康文摘, 2009, 6(31):59.
8. 达志河, 马维晋. 倍他司汀联合银杏达莫治疗椎基底动脉供血不足眩晕146例疗效观察[J]. 中国医药导刊, 2009, 11(12):2079-2080.
9. 邹立宇, 瞿立武. 倍他司汀联合银杏达莫治疗椎基底动脉供血不足眩晕疗效观察[J]. 现代中西医结合杂志, 2008, 17(32):5015.
10. 赵恩平. 银杏达莫联合倍他司汀治疗椎-基底动脉供血不足性眩晕[J]. 中国实用医药, 2013, 8(8):152-153.

West China Medical Journal

Ginkgo Leaf Extract and Dipyridamole Combined with Betahistine Injection for the Treatment of Vertebrobasilar Ischemia with Vertigo: A Meta-analysis

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