Early Application of Etofenamate Gel in the Treatment of Acute Herpes Zoster Pain_West China Medical Journal

Authors：

 QinWanxiang ,  ShiYing , RanBo , NieFachuan

Department of Pain Management, the First Affiliated Hospital of the Third Military Medical University, Chongqing 400038, P. R. China;

Corresponding author：

ShiYing, Email: iris_sy@126.com

Keywords：

Herpes zoster; Pain; Non-steroidal anti-inflammatory drugs

DOI：

10.7507/1002-0179.201600371

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To observe the efficacy and safety of etofenamate gel (foscavir+tramadoli hydrochloridum+gabapentin) in the treatment of acute herpes zoster. Methods Forty patients with acute herpes zoster neuralgia treated between January 2013 and June 2014 were randomly divided into two groups:control group and treatment group, with 20 in each. The patients had a visual analogue scale (VAS) pain score of seven or higher. Patients in the control group accepted conventional treatment, while those in the treatment group were treated with conventional treatment combined with etofenamate gel. Two weeks after treatment, VAS score, quality of life and sleep score, and the degree of improvement in skin paresthesia were evaluated and compared between the two groups. Results The VAS score decreased significantly in both the two groups after treatment (P < 0.05), and the decrease in the treatment group was significantly more obvious (P < 0.05). The quality of life, sleep score and the degree of improvement in skin paresthesia were ameliorated significantly after treatment (P < 0.05), and the amelioration in the treatment group was significantly greater (P < 0.05). Conclusion The early application of Ordofen can strengthen analgesia effect of the conventional treatment, improve the quality of life and sleep, and reduce skin paresthesia.

Citation： QinWanxiang, ShiYing, RanBo, NieFachuan. Early Application of Etofenamate Gel in the Treatment of Acute Herpes Zoster Pain. West China Medical Journal, 2016, 31(8): 1359-1362. doi: 10.7507/1002-0179.201600371 Copy

1.	Loparev VN, Gonzalez A, Deleon-Carnes M, et al. Global identification of three major genotypes of varicella-zoster virus:longitudinal clustering and strategies for genotyping[J]. J Virol, 2004, 78(15):8349-8358.
2.	Gialloreti LE, Merito M, Pezzotti P, et al. Epidemiology and economic burden of herpes zoster and post-herpetic neuralgia in Italy:a retrospective, population-based study[J]. BMC Infect Dis, 2010, 10:230.
3.	黄丽, 罗健.肿瘤心理治疗[M].北京:人民卫生出版社, 2000:433.
4.	罗健, 孙燕.癌症患者生活质量研究[J].中国肿瘤, 2001, 10(2):76-78.
5.	邵岚, 宋正波, 张沂平, 等.肺癌分子分型与靶向治疗研究进展[J].中国肺癌杂志, 2012, 15(9):545-552.
6.	Fashner J, Bell AL. Herpes zoster and postherpetic neuralgia:prevention and management[J]. Am Fam Physician, 2011, 83(12):1432-1437.
7.	Minassian C, Thomas SL, Smeeth L, et al. Acute cardiovascular events after herpes zoster:a self-controlled case series analysis in vaccinated and unvaccinated older residents of the United States[J]. PLoS Med, 2015, 12(12):e1001919.
8.	Bergler-Czop B, Brzezinska-Wcislo L, Miziolek B. Metastases of malignant melanoma to the skin of abdomen and thorax imitating Herpes Zoster infection[J]. Ann Saudi Med, 2015, 35(6):482-483.
9.	Wadih A, Rehm PK, Deng C, et al. Active herpes zoster infection with cutaneous manifestation and adenopathy on FDG PET/CT[J]. Radiol Case Rep, 2015, 10(3):27-29.
10.	Johnson RW, Wasner G, Saddier P, et al. Herpes zoster and postherpetic neuralgia:optimizing management in the elderly patient[J]. Drugs Aging, 2008, 25(12):991-1006.
11.	Hutmacher MM, Frame B, Miller R, et al. Exposure-response modeling of average daily pain score, and dizziness and somnolence, for mirogabalin (DS-5565) in patients with diabetic peripheral neuropathic pain[J]. J Clin Pharmacol, 2016, 56(1):67-77.
12.	楼淑芳, 马睿杰.带状疱疹后遗神经痛的早期干预[J].浙江中西医结合杂志, 2011, 21(1):67-69.
13.	陆春, 朱国兴.皮肤性病科典型病例分析[M].北京:科学技术文献出版社, 2002:16-23.
14.	朱文全.四联疗法治疗带状疱疹后遗神经痛105例临床观察[J].中国医学文摘:皮肤科学, 2008, 25(4):207-208.
15.	刘静野, 陈超.泼尼龙联合阿昔洛韦治疗老年人带状疱疹神经痛的疗效观察[J].中国煤炭工业医学杂志, 2013, 16(4):564-565.
16.	Bricout H, Perinetti E, Marchettini P, et al. Burden of herpes zoster-associated chronic pain in Italian patients aged 50 years and over (2009-2010):a GP-based prospective cohort study[J]. BMC Infect Dis, 2014, 14(1):637.
17.	Rabaud C, Rogeaux O, Launay O, et al. Early antiviral treatment fails to completely prevent herpes-related pain[J]. Med Mal Infect, 2013, 43(11/12):461-466.

1. Loparev VN, Gonzalez A, Deleon-Carnes M, et al. Global identification of three major genotypes of varicella-zoster virus:longitudinal clustering and strategies for genotyping[J]. J Virol, 2004, 78(15):8349-8358.
2. Gialloreti LE, Merito M, Pezzotti P, et al. Epidemiology and economic burden of herpes zoster and post-herpetic neuralgia in Italy:a retrospective, population-based study[J]. BMC Infect Dis, 2010, 10:230.
3. 黄丽, 罗健.肿瘤心理治疗[M].北京:人民卫生出版社, 2000:433.
4. 罗健, 孙燕.癌症患者生活质量研究[J].中国肿瘤, 2001, 10(2):76-78.
5. 邵岚, 宋正波, 张沂平, 等.肺癌分子分型与靶向治疗研究进展[J].中国肺癌杂志, 2012, 15(9):545-552.
6. Fashner J, Bell AL. Herpes zoster and postherpetic neuralgia:prevention and management[J]. Am Fam Physician, 2011, 83(12):1432-1437.
7. Minassian C, Thomas SL, Smeeth L, et al. Acute cardiovascular events after herpes zoster:a self-controlled case series analysis in vaccinated and unvaccinated older residents of the United States[J]. PLoS Med, 2015, 12(12):e1001919.
8. Bergler-Czop B, Brzezinska-Wcislo L, Miziolek B. Metastases of malignant melanoma to the skin of abdomen and thorax imitating Herpes Zoster infection[J]. Ann Saudi Med, 2015, 35(6):482-483.
9. Wadih A, Rehm PK, Deng C, et al. Active herpes zoster infection with cutaneous manifestation and adenopathy on FDG PET/CT[J]. Radiol Case Rep, 2015, 10(3):27-29.
10. Johnson RW, Wasner G, Saddier P, et al. Herpes zoster and postherpetic neuralgia:optimizing management in the elderly patient[J]. Drugs Aging, 2008, 25(12):991-1006.
11. Hutmacher MM, Frame B, Miller R, et al. Exposure-response modeling of average daily pain score, and dizziness and somnolence, for mirogabalin (DS-5565) in patients with diabetic peripheral neuropathic pain[J]. J Clin Pharmacol, 2016, 56(1):67-77.
12. 楼淑芳, 马睿杰.带状疱疹后遗神经痛的早期干预[J].浙江中西医结合杂志, 2011, 21(1):67-69.
13. 陆春, 朱国兴.皮肤性病科典型病例分析[M].北京:科学技术文献出版社, 2002:16-23.
14. 朱文全.四联疗法治疗带状疱疹后遗神经痛105例临床观察[J].中国医学文摘:皮肤科学, 2008, 25(4):207-208.
15. 刘静野, 陈超.泼尼龙联合阿昔洛韦治疗老年人带状疱疹神经痛的疗效观察[J].中国煤炭工业医学杂志, 2013, 16(4):564-565.
16. Bricout H, Perinetti E, Marchettini P, et al. Burden of herpes zoster-associated chronic pain in Italian patients aged 50 years and over (2009-2010):a GP-based prospective cohort study[J]. BMC Infect Dis, 2014, 14(1):637.
17. Rabaud C, Rogeaux O, Launay O, et al. Early antiviral treatment fails to completely prevent herpes-related pain[J]. Med Mal Infect, 2013, 43(11/12):461-466.

Previous Article
Clincal Research on the Effect of Etofenamate Gel on Omarthritis
Next Article
Effect of Autoantibody on the Therapeutic Effect and Safety for Chronic Hepatitis C

West China Medical Journal

Early Application of Etofenamate Gel in the Treatment of Acute Herpes Zoster Pain

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content