中性粒细胞与淋巴细胞比例与心血管疾病的研究进展_West China Medical Journal

Authors：

 朱小江 , 廖行 , 陈晓平

四川大学华西医院心脏内科（成都 610041）;

Corresponding author：

Keywords：

中性粒细胞与淋巴细胞比例; 心血管疾病; 炎症

DOI：

10.7507/1002-0179.201600393

Video：

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大量的研究表明系统性炎症与心血管疾病的发生、发展以及预后有着密切而一致的关系。中性粒细胞与淋巴细胞比例（NLR）是一种新型的炎症指标，它简单且易快速获取，可在疾病传统的危险评分之外，提供额外的危险分层；它不仅与动脉粥样硬化、高血压、心力衰竭、冠状动脉搭桥术后心律失常等息息相关，而且也是稳定性心绞痛及急性冠状动脉综合征短期及长期病死率的独立预测因子。现将NLR与心血管疾病的研究进展作一综述。

Citation： 朱小江, 廖行, 陈晓平. 中性粒细胞与淋巴细胞比例与心血管疾病的研究进展. West China Medical Journal, 2016, 31(8): 1444-1446. doi: 10.7507/1002-0179.201600393 Copy

1.	Ates AH, Canpolat U, Yorgun H, et al. Total white blood cell count is associated with the presence, severity and extent of coronary atherosclerosis detected by dual-source multislice computed tomographic coronary angiography[J]. Cardiol J, 2011, 18(4):371-377.
2.	Buckley DI, Fu R, Freeman M, et al. C-reactive protein as a risk factor for coronary heart disease:a systematic review and meta-analyses for the U.S. Preventive Services Task Force[J]. Ann Intern Med, 2009, 151(7):483-495.
3.	Horne BD, Anderson JL, John JM, et al. Which white blood cell subtypes predict increased cardiovascular risk?[J]. J Am Coll Cardiol, 2005, 45(10):1638-1643.
4.	Papa A, Emdin M, Passino C, et al. Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease[J]. Clin Chim Acta, 2008, 395(1/2):27-31.
5.	Kaya H, Ertaş F, İslamoğlu Y, et al. Association between neutrophil to lymphocyte ratio and severity of coronary artery disease[J]. Clin Appl Thromb Hemost, 2014, 20(1):50-54.
6.	Park BJ, Shim JY, Lee HR, et al. Relationship of neutrophil-lymphocyte ratio with arterial stiffness and coronary calcium score[J]. Clin Chim Acta, 2011, 412(11/12):925-929.
7.	Kalay N, Dogdu O, Koc F, et al. Hematologic parameters and angiographic progression of coronary atherosclerosis[J]. Angiology, 2012, 63(3):213-217.
8.	Mccaig LF, Burt CW. National hospital ambulatory medical care survey:1999 emergency department summary[J]. Adv Data, 2001(320):1-34.
9.	Zazula AD, Précoma-Neto D, Gomes AM, et al. An assessment of neutrophils/lymphocytes ratio in patients suspected of acute coronary syndrome[J]. Arq Bras Cardiol, 2008, 90(1):31-36.
10.	Muhmmed Suliman MA, Bahnacy Juma AA, Ali Almadhani AA, et al. Predictive value of neutrophil to lymphocyte ratio in outcomes of patients with acute coronary syndrome[J]. Arch Med Res, 2010, 41(8):618-622.
11.	Tamhane UU, Aneja S, Montgomery D, et al. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome[J]. Am J Cardiol, 2008, 102(6):653-657.
12.	Duffy BK, Gurm HS, Rajagopal V, et al. Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention[J]. Am J Cardiol, 2006, 97(7):993-996.
13.	Azab B, Zaher M, Weiserbs KF, et al. Usefulness of neutrophil to lymphocyte ratio in predicting short-and long-term mortality after non-ST-elevation myocardial infarction[J]. Am J Cardiol, 2010, 106(4):470-476.
14.	Núñez J, Núñez E, Bodí V, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction[J]. Am J Cardiol, 2008, 101(6):747-752.
15.	Wang X, Zhang G, Jiang X, et al. Neutrophil to lymphocyte ratio in relation to risk of all-cause mortality and cardiovascular events among patients undergoing angiography or cardiac revascularization:a meta-analysis of observational studies[J]. Atherosclerosis, 2014, 234(1):206-213.
16.	Liu X, Zhang Q, Wu H, et al. Blood neutrophil to lymphocyte ratio as a predictor of hypertension[J]. Am J Hypertens, 2015, 28(11):1339-1346.
17.	Sunbul M, Gerin F, Durmus E, et al. Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension[J]. Clin Exp Hypertens, 2014, 36(4):217-221.
18.	Yayla Ç, Canpolat U, Akyel A, et al. Association of neutrophil-lymphocyte ratio with impaired aortic elasticity in newly diagnosed and never-treated hypertensive patients[J]. Blood Press Monit, 2015, 20(3):127-131.
19.	Belen E, Sungur A, Sungur MA, et al. Increased neutrophil to lymphocyte ratio in patients with resistant hypertension[J]. J Clin Hypertens (Greenwich), 2015, 17(7):532-537.
20.	Canpolat U, Aytemir K, Yorgun H, et al. Role of preablation neutrophil/lymphocyte ratio on outcomes of cryoballoon-based atrial fibrillation ablation[J]. Am J Cardiol, 2013, 112(4):513-519.
21.	Yalcin M, Aparci M, Uz O, et al. Neutrophil-lymphocyte ratio may predict left atrial thrombus in patients with nonvalvular atrial fibrillation[J]. Clin Appl Thromb Hemost, 2015, 21(2):166-171.
22.	Ertaş G, Sönmez O, Turfan M, et al. Neutrophil/lymphocyte ratio is associated with thromboembolic stroke in patients with non-valvular atrial fibrillation[J]. J Neurol Sci, 2013, 324(1/2):49-52.
23.	Arıbaş A, Akıllı H, Gül EE, et al. Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?[J]. Anadolu Kardiyol Derg, 2013, 13(2):123-130.
24.	Güngör B, Özcan KS, Erdinler İ, et al. Elevated levels of RDW is associated with non-valvular atrial fibrillation[J]. J Thromb Thrombolysis, 2014, 37(4):404-410.
25.	Uthamalingam S, Patvardhan EA, Subramanian S, et al. Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure[J]. Am J Cardiol, 2011, 107(3), 433-438.
26.	Karagöz A, Vural A, Günaydın ZY, et al. The role of neutrophil to lymphocyte ratio as a predictor of diastolic dysfunction in hypertensive patients[J]. Eur Rev Med Pharmacol Sci, 2015, 19(3):433-440.
27.	Gibson PH, Croal BL, Cuthbertson BH, et al. Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting[J]. Am Heart J, 2007, 154(5):995-1002.
28.	Taşoğlu I, Turak O, Nazli Y, et al. Preoperative neutrophil-lymphocyte ratio and saphenous vein graft patency after coronary artery bypass grafting[J]. Clin Appl Thromb Hemost, 2014, 20(8):819-824.

1. Ates AH, Canpolat U, Yorgun H, et al. Total white blood cell count is associated with the presence, severity and extent of coronary atherosclerosis detected by dual-source multislice computed tomographic coronary angiography[J]. Cardiol J, 2011, 18(4):371-377.
2. Buckley DI, Fu R, Freeman M, et al. C-reactive protein as a risk factor for coronary heart disease:a systematic review and meta-analyses for the U.S. Preventive Services Task Force[J]. Ann Intern Med, 2009, 151(7):483-495.
3. Horne BD, Anderson JL, John JM, et al. Which white blood cell subtypes predict increased cardiovascular risk?[J]. J Am Coll Cardiol, 2005, 45(10):1638-1643.
4. Papa A, Emdin M, Passino C, et al. Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease[J]. Clin Chim Acta, 2008, 395(1/2):27-31.
5. Kaya H, Ertaş F, İslamoğlu Y, et al. Association between neutrophil to lymphocyte ratio and severity of coronary artery disease[J]. Clin Appl Thromb Hemost, 2014, 20(1):50-54.
6. Park BJ, Shim JY, Lee HR, et al. Relationship of neutrophil-lymphocyte ratio with arterial stiffness and coronary calcium score[J]. Clin Chim Acta, 2011, 412(11/12):925-929.
7. Kalay N, Dogdu O, Koc F, et al. Hematologic parameters and angiographic progression of coronary atherosclerosis[J]. Angiology, 2012, 63(3):213-217.
8. Mccaig LF, Burt CW. National hospital ambulatory medical care survey:1999 emergency department summary[J]. Adv Data, 2001(320):1-34.
9. Zazula AD, Précoma-Neto D, Gomes AM, et al. An assessment of neutrophils/lymphocytes ratio in patients suspected of acute coronary syndrome[J]. Arq Bras Cardiol, 2008, 90(1):31-36.
10. Muhmmed Suliman MA, Bahnacy Juma AA, Ali Almadhani AA, et al. Predictive value of neutrophil to lymphocyte ratio in outcomes of patients with acute coronary syndrome[J]. Arch Med Res, 2010, 41(8):618-622.
11. Tamhane UU, Aneja S, Montgomery D, et al. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome[J]. Am J Cardiol, 2008, 102(6):653-657.
12. Duffy BK, Gurm HS, Rajagopal V, et al. Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention[J]. Am J Cardiol, 2006, 97(7):993-996.
13. Azab B, Zaher M, Weiserbs KF, et al. Usefulness of neutrophil to lymphocyte ratio in predicting short-and long-term mortality after non-ST-elevation myocardial infarction[J]. Am J Cardiol, 2010, 106(4):470-476.
14. Núñez J, Núñez E, Bodí V, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction[J]. Am J Cardiol, 2008, 101(6):747-752.
15. Wang X, Zhang G, Jiang X, et al. Neutrophil to lymphocyte ratio in relation to risk of all-cause mortality and cardiovascular events among patients undergoing angiography or cardiac revascularization:a meta-analysis of observational studies[J]. Atherosclerosis, 2014, 234(1):206-213.
16. Liu X, Zhang Q, Wu H, et al. Blood neutrophil to lymphocyte ratio as a predictor of hypertension[J]. Am J Hypertens, 2015, 28(11):1339-1346.
17. Sunbul M, Gerin F, Durmus E, et al. Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension[J]. Clin Exp Hypertens, 2014, 36(4):217-221.
18. Yayla Ç, Canpolat U, Akyel A, et al. Association of neutrophil-lymphocyte ratio with impaired aortic elasticity in newly diagnosed and never-treated hypertensive patients[J]. Blood Press Monit, 2015, 20(3):127-131.
19. Belen E, Sungur A, Sungur MA, et al. Increased neutrophil to lymphocyte ratio in patients with resistant hypertension[J]. J Clin Hypertens (Greenwich), 2015, 17(7):532-537.
20. Canpolat U, Aytemir K, Yorgun H, et al. Role of preablation neutrophil/lymphocyte ratio on outcomes of cryoballoon-based atrial fibrillation ablation[J]. Am J Cardiol, 2013, 112(4):513-519.
21. Yalcin M, Aparci M, Uz O, et al. Neutrophil-lymphocyte ratio may predict left atrial thrombus in patients with nonvalvular atrial fibrillation[J]. Clin Appl Thromb Hemost, 2015, 21(2):166-171.
22. Ertaş G, Sönmez O, Turfan M, et al. Neutrophil/lymphocyte ratio is associated with thromboembolic stroke in patients with non-valvular atrial fibrillation[J]. J Neurol Sci, 2013, 324(1/2):49-52.
23. Arıbaş A, Akıllı H, Gül EE, et al. Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?[J]. Anadolu Kardiyol Derg, 2013, 13(2):123-130.
24. Güngör B, Özcan KS, Erdinler İ, et al. Elevated levels of RDW is associated with non-valvular atrial fibrillation[J]. J Thromb Thrombolysis, 2014, 37(4):404-410.
25. Uthamalingam S, Patvardhan EA, Subramanian S, et al. Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure[J]. Am J Cardiol, 2011, 107(3), 433-438.
26. Karagöz A, Vural A, Günaydın ZY, et al. The role of neutrophil to lymphocyte ratio as a predictor of diastolic dysfunction in hypertensive patients[J]. Eur Rev Med Pharmacol Sci, 2015, 19(3):433-440.
27. Gibson PH, Croal BL, Cuthbertson BH, et al. Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting[J]. Am Heart J, 2007, 154(5):995-1002.
28. Taşoğlu I, Turak O, Nazli Y, et al. Preoperative neutrophil-lymphocyte ratio and saphenous vein graft patency after coronary artery bypass grafting[J]. Clin Appl Thromb Hemost, 2014, 20(8):819-824.

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中性粒细胞与淋巴细胞比例与心血管疾病的研究进展

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