Clinical Pathologic Analysis of Tonsil Tumor_West China Medical Journal

Authors：

 YangLiu ¹ ,  LiuShixi ¹ , ChenMin ¹ , RenJia ¹ , YaoWenqing ²

1. Department of Otolaryngology, Head and Neck Surgery;
2. Department of Pathology;West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

LiuShixi, Email: liusx999@163.com

Keywords：

Tonsil tumor; Pathological types; Clinical manifestations; Treatment

DOI：

10.7507/1002-0179.201600421

Video：

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Objective To summarize the clinical pathologic features of primary tonsil tumor, in order to provide reference for its diagnosis and treatment. Methods We retrospectively analyzed the clinical data from January 2002 to April 2012, and found 810 cases of malignant tumor and 113 cases of benign tumor. The pathologic patterns and clinical manifestations of these cases were recorded for analysis. Results Most tonsil tumors were unilateral, and the malignant types were much more than the benign. The most common malignant tonsil tumors were lymphoma (610 cases), followed by squamous cell carcinoma (172 cases); inverted papilloma was the most common benign tumor (87 cases). Paresthesia in the pharynx was the most common clinical manifestation that existed in almost all cases. Conclusion Tonsil tumor pathological type is very important for its diagnosis, treatment and prognosis. Laying emphasis on pathological diagnosis and differential diagnosis could avoid missed diagnosis, misdiagnosis and improper treatment, which is particularly important for clinical physicians of the otolaryngology, head and neck surgery.

Citation： YangLiu, LiuShixi, ChenMin, RenJia, YaoWenqing. Clinical Pathologic Analysis of Tonsil Tumor. West China Medical Journal, 2016, 31(9): 1546-1550. doi: 10.7507/1002-0179.201600421 Copy

1.	Ghanem TA. Transoral robotic-assisted microvascular reconstruction of the oropharynx[J]. Laryngoscope, 2011, 121(3):580-582.
2.	Hosokai R, Imai C, Takachi T, et al. Reactive tonsillar enlargement with strong ¹⁸F-FDG uptake after chemotherapy for tonsillar diffuse large B-cell lymphoma[J]. J Pediatr Hematol Oncol, 2011, 33(2):e87-e88.
3.	Thavaraj S, Stokes A, Guerra E, et al. Evaluation of human papillomavirus testing for squamous cell carcinoma of the tonsil in clinical practice[J]. J Clin Pathol, 2011, 64(4):308-312.
4.	Carlos Bregni R, Nuyens M, Vassallo J, et al. Marginal zone lymphoma of mucosa-associated lymphoid tissue with prominent plasma cell differentiation affecting the palatine tonsil:histopathological and immunohistochemical analysis[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2012, 113(4):526-532.
5.	Jansen JF, Schöder H, Lee NY, et al. Tumor metabolism and perfusion in head and neck squamous cell carcinoma:pretreatment multimodality imaging with 1H magnetic resonance spectroscopy, dynamic contrast-enhanced MRI, and [¹⁸F]FDG-PET[J]. Int J Radiat Oncol Biol Phys, 2012, 82(1):299-307.
6.	Chuang HC, Fang FM, Huang CC, et al. Clinical and pathological determinants in tonsillar cancer[J]. Head Neck, 2011, 33(12):1703-1707.
7.	Minca EC, Popat SR, Chadha MK, et al. Small lymphocytic lymphoma obscuring microscopic tonsillar squamous cell carcinoma:an unknown occurrence with a known primary[J]. Head Neck Pathol, 2012, 6(1):125-129.
8.	Smith RO, Pokala K, Medina JE, et al. Tonsillar carcinoma in the contralateral tonsil[J]. Laryngoscope, 2010, 120(Suppl 4):S176.
9.	Prestwich RJ, Kancherla K, Oksuz DC, et al. A single centre experience with sequential and concomitant chemoradiotherapy in locally advanced stage Ⅳ tonsillar cancer[J]. Radiat Oncol, 2010 (5):121.
10.	Roeser MM, Alon EE, Olsen KD, et al. Synchronous bilateral tonsil squamous cell carcinoma[J]. Laryngoscope, 2010, 120(Suppl 4):S181.
11.	Skilbeck CJ, Jeannon JP, O'Connell M, et al. Squamous cell carcinoma of the tonsillar remnant--clinical presentation and oncological outcome[J]. Head Neck Oncol, 2011(3):4.
12.	Lee HJ, Kim JS, Roh JL, et al. Utility of quantitative ¹⁸F-fluorodeoxyglucose uptake measurement to identify occult tonsillar carcinoma in patients with cervical metastasis of unknown primary tumours:a retrospective case-control study[J]. Clin Otolaryngol, 2013, 38(1):30-38.
13.	Rotnaglova E, Tachezy R, Salakova MA, et al. HPV involvement in tonsillar cancer:prognostic significance and clinically relevant markers[J]. Int J Cancer, 2011, 129(1):101-110.
14.	Mantsopoulos K, Psychogios G, Waldfahrer F, et al. Surgical treatment of locally limited tonsillar cancer[J]. Surg Oncol, 2012, 21(1):e13-e16.
15.	Lee J, Yoon N, Choi SY, et al. Extent of local invasion and safe resection in cT1-2 tonsil cancer[J]. J Surg Oncol, 2013, 107(5):469-473.
16.	Park G, Lee SW, Kim SY, et al. Can concurrent chemoradiotherapy replace surgery and postoperative radiation for locally advanced stage Ⅲ/Ⅳtonsillar squamous cell carcinoma?[J]. Anticancer Res, 2013, 33(3):1237-1243.
17.	Aung NY, Ohtake H, Iwaba A, et al. Angioimmunoblastic T-cell lymphoma with dual genotype of TCR and IgH genes[J]. Pathol Res Pract, 2011, 207(5):317-321.
18.	Studer G, Glanzmann C. Volumetric staging in oropharyngeal cancer patients treated with definitive IMRT[J]. Oral Oncol, 2013, 49(3):269-276.
19.	Warrick J, Brink DS, Mitchell RB. Paraganglioma of the palatine tonsil[J]. Ear Nose Throat J, 2012, 91(8):E29-E31.
20.	Munck-Wikland E, Hammarstedt L, Lindquist D, et al. Human papillomavirus important factor in the increased incidence of tonsillar cancer[J]. Lakartidningen, 2006, 103(44):3366-3368.
21.	Park JO, Jung CK, Sun DI, et al. Relationships between metastasis-associated protein (MTA) 1 and lymphatic metastasis in tonsil cancer[J]. Eur Arch Otorhinolaryngol, 2011, 268(9):1329-1334.

1. Ghanem TA. Transoral robotic-assisted microvascular reconstruction of the oropharynx[J]. Laryngoscope, 2011, 121(3):580-582.
2. Hosokai R, Imai C, Takachi T, et al. Reactive tonsillar enlargement with strong ¹⁸F-FDG uptake after chemotherapy for tonsillar diffuse large B-cell lymphoma[J]. J Pediatr Hematol Oncol, 2011, 33(2):e87-e88.
3. Thavaraj S, Stokes A, Guerra E, et al. Evaluation of human papillomavirus testing for squamous cell carcinoma of the tonsil in clinical practice[J]. J Clin Pathol, 2011, 64(4):308-312.
4. Carlos Bregni R, Nuyens M, Vassallo J, et al. Marginal zone lymphoma of mucosa-associated lymphoid tissue with prominent plasma cell differentiation affecting the palatine tonsil:histopathological and immunohistochemical analysis[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2012, 113(4):526-532.
5. Jansen JF, Schöder H, Lee NY, et al. Tumor metabolism and perfusion in head and neck squamous cell carcinoma:pretreatment multimodality imaging with 1H magnetic resonance spectroscopy, dynamic contrast-enhanced MRI, and [¹⁸F]FDG-PET[J]. Int J Radiat Oncol Biol Phys, 2012, 82(1):299-307.
6. Chuang HC, Fang FM, Huang CC, et al. Clinical and pathological determinants in tonsillar cancer[J]. Head Neck, 2011, 33(12):1703-1707.
7. Minca EC, Popat SR, Chadha MK, et al. Small lymphocytic lymphoma obscuring microscopic tonsillar squamous cell carcinoma:an unknown occurrence with a known primary[J]. Head Neck Pathol, 2012, 6(1):125-129.
8. Smith RO, Pokala K, Medina JE, et al. Tonsillar carcinoma in the contralateral tonsil[J]. Laryngoscope, 2010, 120(Suppl 4):S176.
9. Prestwich RJ, Kancherla K, Oksuz DC, et al. A single centre experience with sequential and concomitant chemoradiotherapy in locally advanced stage Ⅳ tonsillar cancer[J]. Radiat Oncol, 2010 (5):121.
10. Roeser MM, Alon EE, Olsen KD, et al. Synchronous bilateral tonsil squamous cell carcinoma[J]. Laryngoscope, 2010, 120(Suppl 4):S181.
11. Skilbeck CJ, Jeannon JP, O'Connell M, et al. Squamous cell carcinoma of the tonsillar remnant--clinical presentation and oncological outcome[J]. Head Neck Oncol, 2011(3):4.
12. Lee HJ, Kim JS, Roh JL, et al. Utility of quantitative ¹⁸F-fluorodeoxyglucose uptake measurement to identify occult tonsillar carcinoma in patients with cervical metastasis of unknown primary tumours:a retrospective case-control study[J]. Clin Otolaryngol, 2013, 38(1):30-38.
13. Rotnaglova E, Tachezy R, Salakova MA, et al. HPV involvement in tonsillar cancer:prognostic significance and clinically relevant markers[J]. Int J Cancer, 2011, 129(1):101-110.
14. Mantsopoulos K, Psychogios G, Waldfahrer F, et al. Surgical treatment of locally limited tonsillar cancer[J]. Surg Oncol, 2012, 21(1):e13-e16.
15. Lee J, Yoon N, Choi SY, et al. Extent of local invasion and safe resection in cT1-2 tonsil cancer[J]. J Surg Oncol, 2013, 107(5):469-473.
16. Park G, Lee SW, Kim SY, et al. Can concurrent chemoradiotherapy replace surgery and postoperative radiation for locally advanced stage Ⅲ/Ⅳtonsillar squamous cell carcinoma?[J]. Anticancer Res, 2013, 33(3):1237-1243.
17. Aung NY, Ohtake H, Iwaba A, et al. Angioimmunoblastic T-cell lymphoma with dual genotype of TCR and IgH genes[J]. Pathol Res Pract, 2011, 207(5):317-321.
18. Studer G, Glanzmann C. Volumetric staging in oropharyngeal cancer patients treated with definitive IMRT[J]. Oral Oncol, 2013, 49(3):269-276.
19. Warrick J, Brink DS, Mitchell RB. Paraganglioma of the palatine tonsil[J]. Ear Nose Throat J, 2012, 91(8):E29-E31.
20. Munck-Wikland E, Hammarstedt L, Lindquist D, et al. Human papillomavirus important factor in the increased incidence of tonsillar cancer[J]. Lakartidningen, 2006, 103(44):3366-3368.
21. Park JO, Jung CK, Sun DI, et al. Relationships between metastasis-associated protein (MTA) 1 and lymphatic metastasis in tonsil cancer[J]. Eur Arch Otorhinolaryngol, 2011, 268(9):1329-1334.

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