病毒感染与天疱疮关系的研究进展_West China Medical Journal

Authors：

 王莲 , 卿勇 ,  李薇

四川大学华西医院皮肤科（成都 610041）;

Corresponding author：

李薇, Email: liwei@mcwcums.com

Keywords：

病毒; 感染; 天疱疮

DOI：

10.7507/1002-0179.201600444

Video：

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天疱疮是一组由表皮松解引起的自身免疫性慢性大疱病。遗传易感个体在外界因素如药物、感染、肿瘤、情绪等作用下发病。其中，感染作为天疱疮的诱发因素一直受到热议。已有文献报道感染尤其是病毒感染可以诱发或加重天疱疮的发展。现就病毒感染与天疱疮关系的研究进展进行综述。

Citation： 王莲, 卿勇, 李薇. 病毒感染与天疱疮关系的研究进展. West China Medical Journal, 2016, 31(9): 1623-1626. doi: 10.7507/1002-0179.201600444 Copy

1.	Ruocco V, Ruocco E, Lo Schiavo A, et al. Pemphigus:etiology, pathogenesis, and inducing or triggering factors:facts and controversies[J]. Clin Dermatol, 2013, 31(4):374-381.
2.	Krain LS. Pemphigus. epidemiologic and survival characteristics of 59 patients, 1955-1973[J]. Arch Dermatol, 1974, 110(6):862-865.
3.	Keane JT, Malkinson FD, Bryant J, et al. Herpesvirus hominis hepatitis and disseminated intravascular coagulation. Occurrence in an adult with pemphigus vulgaris[J]. Arch Intern Med, 1976, 136(11):1312-1317.
4.	Schlüpen EM, Wollenberg A, Hänel S, et al. Detection of herpes simplex virus in exacerbated pemphigus vulgaris by polymerase chain reaction[J]. Dermatology, 1996, 192(4):312-316.
5.	Tufano MA, Baroni A, Buommino E, et al. Detection of herpesvirus DNA in peripheral blood mononuclear cells and skin lesions ofpatients with pemphigus by polymerase chain reaction[J]. Br J Dermatol, 1999, 141(6):1033-1039.
6.	Kalra A, Ratho RK, Kaur I, et al. Role of herpes simplex and cytomegalo viruses in recalcitrant oral lesions of pemphigus vulgaris[J]. Int J Dermatol, 2005, 44(3):259-260.
7.	Oliveira DP, Moura HH, Janini ME, et al. Diagnosis andtreatment of persistent oral lesions caused by herpesvirus in a patient with pemphigus vulgaris[J]. Int J Dermatol, 2011, 50(3):335-339.
8.	Brandão ML, Fernandes NC, Batista DP, et al. Refractory pemphigus vulgaris associated with herpes infection:case report and review[J]. Rev Inst Med Trop Sao Paulo, 2011, 53(2):113-117.
9.	Oliveira-Batista DP, Janini ME, Fernandes NC, et al. Laboratory diagnosis of herpesvirus infections in patients with Pemphigus vulgaris lesions[J]. Intervirology, 2013, 56(4):231-236.
10.	Kurata M, Mizukawa Y, Aoyama Y, et al. Herpes simplex virus reactivation as a trigger of mucous lesions in pemphigus vulgaris[J]. Br J Dermatol, 2014, 171(3):554-560.
11.	Pranteda G, Carlesimo M, Bottoni U, et al. Pemphigus vulgaris in a patient with arthritis and uveitis:successful treatment with immunosuppressive therapyand acyclovir[J]. Dermatol Ther, 2014, 27(4):215-218.
12.	Wucherpfennig KW. Mechanisms for the induction of autoimmunity by infectious agents[J]. J Clin Invest, 2001, 108(8):1097-1104.
13.	Dreyfus DH. Herpesviruses and the microbiome[J]. J Allergy Clin Immunol, 2013, 132(6):1278-1286.
14.	Esmaili N, Hallaji Z, Abedini R, et al. Pemphigus vulgaris and herpesviruses:is there any relationship?[J]. Int J Dermatol, 2010, 49(11):1261-1265.
15.	Horiguchi Y, Fujii S, Takase S, et al. Case of pemphigus vulgaris in oral mucosa showing an extension to the body surface with recurrent varicella[J]. Int J Dermatol, 2005, 44(11):951-954.
16.	Murata T, Morita K. Unsuspected varicella-zoster infection complicating mucosal-dominant pemphigus vulgaris[J]. Int J Dermatol, 2013, 52(11):1453-1454.
17.	Barzilai O, Sherer Y, Ram M, et al. Epstein-Barr virus and cytomegalovirus in autoimmune diseases:are they truly notorious? A preliminary report[J]. Ann N Y Acad Sci, 2007, 1108(1):567-577.
18.	Memar OM, Rady PL, Goldblum RM, et al. Human herpesvirus-8 DNA sequences in a patient with pemphigus vulgaris,but without HIV infection or Kaposi's sarcoma[J]. J Invest Dermatol, 1997, 108(1):118-119.
19.	Wang GQ, Xu H, Wang YK, et al. Higher prevalence of human herpesvirus 8 DNA sequence and specific IgG antibodies in patients with pemphigus in China[J]. J Am Acad Dermatol, 2005, 52(3 Pt 1):460-467.
20.	Meibodi NT, Nahidi Y, Mahmoudi M, et al. Evaluation of coexistence of the Human Herpesvirus type 8 (HHV-8) infection and pemphigus[J]. Int J Dermatol, 2010, 49(7):780-783.
21.	Galan A, Hui P, Mcniff JM. Absence of human herpesvirus 8 in pemphigus and bullous pemphigoid[J]. Int J Clin Exp Pathol, 2009, 2(5):456-462.
22.	Mejri K, Kallel Sellami M, Tombari W, et al. Human herpesvirus-8 and hepatitis B and C virus infections in pemphigus[J]. Int J Dermatol, 2014, 53(10):e475-e477.
23.	Triantafyllopoulou A, Moutsopoulos HM. Autoimmunity and coxsackievirus infection in primary Sjogren's syndrome[J]. Ann N Y Acad Sci, 2005, 1050(1):389-396.
24.	Ruocco E, Lo Schiavo A, Baroni A, et al. Pemphigus vulgaris after coxsackievirus infection and cephalosporin treatment:a paraviral eruption?[J]. Dermatology, 2008, 216(4):317-319.
25.	Kaçar N, Cevahir N, Demirkan N, et al. The investigation of the possible relationship between Coxsackie viruses and pemphigus[J]. Int J Dermatol, 2014, 53(3):312-315.
26.	Sinha P, Chatterjee M, Vasudevan B. Pemphigus vulgaris:A dermatological sequel of severe H1N1 infection[J]. Indian Dermatol Online J, 2014, 5(2):216-217.
27.	Niizeki H, Inamoto N, Nakamura K, et al. A case of pemphigus foliaceus after interferon alpha-2a therapy[J]. Dermatology, 1994, 189(Suppl 1):129-130.
28.	Marinho RT, Johnson NW, Fatela NM, et al. Oropharyngeal pemphigus in a patient with chronic hepatitis C during interferon alpha-2a therapy[J]. Eur J Gastroenterol Hepatol, 2001, 13(7):869-872.
29.	Demirci GT, Aydingoz IE, Mansur AT, et al. Hepatitis C and hepatitis B virus infections in the etiopathogenesis of pemphigus[J]. An Bras Dermatol, 2014, 89(3):423-426.
30.	Hodgson TA, Fidler SJ, Speight PM, et al. Oral pemphigus vulgaris associated with HIV infection[J]. J Am Acad Dermatol, 2003, 49(2):313-315.
31.	Marfatia YS, Patel S, Makrandi S, et al. Human immunodeficiency virus and pemphigus vulgaris:an interesting association[J]. Indian J Dermatol Venereol Leprol, 2007, 73(5):354-355.
32.	Tull T, Papineni P, Cook C, et al. Paraneoplastic pemphigus in patient infected with the human immunodeficiency virus[J]. Clin Exp Dermatol, 2014, 39(1):83-85.

1. Ruocco V, Ruocco E, Lo Schiavo A, et al. Pemphigus:etiology, pathogenesis, and inducing or triggering factors:facts and controversies[J]. Clin Dermatol, 2013, 31(4):374-381.
2. Krain LS. Pemphigus. epidemiologic and survival characteristics of 59 patients, 1955-1973[J]. Arch Dermatol, 1974, 110(6):862-865.
3. Keane JT, Malkinson FD, Bryant J, et al. Herpesvirus hominis hepatitis and disseminated intravascular coagulation. Occurrence in an adult with pemphigus vulgaris[J]. Arch Intern Med, 1976, 136(11):1312-1317.
4. Schlüpen EM, Wollenberg A, Hänel S, et al. Detection of herpes simplex virus in exacerbated pemphigus vulgaris by polymerase chain reaction[J]. Dermatology, 1996, 192(4):312-316.
5. Tufano MA, Baroni A, Buommino E, et al. Detection of herpesvirus DNA in peripheral blood mononuclear cells and skin lesions ofpatients with pemphigus by polymerase chain reaction[J]. Br J Dermatol, 1999, 141(6):1033-1039.
6. Kalra A, Ratho RK, Kaur I, et al. Role of herpes simplex and cytomegalo viruses in recalcitrant oral lesions of pemphigus vulgaris[J]. Int J Dermatol, 2005, 44(3):259-260.
7. Oliveira DP, Moura HH, Janini ME, et al. Diagnosis andtreatment of persistent oral lesions caused by herpesvirus in a patient with pemphigus vulgaris[J]. Int J Dermatol, 2011, 50(3):335-339.
8. Brandão ML, Fernandes NC, Batista DP, et al. Refractory pemphigus vulgaris associated with herpes infection:case report and review[J]. Rev Inst Med Trop Sao Paulo, 2011, 53(2):113-117.
9. Oliveira-Batista DP, Janini ME, Fernandes NC, et al. Laboratory diagnosis of herpesvirus infections in patients with Pemphigus vulgaris lesions[J]. Intervirology, 2013, 56(4):231-236.
10. Kurata M, Mizukawa Y, Aoyama Y, et al. Herpes simplex virus reactivation as a trigger of mucous lesions in pemphigus vulgaris[J]. Br J Dermatol, 2014, 171(3):554-560.
11. Pranteda G, Carlesimo M, Bottoni U, et al. Pemphigus vulgaris in a patient with arthritis and uveitis:successful treatment with immunosuppressive therapyand acyclovir[J]. Dermatol Ther, 2014, 27(4):215-218.
12. Wucherpfennig KW. Mechanisms for the induction of autoimmunity by infectious agents[J]. J Clin Invest, 2001, 108(8):1097-1104.
13. Dreyfus DH. Herpesviruses and the microbiome[J]. J Allergy Clin Immunol, 2013, 132(6):1278-1286.
14. Esmaili N, Hallaji Z, Abedini R, et al. Pemphigus vulgaris and herpesviruses:is there any relationship?[J]. Int J Dermatol, 2010, 49(11):1261-1265.
15. Horiguchi Y, Fujii S, Takase S, et al. Case of pemphigus vulgaris in oral mucosa showing an extension to the body surface with recurrent varicella[J]. Int J Dermatol, 2005, 44(11):951-954.
16. Murata T, Morita K. Unsuspected varicella-zoster infection complicating mucosal-dominant pemphigus vulgaris[J]. Int J Dermatol, 2013, 52(11):1453-1454.
17. Barzilai O, Sherer Y, Ram M, et al. Epstein-Barr virus and cytomegalovirus in autoimmune diseases:are they truly notorious? A preliminary report[J]. Ann N Y Acad Sci, 2007, 1108(1):567-577.
18. Memar OM, Rady PL, Goldblum RM, et al. Human herpesvirus-8 DNA sequences in a patient with pemphigus vulgaris,but without HIV infection or Kaposi's sarcoma[J]. J Invest Dermatol, 1997, 108(1):118-119.
19. Wang GQ, Xu H, Wang YK, et al. Higher prevalence of human herpesvirus 8 DNA sequence and specific IgG antibodies in patients with pemphigus in China[J]. J Am Acad Dermatol, 2005, 52(3 Pt 1):460-467.
20. Meibodi NT, Nahidi Y, Mahmoudi M, et al. Evaluation of coexistence of the Human Herpesvirus type 8 (HHV-8) infection and pemphigus[J]. Int J Dermatol, 2010, 49(7):780-783.
21. Galan A, Hui P, Mcniff JM. Absence of human herpesvirus 8 in pemphigus and bullous pemphigoid[J]. Int J Clin Exp Pathol, 2009, 2(5):456-462.
22. Mejri K, Kallel Sellami M, Tombari W, et al. Human herpesvirus-8 and hepatitis B and C virus infections in pemphigus[J]. Int J Dermatol, 2014, 53(10):e475-e477.
23. Triantafyllopoulou A, Moutsopoulos HM. Autoimmunity and coxsackievirus infection in primary Sjogren's syndrome[J]. Ann N Y Acad Sci, 2005, 1050(1):389-396.
24. Ruocco E, Lo Schiavo A, Baroni A, et al. Pemphigus vulgaris after coxsackievirus infection and cephalosporin treatment:a paraviral eruption?[J]. Dermatology, 2008, 216(4):317-319.
25. Kaçar N, Cevahir N, Demirkan N, et al. The investigation of the possible relationship between Coxsackie viruses and pemphigus[J]. Int J Dermatol, 2014, 53(3):312-315.
26. Sinha P, Chatterjee M, Vasudevan B. Pemphigus vulgaris:A dermatological sequel of severe H1N1 infection[J]. Indian Dermatol Online J, 2014, 5(2):216-217.
27. Niizeki H, Inamoto N, Nakamura K, et al. A case of pemphigus foliaceus after interferon alpha-2a therapy[J]. Dermatology, 1994, 189(Suppl 1):129-130.
28. Marinho RT, Johnson NW, Fatela NM, et al. Oropharyngeal pemphigus in a patient with chronic hepatitis C during interferon alpha-2a therapy[J]. Eur J Gastroenterol Hepatol, 2001, 13(7):869-872.
29. Demirci GT, Aydingoz IE, Mansur AT, et al. Hepatitis C and hepatitis B virus infections in the etiopathogenesis of pemphigus[J]. An Bras Dermatol, 2014, 89(3):423-426.
30. Hodgson TA, Fidler SJ, Speight PM, et al. Oral pemphigus vulgaris associated with HIV infection[J]. J Am Acad Dermatol, 2003, 49(2):313-315.
31. Marfatia YS, Patel S, Makrandi S, et al. Human immunodeficiency virus and pemphigus vulgaris:an interesting association[J]. Indian J Dermatol Venereol Leprol, 2007, 73(5):354-355.
32. Tull T, Papineni P, Cook C, et al. Paraneoplastic pemphigus in patient infected with the human immunodeficiency virus[J]. Clin Exp Dermatol, 2014, 39(1):83-85.

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病毒感染与天疱疮关系的研究进展

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