微RNA在脊髓损伤中的作用及研究进展_West China Medical Journal

Authors：

 贺琴琴 ,  王廷华 , 罗朝志

四川大学华西医院麻醉科（成都 610041）;

Corresponding author：

王廷华, Email: tinghua_neuron@263.net

Keywords：

微RNA; 脊髓损伤; 调控

DOI：

10.7507/1002-0179.201600490

Video：

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Abstract Full text Figures/Tables Video References Cited by

脊髓损伤是一种全球高发病率、高致残性和高死亡率的中枢神经系统疾病，不仅严重降低患者的生存质量，还给家庭、社会带来巨大的负担。脊髓损伤后的细胞应答和生物化学紊乱等病理改变主要依赖于特异性基因的表达或抑制。而微RNA（miRNA）在脊髓损伤后基因表达起着重要的开关作用。miRNA是真核生物中的一类由内源基因编码的长度为18～25个核苷酸的非编码RNA。它们在转录后水平调控基因表达，在脊椎动物脊髓损伤后病理调控中起重要作用。miRNA能成为调控细胞状态和分子机制，提高脊髓损伤后功能恢复的有效治疗工具。该文主要就miRNA在脊髓损伤后的表达变化及其在脊髓损伤后病理改变过程中的作用予以综述，探讨基于miRNA治疗脊髓损伤的可行性，以期改善脊髓损伤的临床预后。

Citation： 贺琴琴, 王廷华, 罗朝志. 微RNA在脊髓损伤中的作用及研究进展. West China Medical Journal, 2016, 31(10): 1782-1789. doi: 10.7507/1002-0179.201600490 Copy

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