Clinicopathological Analysis of Mediastinum Nodular Sclerosis Hodgkin Lymphoma_West China Medical Journal

Authors：

 TangXi ¹ ,  ChenYihua ² , FanYanyan ² , JianYi ²

1. Department of Pathology, the Sixth People's Hospital of Chengdu, Chengdu, Sichuan 610051, P. R. China;
2. Department of Pathology, General Hospital of Chengdu Military Command, Chengdu, Sichuan 610083, P. R. China;

Corresponding author：

ChenYihua, Email: chenyihua0520@sina.com

Keywords：

Mediastinum; Nodular sclerosis Hodgkin lymphoma; Immunophenotype; Situ hybridization; Gene rearrangement; Diagnosis; Differentiation

DOI：

10.7507/1002-0179.201600505

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To study the clinicopathological features of mediastinum nodular sclerosis Hodgkin lymphoma (NSHL) in order to improve the recognition of it. Methods The clinical data of 3 cases of mediastinum NSHL between 2003 and 2012 were collected. Then we analyzed the carcinoma pathologic samples by pathomorphology, immunophenotypic phenotype, related gene rearrangement and situ hybridization with EBER. Results The pathomorphologic results showed that broad fibrotic bands subdivided the lymphoid parenchyma into large nodules, the tumoral cells had distinct boundary with empty cytoplasm and small-to-medium-sized nucleoli, and the nodules contained inflammatory cell components. The immunophenotypic phenotype of the tumoral cells were CD15, CD30, PAX-5 and CD20 partly, but anaplastic lymphoma kinase, CD45, cytokeratin, CD79α and S-100 were not expressed. T cell receptor γ and IgH gene were no rearranged, and EBER in situ hybridization was not detected. Conclusion Various lymphomas occur in the mediastinum and mediastinum NSHL is just one of them. Mastering its distinctive pathomorphology and immunophenotypic phenotype is highly significant for diagnosis, differential diagnosis and treatment of the disease.

Citation： TangXi, ChenYihua, FanYanyan, JianYi. Clinicopathological Analysis of Mediastinum Nodular Sclerosis Hodgkin Lymphoma. West China Medical Journal, 2016, 31(11): 1842-1845. doi: 10.7507/1002-0179.201600505 Copy

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1. Van Dongen JJ, Langerak AW, Brüggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations:report of the BIOMED-2 Concerted Action BMH4-CT98-3936[J].Leukemia, 2003, 17(12):2257-2317.
2. Shimabukuro-Vornhagen A, Haverkamp H, Engert A, et al. Lymphocyte-rich classical Hodgkin's lymphoma:clinical presentation and treatment outsome in 100 patients treated within German Hodgkin's study group trials[J].J Clin Oncol, 2005, 23(24):5739-5745.
3. Siddon A, Lozovatsky L, Mohamed A, et al. Human herpesvirus 6 positive Reed-Sternberg cells in nodular sclerosis Hodgkin lymphoma[J].Br J Haematol, 2012, 158(5):635-643.
4. Piccaluga PP, Agostinelli C, Gazzola A, et al. Pathobiology of hodgkin lymphoma[J].Adv Hematol, 2011:920898.
5. Kischel P, Waltregny D, Greffe YA, et al. Identification of stromal proteins overexpressed in nodular sclerosis Hodgkin lymphoma[J].Proteome Sci, 2011, 9(1):63.
6. 张艳, 黎相昭, 温宗华, 等. 霍奇金淋巴瘤背景淋巴细胞免疫表型与组织学类型关系及其意义[J].中国实验血液学杂志, 2009, 17(4):888-893.
7. Hudnall SD, Betancourt E, Barnhart E, et al. Comparative flow immunophenotypic features of the inflammatory infiltrates of Hodgkin lymphoma and lymphoid hyperplasia[J].Cytometry B Clin Cytom, 2008, 74B(1):1-8.
8. Ma Y, Visser L. The CD4⁺CD26^-T-cell population in classical Hodgkin's lymphoma displays a distinctive regulatory T-cell profile[J].Lab Invest, 2008, 88(5):482-490.
9. Penkowa M, Srensen BL, Nielsen SL. Metallothionein as a useful marker in Hodgkin lymphoma subclassification[J].Leuk Lymphoma, 2009, 50(2):200-210.
10. 朱梅刚, 丁向东. 滤泡树突细胞网形态变化在淋巴组织增生性良恶性宝贝鉴别诊断中的应用[J].临床与实验病理学杂志, 2012, 28(11):1231-1234.
11. Vassallo J, Lamant L. ALK-positive anaplastic large cell lymphoma mimicking nodular sclerosis Hodgkin's lymphoma:report of 10 cases[J].Am J Surg Pathol, 2006, 30(2):223-229.
12. Dunleavy K, Grant C. Gray Zone lymphoma:better treated like Hodgkin lymphoma or mediastinal B-cell lymphoma?[J].Curr Hematol Malig Rep, 2012, 7(3):241-247.
13. Mianmi J, Dobashi N. Two cases of mediastinal gray zone lymphoma[J].J Clin Exp Hematop, 2010, 50(2):143-149.
14. Arai H, Iso H. Mediastinal large B-cell lymphoma associated with systemic sclerosis[J].Rinsho Ketsueki, 2009, 50(2):97-101.
15. Cozen W, Li DL, Best T, et al. A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21.32[J].Blood, 2012, 119(2):469-475.

West China Medical Journal

Clinicopathological Analysis of Mediastinum Nodular Sclerosis Hodgkin Lymphoma

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