Comparison between the Effect of Lidocaine Mucilage Diluent and Simethicone Emulsion for Gastroscopy_West China Medical Journal

Authors：

 WangYu ¹ , WenYing ² , ZhangQiongying ¹

1. Endoscopy Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong 518073, P. R. China;

Corresponding author：

Keywords：

Lidocaine hydrochloride mucilage diluent; Simethicone emulsion; Gastroscopy; Effect

DOI：

10.7507/1002-0179.201600506

Video：

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Objective To explore the clinical effect of lidocaine mucilage diluent and simethicone emulsion in gastroscopy examination, in order to provide effective drugs for gastroscopy. Methods We selected 201 outpatients and the inpatients who underwent gastroscopic examination between August and October 2014 as the research subjects. Based on the kind of drug, the patients were randomly divided into research group (n=100) and control group (n=101). Patients in the research group accepted lidocaine mucilage diluent, while those in the control group received simethicone emulsion. Then we observed and compared the definition of gastroscopy, adverse drug reactions, examination time and drug price between the two groups. Results The frequencies of high, medium, and low definition of gastroscopy were respectively 63.00%, 34.00% and 3.00% among the patients in the research group, and 69.31%, 26.73% and 3.96% among patients in the control group; there was no significant differences between the two groups (Z=-0.854, P=0.393). The adverse reaction rates, testing time, and drug prices for the two groups were 0.99% vs.1.00% (P>0.05), (6.5±2.1) minutes vs.(6.6±2.0) minutes (t=0.458, P>0.05), and RMB (9.0±1.2) yuan vs.(42.8±2.8) yuan (t=227.644, P<0.05), respectively. Conclusion Lidocaine mucilage diluent and simethicone emulsion both have good effect for gastroscopic examination, which can raise the gastroscopic definition, promote endoscopic operation and observation by doctors, shorten examination time, and reduce adverse drug reactions. Both are of great value in clinical application, and lidocaine hydrochloride mucilage diluent is cheaper, which can be widely used and promoted clinically.

Citation： WangYu, WenYing, ZhangQiongying. Comparison between the Effect of Lidocaine Mucilage Diluent and Simethicone Emulsion for Gastroscopy. West China Medical Journal, 2016, 31(11): 1846-1849. doi: 10.7507/1002-0179.201600506 Copy

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15.	王芸, 吴飞, 曹治平. 消泡剂的研究现状与展望[J].化学工程师2008, 11(3):26-28.
16.	李聪. 不同剂量地佐辛联合丙泊紛用于无痛胃镜的临床观察[J].中国药物与临床, 2014, 14(2):267-268.
17.	李延领. 芬太尼和咪达唑仑与利多卡因胶浆在无痛胃镜检查中的应用[J].中国现代药物应用, 2012, 6(6):73-74.
18.	武朝霞, 武永生, 苏心镜, 等. 利多卡因预防芬太尼在无痛胃镜检查时咳嗽反射的效果[J].中国误诊学杂志, 2011, 11(22):5340.

1. 廖日斌, 苏燕波, 唐建光, 等. 咪达唑仑单用和联合应用丙泊酚在胃镜检查中的效果比较[J].中国临床医学, 2011, 18(3):355-357.
2. 陈黎, 刘永爵, 龚益清. 西甲硅油乳剂联合利多卡因胶浆在胃镜检查中的效果观察[J].中国现代药物应用, 2014, 8(19):147-148.
3. 董桂祥. 喷他佐辛复合靶控丙泊酚用于老年人无痛胃镜检查术90例[J].中国药业, 2014, 11(13):86-88.
4. Kao SH, Hsu LL, Hsieh SI, et al. The effects of two educational interventions on knowledge and competence of nurses with regard to conveying gastroscopy-related information to patients[J].J Adv Nurs, 2013, 69(4):793-804.
5. 陈伯利, 斯望春, 张杏琴, 等. 西甲硅油在无痛胃镜检查中的应用[J].中国现代医生, 2011, 49(16):58-59.
6. 邓红英. 肥胖患者无痛胃镜检查时血氧饱和度下降分析[J].按摩与康复医学, 2011, 2(26):26-27.
7. 舒丽娟, 魏新.联合用药在肥胖患者无痛胃镜中的应用[J].实用医学杂志, 2011, 27(22):4142-4144.
8. 李长顺, 杨蓬勃, 和小祥, 等. 成年国人内镜下食管长度的研究[J].西安交通大学学报, 2005, 26(3):239-241.
9. 吴在德, 吴肇汉. 外科学[M].北京:人民卫生出版社, 2005:441.
10. 章四杰, 徐磊, 王维红, 等. 西甲硅油和盐酸利多卡因胶浆在胃镜检查中的应用效果比较[J].中国医师进修杂志, 2011, 34(13):64-65.
11. 赖艳新, 李良芳, 陈彦, 等. 不同浓度西甲硅油溶液在无痛胃镜检查中的应用观察与护理[J].临床护理杂志, 2014, 13(1):13-16.
12. 吴云林, 陈丽娜, 王春兰, 等. 西甲硅油在内镜胃体胃底观察中的价值[J].胃肠病学和肝病学杂志, 2006, 15(3):300-302.
13. 高彦花. 利多卡因用于老年患者无痛胃镜检查100例[J].中国老年学杂志, 2012, 32(8):1734-1735.
14. 杨聪玲, 吴行烁, 邱奕, 等. 利多卡因联合丙泊酚行无痛胃镜检查的临床体会[J].中国药物滥用防治杂志, 2011, 17(1):21-23.
15. 王芸, 吴飞, 曹治平. 消泡剂的研究现状与展望[J].化学工程师2008, 11(3):26-28.
16. 李聪. 不同剂量地佐辛联合丙泊紛用于无痛胃镜的临床观察[J].中国药物与临床, 2014, 14(2):267-268.
17. 李延领. 芬太尼和咪达唑仑与利多卡因胶浆在无痛胃镜检查中的应用[J].中国现代药物应用, 2012, 6(6):73-74.
18. 武朝霞, 武永生, 苏心镜, 等. 利多卡因预防芬太尼在无痛胃镜检查时咳嗽反射的效果[J].中国误诊学杂志, 2011, 11(22):5340.

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West China Medical Journal

Comparison between the Effect of Lidocaine Mucilage Diluent and Simethicone Emulsion for Gastroscopy

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