Study of Correlation between Inflammatory Factors and Multiple Factors of Acute Cerebral Infarction_West China Medical Journal

Authors：

 HuangJiajun ,  Dulin , WangYongqiang , Wangwei

Department of Neurology, the Second People's Hospital of Neijiang, Neijiang, Sichuan 644100, P. R. China;

Corresponding author：

Dulin, Email: njyydulin@126.com

Keywords：

Inflammatory factors; Acute cerebral infarction; Multiple linear regression model

DOI：

10.7507/1002-0179.201600542

Video：

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Objective To observe the relationship between the serum level changes of high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-18, intercellular adhesion molecule-1(ICAM1), matrix metalloproteinase (MMP)-9 and lipoprotein-associated phospholipase A2(Lp-PLA2), and the multiple factors of acute cerebral infarction (ACI). Methods We chose 76 patients with ACI treated between July 2012 and June 2014 as our study subjects.On the second day (acute phase) and the 15th day (recovery phase) after onset, we checked the patients for their serum levels of hsCRP, IL-18, ICAM1, MMP-9 and Lp-PLA2.Then, multiple linear regression analysis was performed to observe the correlation of the serum level change degree of inflammatory factors with hypertension, diabetes, coronary heart disease, smoking history, carotid atherosclerotic plaque, lipid levels, infarct size and National Institute of Health Stroke Scale (NIHSS) score. Results The changes of all the inflammatory factors in the acute phase and the recovery phase of cerebral infarction were not significantly related to smoking history, hypertension, coronary heart disease, low-density lipoprotein and NIHSS scores (P > 0.05).The changes of hsCRP and ICAM1 had significant correlation with cerebral infarct size, diabetes mellitus and carotid atherosclerotic plaque (P < 0.05), and the change level of Lp-PLA2 was related to diabetes mellitus, and carotid atherosclerotic plaque (P < 0.05).MMP-9 serum level change had correlation with only cerebral infarct size (P < 0.05). Conclusions Serum level changes of inflammatory factors are related to various factors of cerebral infarction.The main factors that affecting the serum level changes are cerebral infarction area, diabetes mellitus and carotid atherosclerosis.

Citation： HuangJiajun, Dulin, WangYongqiang, Wangwei. Study of Correlation between Inflammatory Factors and Multiple Factors of Acute Cerebral Infarction. West China Medical Journal, 2016, 31(12): 1971-1974. doi: 10.7507/1002-0179.201600542 Copy

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2.	Kogure K, Yamasaki Y, Matsuo Y, et al. Inflammation of thebrain after ischemic[J]. Acta Neurochir Suppl, 1996, 66:40-43.
3.	朱春丽, 彭一鹏, 欧阳存, 等.远端缺血后适应处理对急性脑梗死患者血清促炎因子和抗炎因子的影响及其临床意义[J].疑难病杂志, 2016, 15(3):241-244.
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9.	陈线茹, 豆志伟.基质金属蛋白酶与动脉粥样硬化病变的关系.心血管病学进展[J]. 2012, 33(3):314-317.
10.	李冰, 姜雪松.脑梗死血清基质金属蛋白酶-2, 基质金属蛋白酶-9的动态变化及临床意义[J].华西医学, 2015, 30(11):2009-2012.
11.	陶晶, 李志, 刘卉萍.急性脑梗死患者血清基质金属蛋白酶-9检测的临床意义[J].实用医技杂志, 2011, 18(12):1243-1245.
12.	Kemp EH, Waterman EA, Gawkrodger DJ, et al. Autoantibodies to tyrosinase-related protein-1 detected in the sera of vitiligo patients using a quantitative radiobinding assay[J]. Br J Dermato1, 1998, 139(5):798-805.
13.	刘春燕.血清脂蛋白相关磷脂酶A2及C反应蛋白与颈动脉粥样硬化斑块易损性的关系.中华实用诊断与治疗杂志, 2014, 28(4):350-352.
14.	Zaremba J, Losy J. Interleukin-18 in acute ischemic stroke patients[J]. Neurol Sci, 2003, 24(3):117-124.
15.	刘勇, 杨国铭.糖尿病合并脑梗死患者超敏C反应蛋白水平与颈动脉粥样硬化及预后的关系[J].现代中西医结合杂志, 2012, 21(16):1745-1746.
16.	Mucalo I, Jovanovski E, Rahelic D, et al. Effect of American ginseng (Panax quinquefolius L.) on arterial stiffness in subjects with type-2 diabetes and concomitant hypertension[J]. J Ethnopharmacol, 2013, 150(1):148-153.

1. Wang PY, Kao CH, Mui MY, et al. Leukocyte infiltration in acute hemispheric ischemic stroke[J]. Stroke, 1993, 24(2):236-240.
2. Kogure K, Yamasaki Y, Matsuo Y, et al. Inflammation of thebrain after ischemic[J]. Acta Neurochir Suppl, 1996, 66:40-43.
3. 朱春丽, 彭一鹏, 欧阳存, 等.远端缺血后适应处理对急性脑梗死患者血清促炎因子和抗炎因子的影响及其临床意义[J].疑难病杂志, 2016, 15(3):241-244.
4. 蒋正强, 高金霞.彩色多普勒超声检查颈动脉粥样硬化斑块与脑梗死的相关性研究[J].临床医学, 2010, 30(8):89-90.
5. 黎红华, 汪志忠, 吴非, 等.脑梗死危险因素与颈动脉粥样硬化斑块稳定性及炎性反应因子的关系[J].中国神经免疫学和神经病学杂志, 2011, 18(5):375-376.
6. 王大力, 张江, 张文彦, 等.急性脑梗死患者血清hs-CRP浓度的变化及其临床意义[J].放射免疫学杂志, 2006, 19(3):241-243.
7. 曲欣, 张竞文, 常越, 等.糖尿病高血糖脑缺血再灌注梗死区周围微小血管病理变化[J].神经解剖学杂志, 2015, 31(4):433-438.
8. 毕显梅, 王永久, 刘坤, 等.急性脑梗死患者颈动脉斑块稳定性与血浆IL-18、MMP-9的相关性研究[J].中国神经免疫学和神经病学杂志, 2013, 20(4):256-259.
9. 陈线茹, 豆志伟.基质金属蛋白酶与动脉粥样硬化病变的关系.心血管病学进展[J]. 2012, 33(3):314-317.
10. 李冰, 姜雪松.脑梗死血清基质金属蛋白酶-2, 基质金属蛋白酶-9的动态变化及临床意义[J].华西医学, 2015, 30(11):2009-2012.
11. 陶晶, 李志, 刘卉萍.急性脑梗死患者血清基质金属蛋白酶-9检测的临床意义[J].实用医技杂志, 2011, 18(12):1243-1245.
12. Kemp EH, Waterman EA, Gawkrodger DJ, et al. Autoantibodies to tyrosinase-related protein-1 detected in the sera of vitiligo patients using a quantitative radiobinding assay[J]. Br J Dermato1, 1998, 139(5):798-805.
13. 刘春燕.血清脂蛋白相关磷脂酶A2及C反应蛋白与颈动脉粥样硬化斑块易损性的关系.中华实用诊断与治疗杂志, 2014, 28(4):350-352.
14. Zaremba J, Losy J. Interleukin-18 in acute ischemic stroke patients[J]. Neurol Sci, 2003, 24(3):117-124.
15. 刘勇, 杨国铭.糖尿病合并脑梗死患者超敏C反应蛋白水平与颈动脉粥样硬化及预后的关系[J].现代中西医结合杂志, 2012, 21(16):1745-1746.
16. Mucalo I, Jovanovski E, Rahelic D, et al. Effect of American ginseng (Panax quinquefolius L.) on arterial stiffness in subjects with type-2 diabetes and concomitant hypertension[J]. J Ethnopharmacol, 2013, 150(1):148-153.

West China Medical Journal

Study of Correlation between Inflammatory Factors and Multiple Factors of Acute Cerebral Infarction

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