烧伤患者血浆凝溶胶蛋白水平及其与预后的关系研究_West China Medical Journal

Authors：

 李先慧 , 王晓娟 , 刘德贵 , 杨勇 , 张彦标 ,  薛刚

成都军区总医院烧伤整形科（成都 610083）;

Corresponding author：

薛刚, Email: kpardan@163.com

Keywords：

烧伤; 凝溶胶蛋白; 脓毒症; 预后

DOI：

10.7507/1002-0179.201600555

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目的观察烧伤患者血浆凝溶胶蛋白水平及变化规律，探讨凝溶胶蛋白水平与患者预后的关系。方法采用前瞻性队列研究的方式，选取2010年1月-2013年6月收治的98例烧伤面积≥30%总体表面积患者作为研究对象，分别按照烧伤面积大小、是否出现脓毒症以及脓毒症患者是否死亡分组，比较不同组别患者血浆凝溶胶蛋白水平及变化趋势。结果伤后7 d患者的血浆凝溶胶蛋白水平处于最低值，与其他时间点比较差异有统计学意义（P＜0.001）。血浆凝溶胶蛋白浓度随着烧伤面积增大而降低（P＜0.001）。脓毒症患者血浆凝溶胶蛋白总体均数水平低于非脓毒症患者，差异有统计学意义（F=1 035.41，P＜0.001）。脓毒症死亡患者血浆凝溶胶蛋白总体均数水平低于存活患者，差异有统计学意义（F=958.69，P＜0.001）；伤后7~21 d的血浆凝溶胶蛋白水平低于伤后3 d及入院当天，差异有统计学意义（P＜0.001）。结论烧伤可导致患者血浆凝溶胶蛋白水平降低，烧伤面积越大、合并脓毒症患者的血浆凝溶胶蛋白越低。血浆凝溶胶蛋白是反映大面积烧伤患者预后的一项重要监测指标。

Citation： 李先慧, 王晓娟, 刘德贵, 杨勇, 张彦标, 薛刚. 烧伤患者血浆凝溶胶蛋白水平及其与预后的关系研究. West China Medical Journal, 2016, 31(12): 2027-2029. doi: 10.7507/1002-0179.201600555 Copy

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2. Jin Y, Li Y, Qiu L, et al. Decreased plasma gelsolin is associated with 1-year outcome in patients with traumatic brain injury[J]. J Crit Care, 2012, 27(5):527.e1-527.e6.
3. Cohen S, Bucki Robert, Byfield J, et al. Therapeutic potential of plasma gelsolin administration in a rat model of sepsis[J]. Cytokine, 2011, 54(3):235-238.
4. 黄立峰, 龚平, 姚咏明, 等.凝溶胶蛋白与脓毒症[J].中华老年多器官疾病杂志, 2011, 10(5):469-472.
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6. Sadzyński A, Kurek K, Konończuk T, et al. Gelsolin-variety of structure and functions[J]. Postepy Hig Med Dosw (Online), 2010, 64(2):303-309.
7. Lee S, Bhan I, Thadhani R. The potential role of plasma gelsolin in dialysis-related protein-energy wasting[J]. Blood Purif, 2010, 29(2):99-101.
8. Zhang QH, Chen Q, Kang JR, et al. Treatment with gelsolin reduces brain inflammation and apoptotic signaling in mice following thermal injury[J]. J Neuroinflammation, 2011, 8(1):118.
9. Xu F, Liu G, Dong Q, et al. Change in plasma gelsolin level after traumatic brain injury[J]. J Trauma, 2011, 72(2):491-496.

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烧伤患者血浆凝溶胶蛋白水平及其与预后的关系研究

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