儿童头颈部胚胎型横纹肌肉瘤复发一例报道及文献回顾_West China Medical Journal

Authors：

 张恒丽 ,  李平

四川大学华西医院肿瘤中心（成都 610041）;

Corresponding author：

李平, Email: leepingmd68@yahoo.Com

Keywords：

头颈部; 胚胎型; 横纹肌肉瘤; 复发; 化学治疗; 放射治疗

DOI：

10.7507/1002-0179.20160083

Video：

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Abstract Full text Figures/Tables Video References Cited by

目的胚胎型横纹肌肉瘤（ERMS）是一种幼儿、青少年较多见的的软组织肿瘤。通过介绍典型病例及文献复习，以总结ERMS的治疗经验。方法报道1例腮腺咬肌区来源的头颈部ERMS患儿，二次切除术后再次复发，肿瘤增长速度快，局部侵及面广，累及区域淋巴结。复发后行3个周期TI（紫杉醇脂质体+异环磷酰胺）一线化学疗法（化疗）后给予适形调强放射治疗（放疗），观察患儿治疗后的疗效。完善相关检查，排除肿瘤远处转移后，行3个周期TI化疗，化疗结束2周后行适型调强放疗，化疗期间每周期及放疗前后复查肿瘤原发灶CT，根据实体肿瘤RESEST version 1.1疗效评价标准，测量肿瘤最大径，比较其在治疗前后及过程中的变化，进行疗效评价。结果患儿3个周期化疗后疗效评价部分缓解，放疗结束后疗效评价为完全缓解，治疗后迄今无复发转移征象。结论 ERMS复发后暂无标准治疗方案，对于巨大头颈部横纹肌肉瘤，如果无法手术切除，可进行化疗+放疗综合治疗。新辅助化疗采用TI方案局部肿瘤消退效果好。

Citation： 张恒丽, 李平. 儿童头颈部胚胎型横纹肌肉瘤复发一例报道及文献回顾. West China Medical Journal, 2016, 31(2): 312-315. doi: 10.7507/1002-0179.20160083 Copy

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21.	张谊, 呙芳, 张伟令, 等. ¹²⁵I粒子植入术在头颈部横纹肌肉瘤的临床应用[J]. 中国当代儿科杂志, 2012, 14(6):437-440.
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25.	Nayar RC, Prudhomme F, Parise O, et al. Rhabdomyosarcoma of the head and neck in adults:a study of 26 patients[J]. Laryngoscope, 1993, 103(12):1362-1366.
26.	Callender TA, Weber RS, Janjan N, et al. Rhabdomyosarcoma of the nose and paranasal sinuses in adults and children[J]. Otolaryngol Head Neck Surg, 1995, 112(2):252-257.
27.	Brockstein B. Management of sarcomas of the head and neck[J]. Curr Oncol Rep, 2004, 6(4):321-327.
28.	Crist W, Gehan EA, Ragab AH, et al. The third intergroup rhabdomyosarcoma study[J]. J Clin Oncol, 1995, 13(3):610-630.
29.	李璋林, 闫杰, 张广超. 儿童横纹肌肉瘤术前治疗的探讨(附34例病例分析)[J]. 中国肿瘤临床, 2002, 29(6):407-409.

1. Huh WW, Skapek SX. Childhood rhabdomyosarcoma:new insight on biology and treatment[J]. Curr Oncol Rep, 2010, 12(6):402-410.
2. Leaphart C, Rodeberg D. Pediatric surgical oncology:management of rhabdomyosarcoma[J]. Surg Oncol, 2007, 16(3):173-185.
3. Wang C. Childhood rhabdomyosarcoma:recent advances and prospective views[J]. J Dent Res, 2012, 91(4):341-350.
4. 曹嫣娜, 张广超, 阎杰, 等. 立体定位放射治疗在儿童头颈部横纹肌肉瘤综合治疗中的应用和疗效分析[J]. 中国肿瘤临床, 2012, 39(15):1033-1036.
5. Christopher DF, Julia AB, Pancras CH, et al. WHO classificationoftumours of soft tissue and bone[M]. Lyon:International Agency forResearch on Cancer, 2013:127-135.
6. Dasgupta R, Rodeberg DA. Update on rhabdomyosarcoma[J]. Semin Pediatr Surg, 2012, 21(1):68-78.
7. 殷蔚伯. 肿瘤放射治疗学[M]. 4版. 北京:中国协和医科大学出版社, 2008:1278-1285.
8. 何乐健, 王琳, 孙宁, 等. 儿童横纹肌肉瘤的临床病理研究[J]. 中华病理学杂志, 2004, 33(3):225-228.
9. Cessna MH, Zhou H, Perkins SL, et al. Are myogenin and myoD1 expression specific for rhabdomyosarcoma? A study of 150 cases, with emphasis on spindle cell mimics[J]. Am J Surg Pathol, 2001, 25(9):1150-1157.
10. 魏守礼, 朱振龙, 贾茹, 等. 40例横纹肌肉瘤的病理分析[J]. 诊断病理学杂志, 2000, 7(2):16-18, 87.
11. Charchi H, Mansouri N, Harmouch A, et al. Epidemiological, histological and immunohistochemical analysis of head andneck rhabdomyosarcoma in children[J]. J Afr Cancer, 2011(3):222-226.
12. 赵艳梅, 贺红梅, 田广永. 头颈部横纹肌肉瘤(附8例报告)[J]. 中国耳鼻咽喉颅底外科杂志, 2001, 7(2):103-105.
13. Pappo AS, Meza JL, Donaldson SS, et al. Treatment of localized nonorbital, nonparameningeal head and neck rhabdomyosarcoma:lessons learned from intergroup rhabdomyosarcoma studies Ⅲ and Ⅳ[J]. J Clin Oncol, 2003, 21(4):638-645.
14. Wiener ES. Head and neck rhabdomyosarcoma[J]. Semin Pediatr Surg, 1994, 3:203-206.
15. Walterhouse DO, Pappo AS, Baker KS, et al. Rhabdomyosarcoma of the parotid region occurring in childhood and adolescence. A report from the Intergroup Rhabdomyosarcoma Study Group[J]. Cancer, 2001, 92(12):3135-3146.
16. Wm C, Anderson JR, Meza JL, et al. IntergroupRhabdomyosarcoma Study-Ⅳ:results for patients withonmetastatic disease[J]. J Clin Oncol, 2001(19):3091-3102.
17. Spunt SL, Smith LM, Ruymann FB, et al. Cyclophosphamide dose intensification during induction therapy for intermediate-risk pediatric rhabdomyosarcoma is feasible but does not improve outcome:a report from the soft tissue sarcoma committee of the children's oncology group[J]. Clin Cancer Res, 2004, 10(18 Pt 1):6072-6079.
18. 邱妙珍, 徐菲, 王树森, 等. 109例成人软组织肉瘤化疗的疗效分析[J]. 癌症, 2007, 26(12):1344-1349.
19. Fata F, O'Reilly E, Ilson D, et al. Paclitaxel in the treatment ofpatients with angiosarcoma of the scalp or face[J]. Cancer, 1999, 86(10):2034-2037.
20. 李宝忠, 武要洪, 李晓江, 等. 头颈部横纹肌肉瘤(附12例报告)[J]. 现代肿瘤医学, 2005, 13(1):98-100.
21. 张谊, 呙芳, 张伟令, 等. ¹²⁵I粒子植入术在头颈部横纹肌肉瘤的临床应用[J]. 中国当代儿科杂志, 2012, 14(6):437-440.
22. Lawrence W Jr, Anderson JR, Gehan EA, et al. Pretreatment TNM staging of childhood rhabdomyosarcoma:a report of the intergroup rhabdomyosarcoma study group. Children's cancer study group. Pediatric oncology group[J]. Cancer, 1997, 80(6):1165-1170.
23. Malempati S, Hawkins DS. Rhabdomyosarcoma:review of the children's oncology group (COG) Soft-Tissue Sarcoma committee experience and rationale for current COG studies[J]. Pediatr Blood Cancer, 2012, 59 (1):5-10.
24. Mattke AC, Bailey EJ, Schuck A, et al. Does the time-point of relapse influence outcome in pediatric rhabdomyosarcomas?[J]. Pediatr Blood Cancer, 2009, 52:772-776.
25. Nayar RC, Prudhomme F, Parise O, et al. Rhabdomyosarcoma of the head and neck in adults:a study of 26 patients[J]. Laryngoscope, 1993, 103(12):1362-1366.
26. Callender TA, Weber RS, Janjan N, et al. Rhabdomyosarcoma of the nose and paranasal sinuses in adults and children[J]. Otolaryngol Head Neck Surg, 1995, 112(2):252-257.
27. Brockstein B. Management of sarcomas of the head and neck[J]. Curr Oncol Rep, 2004, 6(4):321-327.
28. Crist W, Gehan EA, Ragab AH, et al. The third intergroup rhabdomyosarcoma study[J]. J Clin Oncol, 1995, 13(3):610-630.
29. 李璋林, 闫杰, 张广超. 儿童横纹肌肉瘤术前治疗的探讨(附34例病例分析)[J]. 中国肿瘤临床, 2002, 29(6):407-409.

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West China Medical Journal

儿童头颈部胚胎型横纹肌肉瘤复发一例报道及文献回顾

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