ObjectiveTo observe the effect of thermal damage in the fresh isolated kidneys of New Zealand white rabbits caused by domestic holmiumlaser. MethodsIn the operation room (constant temperature 22℃, humidity 60%), Guangdong electric (POTENT) domestic holmium laser equipment was chosen. The fresh isolated kidney of New Zealand white rabbit was put into a disposable sterilized syringe with 50 mL normal saline, then the holmium laser optical fiber (550 μm) was put into it, and the temperature of normal saline was measured by a mercury thermometer. The parameters of holmium laser were setted as frequency 20 Hz, energy 2 J, stimulating time 15 seconds, intermittent time 5 seconds, which was repeated. The temperature was measured 2, 5 and 7 minutes after stimulation. Then the kidney was dissected, phtographed, haematoxylin-eosin stained, and pathologically examined.ResultsAt the 2nd minute of stimulation, the temperature of normal saline in the syringe increased from 22℃ to 38℃; the cortex and medulla of rabbit kidney were ruddy, and the cortex, medulla and ureter were almost normal in pathological section. At the 5-minute point, the temperature increased to 57℃, and the cortex turned to be white, while the medulla remained ruddy, but the demarcation between the cortex and medulla was not very clear. At the 7th minute, the temperature was 78℃, and the cortex and medulla were both white and solidification with no clear demarcation. Pathological examination showed severe degeneration and necrosis of glomerulus and renal tubule.ConclusionCommon power of domestic holmium laser would produce increasing thermal damage, which may cause tissue damage in the human body when the temperature increases above 50℃.
Citation：
GONG Chunyu, LI Li, QU Rui, YANG Luo, FENG Yangyang, DENG Huizhuo, LUO Xiaorong, YANG Jing. A primary research of the thermal damage of rabbit kidney by domestic holmium laser in surgery. West China Medical Journal, 2017, 32(7): 984-987. doi: 10.7507/1002-0179.201601009
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Ng EY, Tan HM, Ooi EH. Boundary element method with bioheat equation for skin burn injury. Burns, 2009, 35(7): 987-997.
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龚云辉. 输尿管镜弹道与钬激光碎石治疗输尿管结石致肾功能衰竭的临床分析. 中国医药指南, 2016, 4(26): 194-195.
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- 1. 孙颖浩. 钬激光在泌尿外科中的应用. 中国现代手术学杂志, 2003, 7(5): 331-334.
- 2. 罗建仕. 钬激光技术在泌尿系结石中的应用. 微创医学, 2006, 1(2): 115-117.
- 3. 刘庆. 多用途钬激光: 泌尿外科的新技术. 医疗设备信息, 2005, 20(1): 27-28.
- 4. 王坤杰, 李虹. 输尿管软镜联合钬激光在特殊上尿路结石治疗中的运用. 现代泌尿外科杂志, 2015, 20(11): 761-763.
- 5. 锁锦江. 输尿管镜下钬激光治疗输尿管结石伴息肉疗效分析. 浙江临床医学, 2017, 19(2): 296-297.
- 6. 俞宇宙, 胡明进, 朱洪翔, 等. 微创经皮肾镜钬激光碎石取石术在肾结石中的应用效果分析. 临床医药文献杂志, 2016, 3(43): 8565.
- 7. 袁磊, 马永, 娄腾飞, 等. 改良方法在输尿管镜钬激光治疗输尿管结石中的应用. 淮海医药, 2016, 34(5): 545-546.
- 8. 粟周全, 苟兴连, 杜龙. 输尿管钬激光碎石术和微创经皮肾镜碎石术治疗输尿管上段结石疗效观察. 陕西医学杂志, 2014, 43(4): 443-444.
- 9. 张俊岩, 王德刚, 王文刚. 斜卧位经皮肾输尿管镜下钬激光碎石术治疗复杂性肾结石. 中国医药指南, 2017, 15(2): 153-154.
- 10. 李良菊, 朱泉玉, 胡海燕. 经输尿管镜钬激光碎石日间手术的安全及质量评价. 海南医学, 2017, 28(1): 141-143.
- 11. 崔增林, 张峰, 卞建强. 输尿管镜联合钬激光碎石治疗嵌顿性输尿管上段结石体会. 河南外科学杂志, 2016, 22(2): 112-113.
- 12. 吕国强, 宋东奎, 郝凯. 输尿管镜钬激光碎石术治疗老年输尿管结石疗效及对肾功能的影响观察. 基层医学论坛, 2016, 20 (35): 4950-4951.
- 13. 罗魁德, 殷凡荣. 经输尿管钬激光碎石术治疗输尿管结石 100 例临床疗效. 世界最新医学文摘, 2106, 16(12): 199-120.
- 14. Grasso M, Fraiman M, Levine M. Ureteropyeloscopic diagnosis and treatment of upper urinary tract urothelial malignancies. Urology, 1999, 54(2): 240-246.
- 15. Ng EY, Tan HM, Ooi EH. Boundary element method with bioheat equation for skin burn injury. Burns, 2009, 35(7): 987-997.
- 16. 龚云辉. 输尿管镜弹道与钬激光碎石治疗输尿管结石致肾功能衰竭的临床分析. 中国医药指南, 2016, 4(26): 194-195.
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