产前抑郁的研究进展_West China Medical Journal

Authors：

刘秀萍 ¹ ,  宋锦平 ²

1. ;
2. ;

Corresponding author：

宋锦平, Email: 1423439880@qq.com

Keywords：

孕妇; 抑郁; 产前抑郁; 研究进展; 展望

DOI：

10.7507/1002-0179.201601107

Video：

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该文通过查阅国内外有关产前抑郁的文献资料，描述产前抑郁患病率的现状，并从近期和远期两个方面阐述了产前抑郁对母儿的危害，包括延长产程、增加产后出血的风险、影响胎儿发育、子代远期甚至可能出现情绪问题和行为问题等，并从社会、心理、生物等方面分析发生产前抑郁的危险因素，从而得出产前抑郁患病现况不容忽视，提示我们今后母婴保健应做好产前抑郁的筛查，及早发现产前抑郁的发生倾向和危险因素，以便及早进行干预，保障孕产妇及其子代的身心健康。

Citation： 刘秀萍, 宋锦平. 产前抑郁的研究进展. West China Medical Journal, 2017, 32(12): 1959-1962. doi: 10.7507/1002-0179.201601107 Copy

1.	Haas JS, Jackson RA, Fuentes-Afflick E, et al. Changes in the health status of women during and after pregnancy. J Gen Intern Med, 2005, 20(1): 45-51.
2.	Aderibigbe YA, Gureje O, Omigbodun O. Postnatal emotional disorders in Nigerian women. A study of antecedents and associations. Br J Psychiatry, 1993, 163: 645-650.
3.	Howard LM, Molyneaux E, Dennis CL, et al. Non-psychotic mental disorders in the perinatal period. Lancet, 2014, 384(9956): 1775-1788.
4.	Sawyer A, Ayers S, Smith H. Pre- and postnatal psychological wellbeing in Africa: a systematic review. J Affect Disord, 2010, 123(1/2/3): 17-29.
5.	Weobong B, Soremekun S, Ten Asbroek AH, et al. Prevalence and determinants of antenatal depression among pregnant women in a predominantly rural population in Ghana: the DON population-based study. J Affect Disord, 2014, 165(165): 1-7.
6.	Deave T, Heron J, Evans J, et al. The impact of maternal depression in pregnancy on early child development. BJOG, 2008, 115(8): 1043-1051.
7.	Gavin NI, Gaynes BN, Lohr KN, et al. Perinatal depression: a systematic review of prevalence and incidence. Obstet Gynecol, 2005, 106(5 Pt 1): 1071-1083.
8.	Fisher J, Cabral De Mello M, Patel V, et al. Prevalence and determinants of common perinatal mental disorders in women in low- and lower-middle-income countries: a systematic review. Bull World Health Organ, 2012, 90(2): 139G-149G.
9.	Abujilban SK, Abuidhail J, Al-Modallal HA, et al. Predictors of antenatal depression among Jordanian pregnant women in their third trimester. Health Care Women Int, 2014, 35(2): 200-215.
10.	郭秀静, 王玉琼, 刘樱. 孕晚期抑郁与社会支持的相关性研究. 护理研究, 2010, 24(11): 2932-2933.
11.	蔡芬兰, 张研琳, 黄利兰, 等. 627 例孕妇产前抑郁水平调查分析. 齐鲁护理杂志, 2010, 16(18): 56-57.
12.	李贤芬, 苗云, 陈稀, 等. 1 008 例孕晚期妊娠妇女焦虑、抑郁情绪调查分析//第十三次全国行为医学学术会议论文集. 银川, 2011: 306-308.
13.	周彩虹. 长沙市妊娠晚期孕妇心理压力、焦虑、抑郁与社会支持状况相关性研究. 长沙: 中南大学, 2010.
14.	王玉华. 502 例孕妇心理状况分析. 中国农村卫生事业管理, 2010, 30(11): 972-973.
15.	Liou SR, Wang P, Cheng CY. Longitudinal study of perinatal maternal stress, depressive symptoms and anxiety. Midwifery, 2014, 30(6): 795-801.
16.	于津, 朱丽萍. 上海市不同妊娠时期孕妇的焦虑抑郁症状调查. 中国妇幼健康研究, 2010, 21(1): 21-23.
17.	Youn JH, Jeong IS. Predictors of postpartum depression: prospective cohort study. J Korean Acad Nurs, 2013, 43(2): 225-235.
18.	Wisner KL, Sit DK, Mcshea MC, et al. Onset timing, thoughts of self-harm, and diagnoses in postpartum women with screen-positive depression findings. JAMA Psychiatry, 2013, 70(5): 490-498.
19.	Heron J, O’Connor TG, Evans J, et al. The course of anxiety and depression through pregnancy and the postpartum in a community sample. J Affect Disord, 2004, 80(1):65-73.
20.	Zuckerman B, Amaro H, Bauchner H, et al. Depressive symptoms during pregnancy: relationship to poor health behaviors. Am J Obstet Gynecol, 1989, 160(5 Pt1): 1107-1111.
21.	Andersson L, Sundstrom-Poromaa I, Wulff M, et al. Implications of antenatal depression and anxiety for obstetric outcome. Obstet Gynecol, 2004, 104(3): 467-476.
22.	Swallow BL, Lindow SW, Masson EA, et al. Psychological health in early pregnancy: relationship with nausea and vomiting. J Obstet Gynaecol, 2004, 24(1): 28-32.
23.	刘晓红, 刘娟, 李蕊. 围生期抑郁对于产程的影响. 现代中西医结合杂志, 2012, 21(23): 2560-2561.
24.	李桂友, 吴艳珊. 孕晚期孕妇抑郁情绪对分娩的影响及对策. 现代临床护理, 2007, 6(4): 1-3.
25.	Broekman BF, Chan YH, Chong YS, et al. The influence of anxiety and depressive symptoms during pregnancy on birth size. Paediatr Perinat Epidemiol, 2014, 28(2): 116-126.
26.	Otake Y, Nakajima S, Uno A, et al. Association between maternal antenatal depression and infant development: a hospital-based prospective cohort study. Environ Health Prev Med, 2014, 19(1): 30-45.
27.	Szegda K, Markenson G, Bertone-Johnson ER, et al. Depression during pregnancy: a risk factor for adverse neonatal outcomes? A critical review of the literature. J Matern Fetal Neonatal Med, 2014, 27(9): 960-967.
28.	Leis JA, Heron J, Stuart EA, et al. Associations between maternal mental health and child emotional and behavioral problems: does prenatal mental health matter?. J Abnorm Child Psychol, 2014, 42(1):161-171.
29.	Glover V. Maternal depression, anxiety and stress during pregnancy and child outcome; what needs to be done. Best Pract Res Clin Obstet Gynaecol, 2014, 28(1): 25-35.
30.	Van Batenburg-Eddes T, Brion MJ, Henrichs J, et al. Parental depressive and anxiety symptoms during pregnancy and attention problems in children: a cross-cohort consistency study. J Child Psychol Psychiatry, 2013, 54(5): 591-600.
31.	Betts KS, Williams GM, Najman JM, et al. Maternal depressive, anxious, and stress symptoms during pregnancy predict internalizing problems in adolescence. Depress Anxiety, 2014, 31(1): 9-18.
32.	Plant DT, Barker ED, Waters CS, et al. Intergenerational transmission of maltreatment and psychopathology: the role of antenatal depression. Psychol Med, 2013, 43(3): 519-528.
33.	Lancaster CA, Gold KJ, Flynn HA, et al. Risk factors for depressive symptoms during pregnancy: a systematic review. Am J Obstet Gynecol, 2010, 202(1): 5-14.
34.	Howard LM, Oram S, Galley H, et al. Domestic violence and perinatal mental disorders: a systematic review and meta-analysis. PLoS Med, 2013, 10(5): e1001452.
35.	Finnbogadóttir H, Dykes AK, Wann-Hansson C. Prevalence of domestic violence during pregnancy and related risk factors: a cross-sectional study in southern Sweden. BMC Womens Health, 2014, 14: 63.
36.	Stewart RC, Umar E, Tomenson B, et al. A cross-sectional study of antenatal depression and associated factors in Malawi. Arch Womens Ment Health, 2014, 17(2): 145-154.
37.	Meijer JL, Bockting CL, Stolk RP, et al. Associations of life events during pregnancy with longitudinal change in symptoms of antenatal anxiety and depression. Midwifery, 2014, 30(5): 526-531.
38.	Park CM, Seo HJ, Jung YE, et al. Factors associated with antenatal depression in pregnant Korean females: the effect of bipolarity on depressive symptoms. Neuropsychiatr Dis Treat, 2014, 10: 1017-1023.
39.	Giardinelli L, Innocenti A, Benni L, et al. Depression and anxiety in perinatal period: prevalence and risk factors in an Italian sample. Arch Womens Ment Health, 2012, 15(1): 21-30.
40.	Chong MF, Wong JX, Colega M, et al. Relationships of maternal folate and vitamin B₁₂ status during pregnancy with perinatal depression: the GUSTO study. J Psychiatr Res, 2014, 55: 110-116.
41.	Lukose A, Ramthal A, Thomas T, et al. Nutritional factors associated with antenatal depressive symptoms in the early stage of pregnancy among urban South Indian women. Matern Child Health J, 2014, 18(1): 161-170.
42.	Yilmaz SD, Beji NK. Effects of perinatal loss on current pregnancy in Turkey. Midwifery, 2013, 29(11): 1272-1277.
43.	Nylen K J, Williamson J A, O’Hara M W, et al. Validity of somatic symptoms as indicators of depression in pregnancy. Archives of Womens Mental Health, 2013, 16(3):203-210.
44.	Shidhaye R, Mendenhall E, Sumathipala KA, et al. Association of somatoform disorders with anxiety and depression in women in low and middle income countries: a systematic review. Int Rev Psychiatry, 2013, 25(1): 65-76.
45.	Senturk V, Hanlon C, Medhin G, et al. Impact of perinatal somatic and common mental disorder symptoms on functioning in Ethiopian women: The P-MaMiE population-based cohort study. J Affect Disord, 2012, 136(3): 340-349.
46.	Yelland J, Brown SJ. Asking women about mental health and social adversity in pregnancy: results of an Australian population-based survey. Birth, 2014, 41(1): 79-87.

1. Haas JS, Jackson RA, Fuentes-Afflick E, et al. Changes in the health status of women during and after pregnancy. J Gen Intern Med, 2005, 20(1): 45-51.
2. Aderibigbe YA, Gureje O, Omigbodun O. Postnatal emotional disorders in Nigerian women. A study of antecedents and associations. Br J Psychiatry, 1993, 163: 645-650.
3. Howard LM, Molyneaux E, Dennis CL, et al. Non-psychotic mental disorders in the perinatal period. Lancet, 2014, 384(9956): 1775-1788.
4. Sawyer A, Ayers S, Smith H. Pre- and postnatal psychological wellbeing in Africa: a systematic review. J Affect Disord, 2010, 123(1/2/3): 17-29.
5. Weobong B, Soremekun S, Ten Asbroek AH, et al. Prevalence and determinants of antenatal depression among pregnant women in a predominantly rural population in Ghana: the DON population-based study. J Affect Disord, 2014, 165(165): 1-7.
6. Deave T, Heron J, Evans J, et al. The impact of maternal depression in pregnancy on early child development. BJOG, 2008, 115(8): 1043-1051.
7. Gavin NI, Gaynes BN, Lohr KN, et al. Perinatal depression: a systematic review of prevalence and incidence. Obstet Gynecol, 2005, 106(5 Pt 1): 1071-1083.
8. Fisher J, Cabral De Mello M, Patel V, et al. Prevalence and determinants of common perinatal mental disorders in women in low- and lower-middle-income countries: a systematic review. Bull World Health Organ, 2012, 90(2): 139G-149G.
9. Abujilban SK, Abuidhail J, Al-Modallal HA, et al. Predictors of antenatal depression among Jordanian pregnant women in their third trimester. Health Care Women Int, 2014, 35(2): 200-215.
10. 郭秀静, 王玉琼, 刘樱. 孕晚期抑郁与社会支持的相关性研究. 护理研究, 2010, 24(11): 2932-2933.
11. 蔡芬兰, 张研琳, 黄利兰, 等. 627 例孕妇产前抑郁水平调查分析. 齐鲁护理杂志, 2010, 16(18): 56-57.
12. 李贤芬, 苗云, 陈稀, 等. 1 008 例孕晚期妊娠妇女焦虑、抑郁情绪调查分析//第十三次全国行为医学学术会议论文集. 银川, 2011: 306-308.
13. 周彩虹. 长沙市妊娠晚期孕妇心理压力、焦虑、抑郁与社会支持状况相关性研究. 长沙: 中南大学, 2010.
14. 王玉华. 502 例孕妇心理状况分析. 中国农村卫生事业管理, 2010, 30(11): 972-973.
15. Liou SR, Wang P, Cheng CY. Longitudinal study of perinatal maternal stress, depressive symptoms and anxiety. Midwifery, 2014, 30(6): 795-801.
16. 于津, 朱丽萍. 上海市不同妊娠时期孕妇的焦虑抑郁症状调查. 中国妇幼健康研究, 2010, 21(1): 21-23.
17. Youn JH, Jeong IS. Predictors of postpartum depression: prospective cohort study. J Korean Acad Nurs, 2013, 43(2): 225-235.
18. Wisner KL, Sit DK, Mcshea MC, et al. Onset timing, thoughts of self-harm, and diagnoses in postpartum women with screen-positive depression findings. JAMA Psychiatry, 2013, 70(5): 490-498.
19. Heron J, O’Connor TG, Evans J, et al. The course of anxiety and depression through pregnancy and the postpartum in a community sample. J Affect Disord, 2004, 80(1):65-73.
20. Zuckerman B, Amaro H, Bauchner H, et al. Depressive symptoms during pregnancy: relationship to poor health behaviors. Am J Obstet Gynecol, 1989, 160(5 Pt1): 1107-1111.
21. Andersson L, Sundstrom-Poromaa I, Wulff M, et al. Implications of antenatal depression and anxiety for obstetric outcome. Obstet Gynecol, 2004, 104(3): 467-476.
22. Swallow BL, Lindow SW, Masson EA, et al. Psychological health in early pregnancy: relationship with nausea and vomiting. J Obstet Gynaecol, 2004, 24(1): 28-32.
23. 刘晓红, 刘娟, 李蕊. 围生期抑郁对于产程的影响. 现代中西医结合杂志, 2012, 21(23): 2560-2561.
24. 李桂友, 吴艳珊. 孕晚期孕妇抑郁情绪对分娩的影响及对策. 现代临床护理, 2007, 6(4): 1-3.
25. Broekman BF, Chan YH, Chong YS, et al. The influence of anxiety and depressive symptoms during pregnancy on birth size. Paediatr Perinat Epidemiol, 2014, 28(2): 116-126.
26. Otake Y, Nakajima S, Uno A, et al. Association between maternal antenatal depression and infant development: a hospital-based prospective cohort study. Environ Health Prev Med, 2014, 19(1): 30-45.
27. Szegda K, Markenson G, Bertone-Johnson ER, et al. Depression during pregnancy: a risk factor for adverse neonatal outcomes? A critical review of the literature. J Matern Fetal Neonatal Med, 2014, 27(9): 960-967.
28. Leis JA, Heron J, Stuart EA, et al. Associations between maternal mental health and child emotional and behavioral problems: does prenatal mental health matter?. J Abnorm Child Psychol, 2014, 42(1):161-171.
29. Glover V. Maternal depression, anxiety and stress during pregnancy and child outcome; what needs to be done. Best Pract Res Clin Obstet Gynaecol, 2014, 28(1): 25-35.
30. Van Batenburg-Eddes T, Brion MJ, Henrichs J, et al. Parental depressive and anxiety symptoms during pregnancy and attention problems in children: a cross-cohort consistency study. J Child Psychol Psychiatry, 2013, 54(5): 591-600.
31. Betts KS, Williams GM, Najman JM, et al. Maternal depressive, anxious, and stress symptoms during pregnancy predict internalizing problems in adolescence. Depress Anxiety, 2014, 31(1): 9-18.
32. Plant DT, Barker ED, Waters CS, et al. Intergenerational transmission of maltreatment and psychopathology: the role of antenatal depression. Psychol Med, 2013, 43(3): 519-528.
33. Lancaster CA, Gold KJ, Flynn HA, et al. Risk factors for depressive symptoms during pregnancy: a systematic review. Am J Obstet Gynecol, 2010, 202(1): 5-14.
34. Howard LM, Oram S, Galley H, et al. Domestic violence and perinatal mental disorders: a systematic review and meta-analysis. PLoS Med, 2013, 10(5): e1001452.
35. Finnbogadóttir H, Dykes AK, Wann-Hansson C. Prevalence of domestic violence during pregnancy and related risk factors: a cross-sectional study in southern Sweden. BMC Womens Health, 2014, 14: 63.
36. Stewart RC, Umar E, Tomenson B, et al. A cross-sectional study of antenatal depression and associated factors in Malawi. Arch Womens Ment Health, 2014, 17(2): 145-154.
37. Meijer JL, Bockting CL, Stolk RP, et al. Associations of life events during pregnancy with longitudinal change in symptoms of antenatal anxiety and depression. Midwifery, 2014, 30(5): 526-531.
38. Park CM, Seo HJ, Jung YE, et al. Factors associated with antenatal depression in pregnant Korean females: the effect of bipolarity on depressive symptoms. Neuropsychiatr Dis Treat, 2014, 10: 1017-1023.
39. Giardinelli L, Innocenti A, Benni L, et al. Depression and anxiety in perinatal period: prevalence and risk factors in an Italian sample. Arch Womens Ment Health, 2012, 15(1): 21-30.
40. Chong MF, Wong JX, Colega M, et al. Relationships of maternal folate and vitamin B₁₂ status during pregnancy with perinatal depression: the GUSTO study. J Psychiatr Res, 2014, 55: 110-116.
41. Lukose A, Ramthal A, Thomas T, et al. Nutritional factors associated with antenatal depressive symptoms in the early stage of pregnancy among urban South Indian women. Matern Child Health J, 2014, 18(1): 161-170.
42. Yilmaz SD, Beji NK. Effects of perinatal loss on current pregnancy in Turkey. Midwifery, 2013, 29(11): 1272-1277.
43. Nylen K J, Williamson J A, O’Hara M W, et al. Validity of somatic symptoms as indicators of depression in pregnancy. Archives of Womens Mental Health, 2013, 16(3):203-210.
44. Shidhaye R, Mendenhall E, Sumathipala KA, et al. Association of somatoform disorders with anxiety and depression in women in low and middle income countries: a systematic review. Int Rev Psychiatry, 2013, 25(1): 65-76.
45. Senturk V, Hanlon C, Medhin G, et al. Impact of perinatal somatic and common mental disorder symptoms on functioning in Ethiopian women: The P-MaMiE population-based cohort study. J Affect Disord, 2012, 136(3): 340-349.
46. Yelland J, Brown SJ. Asking women about mental health and social adversity in pregnancy: results of an Australian population-based survey. Birth, 2014, 41(1): 79-87.

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产前抑郁的研究进展

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