宫颈卵巢原发性双癌和宫颈癌卵巢转移的临床分析_West China Medical Journal

Authors：

莫小雨 , 郭清民 , 唐慧芸 ,  郑艾

四川大学华西第二医院妇产科/出生缺陷与相关妇儿疾病教育部重点实验室（成都 610041）;

Corresponding author：

郑艾, Email: 894591422@qq.com

Keywords：

多部位原发性肿瘤; 转移性肿瘤; 宫颈; 卵巢

DOI：

10.7507/1002-0179.201604233

Video：

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女性生殖系统多部位原发恶性肿瘤（multiple primary malignant carcinomas，MPMC）是指在同一女性生殖系统器官中，同时或先后原发于同一器官不同部位、或 2 个甚至多个器官的恶性肿瘤，其中以卵巢内膜原发性双癌发病率最高，宫颈卵巢原发性双癌较为罕见。然而与转移性癌相比较，MPMC 通常期别较早，预后较好，目前尚无国际公认的标准治疗模式。因此在临床诊疗过程中，要注意鉴别多个肿瘤发生关系的原发性和转移性，做到及时诊断、及时治疗，尽量减少误诊、漏诊。该文就宫颈卵巢原发性双癌及宫颈癌卵巢转移方面的临床特点进行了综述。

Citation： 莫小雨, 郭清民, 唐慧芸, 郑艾. 宫颈卵巢原发性双癌和宫颈癌卵巢转移的临床分析. West China Medical Journal, 2017, 32(7): 1108-1111. doi: 10.7507/1002-0179.201604233 Copy

1.	Gursel B, Meydan D, Özbek N, et al. Multiple primary malignant neoplasms from the Black Sea region of Turkey. J Int Med Res, 2011, 39(2): 667-674.
2.	潘源, 王家仓, 梁寒. 消化系多原发癌 116 例临床分析. 中华肿瘤杂志, 2002, 24(2): 191-193.
3.	Tong SY, Lee YS, Park JS, et al. Clinical analysis of synchronous primary neoplasms of the female reproductive tract. Eur J Obstet Gynecol Reprod Biol, 2008, 136(1): 78-82.
4.	Moertel CG, Dockerty MB, Baggenstoss AH. Multiple primary malignant neoplasms. I. Introduction and presentation of data. Cancer, 1961, 14(2): 221-230.
5.	Kaminski PF, Norris HJ. Coexistence of ovarian neoplasms and endocervical adenocarcinoma. Obstet Gynecol, 1984, 64(4): 553-556.
6.	吕伟超, 郑红枫. 卵巢浆液性囊腺癌合并宫颈鳞癌 1 例报告. 医药论坛杂志, 1995(4): 49.
7.	Srivastava KR, Zahra F. Synchronous primary malignancy of ovary and cervix with different histopathology: a rare presentation. Int J Gynecol Obstet, 2009, 12(2): 16-19.
8.	高洁, 王辉, 锡林高娃, 等. 罕见女性生殖器官双原发癌 1 例分析. 中国误诊学杂志, 2011, 11(13): 3238.
9.	Guzin K, Sahin S, Goynumer G, et al. A rare coexistence of villoglandular papillary adenocarcinoma of the uterine cervix and brenner tumor of the ovary. Case Rep Obstet Gynecol, 2014: 342040.
10.	杨东, 曹保利, 薛凤霞. 女性生殖道双原发癌 1 例报道并文献复习. 中华实用诊断与治疗杂志, 2014, 28(2): 203-204.
11.	Huang YD, Hung YC, Yeh LS, et al. Synchronous ovarian endometrioid adenocarcinoma and endocervical mucinous adenocarcinoma. Taiwan J Obstet Gynecol, 2006, 45(3): 264-267.
12.	Kavitha N, Who TS, Kanagasabai S, et al. A case of two synchronous tumour of different histology-advanced cervical adenocarcinoma with borderline mucinous ovarian tumour in a 22 year old virgin. Int J Gynecol Obstet, 2012, 119(3): 179-180.
13.	石莉, 周树林, 姜旖, 等. 妇科恶性肿瘤相关的多发性原发性恶性肿瘤 30 例临床分析. 中华妇产科杂志, 2014, 49(3): 199-203.
14.	沈铿. 女性生殖道多部位原发癌//曹泽毅. 中华妇产科学(下册). 北京: 人民卫生出版社, 1999: 2085-2092.
15.	程易凡, 彭芝兰, 王平, 等. 女性生殖系统多部位原发恶性肿瘤 15 例分析. 四川大学学报: 医学版, 2003, 34(2): 374-375.
16.	沈铿. 女性生殖道多部位原发癌//曹泽毅. 中华妇产科学(下册). 3版. 北京: 人民卫生出版社, 2014: 2549-2553.
17.	Woodruff JD, Solomon D, Sullivant H. Multifocal disease in the upper genital canal. Obstet Gynecol, 1985, 65(5): 695-698.
18.	Zaino R, Whitney C, Brady MF, et al. Simultaneously detected endometrial and ovarian carcinomas--a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol, 2001, 83(2): 355-362.
19.	Alfsen GC, Thoresen SO, Kristensen GB, et al. Histopathologic subtyping of cervical adenocarcinoma reveals increasing incidence rates of endometrioid tumors in all age groups: a population based study with review of all nonsquamous cervical carcinomas in norway from 1966 to 1970, 1976 to 1980, and 1986 to 1990. Cancer, 2000, 89(6): 1291-1299.
20.	Chung HH, Hwang S Y, Jung KW, et al. Ovarian cancer incidence and survival in Korea: 1993-2002. Int J Gynecol Cancer, 2007, 17(3): 595-600.
21.	马绍康, 孙建衡. 子宫颈癌卵巢转移 17 例分析. 中华妇产科杂志, 1996, 31(5): 305-305.
22.	闻强, 邵株燕, 方素华. 宫颈腺癌 321 例卵巢转移情况的临床分析. 现代妇产科进展, 2015, 24(7): 501-503.
23.	Samaila M, Adesiyun AG, Oluwole P. Metastatic ovarian squamous cell carcinoma. Singapore Med J, 2008, 49(5): E139-E141.
24.	Ronnett BM, Yemelyanova AV, Vang R, et al. Endocervical adenocarcinomas with ovarian metastases: analysis of 29 cases with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasms. Am J Surg Pathol, 2008, 32(12): 1835-1853.
25.	梅泉, 李双, 马丁. 宫颈癌卵巢转移研究进展. 中国实用妇科与产科杂志, 2010(3): 238-240.
26.	Shimada M, Kigawa J, Nishimura R, et al. Ovarian metastasis in carcinoma of the uterine cervix. Gynecol Oncol, 2006, 101(2): 234-237.
27.	Yamamoto R, Okamoto K, Yukiharu T, et al. A study of risk factors for ovarian metastases in stage Ⅰb-Ⅲb cervical carcinoma and analysis of ovarian function after a transposition. Gynecol Oncol, 2001, 82(2): 312-316.
28.	Ivanov S, Zervoudis S. Metastatic cancer in transposed ovaries after radical Wertheim-Meigs hysterectomy for a stageⅠB and ⅡA cervical cancer. Akush Ginekol(Sofiia), 2003, 42(5): 22-24.
29.	Sanjuán A, Martínez Román S, Martínez-Zamora MA, et al. Bilateral ovarian metastasis on transposed ovaries from cervical carcinoma. Int J Gynaecol Obstet, 2007, 99(1): 64-65.
30.	Piketty M, Barranger E, Najat M, et al. Ovarian recurrence after radical trachelectomy for adenocarcinoma of the cervix. Am J Obstet Gynecol, 2005, 193(4): 1382-1383.
31.	Krasević M, Haller H, Rupcić S, et al. Massive edema of the ovary: a report of two cases due to lymphatic permeation by metastatic carcinoma from the uterine cervix. Gynecol Oncol, 2004, 93(2): 564-567.
32.	Landoni F, Zanagnolo V, Lovato-Diaz L, et al. Ovarian metastases in early-stage cervical cancer (ⅠA 2-ⅡA): a multicenter retrospective study of 1965 patients (a cooperative task force study). Int J Gynecol Cancer, 2007, 17(3): 623-628.
33.	Nakanishi T, Wakai K, Ishikawa H, et al. A comparison of ovarian metastasis between squamous cell carcinoma and adenocarcinoma of the uterine cervix. Gynecol Oncol, 2001, 82(3): 504-509.
34.	勾金海, 李征宇. 宫颈癌诊治中的几个热点问题. 华西医学, 2014, 29(2): 377-381.

1. Gursel B, Meydan D, Özbek N, et al. Multiple primary malignant neoplasms from the Black Sea region of Turkey. J Int Med Res, 2011, 39(2): 667-674.
2. 潘源, 王家仓, 梁寒. 消化系多原发癌 116 例临床分析. 中华肿瘤杂志, 2002, 24(2): 191-193.
3. Tong SY, Lee YS, Park JS, et al. Clinical analysis of synchronous primary neoplasms of the female reproductive tract. Eur J Obstet Gynecol Reprod Biol, 2008, 136(1): 78-82.
4. Moertel CG, Dockerty MB, Baggenstoss AH. Multiple primary malignant neoplasms. I. Introduction and presentation of data. Cancer, 1961, 14(2): 221-230.
5. Kaminski PF, Norris HJ. Coexistence of ovarian neoplasms and endocervical adenocarcinoma. Obstet Gynecol, 1984, 64(4): 553-556.
6. 吕伟超, 郑红枫. 卵巢浆液性囊腺癌合并宫颈鳞癌 1 例报告. 医药论坛杂志, 1995(4): 49.
7. Srivastava KR, Zahra F. Synchronous primary malignancy of ovary and cervix with different histopathology: a rare presentation. Int J Gynecol Obstet, 2009, 12(2): 16-19.
8. 高洁, 王辉, 锡林高娃, 等. 罕见女性生殖器官双原发癌 1 例分析. 中国误诊学杂志, 2011, 11(13): 3238.
9. Guzin K, Sahin S, Goynumer G, et al. A rare coexistence of villoglandular papillary adenocarcinoma of the uterine cervix and brenner tumor of the ovary. Case Rep Obstet Gynecol, 2014: 342040.
10. 杨东, 曹保利, 薛凤霞. 女性生殖道双原发癌 1 例报道并文献复习. 中华实用诊断与治疗杂志, 2014, 28(2): 203-204.
11. Huang YD, Hung YC, Yeh LS, et al. Synchronous ovarian endometrioid adenocarcinoma and endocervical mucinous adenocarcinoma. Taiwan J Obstet Gynecol, 2006, 45(3): 264-267.
12. Kavitha N, Who TS, Kanagasabai S, et al. A case of two synchronous tumour of different histology-advanced cervical adenocarcinoma with borderline mucinous ovarian tumour in a 22 year old virgin. Int J Gynecol Obstet, 2012, 119(3): 179-180.
13. 石莉, 周树林, 姜旖, 等. 妇科恶性肿瘤相关的多发性原发性恶性肿瘤 30 例临床分析. 中华妇产科杂志, 2014, 49(3): 199-203.
14. 沈铿. 女性生殖道多部位原发癌//曹泽毅. 中华妇产科学(下册). 北京: 人民卫生出版社, 1999: 2085-2092.
15. 程易凡, 彭芝兰, 王平, 等. 女性生殖系统多部位原发恶性肿瘤 15 例分析. 四川大学学报: 医学版, 2003, 34(2): 374-375.
16. 沈铿. 女性生殖道多部位原发癌//曹泽毅. 中华妇产科学(下册). 3版. 北京: 人民卫生出版社, 2014: 2549-2553.
17. Woodruff JD, Solomon D, Sullivant H. Multifocal disease in the upper genital canal. Obstet Gynecol, 1985, 65(5): 695-698.
18. Zaino R, Whitney C, Brady MF, et al. Simultaneously detected endometrial and ovarian carcinomas--a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol, 2001, 83(2): 355-362.
19. Alfsen GC, Thoresen SO, Kristensen GB, et al. Histopathologic subtyping of cervical adenocarcinoma reveals increasing incidence rates of endometrioid tumors in all age groups: a population based study with review of all nonsquamous cervical carcinomas in norway from 1966 to 1970, 1976 to 1980, and 1986 to 1990. Cancer, 2000, 89(6): 1291-1299.
20. Chung HH, Hwang S Y, Jung KW, et al. Ovarian cancer incidence and survival in Korea: 1993-2002. Int J Gynecol Cancer, 2007, 17(3): 595-600.
21. 马绍康, 孙建衡. 子宫颈癌卵巢转移 17 例分析. 中华妇产科杂志, 1996, 31(5): 305-305.
22. 闻强, 邵株燕, 方素华. 宫颈腺癌 321 例卵巢转移情况的临床分析. 现代妇产科进展, 2015, 24(7): 501-503.
23. Samaila M, Adesiyun AG, Oluwole P. Metastatic ovarian squamous cell carcinoma. Singapore Med J, 2008, 49(5): E139-E141.
24. Ronnett BM, Yemelyanova AV, Vang R, et al. Endocervical adenocarcinomas with ovarian metastases: analysis of 29 cases with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasms. Am J Surg Pathol, 2008, 32(12): 1835-1853.
25. 梅泉, 李双, 马丁. 宫颈癌卵巢转移研究进展. 中国实用妇科与产科杂志, 2010(3): 238-240.
26. Shimada M, Kigawa J, Nishimura R, et al. Ovarian metastasis in carcinoma of the uterine cervix. Gynecol Oncol, 2006, 101(2): 234-237.
27. Yamamoto R, Okamoto K, Yukiharu T, et al. A study of risk factors for ovarian metastases in stage Ⅰb-Ⅲb cervical carcinoma and analysis of ovarian function after a transposition. Gynecol Oncol, 2001, 82(2): 312-316.
28. Ivanov S, Zervoudis S. Metastatic cancer in transposed ovaries after radical Wertheim-Meigs hysterectomy for a stageⅠB and ⅡA cervical cancer. Akush Ginekol(Sofiia), 2003, 42(5): 22-24.
29. Sanjuán A, Martínez Román S, Martínez-Zamora MA, et al. Bilateral ovarian metastasis on transposed ovaries from cervical carcinoma. Int J Gynaecol Obstet, 2007, 99(1): 64-65.
30. Piketty M, Barranger E, Najat M, et al. Ovarian recurrence after radical trachelectomy for adenocarcinoma of the cervix. Am J Obstet Gynecol, 2005, 193(4): 1382-1383.
31. Krasević M, Haller H, Rupcić S, et al. Massive edema of the ovary: a report of two cases due to lymphatic permeation by metastatic carcinoma from the uterine cervix. Gynecol Oncol, 2004, 93(2): 564-567.
32. Landoni F, Zanagnolo V, Lovato-Diaz L, et al. Ovarian metastases in early-stage cervical cancer (ⅠA 2-ⅡA): a multicenter retrospective study of 1965 patients (a cooperative task force study). Int J Gynecol Cancer, 2007, 17(3): 623-628.
33. Nakanishi T, Wakai K, Ishikawa H, et al. A comparison of ovarian metastasis between squamous cell carcinoma and adenocarcinoma of the uterine cervix. Gynecol Oncol, 2001, 82(3): 504-509.
34. 勾金海, 李征宇. 宫颈癌诊治中的几个热点问题. 华西医学, 2014, 29(2): 377-381.

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West China Medical Journal

宫颈卵巢原发性双癌和宫颈癌卵巢转移的临床分析

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