DU Jiyu , LIU Rong , LI Yan , WANG Xiaoshuang , YANG Jinyu , XIE Li
  • Department of Paediatrics, Mianyang Central Hospital, Mianyang, Sichuan 621000, P. R. China;
LIU Rong, Email: 734287795@qq.com
Childhood asthma; Inducing factor; Serum total immunoglobulin E; Serum specific immunoglobulin E
10.7507/1002-0179.201605043
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Objective  To explore the inducing factors, the serum total immunoglobulin E (IgE) and specific IgE of bronchial asthma in Mianyang children, for better control of childhood asthma. Methods  A total of 1 288 cases of asthma who were hospitalized in pediatric respiratory ward or asthma clinic from March 2013 to February 2016 were enrolled in the study. All cases complied with the diagnostic criteria for acute episode of childhood bronchial asthma revised in 2008 by the National Children’s Asthma Cooperative Group. The causes of asthma attack were asked by doctors, and the patient’s serum total IgE and specific IgE was tested. Results  Respiratory tract infections were the most common cause (1 057 cases, 82.1%), which was followed by weather changes and exposure to cold air (694 cases, 53.9%), and then food (304, 23.6%). The risk of asthma induced by respiratory infections was highest in <2-year old group (358 cases, 97.5%), and lowest in 10-14-year old group (42 cases, 33.3%), with a decreasing trend with age (χ2trend=239.865, P<0.001). Food was also an important inducing factor, and seafood was the most frequent (121 cases, 39.8%). Total serum IgE was positive in 868 cases (67.4%). The positive rate in <2-year old group (52.6%) was the lowest, and the positive rate in 10-14-year old group (89.7%) was the highest, with an increasing trend with age (χ2trend=88.055, P<0.001). Serum specific IgE was positive in 733 cases (56.9%). The positive rate in <2-year old group (37.1%) was the lowest, and the positive rate in 10-14-year old group (92.6%) was the highest, with an increasing trend with age (χ2trend=150.361, P<0.001). The progressive rate of dust mites in inhalation and dietary allergens was highest (668 cases, 51.8%), which was followed by house dust (431 cases, 33.4%). Conclusions  The most common inducing factor for bronchial asthma in Mianyang children is respiratory tract infection, followed by the weather changes and cold air exposure, and then food. Detection of serum total IgE and specific IgE is more valuable in elderly children with bronchial asthma.

Citation： DU Jiyu, LIU Rong, LI Yan, WANG Xiaoshuang, YANG Jinyu, XIE Li. Analysis of the inducing factors, the serum total immunoglobulin E and specific immunoglobulin E of bronchial asthma in Mianyang children. West China Medical Journal, 2017, 32(7): 1029-1032. doi: 10.7507/1002-0179.201605043 Copy

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