强迫症脑成像研究进展_West China Medical Journal

Authors：

曾敏怡 ,  卢宁

深圳大学应用心理学研究与咨询中心（广东深圳 518060）;

Corresponding author：

卢宁, Email: lnpsy@163.com

Keywords：

强迫症; 脑结构异常; 脑功能异常; 病理机制

DOI：

10.7507/1002-0179.201608155

Video：

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Abstract Full text Figures/Tables Video References Cited by

强迫症是一种常见的、具有复发性和难治性的精神疾病，它以反复出现的强迫行为和强迫观念为主要特征。以往大量脑成像研究证实了强迫症患者存在皮质-纹状体-丘脑-皮质环路的异常，特别是眶额叶、扣带回、尾状核、丘脑、颞叶、脑岛、胼胝体等组织存在结构和功能异常。近年来的研究还发现强迫症患者的背外侧前额叶、顶叶、枕叶、小脑等脑区也存在着结构和功能障碍。此提示，强迫症患者可能还存在其他环路或系统的异常，就此进行探索有助于深入了解强迫症的病理机制。因此，该文尝试对近年来强迫症的脑结构和功能成像的研究进行综述，以期全面研究分析强迫症的神经生物学基础研究的最新动态，为临床诊断与治疗提供参考。

Citation： 曾敏怡, 卢宁. 强迫症脑成像研究进展. West China Medical Journal, 2017, 32(12): 1950-1954. doi: 10.7507/1002-0179.201608155 Copy

1.	中华医学会精神科分会. 中国精神障碍分类与诊断标准. 3 版. 济南: 山东科学技术出版社, 2001: 167-169.
2.	Abe Y, Sakai Y, Nishida S, et al. Hyper-influence of the orbitofrontal cortex over the ventral striatum in obsessive-compulsive disorder. Eur Neuropsychopharmacol, 2015, 25(11): 1898-1905.
3.	Alexander GE, Delong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci, 1986, 9(4): 357-381.
4.	Biswal B, Yetkin FZ, Haughton VM, et al. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med, 1995, 34(4): 537-541.
5.	陶甜美. 强迫症患者脑灰质基于体素的形态学研究. 芜湖: 皖南医学院, 2014: 34.
6.	张杨, 侯景明, 武文婧, 等. 基于体素的形态学 MRI 观察未经药物治疗的强迫症患者脑灰质结构改变. 第三军医大学学报, 2015, 37(10): 1026-1029.
7.	Togao O, Yoshiura T, Nakao T, et al. Regional gray and white matter volume abnormalities in obsessive-compulsive disorder: a voxel-based morphometry study. Psychiatry Res, 2010, 184(1): 29-37.
8.	Yang XY, Sun J, Luo J, et al. Regional homogeneity of spontaneous brain activity in adult patients with obsessive-compulsive disorder before and after cognitive behavioural therapy. J Affect Disord, 2015, 188(5): 243-251.
9.	Zhan SK, Liu W, Li DY, et al. Long-term follow-up of bilateral anterior capsulotomy in patients with refractory obsessive-compulsive disorder. Clin Neurol Neurosurg, 2014, 119(6): 91-95.
10.	Yoo SY, Roh MS, Choi JS, et al. Voxel-based morphometry study of gray matter abnormalities in obsessive-compulsive-disorder. J Korean Med Sci, 2008, 23(1): 30.
11.	Nakamae T, Narumoto J, Sakai Y, et al. Diffusion tensor imaging and tract-based spatial statistics in obsessive-compulsive disorder. J Psychiatr Res, 2011, 45(5): 687-690.
12.	Zarei M, Mataix-Cols D, Heyman I, et al. Changes in Gray matter volume and white matter microstructure in adolescents with obsessive-compulsive disorder. Biol Psychiatry, 2011, 70(11): 1083-1090.
13.	武文婧. 强迫症患者及其一级亲属的扩散张量成像研究. 重庆: 第三军医大学, 2012.
14.	Ha TH, Kang DH, Park JS, et al. Whits matter alterations in male patients with obsessive-compulsive disorder. Neuroreport, 2009, 20(7): 735-739.
15.	杨涛. 首次发病未服药强迫症患者静息态脑功能影像学研究. 昆明: 昆明医学院, 2010: 62.
16.	侯景明, 黎海涛, 武文婧, 等. 强迫症患者 fMRI Stroop 试验脑功能异常. 中国医学影像技术, 2011, 27(10): 1977-1980.
17.	管一晖, 孙伯民, 张海英, 等. ¹⁸F-FDG PET显像对强迫症手术治疗前后的观察. 中华核医学杂志, 2001, 21(1): 17-19.
18.	Pujol J, Soriano-Mas C, Gispert JD, et al. Variations in the shape of the frontobasal brain region in obsessive-compulsive disorder. Hum Brain Mapp, 2011, 32(7): 1100-1108.
19.	Hou JM, Zhao M, Zhang W, et al. Resting-state functional connectivity abnormalities in patients with obsessive–compulsive disorder and their healthy first-degree relatives. J Psychiatry Neurosci, 2014, 39(5): 304-311.
20.	Nakanishi M, Oshita H, Tanaka Y, et al. Near-infrared spectroscopy during the verbal fluency task before and after treatment with image exposure and SSRI therapy in patients with obsessive-compulsive disorder. Case Rep Psychiatry. 2014, 2014: 591023.
21.	卢蕴容, 林铮, 李惠春. 强迫症患者前额叶、海马磁共振质子波谱成像的研究. 浙江医学, 2007, 29(3): 226-228.
22.	赵秀芝. 强迫症患者的氢质子磁共振波谱分析及认知功能研究. 济南: 山东大学, 2011.
23.	Jhung K, Ku J, Kim SJ, et al. Distinct functional connectivity of limbic network in the washing type obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry, 2014, 53(8): 149-155.
24.	陈远浩. 首诊成人强迫症患者的脑 3D-多体素氢质子磁共振波谱分析研究. 宁波: 宁波大学, 2012.
25.	Park SE, Jeong GW. Cerebral white matter volume changes in patients with obsessive-compulsive disorder: voxel-based morphometry. Psychiatry Clin Neurosci, 2015, 69(11): 717-723.
26.	Ota T, Iida J, Sawada M, et al. Reduced prefrontal hemodynamic response in pediatric obsessive-compulsive disorder as measured by near-infrared spectroscopy. Child Psychiatry Hum Dev, 2013, 44(2): 265-277.
27.	Okada K, Ota T, Iida J, et al. Lower prefrontal activity in adults with obsessive-compulsive disorder as measured by near-infrared spectroscopy. Prog Neuropsychopharmacol Biol Psychiatry, 2013, 43: 7-13.
28.	Lázaro L, Castro-Fornieles J, Cullell C, et al. A voxel-based morphometric MRI study of stabilized obsessive -compulsive adolescent patients. Prog Neuropsychopharmacol Biol Psychiatry, 2011, 35 (8): 1863-1869.
29.	田峰, 徐成, 崔晓红. 强迫症患者静息态脑功能局部一致性研究. 中华行为医学与脑科学杂志, 2010, 19(3): 197-199.

1. 中华医学会精神科分会. 中国精神障碍分类与诊断标准. 3 版. 济南: 山东科学技术出版社, 2001: 167-169.
2. Abe Y, Sakai Y, Nishida S, et al. Hyper-influence of the orbitofrontal cortex over the ventral striatum in obsessive-compulsive disorder. Eur Neuropsychopharmacol, 2015, 25(11): 1898-1905.
3. Alexander GE, Delong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci, 1986, 9(4): 357-381.
4. Biswal B, Yetkin FZ, Haughton VM, et al. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med, 1995, 34(4): 537-541.
5. 陶甜美. 强迫症患者脑灰质基于体素的形态学研究. 芜湖: 皖南医学院, 2014: 34.
6. 张杨, 侯景明, 武文婧, 等. 基于体素的形态学 MRI 观察未经药物治疗的强迫症患者脑灰质结构改变. 第三军医大学学报, 2015, 37(10): 1026-1029.
7. Togao O, Yoshiura T, Nakao T, et al. Regional gray and white matter volume abnormalities in obsessive-compulsive disorder: a voxel-based morphometry study. Psychiatry Res, 2010, 184(1): 29-37.
8. Yang XY, Sun J, Luo J, et al. Regional homogeneity of spontaneous brain activity in adult patients with obsessive-compulsive disorder before and after cognitive behavioural therapy. J Affect Disord, 2015, 188(5): 243-251.
9. Zhan SK, Liu W, Li DY, et al. Long-term follow-up of bilateral anterior capsulotomy in patients with refractory obsessive-compulsive disorder. Clin Neurol Neurosurg, 2014, 119(6): 91-95.
10. Yoo SY, Roh MS, Choi JS, et al. Voxel-based morphometry study of gray matter abnormalities in obsessive-compulsive-disorder. J Korean Med Sci, 2008, 23(1): 30.
11. Nakamae T, Narumoto J, Sakai Y, et al. Diffusion tensor imaging and tract-based spatial statistics in obsessive-compulsive disorder. J Psychiatr Res, 2011, 45(5): 687-690.
12. Zarei M, Mataix-Cols D, Heyman I, et al. Changes in Gray matter volume and white matter microstructure in adolescents with obsessive-compulsive disorder. Biol Psychiatry, 2011, 70(11): 1083-1090.
13. 武文婧. 强迫症患者及其一级亲属的扩散张量成像研究. 重庆: 第三军医大学, 2012.
14. Ha TH, Kang DH, Park JS, et al. Whits matter alterations in male patients with obsessive-compulsive disorder. Neuroreport, 2009, 20(7): 735-739.
15. 杨涛. 首次发病未服药强迫症患者静息态脑功能影像学研究. 昆明: 昆明医学院, 2010: 62.
16. 侯景明, 黎海涛, 武文婧, 等. 强迫症患者 fMRI Stroop 试验脑功能异常. 中国医学影像技术, 2011, 27(10): 1977-1980.
17. 管一晖, 孙伯民, 张海英, 等. ¹⁸F-FDG PET显像对强迫症手术治疗前后的观察. 中华核医学杂志, 2001, 21(1): 17-19.
18. Pujol J, Soriano-Mas C, Gispert JD, et al. Variations in the shape of the frontobasal brain region in obsessive-compulsive disorder. Hum Brain Mapp, 2011, 32(7): 1100-1108.
19. Hou JM, Zhao M, Zhang W, et al. Resting-state functional connectivity abnormalities in patients with obsessive–compulsive disorder and their healthy first-degree relatives. J Psychiatry Neurosci, 2014, 39(5): 304-311.
20. Nakanishi M, Oshita H, Tanaka Y, et al. Near-infrared spectroscopy during the verbal fluency task before and after treatment with image exposure and SSRI therapy in patients with obsessive-compulsive disorder. Case Rep Psychiatry. 2014, 2014: 591023.
21. 卢蕴容, 林铮, 李惠春. 强迫症患者前额叶、海马磁共振质子波谱成像的研究. 浙江医学, 2007, 29(3): 226-228.
22. 赵秀芝. 强迫症患者的氢质子磁共振波谱分析及认知功能研究. 济南: 山东大学, 2011.
23. Jhung K, Ku J, Kim SJ, et al. Distinct functional connectivity of limbic network in the washing type obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry, 2014, 53(8): 149-155.
24. 陈远浩. 首诊成人强迫症患者的脑 3D-多体素氢质子磁共振波谱分析研究. 宁波: 宁波大学, 2012.
25. Park SE, Jeong GW. Cerebral white matter volume changes in patients with obsessive-compulsive disorder: voxel-based morphometry. Psychiatry Clin Neurosci, 2015, 69(11): 717-723.
26. Ota T, Iida J, Sawada M, et al. Reduced prefrontal hemodynamic response in pediatric obsessive-compulsive disorder as measured by near-infrared spectroscopy. Child Psychiatry Hum Dev, 2013, 44(2): 265-277.
27. Okada K, Ota T, Iida J, et al. Lower prefrontal activity in adults with obsessive-compulsive disorder as measured by near-infrared spectroscopy. Prog Neuropsychopharmacol Biol Psychiatry, 2013, 43: 7-13.
28. Lázaro L, Castro-Fornieles J, Cullell C, et al. A voxel-based morphometric MRI study of stabilized obsessive -compulsive adolescent patients. Prog Neuropsychopharmacol Biol Psychiatry, 2011, 35 (8): 1863-1869.
29. 田峰, 徐成, 崔晓红. 强迫症患者静息态脑功能局部一致性研究. 中华行为医学与脑科学杂志, 2010, 19(3): 197-199.

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