食管癌相关标志物研究进展_West China Medical Journal

Authors：

 黄清梅 ^1,2,1,2 , 杜小波 ^2,2

1. ;
2. ;

Corresponding author：

黄清梅, Email: 1101351579@qq.com

Keywords：

食管癌; 标志物; 预后

DOI：

10.7507/1002-0179.201609091

Video：

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食管癌为我国最常见的恶性肿瘤之一，发病率高，依据 2015 年中国癌症数据统计报告，其发病率和致死率分别位于恶性肿瘤的第 4 位和第 5 位；而在高发区，如河南林县等，其发病率和死亡率则居恶性肿瘤首位。在我国，食管癌病理类型主要为食管鳞状细胞癌，其次为腺癌，食管小细胞及其他病理类型较少见。食管癌预后差，中晚期患者 5 年生存率约为 10%，但早期食管癌术后 5 年生存率可达 90%。鉴于上述特点，该文对食管癌发生、发展及预后过程中的相关血清、分子及基因标志物作一综述，旨在为临床早期诊断及判断预后等提供参考依据。

Citation： 黄清梅, 杜小波. 食管癌相关标志物研究进展. West China Medical Journal, 2017, 32(10): 1620-1623. doi: 10.7507/1002-0179.201609091 Copy

1.	郭晶, 卢春来, 古杰, 等. 趋化因子受体 7 (CXCR7) 在食管鳞形细胞癌组织中的表达及其临床意义. 复旦学报: 医学版, 2013, 40(1): 26-30, 43.
2.	Tachezy M, Zander H, Gebauer F, et al. CXCR7 expression in esophageal cancer. J Transl Med, 2013, 11: 238.
3.	Clauditz TS, Von Rheinbaben K, Lebok P, et al. Activated leukocyte cell adhesion molecule (ALCAM/CD166) expression in head and neck squamous cell carcinoma (HNSSC). Pathol Res Pract, 2014, 210(10): 649-655.
4.	朱震, 陈兵, 王金泉, 等. 肿瘤干细胞标记物 CD166 CD44v6 在食管癌中的表达及其意义. 浙江临床医学, 2012, 14(5): 519-521.
5.	Wei W, Wang Y, Yu X, et al. Expression of <italic>TP53</italic>, <italic>BCL-2</italic>, and <italic>VEGFA</italic> genes in esophagus carcinoma and its biological significance. Med Sci Monit, 2015, 21(21): 3016-3022.
6.	Yang Z, Wang YG, Su K. VEGF-C and VEGF-D expression and its correlation with lymph node metastasis in esophageal squamous cell cancer tissue. Asian Pac J Cancer Prev, 2015, 16(1): 271-274.
7.	Natsugoe S, Xiangming C, Matsumoto M, et al. Smad4 and transforming growth factor beta1 expression in patients with squamous cell carcinoma of the esophagus. Clin Cancer Res, 2002, 8(6): 1838-1842.
8.	Wang Z, He W, Yang G, et al. Decreased expression of GST pi is correlated with a poor prognosis in human esophageal squamous carcinoma. BMC Cancer, 2010, 10: 352.
9.	付保进, 张云汉, 王尧河, 等. 食管癌发生发展过程中 <italic>GST-π</italic> 基因表达的研究. 中华肿瘤杂志, 1999, 21(1): 29-31.
10.	Fan NJ, Gao CF, Wang XL. Tubulin beta chain, filamin A alpha isoform 1, and cytochrome b-c1 complex subunit 1 as serological diagnostic biomarkers of esophageal squamous cell carcinoma: a proteomics study. OMICS, 2013, 17(4): 215-223.
11.	Chen MF, Chen PT, Lu MS, et al. IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus. Mol Cancer, 2013, 12: 26.
12.	Groblewska M, Mroczko B, Sosnowska D, et al. Interleukin 6 and C-reactive protein in esophageal cancer. Clin Chim Acta, 2012, 413(19-20): 1583-1590.
13.	王竞, 姜斌. STAT3 与恶性肿瘤耐药的研究进展. 医学综述, 2012, 18(12): 1845-1847.
14.	Schoppmann SF, Jesch B, Friedrich J, et al. Phosphorylation of signal transducer and activator of transcription 3 (STAT3) correlates with Her-2 status, carbonic anhydrase 9 expression and prognosis in esophageal cancer. Clin Exp Metastasis, 2012, 29(6): 615-624.
15.	Wang YQ, Dai WM, Chu XY, et al. Downregulation of LKB1 suppresses Stat3 activity to promote the proliferation of esophageal carcinoma cells. Mol Med Rep, 2014, 9(6): 2400-2404.
16.	Wang X, Niu H, Fan Q, et al. Predictive value of EGFR overexpression and gene amplification on icotinib efficacy in patients with advanced esophageal squamous cell carcinoma. Oncotarget, 2016, 7(17): 24744-24751.
17.	Cronin J, Mcadam E, Danikas A, et al. Epidermal growth factor receptor (EGFR) is overexpressed in high-grade dysplasia and adenocarcinoma of the esophagus and May represent a biomarker of histological progression in Barrett’s esophagus (BE) Am J Gastroenterol, 2011, 106(1): 46-56.
18.	Pretto G, Gurski RR, Binato M, et al. Increase of epidermal growth factor receptor expression in progression of GERD, Barrett, and adenocarcinoma of esophagus. Dig Dis Sci, 2013, 58(1): 115-122.
19.	Yang L, Zhang X, Zhang M, et al. Increased nanog expression promotes tumor development and cisplatin resistance in human esophageal cancer cells. Cell Physiol Biochem, 2012, 30(4): 943-952.
20.	李秀娟, 赵轶峰, 李明霞, 等. 食管鳞癌组织 Nanog 表达临床意义分析. 中华肿瘤防治杂志, 2014, 21(24): 1962-1965.
21.	谭劲淘, 余春俊, 陈晓杰, 等. HER-2 对食管癌患者 5 年生存率的影响 Meta 分析. 山东医药, 2015, 55(10): 51.

1. 郭晶, 卢春来, 古杰, 等. 趋化因子受体 7 (CXCR7) 在食管鳞形细胞癌组织中的表达及其临床意义. 复旦学报: 医学版, 2013, 40(1): 26-30, 43.
2. Tachezy M, Zander H, Gebauer F, et al. CXCR7 expression in esophageal cancer. J Transl Med, 2013, 11: 238.
3. Clauditz TS, Von Rheinbaben K, Lebok P, et al. Activated leukocyte cell adhesion molecule (ALCAM/CD166) expression in head and neck squamous cell carcinoma (HNSSC). Pathol Res Pract, 2014, 210(10): 649-655.
4. 朱震, 陈兵, 王金泉, 等. 肿瘤干细胞标记物 CD166 CD44v6 在食管癌中的表达及其意义. 浙江临床医学, 2012, 14(5): 519-521.
5. Wei W, Wang Y, Yu X, et al. Expression of <italic>TP53</italic>, <italic>BCL-2</italic>, and <italic>VEGFA</italic> genes in esophagus carcinoma and its biological significance. Med Sci Monit, 2015, 21(21): 3016-3022.
6. Yang Z, Wang YG, Su K. VEGF-C and VEGF-D expression and its correlation with lymph node metastasis in esophageal squamous cell cancer tissue. Asian Pac J Cancer Prev, 2015, 16(1): 271-274.
7. Natsugoe S, Xiangming C, Matsumoto M, et al. Smad4 and transforming growth factor beta1 expression in patients with squamous cell carcinoma of the esophagus. Clin Cancer Res, 2002, 8(6): 1838-1842.
8. Wang Z, He W, Yang G, et al. Decreased expression of GST pi is correlated with a poor prognosis in human esophageal squamous carcinoma. BMC Cancer, 2010, 10: 352.
9. 付保进, 张云汉, 王尧河, 等. 食管癌发生发展过程中 <italic>GST-π</italic> 基因表达的研究. 中华肿瘤杂志, 1999, 21(1): 29-31.
10. Fan NJ, Gao CF, Wang XL. Tubulin beta chain, filamin A alpha isoform 1, and cytochrome b-c1 complex subunit 1 as serological diagnostic biomarkers of esophageal squamous cell carcinoma: a proteomics study. OMICS, 2013, 17(4): 215-223.
11. Chen MF, Chen PT, Lu MS, et al. IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus. Mol Cancer, 2013, 12: 26.
12. Groblewska M, Mroczko B, Sosnowska D, et al. Interleukin 6 and C-reactive protein in esophageal cancer. Clin Chim Acta, 2012, 413(19-20): 1583-1590.
13. 王竞, 姜斌. STAT3 与恶性肿瘤耐药的研究进展. 医学综述, 2012, 18(12): 1845-1847.
14. Schoppmann SF, Jesch B, Friedrich J, et al. Phosphorylation of signal transducer and activator of transcription 3 (STAT3) correlates with Her-2 status, carbonic anhydrase 9 expression and prognosis in esophageal cancer. Clin Exp Metastasis, 2012, 29(6): 615-624.
15. Wang YQ, Dai WM, Chu XY, et al. Downregulation of LKB1 suppresses Stat3 activity to promote the proliferation of esophageal carcinoma cells. Mol Med Rep, 2014, 9(6): 2400-2404.
16. Wang X, Niu H, Fan Q, et al. Predictive value of EGFR overexpression and gene amplification on icotinib efficacy in patients with advanced esophageal squamous cell carcinoma. Oncotarget, 2016, 7(17): 24744-24751.
17. Cronin J, Mcadam E, Danikas A, et al. Epidermal growth factor receptor (EGFR) is overexpressed in high-grade dysplasia and adenocarcinoma of the esophagus and May represent a biomarker of histological progression in Barrett’s esophagus (BE) Am J Gastroenterol, 2011, 106(1): 46-56.
18. Pretto G, Gurski RR, Binato M, et al. Increase of epidermal growth factor receptor expression in progression of GERD, Barrett, and adenocarcinoma of esophagus. Dig Dis Sci, 2013, 58(1): 115-122.
19. Yang L, Zhang X, Zhang M, et al. Increased nanog expression promotes tumor development and cisplatin resistance in human esophageal cancer cells. Cell Physiol Biochem, 2012, 30(4): 943-952.
20. 李秀娟, 赵轶峰, 李明霞, 等. 食管鳞癌组织 Nanog 表达临床意义分析. 中华肿瘤防治杂志, 2014, 21(24): 1962-1965.
21. 谭劲淘, 余春俊, 陈晓杰, 等. HER-2 对食管癌患者 5 年生存率的影响 Meta 分析. 山东医药, 2015, 55(10): 51.

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食管癌相关标志物研究进展

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