缺血性卒中发病的季节性变化及其影响因素_West China Medical Journal

Authors：

周知微 , 唐丽 , 郭毅佳 ,  何俐

四川大学华西医院神经内科（成都 610041）;

Corresponding author：

何俐, Email: heli2003new@126.com

Keywords：

缺血性卒中; 发病; 季节

DOI：

10.7507/1002-0179.201610048

Video：

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缺血性卒中是世界范围内致死和致残的主要原因。以往的研究结果显示缺血性卒中的发病具有季节性规律，在不同的地区呈现不同的季节性上升趋势，这可能与当地气温变化及与气温变化有关的血压波动、血液成分变化、感染等有关。为控制缺血性卒中发病的季节性增加，降低缺血性卒中的致残率、致死率，该文对世界各地缺血性卒中发病的季节性变化及其可能的影响因素进行了综述。

Citation： 周知微, 唐丽, 郭毅佳, 何俐. 缺血性卒中发病的季节性变化及其影响因素. West China Medical Journal, 2017, 32(5): 684-687. doi: 10.7507/1002-0179.201610048 Copy

1.	Towfighi A, Saver JL. Stroke declines from third to fourth leading cause of death in the United States: historical perspective and challenges ahead. Stroke, 2011, 42(8): 2351-2355.
2.	Sun H, Zou X, Liu L. Epidemiological factors of stroke: a survey of the current status in China. J Stroke, 2013, 15(2): 109-114.
3.	Tan CS, Müller-Riemenschneider F, Ng SH, et al. Trends in stroke incidence and 28-Day case fatality in a nationwide stroke registry of a multiethnic Asian population. Stroke, 2015, 46(10): 2728-2734.
4.	Wang H, Sekine M, Chen X, et al. A study of weekly and seasonal variation of stroke onset. Int J Biometeorol, 2002, 47(1): 13-20.
5.	Ricci S, Celani MG, Vitali R, et al. Diurnal and seasonal variations in the occurrence of stroke: a community-based study. Neuroepidemiology, 1992, 11(2): 59-64.
6.	Han MH, Yi HJ, Kim YS, et al. Effect of seasonal and monthly variation in weather and air pollution factors on stroke incidence in Seoul, Korea. Stroke, 2015, 46(4): 927-935.
7.	Cowperthwaite MC, Burnett MG. An analysis of admissions from 155 United States hospitals to determine the influence of weather on stroke incidence. J Clin Neurosci, 2011, 18(5): 618-623.
8.	Lichtman JH, Leifheit-Limson EC, Jones SB, et al. Average temperature, diurnal temperature variation, and stroke hospitalizations. J Stroke Cerebrovasc Dis, 2016, 25(6): 1489-1494.
9.	Guo P, Zheng M, Feng W, et al. Effects of ambient temperature on stroke hospital admissions: Results from a time-series analysis of 104,432 strokes in Guangzhou, China. Sci Total Environ, 2017, 580: 307-315.
10.	Wang Y, Levi CR, Attia JR, et al. Seasonal variation in stroke in the Hunter Region, Australia: a 5-year hospital-based study, 1995-2000. Stroke, 2003, 34(5): 1144-1150.
11.	Berginer VM, Goldsmith J, Batz U, et al. Clustering of strokes in association with meteorologic factors in the Negev Desert of Israel: 1981-1983. Stroke, 1989, 20(1): 65-69.
12.	Turin TC, Kita Y, Murakami Y, et al. Higher stroke incidence in the spring season regardless of conventional risk factors: Takashima Stroke Registry, Japan, 1988-2001. Stroke, 2008, 39(3): 745-752.
13.	Sobel E, Zhang ZX, Alter M, et al. Stroke in the lehigh valley: seasonal variation in incidence rates. Stroke, 1987, 18(1): 38-42.
14.	Shinkawa A, Ueda K, Hasuo Y, et al. Seasonal variation in stroke incidence in Hisayama, Japan. Stroke, 1990, 21(9): 1262-1267.
15.	Kelly-Hayes M, Wolf PA, Kase CS, et al. Temporal patterns of stroke onset. The Framingham Study. Stroke, 1995, 26(8): 1343-1347.
16.	Jakovljević D, Salomaa V, Sivenius J, et al. Seasonal variation in the occurrence of stroke in a Finnish adult population. Stroke, 1996, 27(10): 1774-1779.
17.	Goggins WB, Woo J, Ho S, et al. Weather, season, and daily stroke admissions in Hong Kong. Int J Biometeorol, 2012, 56(5): 865-872.
18.	Khan FA, Engstrom G, Jerntorp I, et al. Seasonal patterns of incidence and case fatality of stroke in Malmo, Sweden: the STROMA study. Neuroepidemiology, 2005, 24(1/2): 26-31.
19.	Palm F, Dos Santos M, Urbanek C, et al. Stroke seasonality associations with subtype, etiology and laboratory results in the Ludwigshafen Stroke Study (LuSSt) Eur J Epidemiol, 2013, 28(5): 373-381.
20.	Telman G, Fahoum S, Sprecher E, et al. Seasonal, monthly, and weekly variations in admissions, in-hospital mortality, and length of stay in acute ischemic stroke in northern Israel. J Neurol Transl Neurosci, 2013, 1: 1007-1012.
21.	Tsementzis SA, Kennet RP, Hitchcock ER, et al. Seasonal variation of cerebrovascular diseases. Acta Neurochir (Wien), 1991, 111(3/4): 80-83.
22.	Feigin VL, Nikitin YP. Seasonal variation in the occurrence of ischemic stroke and subarachnoid hemorrhage in Siberia. A population-based study. Eur J Neurol, 1998, 5(1): 23-27.
23.	Reavey M, Saner H, Paccaud F, et al. Exploring the periodicity of cardiovascular events in Switzerland: variation in deaths and hospitalizations across seasons, day of the week and hour of the day. Int J Cardiol, 2013, 168(3): 2195-2200.
24.	Sharma N, Lewsey J, Inglis S, et al. Effect of seasonal variation on the frequency of incident stroke hospitalizations in Scotland. Saudi J Health Sci, 2015, 4(1): 23.
25.	Xu B, Liu H, Su N, et al. Association between winter season and risk of death from cardiovascular diseases: a study in more than half a million inpatients in Beijing, China. BMC Cardiovasc Disord, 2013, 13: 93.
26.	Myint PK, Vowler SL, Woodhouse PR, et al. Winter excess in hospital admissions, in-patient mortality and length of acute hospital stay in stroke: a hospital database study over six seasonal years in Norfolk, UK. Neuroepidemiology, 2007, 28(2): 79-85.
27.	Spengos K, Vemmos KN, Tsivgoulis G, et al. Seasonal variation of hospital admissions caused by acute stroke in Athens, Greece. J Stroke Cerebrovasc Dis, 2007, 12(2): 93-96.
28.	Frost L, Vukelic AL, Mortensen LS, et al. Seasonal variation in stroke and stroke-associated mortality in patients with a hospital diagnosis of nonvalvular atrial fibrillation or flutter. A population-based study in Denmark. Neuroepidemiology, 2006, 26(4): 220-225.
29.	Díaz A, Gerschcovich ER, Díaz AA, et al. Seasonal variation and trends in stroke hospitalizations and mortality in a South American community hospital. J Stroke Cerebrovasc Dis, 2013, 22(7): e66-e69.
30.	Manfredini R, Fabbian F, Pala M, et al. Seasonal and weekly patterns of occurrence of acute cardiovascular diseases: does a gender difference exist?. J Womens Health (Larchmt), 2011, 20(11): 1663-1668.
31.	Karagiannis A, Tziomalos K, Mikhailidis DP, et al. Seasonal variation in the occurrence of stroke in Northern Greece: a 10 year study in 8204 patients. Neurol Res, 2010, 32(3): 326-331.
32.	Mao Y, Schnytzer Y, Busija L, et al. MOONSTROKE. Lunar patterns of stroke occurrence combined with circadian and seasonal rhythmicity. A hospital based study. Chronobiol Int, 2015, 32(7): 881-888.
33.	Anlar O, Tombul T, Unal O, et al. Seasonal and environmental temperature variation in the occurrence of ischemic strokes and intracerebral hemorrhages in a Turkish adult population. Int J Neurosci, 2002, 112(8): 959-963.
34.	Divyanshu D, Anshudha S, Arvind K, et al. A study of anatomical, seasonal and diurnal variation in the occurrence of ischemic stroke. Int J Collab Res Intern Med Public Health, 2011, 3(10): 781-788.
35.	Takizawa S, Shibata T, Takagi S, et al. Seasonal variation of stroke incidence in Japan for 35631 stroke patients in the Japanese Standard Stroke Registry, 1998-2007. J Stroke Cerebrovasc Dis, 2013, 22(1): 36-41.
36.	Biller J, Jones MP, Bruno A, et al. Seasonal variation of stroke--does it exist?. Neuroepidemiology, 1988, 7(2): 89-98.
37.	Magalhães R, Silva MC, Correia M, et al. Are stroke occurrence and outcome related to weather parameters? Results from a population-based study in northern Portugal. Cerebrovasc Dis, 2011, 32(6): 542-551.
38.	Gomes J, Damasceno A, Carrilho C, et al. The effect of season and temperature variation on hospital admissions for incident stroke events in Maputo, Mozambique. J Stroke Cerebrovasc Dis, 2014, 23(2): 271-277.
39.	Rothwell PM, Wroe SJ, Slattery J, et al. Is stroke incidence related to season or temperature. The Oxfordshire Community Stroke Project. Lancet, 1996, 347(9006): 934-936.
40.	Raj K, Bhatia R, Prasad K, et al. Seasonal differences and circadian variation in stroke occurrence and stroke subtypes. J Stroke Cerebrovasc Dis, 2015, 24(1): 10-16.
41.	Soomro MA, Solangi GA, Shaikh BA, et al. Stroke types in relation to seasonal variation and months of a year. Med Channel, 2011, 17(2): 57-62.
42.	Gill JS, Davies P, Gill SK, et al. Wind-chill and the seasonal variation of cerebrovascular disease. J Clin Epidemiol, 1988, 41(3): 225-230.
43.	Woo J, Kay R, Nicholls MG. Environmental temperature and stroke in a subtropical climate. Neuroepidemiology, 1991, 10(5/6): 260-265.
44.	Sipilä JO, Ruuskanen JO, Kauko T, et al. Seasonality of stroke in Finland. Ann Med, 2016: 1-9. DOI: 10.1080/07853890.2016.1254350.
45.	Giua A, Abbas MA, Murgia N, et al. Climate and stroke: a controversial association. Int J Biometeorol, 2010, 54(1): 1-3.
46.	Hong YC, Rha JH, Lee JT, et al. Ischemic stroke associated with decrease in temperature. Epidemiology, 2003, 14(4): 473-478.
47.	Hori A, Hashizume M, Tsuda Y, et al. Effects of weather variability and air pollutants on emergency admissions for cardiovascular and cerebrovascular diseases. Int J Environ Health Res, 2012, 22(5): 416-430.
48.	Wang Q, Gao C, Wang H, et al. Ischemic stroke hospital admission associated with ambient temperature in Jinan, China. PLoS One, 2013, 8(11): e80381.
49.	Woodhouse PR, Khaw KT, Plummer M, et al. Seasonal variations of plasma fibrinogen and factor Ⅶ activity in the elderly: winter infections and death from cardiovascular disease. Lancet, 1994, 343(8895): 435-439.
50.	Basu R, Pearson D, Malig B, et al. The effect of high ambient temperature on emergency room visits. Epidemiology, 2012, 23(6): 813-820.
51.	Nawrot TS, Staessen JA, Fagard RH, et al. Endothelial function and outdoor temperature. Eur J Epidemiol, 2005, 20(5): 407-410.

1. Towfighi A, Saver JL. Stroke declines from third to fourth leading cause of death in the United States: historical perspective and challenges ahead. Stroke, 2011, 42(8): 2351-2355.
2. Sun H, Zou X, Liu L. Epidemiological factors of stroke: a survey of the current status in China. J Stroke, 2013, 15(2): 109-114.
3. Tan CS, Müller-Riemenschneider F, Ng SH, et al. Trends in stroke incidence and 28-Day case fatality in a nationwide stroke registry of a multiethnic Asian population. Stroke, 2015, 46(10): 2728-2734.
4. Wang H, Sekine M, Chen X, et al. A study of weekly and seasonal variation of stroke onset. Int J Biometeorol, 2002, 47(1): 13-20.
5. Ricci S, Celani MG, Vitali R, et al. Diurnal and seasonal variations in the occurrence of stroke: a community-based study. Neuroepidemiology, 1992, 11(2): 59-64.
6. Han MH, Yi HJ, Kim YS, et al. Effect of seasonal and monthly variation in weather and air pollution factors on stroke incidence in Seoul, Korea. Stroke, 2015, 46(4): 927-935.
7. Cowperthwaite MC, Burnett MG. An analysis of admissions from 155 United States hospitals to determine the influence of weather on stroke incidence. J Clin Neurosci, 2011, 18(5): 618-623.
8. Lichtman JH, Leifheit-Limson EC, Jones SB, et al. Average temperature, diurnal temperature variation, and stroke hospitalizations. J Stroke Cerebrovasc Dis, 2016, 25(6): 1489-1494.
9. Guo P, Zheng M, Feng W, et al. Effects of ambient temperature on stroke hospital admissions: Results from a time-series analysis of 104,432 strokes in Guangzhou, China. Sci Total Environ, 2017, 580: 307-315.
10. Wang Y, Levi CR, Attia JR, et al. Seasonal variation in stroke in the Hunter Region, Australia: a 5-year hospital-based study, 1995-2000. Stroke, 2003, 34(5): 1144-1150.
11. Berginer VM, Goldsmith J, Batz U, et al. Clustering of strokes in association with meteorologic factors in the Negev Desert of Israel: 1981-1983. Stroke, 1989, 20(1): 65-69.
12. Turin TC, Kita Y, Murakami Y, et al. Higher stroke incidence in the spring season regardless of conventional risk factors: Takashima Stroke Registry, Japan, 1988-2001. Stroke, 2008, 39(3): 745-752.
13. Sobel E, Zhang ZX, Alter M, et al. Stroke in the lehigh valley: seasonal variation in incidence rates. Stroke, 1987, 18(1): 38-42.
14. Shinkawa A, Ueda K, Hasuo Y, et al. Seasonal variation in stroke incidence in Hisayama, Japan. Stroke, 1990, 21(9): 1262-1267.
15. Kelly-Hayes M, Wolf PA, Kase CS, et al. Temporal patterns of stroke onset. The Framingham Study. Stroke, 1995, 26(8): 1343-1347.
16. Jakovljević D, Salomaa V, Sivenius J, et al. Seasonal variation in the occurrence of stroke in a Finnish adult population. Stroke, 1996, 27(10): 1774-1779.
17. Goggins WB, Woo J, Ho S, et al. Weather, season, and daily stroke admissions in Hong Kong. Int J Biometeorol, 2012, 56(5): 865-872.
18. Khan FA, Engstrom G, Jerntorp I, et al. Seasonal patterns of incidence and case fatality of stroke in Malmo, Sweden: the STROMA study. Neuroepidemiology, 2005, 24(1/2): 26-31.
19. Palm F, Dos Santos M, Urbanek C, et al. Stroke seasonality associations with subtype, etiology and laboratory results in the Ludwigshafen Stroke Study (LuSSt) Eur J Epidemiol, 2013, 28(5): 373-381.
20. Telman G, Fahoum S, Sprecher E, et al. Seasonal, monthly, and weekly variations in admissions, in-hospital mortality, and length of stay in acute ischemic stroke in northern Israel. J Neurol Transl Neurosci, 2013, 1: 1007-1012.
21. Tsementzis SA, Kennet RP, Hitchcock ER, et al. Seasonal variation of cerebrovascular diseases. Acta Neurochir (Wien), 1991, 111(3/4): 80-83.
22. Feigin VL, Nikitin YP. Seasonal variation in the occurrence of ischemic stroke and subarachnoid hemorrhage in Siberia. A population-based study. Eur J Neurol, 1998, 5(1): 23-27.
23. Reavey M, Saner H, Paccaud F, et al. Exploring the periodicity of cardiovascular events in Switzerland: variation in deaths and hospitalizations across seasons, day of the week and hour of the day. Int J Cardiol, 2013, 168(3): 2195-2200.
24. Sharma N, Lewsey J, Inglis S, et al. Effect of seasonal variation on the frequency of incident stroke hospitalizations in Scotland. Saudi J Health Sci, 2015, 4(1): 23.
25. Xu B, Liu H, Su N, et al. Association between winter season and risk of death from cardiovascular diseases: a study in more than half a million inpatients in Beijing, China. BMC Cardiovasc Disord, 2013, 13: 93.
26. Myint PK, Vowler SL, Woodhouse PR, et al. Winter excess in hospital admissions, in-patient mortality and length of acute hospital stay in stroke: a hospital database study over six seasonal years in Norfolk, UK. Neuroepidemiology, 2007, 28(2): 79-85.
27. Spengos K, Vemmos KN, Tsivgoulis G, et al. Seasonal variation of hospital admissions caused by acute stroke in Athens, Greece. J Stroke Cerebrovasc Dis, 2007, 12(2): 93-96.
28. Frost L, Vukelic AL, Mortensen LS, et al. Seasonal variation in stroke and stroke-associated mortality in patients with a hospital diagnosis of nonvalvular atrial fibrillation or flutter. A population-based study in Denmark. Neuroepidemiology, 2006, 26(4): 220-225.
29. Díaz A, Gerschcovich ER, Díaz AA, et al. Seasonal variation and trends in stroke hospitalizations and mortality in a South American community hospital. J Stroke Cerebrovasc Dis, 2013, 22(7): e66-e69.
30. Manfredini R, Fabbian F, Pala M, et al. Seasonal and weekly patterns of occurrence of acute cardiovascular diseases: does a gender difference exist?. J Womens Health (Larchmt), 2011, 20(11): 1663-1668.
31. Karagiannis A, Tziomalos K, Mikhailidis DP, et al. Seasonal variation in the occurrence of stroke in Northern Greece: a 10 year study in 8204 patients. Neurol Res, 2010, 32(3): 326-331.
32. Mao Y, Schnytzer Y, Busija L, et al. MOONSTROKE. Lunar patterns of stroke occurrence combined with circadian and seasonal rhythmicity. A hospital based study. Chronobiol Int, 2015, 32(7): 881-888.
33. Anlar O, Tombul T, Unal O, et al. Seasonal and environmental temperature variation in the occurrence of ischemic strokes and intracerebral hemorrhages in a Turkish adult population. Int J Neurosci, 2002, 112(8): 959-963.
34. Divyanshu D, Anshudha S, Arvind K, et al. A study of anatomical, seasonal and diurnal variation in the occurrence of ischemic stroke. Int J Collab Res Intern Med Public Health, 2011, 3(10): 781-788.
35. Takizawa S, Shibata T, Takagi S, et al. Seasonal variation of stroke incidence in Japan for 35631 stroke patients in the Japanese Standard Stroke Registry, 1998-2007. J Stroke Cerebrovasc Dis, 2013, 22(1): 36-41.
36. Biller J, Jones MP, Bruno A, et al. Seasonal variation of stroke--does it exist?. Neuroepidemiology, 1988, 7(2): 89-98.
37. Magalhães R, Silva MC, Correia M, et al. Are stroke occurrence and outcome related to weather parameters? Results from a population-based study in northern Portugal. Cerebrovasc Dis, 2011, 32(6): 542-551.
38. Gomes J, Damasceno A, Carrilho C, et al. The effect of season and temperature variation on hospital admissions for incident stroke events in Maputo, Mozambique. J Stroke Cerebrovasc Dis, 2014, 23(2): 271-277.
39. Rothwell PM, Wroe SJ, Slattery J, et al. Is stroke incidence related to season or temperature. The Oxfordshire Community Stroke Project. Lancet, 1996, 347(9006): 934-936.
40. Raj K, Bhatia R, Prasad K, et al. Seasonal differences and circadian variation in stroke occurrence and stroke subtypes. J Stroke Cerebrovasc Dis, 2015, 24(1): 10-16.
41. Soomro MA, Solangi GA, Shaikh BA, et al. Stroke types in relation to seasonal variation and months of a year. Med Channel, 2011, 17(2): 57-62.
42. Gill JS, Davies P, Gill SK, et al. Wind-chill and the seasonal variation of cerebrovascular disease. J Clin Epidemiol, 1988, 41(3): 225-230.
43. Woo J, Kay R, Nicholls MG. Environmental temperature and stroke in a subtropical climate. Neuroepidemiology, 1991, 10(5/6): 260-265.
44. Sipilä JO, Ruuskanen JO, Kauko T, et al. Seasonality of stroke in Finland. Ann Med, 2016: 1-9. DOI: 10.1080/07853890.2016.1254350.
45. Giua A, Abbas MA, Murgia N, et al. Climate and stroke: a controversial association. Int J Biometeorol, 2010, 54(1): 1-3.
46. Hong YC, Rha JH, Lee JT, et al. Ischemic stroke associated with decrease in temperature. Epidemiology, 2003, 14(4): 473-478.
47. Hori A, Hashizume M, Tsuda Y, et al. Effects of weather variability and air pollutants on emergency admissions for cardiovascular and cerebrovascular diseases. Int J Environ Health Res, 2012, 22(5): 416-430.
48. Wang Q, Gao C, Wang H, et al. Ischemic stroke hospital admission associated with ambient temperature in Jinan, China. PLoS One, 2013, 8(11): e80381.
49. Woodhouse PR, Khaw KT, Plummer M, et al. Seasonal variations of plasma fibrinogen and factor Ⅶ activity in the elderly: winter infections and death from cardiovascular disease. Lancet, 1994, 343(8895): 435-439.
50. Basu R, Pearson D, Malig B, et al. The effect of high ambient temperature on emergency room visits. Epidemiology, 2012, 23(6): 813-820.
51. Nawrot TS, Staessen JA, Fagard RH, et al. Endothelial function and outdoor temperature. Eur J Epidemiol, 2005, 20(5): 407-410.

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缺血性卒中发病的季节性变化及其影响因素

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