克唑替尼一线治疗外周血下一代测序技术检测 <i>ROS1</i> 阳性晚期多合并症肺腺癌一例 _West China Medical Journal

Authors：

张瑜 ,  彭枫

四川大学华西医院胸部肿瘤科（成都 610041）;

Corresponding author：

彭枫, Email: pfwork@126.com

Keywords：

肺腺癌; 外周血下一代测序技术; ROS1 基因; 靶向治疗; 克唑替尼

DOI：

10.7507/1002-0179.201611164

Video：

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Citation： 张瑜, 彭枫. 克唑替尼一线治疗外周血下一代测序技术检测 ROS1 阳性晚期多合并症肺腺癌一例 . West China Medical Journal, 2017, 32(12): 2024-2026. doi: 10.7507/1002-0179.201611164 Copy

1.	Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature, 2007, 448(7153): 561-566.
2.	Rikova K, Guo AL, Zeng QF, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell, 2007, 131(6): 1190-1203.
3.	Camidge DR, Bang YJ, Kwak EL, et al. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol, 2012, 13(10): 1011-1019.
4.	Crinò L, Kim D, Riely GJ, et al. Initial phaseⅡ results with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC): PROFILE 1005. J Clin Oncol, 2011, 29(S 15): 7514.
5.	董江萍. FDA 批准克里唑替尼及其基因测试法治疗晚期非小细胞肺癌. 药物评价研究, 2011, 34(5): 402.
6.	Seo JS, Ju YS, Lee WC, et al. The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res, 2012, 22(11): 2109-2119.
7.	Bergethon K, Shaw AT, Ou SH, et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol, 2012, 30(8): 863-870.
8.	Shaw AT, Ou SH, Bang YJ, et al. Crizotinib in ROS1-rearranged non-small-cell lung cancer. N Engl J Med, 2014, 371(21): 1963-1971.

1. Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature, 2007, 448(7153): 561-566.
2. Rikova K, Guo AL, Zeng QF, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell, 2007, 131(6): 1190-1203.
3. Camidge DR, Bang YJ, Kwak EL, et al. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol, 2012, 13(10): 1011-1019.
4. Crinò L, Kim D, Riely GJ, et al. Initial phaseⅡ results with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC): PROFILE 1005. J Clin Oncol, 2011, 29(S 15): 7514.
5. 董江萍. FDA 批准克里唑替尼及其基因测试法治疗晚期非小细胞肺癌. 药物评价研究, 2011, 34(5): 402.
6. Seo JS, Ju YS, Lee WC, et al. The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res, 2012, 22(11): 2109-2119.
7. Bergethon K, Shaw AT, Ou SH, et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol, 2012, 30(8): 863-870.
8. Shaw AT, Ou SH, Bang YJ, et al. Crizotinib in ROS1-rearranged non-small-cell lung cancer. N Engl J Med, 2014, 371(21): 1963-1971.

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West China Medical Journal

克唑替尼一线治疗外周血下一代测序技术检测 ROS1 阳性晚期多合并症肺腺癌一例

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