Diagnosis and treatment progress of cough variant asthma_West China Medical Journal

Authors：

TIAN Xue ,  ZHOU Xin

Department of Respiratory Medicine, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai 200080, P. R. China;

Corresponding author：

ZHOU Xin, Email: xzhou53@163.com

Keywords：

Cough variant asthma; Diagnosis; Treatment

DOI：

10.7507/1002-0179.201710013

Video：

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Cough variant asthma is a special type of asthma, of which the only or main symptom is cough, and it is the main cause of chronic cough. Early diagnosis and treatment can prevent cough variant asthma developing into typical asthma. This article summarizes the progress in pathogenesis, diagnosis and assessment, treatment, and prognosis of cough variant asthma, aiming to improve the prevention and treatment of this disease, and increase the patients’ quality of life.

Citation： TIAN Xue, ZHOU Xin. Diagnosis and treatment progress of cough variant asthma. West China Medical Journal, 2018, 33(1): 99-103. doi: 10.7507/1002-0179.201710013 Copy

1.	Glauser FL. Variant asthma. Ann Allergy, 1972, 30(8): 457-459.
2.	Corrao WM, Braman SS, Irwin RS. Chronic cough as the sole presenting manifestation of bronchial asthma. N Engl J Med, 1979, 300(12): 633-637.
3.	Lai K, Chen R, Lin J, et al. A prospective, multicenter survey on causes of chornic cough in China. Chest, 2013, 143(3): 613-620.
4.	Niimi A, Matsumoto H, Mishima M. Eosinophiliv airway disorders associated with chronic cough. Pulm Pharmaeol Ther, 2009, 22(2): 114-120.
5.	Ohta K, Yamaguchi M, Akiyama K, et al. Japanese guideline for adult asthma. Allergol Int, 2011, 60(2): 115-145.
6.	Niimi A, Brightling CE, Dicpinigaitis PV. Cough in asthma is due to eosinophilic airway inflammation: a pro/con debate. Lung, 2014, 192(1): 33-38.
7.	Obase Y, Shimoda T, Kishikawa R, et al. Trigger of bronchial hyperresponsiveness development may not always need eosinophilic airway inflammation in very early stage of asthma. Allergy Rhinol (Providence), 2016, 7(1): 1-7.
8.	Zhang YX, Liu Y, Xue Y, et al. Correlational study on atmospheric concentrations of fine particulate matter and children cough variant asthma. Eur Rev Med Pharmacol Sci, 2016, 20(12): 2650-2654.
9.	Prakash YS, Martin RJ. Brain-derived neurotrophic factor in the airways. Pharmacol Ther, 2014, 143(1): 74-86.
10.	Guc BU, Asilsoy S, Cihan FG. Brain-derived neurotrophic factor levels in children with asthma and isolated chronic cough. Pediatr Allergy Immunol Pulmonol, 2016, 29(1): 29-33.
11.	中华医学会呼吸病学分会哮喘学组. 咳嗽的诊断与治疗指南(2015) .中华结核和呼吸杂志, 2016, 39(5): 323-354.
12.	Lougheed MD, Turcotte SE, Fisher T. Cough variant asthma: lessons learned from deep inspirations. Lung, 2012, 190(1): 17-22.
13.	Koh YY, Park Y, Kim CK. The importance of maximal airway response to methacholine in the prediction of wheezing development in patients with cough-variant asthma. Allergy, 2002, 57(12): 1165-1170.
14.	Fang Y, Wei L, Chen RC, et al. Predictive value of fractional exhaled nitric oxide of airway eosinophilic inflammation in chonic cough and classic asthma. Chest, 2016, 149(4): A21.
15.	Shimoda T, Obase Y, Kishikawa R, et al. The fractional exhaled nitric oxide and serum high sensitivity C-reactive protein levels in cough variant asthma and typical bronchial asthma. Allergol Int, 2013, 62(2): 251-257.
16.	Asano T, Takemura M, Fukumitsu K, et al. Diagnostic utility of fractional exhaled nitric oxide in prolonged and chronic cough according to atopic status. Allergol Int, 2017, 66(2): 344-350.
17.	Song WJ, Kim HJ, Shim JS, et al. Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough-variant asthma and eosinophilic bronchitis in adults with chronic cough: a systematic review and meta-analysis. J Allergy Clin Immunol. 2017, 140(3): 701-709.
18.	Kanemitsu Y, Matsumoto H, Osman N, et al. " Cold air” and/or " talking” as cough triggers, a sign for the diagnosis of cough variant asthma. Respir Investig, 2016, 54(6): 413-418.
19.	Marsden PA, Satia I, Ibrahim B, et al. Objective cough frequency, airway inflammation, and disease control in asthma. Chest, 2016, 149(6): 1460-1466.
20.	Matsuoka H, Niimi A, Matsumoto H, et al. Inflammatory subtypes in cough-variant asthma: association with maintenance doses of inhaled corticosteroids. Chest, 2010, 138(6): 1418-1425.
21.	李馨, 余莉, 魏为利, 等. 支气管扩张剂治疗有效和无效咳嗽变异性哮喘的比较研究. 同济大学学报: 医学版, 2011, 32(1): 95-100.
22.	Takemura M, Niimi A, Matsumoto H, et al. Clinical, physiological and anti-inflammatory effect of montelukast in patients with cough variant asthma. Respiration, 2012, 83(4): 308-315.
23.	Zhou X, Hong J, Cheng H, et al. Budesonide suspension nebulization treatment in Chinese pediatric patients with cough variant asthma: a multi-center observational study. J Asthma, 2016, 53(5): 532-537.
24.	Song P, Zeng L, Liang Z, et al. Clinical efficacy and safety of Chinese herbal medicine auxiliary therapy for childhood cough variant asthma: a systematic review and meta-analysis of 20 randomized controlled trials. Intern Med, 2016, 55(16): 2135-2143.
25.	Saito N, Itoga M, Tamaki M, et al. Cough variant asthma patients are more depressed and anxious than classic asthma patients. J Psychosom Res, 2015, 79(1): 18-26.
26.	Nakajima T, Nishimura Y, Nishiuma T, et al. Characteristics of patients with chronic cough who developed classic asthma during the course of cough variant asthma: a longitudinal study. Respiration, 2005, 72(6): 606-611.

1. Glauser FL. Variant asthma. Ann Allergy, 1972, 30(8): 457-459.
2. Corrao WM, Braman SS, Irwin RS. Chronic cough as the sole presenting manifestation of bronchial asthma. N Engl J Med, 1979, 300(12): 633-637.
3. Lai K, Chen R, Lin J, et al. A prospective, multicenter survey on causes of chornic cough in China. Chest, 2013, 143(3): 613-620.
4. Niimi A, Matsumoto H, Mishima M. Eosinophiliv airway disorders associated with chronic cough. Pulm Pharmaeol Ther, 2009, 22(2): 114-120.
5. Ohta K, Yamaguchi M, Akiyama K, et al. Japanese guideline for adult asthma. Allergol Int, 2011, 60(2): 115-145.
6. Niimi A, Brightling CE, Dicpinigaitis PV. Cough in asthma is due to eosinophilic airway inflammation: a pro/con debate. Lung, 2014, 192(1): 33-38.
7. Obase Y, Shimoda T, Kishikawa R, et al. Trigger of bronchial hyperresponsiveness development may not always need eosinophilic airway inflammation in very early stage of asthma. Allergy Rhinol (Providence), 2016, 7(1): 1-7.
8. Zhang YX, Liu Y, Xue Y, et al. Correlational study on atmospheric concentrations of fine particulate matter and children cough variant asthma. Eur Rev Med Pharmacol Sci, 2016, 20(12): 2650-2654.
9. Prakash YS, Martin RJ. Brain-derived neurotrophic factor in the airways. Pharmacol Ther, 2014, 143(1): 74-86.
10. Guc BU, Asilsoy S, Cihan FG. Brain-derived neurotrophic factor levels in children with asthma and isolated chronic cough. Pediatr Allergy Immunol Pulmonol, 2016, 29(1): 29-33.
11. 中华医学会呼吸病学分会哮喘学组. 咳嗽的诊断与治疗指南(2015) .中华结核和呼吸杂志, 2016, 39(5): 323-354.
12. Lougheed MD, Turcotte SE, Fisher T. Cough variant asthma: lessons learned from deep inspirations. Lung, 2012, 190(1): 17-22.
13. Koh YY, Park Y, Kim CK. The importance of maximal airway response to methacholine in the prediction of wheezing development in patients with cough-variant asthma. Allergy, 2002, 57(12): 1165-1170.
14. Fang Y, Wei L, Chen RC, et al. Predictive value of fractional exhaled nitric oxide of airway eosinophilic inflammation in chonic cough and classic asthma. Chest, 2016, 149(4): A21.
15. Shimoda T, Obase Y, Kishikawa R, et al. The fractional exhaled nitric oxide and serum high sensitivity C-reactive protein levels in cough variant asthma and typical bronchial asthma. Allergol Int, 2013, 62(2): 251-257.
16. Asano T, Takemura M, Fukumitsu K, et al. Diagnostic utility of fractional exhaled nitric oxide in prolonged and chronic cough according to atopic status. Allergol Int, 2017, 66(2): 344-350.
17. Song WJ, Kim HJ, Shim JS, et al. Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough-variant asthma and eosinophilic bronchitis in adults with chronic cough: a systematic review and meta-analysis. J Allergy Clin Immunol. 2017, 140(3): 701-709.
18. Kanemitsu Y, Matsumoto H, Osman N, et al. " Cold air” and/or " talking” as cough triggers, a sign for the diagnosis of cough variant asthma. Respir Investig, 2016, 54(6): 413-418.
19. Marsden PA, Satia I, Ibrahim B, et al. Objective cough frequency, airway inflammation, and disease control in asthma. Chest, 2016, 149(6): 1460-1466.
20. Matsuoka H, Niimi A, Matsumoto H, et al. Inflammatory subtypes in cough-variant asthma: association with maintenance doses of inhaled corticosteroids. Chest, 2010, 138(6): 1418-1425.
21. 李馨, 余莉, 魏为利, 等. 支气管扩张剂治疗有效和无效咳嗽变异性哮喘的比较研究. 同济大学学报: 医学版, 2011, 32(1): 95-100.
22. Takemura M, Niimi A, Matsumoto H, et al. Clinical, physiological and anti-inflammatory effect of montelukast in patients with cough variant asthma. Respiration, 2012, 83(4): 308-315.
23. Zhou X, Hong J, Cheng H, et al. Budesonide suspension nebulization treatment in Chinese pediatric patients with cough variant asthma: a multi-center observational study. J Asthma, 2016, 53(5): 532-537.
24. Song P, Zeng L, Liang Z, et al. Clinical efficacy and safety of Chinese herbal medicine auxiliary therapy for childhood cough variant asthma: a systematic review and meta-analysis of 20 randomized controlled trials. Intern Med, 2016, 55(16): 2135-2143.
25. Saito N, Itoga M, Tamaki M, et al. Cough variant asthma patients are more depressed and anxious than classic asthma patients. J Psychosom Res, 2015, 79(1): 18-26.
26. Nakajima T, Nishimura Y, Nishiuma T, et al. Characteristics of patients with chronic cough who developed classic asthma during the course of cough variant asthma: a longitudinal study. Respiration, 2005, 72(6): 606-611.

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