Evidence-based proofs for low-level laser therapy of osteoarthritis_West China Medical Journal

Authors：

LIU Shaxin , YE Wen , WANG Fengyi , LI Dinggen , DONG Yiyue ,  HE Chengqi

Rehabilitation Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

HE Chengqi, Email: hxkfhcq@126.com

Keywords：

Low-level laser therapy; Osteoarthritis; Evidence-based proofs

DOI：

10.7507/1002-0179.201711064

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Low-level laser therapy (LLLT) as an effective therapy with biochemical change has gained more and more attention in clinical treatment. This review sorts many fundamental experiment studis and clinical applications about LLLT published in recent years, and summarizes the advances of evidence-based proofs of the potential mechanisms of LLLT with different wavelengths in treating osteoarthritis. It shows that LLLT could relieve pain, modulate inflammatory response, protect cartilage, and prevent cartilage degeneration, through increasing cell proliferation, stimulating fibroblasts to produce collagen, bone repair, and regulating inflammatory markers and so on. LLLT with different wavelengths has different effect, and it is important for clinical practice.

Citation： LIU Shaxin, YE Wen, WANG Fengyi, LI Dinggen, DONG Yiyue, HE Chengqi. Evidence-based proofs for low-level laser therapy of osteoarthritis. West China Medical Journal, 2018, 33(10): 1316-1320. doi: 10.7507/1002-0179.201711064 Copy

1.	卓大宏. 中国康复医学. 北京: 华夏出版社, 2003: 1198-1210.
2.	Yelin E, Callahan LF. The economic cost and social and psychological impact of musculoskeletal conditions. National Arthritis Data Work Groups. Arthritis Rheum, 1995, 38(10): 1351-1362.
3.	Solomon L. Chnical features of osteoarthritis//KelIy WN, Harris ED Jr, Ruddy S, et al. Textbook of rheumatology. 5th ed. Philadelphia: WB Saunders, 1997: 1383-1393.
4.	McAlindon TE, Bannuru RR, Sullivan MC, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage, 2014, 22(3): 363-388.
5.	季晓闻, 赵咏芳. 非手术疗法治疗膝骨关节炎概述. 上海中医药大学学报, 2012, 26(5): 112-115.
6.	American Academy of Orthopaedic Surgeons. Treatment of osteoarthritis of the knee: evidence-based guideline 2nd edition. Rosemont: American Academy of Orthopaedic Surgeons, 2013. https://www.aaos.org/research/guidelines/TreatmentofOsteoarthritisoftheKneeGuideline.pdf.
7.	郝素丽, 陈聪, 张龙达. 影响低强度激光治疗退行性关节炎和镇痛有效性的激光参数. 中国激光医学杂志, 2017, 26(1): 39-44.
8.	郑莉琴, 王瑜华, 陈小钢, 等. 低强度激光疗法作用机制的新进展. 中国激光医学杂志, 2014, 23(5): 233-241.
9.	Rola P, Doroszko A, Derkacz A. The use of low-level energy laser radiation in basic and clinical research. Adv Clin Exp Med, 2014, 23(5): 835-842.
10.	Aguiar GC, Do Nascimento MR, De Miranda AS, et al. Effects of an exercise therapy protocol on inflammatory markers, perception of pain, and physical performance in individuals with knee osteoarthritis. Rheumatol Int, 2015, 35(3): 525-531.
11.	Hamblin MR. Can osteoarthritis be treated with light?. ArthritisRes Ther, 2013, 29(15): 120.
12.	Cho HJ, Lim SC, Kim SG, et al. Effect of low-level laser therapy on osteoarthropathy in rabbit. In Vivo, 2004, 18(5): 585-591.
13.	Herman JH, Khosla RC. In vitro effects of Nd: YAG laser radiation on cartilage metabolism. J Rheumatol, 1998, 15(12): 1818-1826.
14.	Assis L, Milares LP, Almeida T, et al. Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in rats. Osteoarthritis Cartilage, 2016, 24(1): 169-177.
15.	de Oliveira VL, Silva JA Jr, Serra AJ, et al. Photobiomodulation therapy in the modulation of inflammatory mediators and bradykinin receptors in an experimental model of acute osteoarthritis. Lasers Med Sci, 2017, 32(1): 87-94.
16.	Cialdai C, Giuliani S, Valenti C, et al. Effect of Intra-articular 4-(S)-amino-5-(4-4-[2,4-dichloro-3-(2,4-dimethyl-8-quinolyloxymethyl)phenylsulfonamido]-tetrahydro-2H-4-pyranylcarbonyl piperazino)-5-oxopentyl](trimethyl)ammonium chloride hydrochloride (MEN16132), a kinin B2 receptor antagonist, on nociceptive response in monosodium iodoacetate-induced experimental osteoarthritis in rats. J Pharmacol Exp Ther, 2009, 331(3): 1025-1032.
17.	Valenti C, Giuliani S, Cialdai C, et al. Anti-inflammatory synergy of MEN16132, a kinin B(2) receptor antagonist, and dexamethasone in carrageenan-induced knee joint arthritis in rats. Br J Pharmacol, 2010, 161(7): 1616-1627.
18.	Mangueira NM, Xavier M, de Souza RA, et al. Effect of low-level laser therapy in an experimental model of osteoarthritis in rats evaluated through Raman spectroscopy. Photomed Laser Surg, 2015, 33(3): 145-153.
19.	Assis L, Almeida T, Milares LP, et al. Musculoskeletal atrophy in an experimental model of knee osteoarthritis: the effects of exercise training and low-level laser therapy. Am J Phys Med Rehabil, 2015, 94(8): 609-616.
20.	Ip D, Fu NY. Can combined use of low-level lasers and hyaluronic acid injections prolong the longevity of degenerative knee joints?. Clin Interv Aging, 2015, 10: 1255-1258.
21.	Huang Z, Chen J, Ma J, et al. Effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis. Osteoarthritis Cartilage, 2015, 23(9): 1437-1444.
22.	Lam TS, Abergel RP, Meeker CA, et al. Laser stimulation of collagen synthesis in human skin fibroblasts cultures. Lasers. Life Sci, 1986, 1(1): 61-77.
23.	de Oliveira Melo M, Pompeo KD, Baroni BM, et al. Effects of neuromuscular electrical stimulation and low-level laser therapy on neuromuscular parameters and health status in elderly women with knee osteoarthritis: A randomized trial. J Rehabil Med, 2016, 48(3): 293-299.
24.	Pisters MF, Veenhof C, van Dijk GM, et al. Avoidance of activity and limitations in activities in patients with osteoarthritis of the hip or knee: a 5 year follow-up study on the mediating role of reduced muscle strength. Osteoarthritis Cartilage, 2014, 22(2): 171-177.
25.	Weng MC, Lee CL, Chen CH, et al. Effects of different stretching techniques on the outcomes of isokinetic exercise in patients with knee osteoarthritis. Kaohsiung J Med Sci, 2009, 25(6): 306-315.
26.	Alfredo PP, Bjordal JM, Junior WS, et al. Long-term results of a randomized, controlled, double-blind study of low-level laser therapy before exercises in knee osteoarthritis: laser and exercises in knee osteoarthritis. Clin Rehabil, 2018, 32(2): 173-178.
27.	Ferreira de Meneses SR, Hunter DJ, Young Docko E, et al. Effect of low-level laser therapy (904 nm) and static stretching in patients with knee osteoarthritis: a protocol of randomised controlled trial. BMC Musculoskelet Disord, 2015, 16: 252.
28.	Nambi SG, Kamal W, George J, et al. Radiological and biochemical effects (CTX-Ⅱ, MMP-3, 8, and 13) of low-level laser therapy (LLLT) in chronic osteoarthritis in Al-Kharj, Saudi Arabia. Lasers Med Sci, 2017, 32(2): 297-303.
29.	Bondeson J, Wainwright SD, Lauder S, et al. The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrixmetallo proteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Res Ther, 2006, 8(6): R187.
30.	Rübenhagen R, Schüttrumpf JP, Stürmer KM, et al. Interleukin-7 levels in synovial fluid increase with age and MMP-1 levels decrease with progression of osteoarthritis. Acta Orthop, 2012, 83(1): 59-64.
31.	Paolillo AR, Paolillo FR, João JP, et al. Synergic effects of ultrasound and laser on the pain relief in women with hand osteoarthritis. Lasers Med Sci, 2015, 30(1): 279-286.
32.	Rayegani SM, Raeissadat SA, Heidari S, et al. Safety and effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis. Lasers Med Sci, 2017, 8(Suppl 1): S12-S19.
33.	Hegedus B, Viharos L, Gervain M, et al. The effect of low-level laser in knee osteoarthritis: a double-blind, randomized, placebo-controlled trial. Photomed Laser Surg, 2009, 27(4): 577-584.
34.	World Association of Laser Therapy (WALT). Does table 780-860nm for low level laser therapy WALT 2010. (2010-05-01)[2018-02-01]. https://waltza.co.za/wp-content/uploads/2012/08/Dose_table_780-860nm_for_Low_Level_Laser_ Therapy_WALT-2010.pdf.
35.	World Association of Laser Therapy (WALT). Dose table 904nm for low level laser therapy WALT 2010. (2010-05-01)[2018-02-01]. https://waltza.co.za/wp-content/uploads/2012/08/ Dose_table_904nm_for_Low_Level_Laser_Therapy_WALT-2010.pdf.

1. 卓大宏. 中国康复医学. 北京: 华夏出版社, 2003: 1198-1210.
2. Yelin E, Callahan LF. The economic cost and social and psychological impact of musculoskeletal conditions. National Arthritis Data Work Groups. Arthritis Rheum, 1995, 38(10): 1351-1362.
3. Solomon L. Chnical features of osteoarthritis//KelIy WN, Harris ED Jr, Ruddy S, et al. Textbook of rheumatology. 5th ed. Philadelphia: WB Saunders, 1997: 1383-1393.
4. McAlindon TE, Bannuru RR, Sullivan MC, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage, 2014, 22(3): 363-388.
5. 季晓闻, 赵咏芳. 非手术疗法治疗膝骨关节炎概述. 上海中医药大学学报, 2012, 26(5): 112-115.
6. American Academy of Orthopaedic Surgeons. Treatment of osteoarthritis of the knee: evidence-based guideline 2nd edition. Rosemont: American Academy of Orthopaedic Surgeons, 2013. https://www.aaos.org/research/guidelines/TreatmentofOsteoarthritisoftheKneeGuideline.pdf.
7. 郝素丽, 陈聪, 张龙达. 影响低强度激光治疗退行性关节炎和镇痛有效性的激光参数. 中国激光医学杂志, 2017, 26(1): 39-44.
8. 郑莉琴, 王瑜华, 陈小钢, 等. 低强度激光疗法作用机制的新进展. 中国激光医学杂志, 2014, 23(5): 233-241.
9. Rola P, Doroszko A, Derkacz A. The use of low-level energy laser radiation in basic and clinical research. Adv Clin Exp Med, 2014, 23(5): 835-842.
10. Aguiar GC, Do Nascimento MR, De Miranda AS, et al. Effects of an exercise therapy protocol on inflammatory markers, perception of pain, and physical performance in individuals with knee osteoarthritis. Rheumatol Int, 2015, 35(3): 525-531.
11. Hamblin MR. Can osteoarthritis be treated with light?. ArthritisRes Ther, 2013, 29(15): 120.
12. Cho HJ, Lim SC, Kim SG, et al. Effect of low-level laser therapy on osteoarthropathy in rabbit. In Vivo, 2004, 18(5): 585-591.
13. Herman JH, Khosla RC. In vitro effects of Nd: YAG laser radiation on cartilage metabolism. J Rheumatol, 1998, 15(12): 1818-1826.
14. Assis L, Milares LP, Almeida T, et al. Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in rats. Osteoarthritis Cartilage, 2016, 24(1): 169-177.
15. de Oliveira VL, Silva JA Jr, Serra AJ, et al. Photobiomodulation therapy in the modulation of inflammatory mediators and bradykinin receptors in an experimental model of acute osteoarthritis. Lasers Med Sci, 2017, 32(1): 87-94.
16. Cialdai C, Giuliani S, Valenti C, et al. Effect of Intra-articular 4-(S)-amino-5-(4-4-[2,4-dichloro-3-(2,4-dimethyl-8-quinolyloxymethyl)phenylsulfonamido]-tetrahydro-2H-4-pyranylcarbonyl piperazino)-5-oxopentyl](trimethyl)ammonium chloride hydrochloride (MEN16132), a kinin B2 receptor antagonist, on nociceptive response in monosodium iodoacetate-induced experimental osteoarthritis in rats. J Pharmacol Exp Ther, 2009, 331(3): 1025-1032.
17. Valenti C, Giuliani S, Cialdai C, et al. Anti-inflammatory synergy of MEN16132, a kinin B(2) receptor antagonist, and dexamethasone in carrageenan-induced knee joint arthritis in rats. Br J Pharmacol, 2010, 161(7): 1616-1627.
18. Mangueira NM, Xavier M, de Souza RA, et al. Effect of low-level laser therapy in an experimental model of osteoarthritis in rats evaluated through Raman spectroscopy. Photomed Laser Surg, 2015, 33(3): 145-153.
19. Assis L, Almeida T, Milares LP, et al. Musculoskeletal atrophy in an experimental model of knee osteoarthritis: the effects of exercise training and low-level laser therapy. Am J Phys Med Rehabil, 2015, 94(8): 609-616.
20. Ip D, Fu NY. Can combined use of low-level lasers and hyaluronic acid injections prolong the longevity of degenerative knee joints?. Clin Interv Aging, 2015, 10: 1255-1258.
21. Huang Z, Chen J, Ma J, et al. Effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis. Osteoarthritis Cartilage, 2015, 23(9): 1437-1444.
22. Lam TS, Abergel RP, Meeker CA, et al. Laser stimulation of collagen synthesis in human skin fibroblasts cultures. Lasers. Life Sci, 1986, 1(1): 61-77.
23. de Oliveira Melo M, Pompeo KD, Baroni BM, et al. Effects of neuromuscular electrical stimulation and low-level laser therapy on neuromuscular parameters and health status in elderly women with knee osteoarthritis: A randomized trial. J Rehabil Med, 2016, 48(3): 293-299.
24. Pisters MF, Veenhof C, van Dijk GM, et al. Avoidance of activity and limitations in activities in patients with osteoarthritis of the hip or knee: a 5 year follow-up study on the mediating role of reduced muscle strength. Osteoarthritis Cartilage, 2014, 22(2): 171-177.
25. Weng MC, Lee CL, Chen CH, et al. Effects of different stretching techniques on the outcomes of isokinetic exercise in patients with knee osteoarthritis. Kaohsiung J Med Sci, 2009, 25(6): 306-315.
26. Alfredo PP, Bjordal JM, Junior WS, et al. Long-term results of a randomized, controlled, double-blind study of low-level laser therapy before exercises in knee osteoarthritis: laser and exercises in knee osteoarthritis. Clin Rehabil, 2018, 32(2): 173-178.
27. Ferreira de Meneses SR, Hunter DJ, Young Docko E, et al. Effect of low-level laser therapy (904 nm) and static stretching in patients with knee osteoarthritis: a protocol of randomised controlled trial. BMC Musculoskelet Disord, 2015, 16: 252.
28. Nambi SG, Kamal W, George J, et al. Radiological and biochemical effects (CTX-Ⅱ, MMP-3, 8, and 13) of low-level laser therapy (LLLT) in chronic osteoarthritis in Al-Kharj, Saudi Arabia. Lasers Med Sci, 2017, 32(2): 297-303.
29. Bondeson J, Wainwright SD, Lauder S, et al. The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrixmetallo proteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Res Ther, 2006, 8(6): R187.
30. Rübenhagen R, Schüttrumpf JP, Stürmer KM, et al. Interleukin-7 levels in synovial fluid increase with age and MMP-1 levels decrease with progression of osteoarthritis. Acta Orthop, 2012, 83(1): 59-64.
31. Paolillo AR, Paolillo FR, João JP, et al. Synergic effects of ultrasound and laser on the pain relief in women with hand osteoarthritis. Lasers Med Sci, 2015, 30(1): 279-286.
32. Rayegani SM, Raeissadat SA, Heidari S, et al. Safety and effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis. Lasers Med Sci, 2017, 8(Suppl 1): S12-S19.
33. Hegedus B, Viharos L, Gervain M, et al. The effect of low-level laser in knee osteoarthritis: a double-blind, randomized, placebo-controlled trial. Photomed Laser Surg, 2009, 27(4): 577-584.
34. World Association of Laser Therapy (WALT). Does table 780-860nm for low level laser therapy WALT 2010. (2010-05-01)[2018-02-01]. https://waltza.co.za/wp-content/uploads/2012/08/Dose_table_780-860nm_for_Low_Level_Laser_ Therapy_WALT-2010.pdf.
35. World Association of Laser Therapy (WALT). Dose table 904nm for low level laser therapy WALT 2010. (2010-05-01)[2018-02-01]. https://waltza.co.za/wp-content/uploads/2012/08/ Dose_table_904nm_for_Low_Level_Laser_Therapy_WALT-2010.pdf.

Previous Article
Progress on rehabilitation treatment of lumbar disc herniation
Next Article
The research progress of radiographic assessments for patients with scoliosis

West China Medical Journal

Evidence-based proofs for low-level laser therapy of osteoarthritis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content