Progress in the study of elderly sarcopenia_West China Medical Journal

Authors：

 SANG Dechun

School of Rehabilitation Medicine, Capital Medical University; China Rehabilitation Research Center; Beijing 100068, P. R. China;

Corresponding author：

SANG Dechun, Email: sdc12663@126.com

Keywords：

The elderly; Sarcopenia; Research

DOI：

10.7507/1002-0179.201805182

Video：

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Senile sarcopenia has become a prominent problem affecting the normal life and self-care ability of the elderly. More attention to the research on senile sarcopenia is conducive to its prevention and treatment. This article states information details about the epidemiology, influencing factors and mechanism, clinical manifestations and diagnostic criteria, evaluation methods and rehabilitation therapy, so as to provide reference for research on elderly sarcopenia.

Citation： SANG Dechun. Progress in the study of elderly sarcopenia. West China Medical Journal, 2018, 33(10): 1219-1223. doi: 10.7507/1002-0179.201805182 Copy

1.	Rosenberg I. Summary comments: epidemiological and methodological problems in determining nutritional status of older persons. Am J Clin Nutr, 1989, 50: 1231-1233.
2.	徐国会, 郑洁皎, 董璐. 肌肉衰减综合征的研究进展. 国际老年医学杂志, 2012, 33(1): 11-14.
3.	卢健. 骨骼肌衰减症与运动干预研究进展. 体育研究, 2015, 36(3): 1-7.
4.	Gariballa S, Alessa A. Sarcopenia: prevalence and prognostic significance in hospitalized patients. Clin Nutr, 2013, 32(5): 772-776.
5.	Volpato S, Bianchi L, Cherubini A, et al. Prevalence and clinical correlates of sarcopenia in community-dwelling older people: application of the EWGSOP definition and diagnostic algorithm. J Gerontol A Biol Sci Med Sci, 2014, 69(4): 438-446.
6.	贾静, 刘谦, 刘琦, 等. 关注老年骨骼肌减少症. 实用老年医学, 2017, 31(2): 181-183.
7.	Ferrucci L, Guralnik JM, Buchner D, et al. Departures from linearity in the relationship between measures of muscular strength and physical performance of the lower extremities: the Women’s Health and Aging Study. J Gerontol A Biol Sci Med Sci, 1997, 52(5).
8.	Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing, 2010, 39(4): 412-423.
9.	Wu IC, Lin CC, Hsiung CA, et al. Epidemiology of sarcopenia among community-dwelling older adults in Taiwan: a pooled analysis for a broader adoption of sarcopenia assessments. Geriatr Gerontol Int, 2014, 14(1, S): 52-60.
10.	Landi F, Liperoti R, Fusco D, et al. Prevalence and risk factors of sarcopenia among nursing home older residents. J Gerontol A Biol Sci Med Sci, 2012, 67(1): 48-55.
11.	Masanes F, Culla A, Navarro-Gonzalez M, et al. Prevalence of sarcopenia in healthy community-dwelling elderly in an urban area of Barcelona (Spain). J Nutr Health Aging, 2012, 16(2): 184-187.
12.	Looker AC, Wang CY. Prevalence of reduced muscle strength in older U.S. adults: United States, 2011-2012. NCHS Data Brief, 2015, 1(179): 1-8.
13.	Lexell J, Henriksson-Larsén K, Winblad B, et al. Distribution of different fiber types in human skeletal muscles: effects of aging studied in whole muscle cross sections. Muscle Nerve, 1983, 6(8): 588-595.
14.	Frontera WR, Hughes VA, Fielding RA, et al. Aging of skeletal muscle: a 12-yr longitudinal study. J Appl Physiol, 2000, 88(4): 1321-1326.
15.	桑德春, 贾子善. 老年康复学. 北京: 北京科学技术出版社, 2016: 15.
16.	Cruz-Jentoft AJ, Landi F, Schneider SM, et al. Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS). Age Ageing, 2014, 43(6): 748-759.
17.	中国营养学会老年营养分会, 中国营养学会临床营养分会, 中华医学会肠外肠内营养学分会老年营养支持学组. 肌肉衰减综合征营养与运动干预中国专家共识 (节录). 营养学报, 2015, 37(4): 320-324.
18.	Alemán-Mateo H, López Teros MT, Ramírez FA, et al. Association between insulin resistance and low relative appendicular skeletal muscle mass: evidence from a cohort study in community-dwelling older men and women participants. J Gerontol A Biol Sci Med Sci, 2014, 69(7): 871-877.
19.	郭静静, 莫宝庆. 老年人群肌肉衰减症的影响因素研究. 环球中医药, 2015, 8(2): 11-12.
20.	Hung J, McQuillan BM, Thompson PL, et al. Circulating adiponectin levels associate with inflammatory markers, insulin resistance and metabolic syndrome independent of obesity. Int J Obes (Lond), 2008, 32(5): 772-779.
21.	Greeves JP, Cable NT, Reilly T, et al. Changes in muscle strength in women following the menopause: a longitudinal assessment of the efficacy of hormone replacement therapy. Clin Sci (Lond), 1999, 97(1): 79-84.
22.	刘晓亭, 于睿, 张欢. 肌肉衰减综合征的研究进展. 中华中医药学刊, 2016, 34(3): 651-653.
23.	董定文, 董碧蓉. 骨骼肌减少症研究进展. 现代临床医学, 2013, 39(2): 145-149.
24.	Teixeira VO, Filippin LI, Xavier RM. Mechanisms of muscle wasting in sarcopenia. Rev Bras Reumatol, 2012, 52(2): 252-259.
25.	Morley JE. Sarcopenia in the elderly. Fam Pract, 2012, 29(Suppl 1): i44-i48.
26.	杜玲, 刘晓亭. 肌肉衰减综合征的诊断及治疗现状. 临床合理用药, 2016, 9(2): 160-161.
27.	Baumgartner RN, Koehler KM, Gallagher D, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol, 1998, 147(8): 755-763.
28.	Janssen I, Baumgartner RN, Ross R, et al. Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. Am J Epidemiol, 2004, 159(4): 413-421.
29.	唐玉成, 吴卅. 国外老年人肌肉力量评价指标综述. 中国运动医学杂志, 2012, 31(5): 456-461.
30.	Häkkinen K, Pakarinen A, Kraemer WJ, et al. Selective muscle hypertrophy, changes in EMG and force, and serum hormones during strength training in older women. J Appl Physiol, 2001, 91(2): 569-580.
31.	Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol, 1994, 49(2): M85-M94.
32.	Guralnik JM, Winograd CH. Physical performance measures in the assessment of older persons. Aging (Milano), 1994, 6(5): 303-305.
33.	Hawley JA, Hargreaves M, Zierath JR. Signalling mechanisms in skeletal muscle: role in substrate selection and muscle adaptation. Essays Biochem, 2006, 42: 1-12.
34.	Forbes SC, Little JP, Candow DG. Exercise and nutritional interventions for improving aging muscle health. Endocrine, 2012, 42(1): 29-38.
35.	Ossowski ZM, Skrobot W, Aschenbrenner P, et al. Effects of short-term Nordic walking training on sarcopenia-related parameters in women with low bone mass: a preliminary study. Clin Interv Aging, 2016, 11(11): 1763-1771.
36.	Roth SM, Ivey FM, Martel GF, et al. Muscle size responses to strength training in young and older men and women. J Am Geriatr Soc, 2001, 49(11): 1428-1433.
37.	韩佩佩, 郭琪, 潘翔, 等. 老年人肌肉衰减综合征的诊断标准与运动疗法. 中国康复医学杂志, 2015, 30(3): 290-294.
38.	温煦, 王梅, 许世全, 等. 骨骼肌减少症研究进展. 中国运动医学杂志, 2008, 27(5): 670-673.
39.	刘日辉, 聂荣华, 陈家军, 等. 风心瓣膜病患者围术期蛋白质代谢的变化及重组人生长激素的作用. 实用医学杂志, 2013, 29(11): 1799-1802.

1. Rosenberg I. Summary comments: epidemiological and methodological problems in determining nutritional status of older persons. Am J Clin Nutr, 1989, 50: 1231-1233.
2. 徐国会, 郑洁皎, 董璐. 肌肉衰减综合征的研究进展. 国际老年医学杂志, 2012, 33(1): 11-14.
3. 卢健. 骨骼肌衰减症与运动干预研究进展. 体育研究, 2015, 36(3): 1-7.
4. Gariballa S, Alessa A. Sarcopenia: prevalence and prognostic significance in hospitalized patients. Clin Nutr, 2013, 32(5): 772-776.
5. Volpato S, Bianchi L, Cherubini A, et al. Prevalence and clinical correlates of sarcopenia in community-dwelling older people: application of the EWGSOP definition and diagnostic algorithm. J Gerontol A Biol Sci Med Sci, 2014, 69(4): 438-446.
6. 贾静, 刘谦, 刘琦, 等. 关注老年骨骼肌减少症. 实用老年医学, 2017, 31(2): 181-183.
7. Ferrucci L, Guralnik JM, Buchner D, et al. Departures from linearity in the relationship between measures of muscular strength and physical performance of the lower extremities: the Women’s Health and Aging Study. J Gerontol A Biol Sci Med Sci, 1997, 52(5).
8. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing, 2010, 39(4): 412-423.
9. Wu IC, Lin CC, Hsiung CA, et al. Epidemiology of sarcopenia among community-dwelling older adults in Taiwan: a pooled analysis for a broader adoption of sarcopenia assessments. Geriatr Gerontol Int, 2014, 14(1, S): 52-60.
10. Landi F, Liperoti R, Fusco D, et al. Prevalence and risk factors of sarcopenia among nursing home older residents. J Gerontol A Biol Sci Med Sci, 2012, 67(1): 48-55.
11. Masanes F, Culla A, Navarro-Gonzalez M, et al. Prevalence of sarcopenia in healthy community-dwelling elderly in an urban area of Barcelona (Spain). J Nutr Health Aging, 2012, 16(2): 184-187.
12. Looker AC, Wang CY. Prevalence of reduced muscle strength in older U.S. adults: United States, 2011-2012. NCHS Data Brief, 2015, 1(179): 1-8.
13. Lexell J, Henriksson-Larsén K, Winblad B, et al. Distribution of different fiber types in human skeletal muscles: effects of aging studied in whole muscle cross sections. Muscle Nerve, 1983, 6(8): 588-595.
14. Frontera WR, Hughes VA, Fielding RA, et al. Aging of skeletal muscle: a 12-yr longitudinal study. J Appl Physiol, 2000, 88(4): 1321-1326.
15. 桑德春, 贾子善. 老年康复学. 北京: 北京科学技术出版社, 2016: 15.
16. Cruz-Jentoft AJ, Landi F, Schneider SM, et al. Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS). Age Ageing, 2014, 43(6): 748-759.
17. 中国营养学会老年营养分会, 中国营养学会临床营养分会, 中华医学会肠外肠内营养学分会老年营养支持学组. 肌肉衰减综合征营养与运动干预中国专家共识 (节录). 营养学报, 2015, 37(4): 320-324.
18. Alemán-Mateo H, López Teros MT, Ramírez FA, et al. Association between insulin resistance and low relative appendicular skeletal muscle mass: evidence from a cohort study in community-dwelling older men and women participants. J Gerontol A Biol Sci Med Sci, 2014, 69(7): 871-877.
19. 郭静静, 莫宝庆. 老年人群肌肉衰减症的影响因素研究. 环球中医药, 2015, 8(2): 11-12.
20. Hung J, McQuillan BM, Thompson PL, et al. Circulating adiponectin levels associate with inflammatory markers, insulin resistance and metabolic syndrome independent of obesity. Int J Obes (Lond), 2008, 32(5): 772-779.
21. Greeves JP, Cable NT, Reilly T, et al. Changes in muscle strength in women following the menopause: a longitudinal assessment of the efficacy of hormone replacement therapy. Clin Sci (Lond), 1999, 97(1): 79-84.
22. 刘晓亭, 于睿, 张欢. 肌肉衰减综合征的研究进展. 中华中医药学刊, 2016, 34(3): 651-653.
23. 董定文, 董碧蓉. 骨骼肌减少症研究进展. 现代临床医学, 2013, 39(2): 145-149.
24. Teixeira VO, Filippin LI, Xavier RM. Mechanisms of muscle wasting in sarcopenia. Rev Bras Reumatol, 2012, 52(2): 252-259.
25. Morley JE. Sarcopenia in the elderly. Fam Pract, 2012, 29(Suppl 1): i44-i48.
26. 杜玲, 刘晓亭. 肌肉衰减综合征的诊断及治疗现状. 临床合理用药, 2016, 9(2): 160-161.
27. Baumgartner RN, Koehler KM, Gallagher D, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol, 1998, 147(8): 755-763.
28. Janssen I, Baumgartner RN, Ross R, et al. Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. Am J Epidemiol, 2004, 159(4): 413-421.
29. 唐玉成, 吴卅. 国外老年人肌肉力量评价指标综述. 中国运动医学杂志, 2012, 31(5): 456-461.
30. Häkkinen K, Pakarinen A, Kraemer WJ, et al. Selective muscle hypertrophy, changes in EMG and force, and serum hormones during strength training in older women. J Appl Physiol, 2001, 91(2): 569-580.
31. Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol, 1994, 49(2): M85-M94.
32. Guralnik JM, Winograd CH. Physical performance measures in the assessment of older persons. Aging (Milano), 1994, 6(5): 303-305.
33. Hawley JA, Hargreaves M, Zierath JR. Signalling mechanisms in skeletal muscle: role in substrate selection and muscle adaptation. Essays Biochem, 2006, 42: 1-12.
34. Forbes SC, Little JP, Candow DG. Exercise and nutritional interventions for improving aging muscle health. Endocrine, 2012, 42(1): 29-38.
35. Ossowski ZM, Skrobot W, Aschenbrenner P, et al. Effects of short-term Nordic walking training on sarcopenia-related parameters in women with low bone mass: a preliminary study. Clin Interv Aging, 2016, 11(11): 1763-1771.
36. Roth SM, Ivey FM, Martel GF, et al. Muscle size responses to strength training in young and older men and women. J Am Geriatr Soc, 2001, 49(11): 1428-1433.
37. 韩佩佩, 郭琪, 潘翔, 等. 老年人肌肉衰减综合征的诊断标准与运动疗法. 中国康复医学杂志, 2015, 30(3): 290-294.
38. 温煦, 王梅, 许世全, 等. 骨骼肌减少症研究进展. 中国运动医学杂志, 2008, 27(5): 670-673.
39. 刘日辉, 聂荣华, 陈家军, 等. 风心瓣膜病患者围术期蛋白质代谢的变化及重组人生长激素的作用. 实用医学杂志, 2013, 29(11): 1799-1802.

West China Medical Journal

Progress in the study of elderly sarcopenia

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