Progress of resting-state network related to cognitive function in epileptic patients_West China Medical Journal

Authors：

HOU Jin ¹ , ZHAO Yiwei ² , WU Xuerui ¹ , Li Shaoping ¹ , DENG Yilun ¹ ,  ZOU Xiaoyi ¹

1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Brain and Mind Center, University of Sydney, Sydney 2000, Australia;

Corresponding author：

ZOU Xiaoyi, Email: xiaoyizou@163.com

Keywords：

Epilepsy; Cognitive function; Resting-state network; Functional magnetic resonance imaging

DOI：

10.7507/1002-0179.201901096

Video：

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Nowadays, an increasing number of researches have shown that epilepsy, as a kind of neural network disease, not only affects the brain region of seizure onset, but also remote regions at which the brain network structures are damaged or dysfunctional. These changes are associated with abnormal network of epilepsy. Resting-state network is closely related to human cognitive function and plays an important role in cognitive process. Cognitive dysfunction, a common comorbidity of epilepsy, has adverse impacts on life quality of patients with epilepsy. The mechanism of cognitive dysfunction in epileptic patients is still incomprehensible, but the change of resting-state brain network may be associated with their cognitive impairment. In order to further understand the changes of resting-state network associated with the cognitive function and explore the brain network mechanism of the occurrence of cognitive dysfunction in patients with epilepsy, we review the related researches in recent years.

Citation： HOU Jin, ZHAO Yiwei, WU Xuerui, Li Shaoping, DENG Yilun, ZOU Xiaoyi. Progress of resting-state network related to cognitive function in epileptic patients. West China Medical Journal, 2019, 34(6): 706-711. doi: 10.7507/1002-0179.201901096 Copy

1.	van den Heuvel MP, Hulshoff Pol HE. Exploring the brain network: a review on resting-state fMRI functional connectivity. Eur Neuropsychopharmacol, 2010, 20(8): 519-534.
2.	Biswal B, Yetkin FZ, Haughton VM, et al. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med, 1995, 34(4): 537-541.
3.	Cataldi M, Avoli M, de Villers-Sidani E. Resting state networks in temporal lobe epilepsy. Epilepsia, 2013, 54(12): 2048-2059.
4.	Wei H, An J, Shen H, et al. Altered effective connectivity among core neurocognitive networks in idiopathic generalized epilepsy: an fMRI evidence. Front Hum Neurosci, 2016, 10: 447.
5.	Logothetis NK, Pauls J, Augath M, et al. Neurophysiological investigation of the basis of the fMRI signal. Nature, 2001, 412(6843): 150-157.
6.	Yang H, Long XY, Yang Y, et al. Amplitude of low frequency fluctuation within visual areas revealed by resting-state functional MRI. Neuroimage, 2007, 36(1): 144-152.
7.	Waites AB, Briellmann RS, Saling MM, et al. Functional connectivity networks are disrupted in left temporal lobe epilepsy. Ann Neurol, 2006, 59(2): 335-343.
8.	Cheng L, Zhu Y, Sun J, et al. Principal states of dynamic functional connectivity reveal the link between resting-state and task-state brain: an fMRI study. Int J Neural Syst, 2018, 28(7): 1850002.
9.	Buckner RL, Andrews-Hanna JR, Schacter DL. The brain’s default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci, 2008, 1124: 1-38.
10.	Hu CY, Gao X, Long L, et al. Altered DMN functional connectivity and regional homogeneity in partial epilepsy patients: a seventy cases study. Oncotarget, 2017, 8(46): 81475-81484.
11.	Burianová H, Faizo NL, Gray M, et al. Altered functional connectivity in mesial temporal lobe epilepsy. Epilepsy Res, 2017, 137: 45-52.
12.	Liao W, Zhang Z, Pan Z, et al. Default mode network abnormalities in mesial temporal lobe epilepsy: a study combining fMRI and DTI. Hum Brain Mapp, 2011, 32(6): 883-895.
13.	Zhang Z, Lu G, Zhong Y, et al. Altered spontaneous neuronal activity of the default-mode network in mesial temporal lobe epilepsy. Brain Res, 2010, 1323: 152-160.
14.	Haneef Z, Lenartowicz A, Yeh HJ, et al. Effect of lateralized temporal lobe epilepsy on the default mode network. Epilepsy Behav, 2012, 25(3): 350-357.
15.	Pittau F, Grova C, Moeller F, et al. Patterns of altered functional connectivity in mesial temporal lobe epilepsy. Epilepsia, 2012, 53(6): 1013-1023.
16.	Pereira FR, Alessio A, Sercheli MS, et al. Asymmetrical hippocampal connectivity in mesial temporal lobe epilepsy: evidence from resting state fMRI. BMC Neurosci, 2010, 11: 66.
17.	Peng W, Mao L, Yin D, et al. Functional network changes in the hippocampus contribute to depressive symptoms in epilepsy. Seizure, 2018, 60: 16-22.
18.	Kemmotsu N, Kucukboyaci NE, Leyden KM, et al. Frontolimbic brain networks predict depressive symptoms in temporal lobe epilepsy. Epilepsy Res, 2014, 108(9): 1554-1563.
19.	de Kwaasteniet B, Ruhe E, Caan M, et al. Relation between structural and functional connectivity in major depressive disorder. Biol Psychiatry, 2013, 74(1): 40-47.
20.	Li R, Ji GJ, Yu YY, et al. Epileptic discharge related functional connectivity within and between networks in benign epilepsy with centrotemporal spikes. Int J Neural Syst, 2017, 27(7, SI): 1750018.
21.	Zang Y, Jiang T, Lu Y, et al. Regional homogeneity approach to fMRI data analysis. Neuroimage, 2004, 22(1): 394-400.
22.	Wang ZG, Lu GM, Zhang ZQ, et al. Altered resting state networks in epileptic patients with generalized tonic-clonic seizures. Brain Res, 2011, 1374: 134-141.
23.	Henson RN, Greve A, Cooper E, et al. The effects of hippocampal lesions on MRI measures of structural and functional connectivity. Hippocampus, 2016, 26(11): 1447-1463.
24.	Campo P, Garrido MI, Moran RJ, et al. Remote effects of hippocampal sclerosis on effective connectivity during working memory encoding: a case of connectional diaschisis?. Cereb Cortex, 2012, 22(6): 1225-1236.
25.	Seeley WW, Menon V, Schatzberg AF, et al. Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci, 2007, 27(9): 2349-2356.
26.	Menon V, Uddin LQ. Saliency, switching, attention and control: a network model of insula function. Brain Struct Funct, 2010, 214(5/6): 655-667.
27.	Fox MD, Snyder AZ, Vincent JL, et al. The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci USA, 2005, 102(27): 9673-9678.
28.	Luo C, Yang T, Tu S, et al. Altered intrinsic functional connectivity of the salience network in childhood absence epilepsy. J Neurol Sci, 2014, 339(1/2): 189-195.
29.	Zhang C, Yang H, Qin W, et al. Characteristics of resting-state functional connectivity in intractable unilateral temporal lobe epilepsy patients with impaired executive control function. Front Hum Neurosci, 2017, 11: 609.
30.	Curtis CE, D’Esposito M. Persistent activity in the prefrontal cortex during working memory. Trends Cogn Sci, 2003, 7(9): 415-423.
31.	Vlooswijk MC, Jansen JF, Jeukens CR, et al. Memory processes and prefrontal network dysfunction in cryptogenic epilepsy. Epilepsia, 2011, 52(8): 1467-1475.
32.	Yang H, Zhang C, Liu C, et al. Brain network alteration in patients with temporal lobe epilepsy with cognitive impairment. Epilepsy Behav, 2018, 81: 41-48.
33.	Corbetta M, Shulman GL. Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci, 2002, 3(3): 201-215.
34.	Andrews-Hanna JR, Smallwood J, Spreng RN. The default network and self-generated thought: component processes, dynamic control, and clinical relevance. Ann N Y Acad Sci, 2014, 1316: 29-52.
35.	Spreng RN, Sepulcre J, Turner GR, et al. Intrinsic architecture underlying the relations among the default, dorsal attention, and frontoparietal control networks of the human brain. J Cogn Neurosci, 2012, 25(1): 74-86.
36.	Fox MD, Corbetta M, Snyder AZ, et al. Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems. Proc Natl Acad Sci USA, 2006, 103(26): 10046-10051.
37.	Zhang Z, Lu G, Zhong Y, et al. Impaired attention network in temporal lobe epilepsy: a resting FMRI study. Neurosci Lett, 2009, 458(3): 97-101.
38.	Zheng J, Qin B, Dang C, et al. Alertness network in patients with temporal lobe epilepsy: a fMRI study. Epilepsy Res, 2012, 100(1/2): 67-73.
39.	Sturm W, Longoni F, Fimm B, et al. Network for auditory intrinsic alertness: a PET study. Neuropsychologia, 2004, 42(5): 563-568.
40.	Li J, Chen X, Ye W, et al. Alteration of the alertness-related network in patients with right temporal lobe epilepsy: a resting state fMRI study. Epilepsy Res, 2016, 127: 252-259.
41.	Xuan B, Mackie MA, Spagna A, et al. The activation of interactive attentional networks. Neuroimage, 2016, 129: 308-319.
42.	Xiao F, Li L, An D, et al. Altered attention networks in benign childhood epilepsy with centrotemporal spikes (BECTS): a resting-state fMRI study. Epilepsy Behav, 2015, 45: 234-241.
43.	Cubillo A, Halari R, Smith A, et al. A review of fronto-striatal and fronto-cortical brain abnormalities in children and adults with Attention Deficit Hyperactivity Disorder (ADHD) and new evidence for dysfunction in adults with ADHD during motivation and attention. Cortex, 2012, 48(2): 194-215.
44.	Gao Y, Zheng J, Li Y, et al. Decreased functional connectivity and structural deficit in alertness network with right-sided temporal lobe epilepsy. Medicine (Baltimore), 2018, 97(14): e0134.
45.	Tomasi D, Volkow ND. Resting functional connectivity of language networks: characterization and reproducibility. Mol Psychiatry, 2012, 17(8): 841-854.
46.	Vlooswijk MC, Jansen JF, Majoie HJ, et al. Functional connectivity and language impairment in cryptogenic localization-related epilepsy. Neurology, 2010, 75(5): 395-402.
47.	McGinnity CJ, Smith AB, Yaakub SN, et al. Decreased functional connectivity within a language subnetwork in benign epilepsy with centrotemporal spikes. Epilepsia Open, 2017, 2(2): 214-225.
48.	Gong L, Yin Y, He C, et al. Disrupted reward circuits is associated with cognitive deficits and depression severity in major depressive disorder. J Psychiatr Res, 2017, 84: 9-17.
49.	Downar J, Geraci J, Salomons TV, et al. Anhedonia and reward-circuit connectivity distinguish nonresponders from responders to dorsomedial prefrontal repetitive transcranial magnetic stimulation in major depression. Biol Psychiatry, 2014, 76(3): 176-185.
50.	Doucet GE, Skidmore C, Sharan AD, et al. Functional connectivity abnormalities vary by amygdala subdivision and are associated with psychiatric symptoms in unilateral temporal epilepsy. Brain Cogn, 2013, 83(2): 171-182.
51.	Lee MH, Smyser CD, Shimony JS. Resting-state fMRI: a review of methods and clinical applications. AJNR Am J Neuroradiol, 2013, 34(10): 1866-1872.
52.	Tran SM, McGregor KM, James GA, et al. Task-residual functional connectivity of language and attention networks. Brain Cogn, 2018, 122: 52-58.

1. van den Heuvel MP, Hulshoff Pol HE. Exploring the brain network: a review on resting-state fMRI functional connectivity. Eur Neuropsychopharmacol, 2010, 20(8): 519-534.
2. Biswal B, Yetkin FZ, Haughton VM, et al. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med, 1995, 34(4): 537-541.
3. Cataldi M, Avoli M, de Villers-Sidani E. Resting state networks in temporal lobe epilepsy. Epilepsia, 2013, 54(12): 2048-2059.
4. Wei H, An J, Shen H, et al. Altered effective connectivity among core neurocognitive networks in idiopathic generalized epilepsy: an fMRI evidence. Front Hum Neurosci, 2016, 10: 447.
5. Logothetis NK, Pauls J, Augath M, et al. Neurophysiological investigation of the basis of the fMRI signal. Nature, 2001, 412(6843): 150-157.
6. Yang H, Long XY, Yang Y, et al. Amplitude of low frequency fluctuation within visual areas revealed by resting-state functional MRI. Neuroimage, 2007, 36(1): 144-152.
7. Waites AB, Briellmann RS, Saling MM, et al. Functional connectivity networks are disrupted in left temporal lobe epilepsy. Ann Neurol, 2006, 59(2): 335-343.
8. Cheng L, Zhu Y, Sun J, et al. Principal states of dynamic functional connectivity reveal the link between resting-state and task-state brain: an fMRI study. Int J Neural Syst, 2018, 28(7): 1850002.
9. Buckner RL, Andrews-Hanna JR, Schacter DL. The brain’s default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci, 2008, 1124: 1-38.
10. Hu CY, Gao X, Long L, et al. Altered DMN functional connectivity and regional homogeneity in partial epilepsy patients: a seventy cases study. Oncotarget, 2017, 8(46): 81475-81484.
11. Burianová H, Faizo NL, Gray M, et al. Altered functional connectivity in mesial temporal lobe epilepsy. Epilepsy Res, 2017, 137: 45-52.
12. Liao W, Zhang Z, Pan Z, et al. Default mode network abnormalities in mesial temporal lobe epilepsy: a study combining fMRI and DTI. Hum Brain Mapp, 2011, 32(6): 883-895.
13. Zhang Z, Lu G, Zhong Y, et al. Altered spontaneous neuronal activity of the default-mode network in mesial temporal lobe epilepsy. Brain Res, 2010, 1323: 152-160.
14. Haneef Z, Lenartowicz A, Yeh HJ, et al. Effect of lateralized temporal lobe epilepsy on the default mode network. Epilepsy Behav, 2012, 25(3): 350-357.
15. Pittau F, Grova C, Moeller F, et al. Patterns of altered functional connectivity in mesial temporal lobe epilepsy. Epilepsia, 2012, 53(6): 1013-1023.
16. Pereira FR, Alessio A, Sercheli MS, et al. Asymmetrical hippocampal connectivity in mesial temporal lobe epilepsy: evidence from resting state fMRI. BMC Neurosci, 2010, 11: 66.
17. Peng W, Mao L, Yin D, et al. Functional network changes in the hippocampus contribute to depressive symptoms in epilepsy. Seizure, 2018, 60: 16-22.
18. Kemmotsu N, Kucukboyaci NE, Leyden KM, et al. Frontolimbic brain networks predict depressive symptoms in temporal lobe epilepsy. Epilepsy Res, 2014, 108(9): 1554-1563.
19. de Kwaasteniet B, Ruhe E, Caan M, et al. Relation between structural and functional connectivity in major depressive disorder. Biol Psychiatry, 2013, 74(1): 40-47.
20. Li R, Ji GJ, Yu YY, et al. Epileptic discharge related functional connectivity within and between networks in benign epilepsy with centrotemporal spikes. Int J Neural Syst, 2017, 27(7, SI): 1750018.
21. Zang Y, Jiang T, Lu Y, et al. Regional homogeneity approach to fMRI data analysis. Neuroimage, 2004, 22(1): 394-400.
22. Wang ZG, Lu GM, Zhang ZQ, et al. Altered resting state networks in epileptic patients with generalized tonic-clonic seizures. Brain Res, 2011, 1374: 134-141.
23. Henson RN, Greve A, Cooper E, et al. The effects of hippocampal lesions on MRI measures of structural and functional connectivity. Hippocampus, 2016, 26(11): 1447-1463.
24. Campo P, Garrido MI, Moran RJ, et al. Remote effects of hippocampal sclerosis on effective connectivity during working memory encoding: a case of connectional diaschisis?. Cereb Cortex, 2012, 22(6): 1225-1236.
25. Seeley WW, Menon V, Schatzberg AF, et al. Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci, 2007, 27(9): 2349-2356.
26. Menon V, Uddin LQ. Saliency, switching, attention and control: a network model of insula function. Brain Struct Funct, 2010, 214(5/6): 655-667.
27. Fox MD, Snyder AZ, Vincent JL, et al. The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci USA, 2005, 102(27): 9673-9678.
28. Luo C, Yang T, Tu S, et al. Altered intrinsic functional connectivity of the salience network in childhood absence epilepsy. J Neurol Sci, 2014, 339(1/2): 189-195.
29. Zhang C, Yang H, Qin W, et al. Characteristics of resting-state functional connectivity in intractable unilateral temporal lobe epilepsy patients with impaired executive control function. Front Hum Neurosci, 2017, 11: 609.
30. Curtis CE, D’Esposito M. Persistent activity in the prefrontal cortex during working memory. Trends Cogn Sci, 2003, 7(9): 415-423.
31. Vlooswijk MC, Jansen JF, Jeukens CR, et al. Memory processes and prefrontal network dysfunction in cryptogenic epilepsy. Epilepsia, 2011, 52(8): 1467-1475.
32. Yang H, Zhang C, Liu C, et al. Brain network alteration in patients with temporal lobe epilepsy with cognitive impairment. Epilepsy Behav, 2018, 81: 41-48.
33. Corbetta M, Shulman GL. Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci, 2002, 3(3): 201-215.
34. Andrews-Hanna JR, Smallwood J, Spreng RN. The default network and self-generated thought: component processes, dynamic control, and clinical relevance. Ann N Y Acad Sci, 2014, 1316: 29-52.
35. Spreng RN, Sepulcre J, Turner GR, et al. Intrinsic architecture underlying the relations among the default, dorsal attention, and frontoparietal control networks of the human brain. J Cogn Neurosci, 2012, 25(1): 74-86.
36. Fox MD, Corbetta M, Snyder AZ, et al. Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems. Proc Natl Acad Sci USA, 2006, 103(26): 10046-10051.
37. Zhang Z, Lu G, Zhong Y, et al. Impaired attention network in temporal lobe epilepsy: a resting FMRI study. Neurosci Lett, 2009, 458(3): 97-101.
38. Zheng J, Qin B, Dang C, et al. Alertness network in patients with temporal lobe epilepsy: a fMRI study. Epilepsy Res, 2012, 100(1/2): 67-73.
39. Sturm W, Longoni F, Fimm B, et al. Network for auditory intrinsic alertness: a PET study. Neuropsychologia, 2004, 42(5): 563-568.
40. Li J, Chen X, Ye W, et al. Alteration of the alertness-related network in patients with right temporal lobe epilepsy: a resting state fMRI study. Epilepsy Res, 2016, 127: 252-259.
41. Xuan B, Mackie MA, Spagna A, et al. The activation of interactive attentional networks. Neuroimage, 2016, 129: 308-319.
42. Xiao F, Li L, An D, et al. Altered attention networks in benign childhood epilepsy with centrotemporal spikes (BECTS): a resting-state fMRI study. Epilepsy Behav, 2015, 45: 234-241.
43. Cubillo A, Halari R, Smith A, et al. A review of fronto-striatal and fronto-cortical brain abnormalities in children and adults with Attention Deficit Hyperactivity Disorder (ADHD) and new evidence for dysfunction in adults with ADHD during motivation and attention. Cortex, 2012, 48(2): 194-215.
44. Gao Y, Zheng J, Li Y, et al. Decreased functional connectivity and structural deficit in alertness network with right-sided temporal lobe epilepsy. Medicine (Baltimore), 2018, 97(14): e0134.
45. Tomasi D, Volkow ND. Resting functional connectivity of language networks: characterization and reproducibility. Mol Psychiatry, 2012, 17(8): 841-854.
46. Vlooswijk MC, Jansen JF, Majoie HJ, et al. Functional connectivity and language impairment in cryptogenic localization-related epilepsy. Neurology, 2010, 75(5): 395-402.
47. McGinnity CJ, Smith AB, Yaakub SN, et al. Decreased functional connectivity within a language subnetwork in benign epilepsy with centrotemporal spikes. Epilepsia Open, 2017, 2(2): 214-225.
48. Gong L, Yin Y, He C, et al. Disrupted reward circuits is associated with cognitive deficits and depression severity in major depressive disorder. J Psychiatr Res, 2017, 84: 9-17.
49. Downar J, Geraci J, Salomons TV, et al. Anhedonia and reward-circuit connectivity distinguish nonresponders from responders to dorsomedial prefrontal repetitive transcranial magnetic stimulation in major depression. Biol Psychiatry, 2014, 76(3): 176-185.
50. Doucet GE, Skidmore C, Sharan AD, et al. Functional connectivity abnormalities vary by amygdala subdivision and are associated with psychiatric symptoms in unilateral temporal epilepsy. Brain Cogn, 2013, 83(2): 171-182.
51. Lee MH, Smyser CD, Shimony JS. Resting-state fMRI: a review of methods and clinical applications. AJNR Am J Neuroradiol, 2013, 34(10): 1866-1872.
52. Tran SM, McGregor KM, James GA, et al. Task-residual functional connectivity of language and attention networks. Brain Cogn, 2018, 122: 52-58.

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