Objective To compare the clinical characteristics of inpatients with different influenza subtypes, so as to identify the subtypes at an early stage.Methods A retrospective case study was conducted, using influenza surveillance data from January 1st, 2016 to December 31st, 2018 at a tertiary surveillance outpost hospital in Chengdu. Patients diagnosed with different subtypes of influenza by nucleic acid testing or virus isolation and culture were investigated, and their clinical characteristics, laboratory test results, and prognosis were analyzed and compared among the four subtypes including H1N1, H3N2, Victoria (BV), and Yamagata (BY).Results There were 127 inpatients with laboratory-confirmed influenza. Among the confirmed influenza patients, 85.8% (109/127) had low or normal white blood cell counts, and 78.8% (89/113) had abnormally high procalcitonin levels. Among the patients with different subtypes, statistical differences existed in age (P<0.001), low or normal white blood cell count (P=0.041), positive bacteria/fungus/mycoplasma/chlamydia culture (P=0.001), kidney damage (P=0.013), outcome at discharge (P<0.001), and hospitalization expenses (P=0.016). However, there was no statistical difference in gender, clinical symptoms, liver damage, cardiac damage, or length of hospital stay (P>0.05).Conclusion The infection of influenza can lead to severe clinical complications or even death. The outcomes of patients with influenza A may be more severe. An elevated procalcitonin level can be detected in quite a few patients with influenza.
Citation：
XIANG Lijia, GU Mingqin, XIE Mei, ZHENG Lan. A comparative analysis of clinical characteristics of 127 inpatients with different subtypes of influenza confirmed at a surveillance outpost hospital in Chengdu from 2016 to 2018. West China Medical Journal, 2019, 34(3): 295-298. doi: 10.7507/1002-0179.201901165
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- 1. 中华人民共和国国家卫生和计划生育委员会. 流行性感冒诊疗方案(2018年版). 中华临床感染病杂志, 2018, 11(1): 1-5.
- 2. 舒跃龙. 流感监测的发展历史及思考. 中华流行病学杂志, 2011, 32(4): 334-336.
- 3. 秦颖, 赵梦娇, 谭亚运, 等. 中国流感大流行的百年历史. 中华流行病学杂志, 2018, 39(8): 1028-1031.
- 4. 王子军. 设立" 世界流感日”,开创流感防控新时代. 中华预防医学杂志, 2018, 39(11): 1536.
- 5. 彭质斌, 郑建东, 姜慧, 等. 全国住院严重急性呼吸道感染病例哨点监测阶段性分析. 疾病监测, 2017, 32(1): 3-5.
- 6. 车飞虎, 崔大伟, 孙海燕, 等. 2013-2015年浙江地区新型甲型H1N1流行性感冒的流行病学和临床特征调查. 临床检验杂志, 2016, 34(4): 307-311.
- 7. 孙海萍, 刘明, 宋黎黎, 等. 类流感(H1N1、H3N2、乙型)患者的血常规结果分析. 诊断学理论与实践, 2013, 12(4): 452-456.
- 8. 李丽, 王凌航. 流行性感冒的并发症. 国际病毒学杂志, 2018, 25(3): 210-212.
- 9. 姜慧, 于德山, 阮峰, 等. 中国10省(市)流感成年人住院病例的临床特征及重症危险因素分析. 中华流行病学杂志, 2015, 36(3): 216-221.
- 10. 吴礁. 2010-2013年成都市流感疫苗接种情况分析. 预防医学情报杂志, 2015, 31(9): 688-690.
- 11. 张蓉. 2013年全球流感监测咨询会议纪要. 疾病监测, 2014, 29(7): 590-592.
- 12. 李航, 鲁植艳. 美国近期严重流感疫情引发的思考. 新发传染病电子杂志, 2018, 3(1): 5-7.
- 13. 高洁, 严敏, 付婷, 等. 甲型H1N1流感病毒快速核酸检测方法探究. 中国实用医药, 2018, 13(17): 93-94.
