Advances in the role of neutrophils in pulmonary vascular endothelial injury after cardiopulmonary resuscitation_West China Medical Journal

Authors：

ZHANG Jianjun ^1,2 , XU Ping ² ,  CAO Yu ¹

1. Department of Emergency, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Emergency, Zigong Fourth People’s Hospital, Zigong, Sichuan 643000, P. R. China;

Corresponding author：

CAO Yu, Email: yuyuer@126.com

Keywords：

Cardiopulmonary resuscitation; Pulmonary vascular endothelial injury; Neutrophils

DOI：

10.7507/1002-0179.201901166

Video：

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The body of patient undergoing cardiopulmonary resuscitation after cardiac arrest experiences a process of ischemia, hypoxia, and reperfusion injury. This state of intense stress response is accompanied with hemodynamic instability, systemic hypoperfusion, and subsequent multiple organ dysfunction, and is life-threatening. Pulmonary vascular endothelial injury after cardiopulmonary resuscitation is a pathological manifestation of lung injury in multiple organ injury. Possible mechanisms include inflammatory response, neutrophil infiltration, microcirculatory disorder, tissue oxygen uptake and utilization disorder, etc. Neutrophils can directly damage or indirectly damage lung vascular endothelial cells through activation and migration activities. They also activate the body to produce large amounts of oxygen free radicals and release a series of damaging cytokines that further impaire the lung tissue.

Citation： ZHANG Jianjun, XU Ping, CAO Yu. Advances in the role of neutrophils in pulmonary vascular endothelial injury after cardiopulmonary resuscitation. West China Medical Journal, 2019, 34(4): 429-432. doi: 10.7507/1002-0179.201901166 Copy

1.	蒋华驰, 刘峰, 郑明峰, 等. 再次肺移植治疗肺移植术后闭塞性细支气管炎综合征. 中华移植杂志(电子版), 2017, 11(4): 221-224.
2.	叶心怡, 陈刚领, 刘晗, 等. 中性粒细胞NADPH氧化酶与组织缺血再灌注关系的研究进展. 现代生物医学进展, 2017, 32(17): 6380-6385.
3.	张庆光, 凌霜, 刘俊, 等. 嗜中性粒细胞胞外诱捕网对缺血再灌注损伤的影响及中医药干预研究进展. 上海中医药大学学报, 2018, 32(3): 97-102, 108.
4.	镇艳, 易伟民, 王华军, 等. 缺血处理对大鼠缺血再灌注性压疮中性粒细胞浸润度的影响. 岭南急诊医学杂志, 2018, 23(1): 17-19, 23.
5.	孙丽, 郭瑜, 朱利娟, 等. 心肺复苏后脑缺血再灌注损伤治疗理念及相关动物模型研究进展. 现代生物医学进展, 2014, 14(32): 6379-6382.
6.	Zhou X, Yong L, Huang Y, et al. The protective effects of distal ischemic treatment on apoptosis and mitochondrial permeability in the hippocampus after cardiopulmonary resuscitation. J Cell Physiol, 2018, 233(9): 6902-6910.
7.	Dong LY, Zheng JH, Qiu XX, et al. Ischemic preconditioning reduces deep hypothermic circulatory arrest cardiopulmonary bypass induced lung injury. Eur Rev Med Pharmacol Sci, 2013, 17(13): 1789-1799.
8.	Fink K, Moebes M, Vetter C, et al. Selenium prevents microparticle-induced endothelial inflammation in patients after cardiopulmonary resuscitation. Crit Care, 2015, 19(1): 58.
9.	武军元, 王烁, 李春盛, 等. 乌司他丁对改善猪心肺复苏后炎症反应和心肺组织损伤的作用. 中华危重病急救医学, 2013, 25(2): 106-108.
10.	梁颖红, 张成诗, 魏明, 等. 输血相关急性肺损伤大鼠肺组织细胞间黏附分子1和细胞因子诱导的中性粒细胞趋化因子1的表达. 中华生物医学工程杂志, 2016, 22(4): 287-292.
11.	Li B, Lu X, Wang J, et al. The metabonomics study of P-selectin glycoprotein ligand-1 (PSGL-1) deficiency inhibiting the progression of atherosclerosis in LDLR^-/- mice. Int J Biol Sci, 2018, 14(1): 36-46.
12.	Ge L, Zhou X, Ji WJ, et al. Neutrophil extracellular traps in ischemia-reperfusion injury-induced myocardial no-reflow: therapeutic potential of DNase-based reperfusion strategy. Am J Physiol Heart Circ Physiol, 2015, 308(5): H500-H509.
13.	Cedervall J, Zhang YY, Huang H, et al. Neutrophil extracellular traps accumulate in peripheral blood vessels and compromise organ function in tumor-bearing animals. Cancer Res, 2015, 75(13): 2653-2662.
14.	Takhtfooladi HA, Hesaraki S, Razmara F, et al. Effects of N-acetylcysteine and pentoxifylline on remote lung injury in a rat model of hind limb ischemia/reperfusion injury. J Bras Pneumol, 2016, 42(1): 9-14.
15.	李璐, 傅海东. 中性粒细胞胞外诱捕网在儿童系统性红斑狼疮的研究进展. 中国当代儿科杂志, 2018, 20(3): 251-255.
16.	Albadawi H, Oklu R, Malley RE, et al. Effect of DNase I treatment and neutrophil depletion on acute limb ischemia-reperfusion injury in mice. J Vasc Surg, 2016, 64(2): 484-493.
17.	Doris P, Mathieu-Benoît V, Abigail W, et al. Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med, 2012, 209(6): 1219-1234.
18.	赵利军, 李开济, 卢秋玲, 等. 缺血后处理对大鼠肢体缺血再灌注后肺损伤的保护作用及其机制. 吉林大学学报(医学版), 2016, 42(2): 255-259.
19.	张燕, 严冰, 刘毅. 中性粒细胞胞外陷阱诱导血管内皮细胞损伤在皮肌炎合并肺间质病变中的作用. 中华内科杂志, 2017, 56(9): 650-654.
20.	Gomes EC, An SA, de Oliveira MR. Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species. Oxid Med Cell Longev, 2012(3): 756132.
21.	Naha PC, Davoren M, Lyng FM, et al. Reactive Oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cells. Toxicol Appl Pharmacol, 2010, 246(1/2): 91-99.
22.	Soccal PM, Gasche Y, Miniati DN, et al. Matrix metalloproteinase inhibition decreases ischemia-reperfusion injury after lung transplantation. Am J Transplant, 2015, 4(1): 41-50.
23.	杨斌, 陈海龙. 中性粒细胞弹性蛋白酶在重症急性胰腺炎并急性肺损伤发病中的表达和意义. 临床军医杂志, 2012, 40(4): 765-769, 封4.
24.	Mihara K, Ramachandran R, Renaux BA, et al. Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1). J Biol Chem, 2013, 288(46): 32979-32990.
25.	陶元东, 唐丽. 中性粒细胞异质性的研究进展. 细胞与分子免疫学杂志, 2016, 32(12): 1704-1706.

1. 蒋华驰, 刘峰, 郑明峰, 等. 再次肺移植治疗肺移植术后闭塞性细支气管炎综合征. 中华移植杂志(电子版), 2017, 11(4): 221-224.
2. 叶心怡, 陈刚领, 刘晗, 等. 中性粒细胞NADPH氧化酶与组织缺血再灌注关系的研究进展. 现代生物医学进展, 2017, 32(17): 6380-6385.
3. 张庆光, 凌霜, 刘俊, 等. 嗜中性粒细胞胞外诱捕网对缺血再灌注损伤的影响及中医药干预研究进展. 上海中医药大学学报, 2018, 32(3): 97-102, 108.
4. 镇艳, 易伟民, 王华军, 等. 缺血处理对大鼠缺血再灌注性压疮中性粒细胞浸润度的影响. 岭南急诊医学杂志, 2018, 23(1): 17-19, 23.
5. 孙丽, 郭瑜, 朱利娟, 等. 心肺复苏后脑缺血再灌注损伤治疗理念及相关动物模型研究进展. 现代生物医学进展, 2014, 14(32): 6379-6382.
6. Zhou X, Yong L, Huang Y, et al. The protective effects of distal ischemic treatment on apoptosis and mitochondrial permeability in the hippocampus after cardiopulmonary resuscitation. J Cell Physiol, 2018, 233(9): 6902-6910.
7. Dong LY, Zheng JH, Qiu XX, et al. Ischemic preconditioning reduces deep hypothermic circulatory arrest cardiopulmonary bypass induced lung injury. Eur Rev Med Pharmacol Sci, 2013, 17(13): 1789-1799.
8. Fink K, Moebes M, Vetter C, et al. Selenium prevents microparticle-induced endothelial inflammation in patients after cardiopulmonary resuscitation. Crit Care, 2015, 19(1): 58.
9. 武军元, 王烁, 李春盛, 等. 乌司他丁对改善猪心肺复苏后炎症反应和心肺组织损伤的作用. 中华危重病急救医学, 2013, 25(2): 106-108.
10. 梁颖红, 张成诗, 魏明, 等. 输血相关急性肺损伤大鼠肺组织细胞间黏附分子1和细胞因子诱导的中性粒细胞趋化因子1的表达. 中华生物医学工程杂志, 2016, 22(4): 287-292.
11. Li B, Lu X, Wang J, et al. The metabonomics study of P-selectin glycoprotein ligand-1 (PSGL-1) deficiency inhibiting the progression of atherosclerosis in LDLR^-/- mice. Int J Biol Sci, 2018, 14(1): 36-46.
12. Ge L, Zhou X, Ji WJ, et al. Neutrophil extracellular traps in ischemia-reperfusion injury-induced myocardial no-reflow: therapeutic potential of DNase-based reperfusion strategy. Am J Physiol Heart Circ Physiol, 2015, 308(5): H500-H509.
13. Cedervall J, Zhang YY, Huang H, et al. Neutrophil extracellular traps accumulate in peripheral blood vessels and compromise organ function in tumor-bearing animals. Cancer Res, 2015, 75(13): 2653-2662.
14. Takhtfooladi HA, Hesaraki S, Razmara F, et al. Effects of N-acetylcysteine and pentoxifylline on remote lung injury in a rat model of hind limb ischemia/reperfusion injury. J Bras Pneumol, 2016, 42(1): 9-14.
15. 李璐, 傅海东. 中性粒细胞胞外诱捕网在儿童系统性红斑狼疮的研究进展. 中国当代儿科杂志, 2018, 20(3): 251-255.
16. Albadawi H, Oklu R, Malley RE, et al. Effect of DNase I treatment and neutrophil depletion on acute limb ischemia-reperfusion injury in mice. J Vasc Surg, 2016, 64(2): 484-493.
17. Doris P, Mathieu-Benoît V, Abigail W, et al. Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med, 2012, 209(6): 1219-1234.
18. 赵利军, 李开济, 卢秋玲, 等. 缺血后处理对大鼠肢体缺血再灌注后肺损伤的保护作用及其机制. 吉林大学学报(医学版), 2016, 42(2): 255-259.
19. 张燕, 严冰, 刘毅. 中性粒细胞胞外陷阱诱导血管内皮细胞损伤在皮肌炎合并肺间质病变中的作用. 中华内科杂志, 2017, 56(9): 650-654.
20. Gomes EC, An SA, de Oliveira MR. Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species. Oxid Med Cell Longev, 2012(3): 756132.
21. Naha PC, Davoren M, Lyng FM, et al. Reactive Oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cells. Toxicol Appl Pharmacol, 2010, 246(1/2): 91-99.
22. Soccal PM, Gasche Y, Miniati DN, et al. Matrix metalloproteinase inhibition decreases ischemia-reperfusion injury after lung transplantation. Am J Transplant, 2015, 4(1): 41-50.
23. 杨斌, 陈海龙. 中性粒细胞弹性蛋白酶在重症急性胰腺炎并急性肺损伤发病中的表达和意义. 临床军医杂志, 2012, 40(4): 765-769, 封4.
24. Mihara K, Ramachandran R, Renaux BA, et al. Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1). J Biol Chem, 2013, 288(46): 32979-32990.
25. 陶元东, 唐丽. 中性粒细胞异质性的研究进展. 细胞与分子免疫学杂志, 2016, 32(12): 1704-1706.

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