Progress in CT-guided implantation of iodine-125 seeds for malignant tumors assisted by individualized 3D template_West China Medical Journal

Authors：

LI Xingchang , LI Yixing , LIU Dehui , HU Pan ,  LAI Jianping

Department of Nuclear Medicine, the People’s Hospital of Three Gorges University, the First People’s Hospital of Yichang, Yichang, Hubei 443000, P. R. China;

Corresponding author：

LAI Jianping, Email: ljp2116cn@163.com

Keywords：

Individualized 3D template; CT-guided; Iodine-125 seeds implantation; Malignant tumor

DOI：

10.7507/1002-0179.201904138

Video：

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Abstract Full text Figures/Tables Video References Cited by

The iodine-125 (¹²⁵I) seeds interstitial implantation has the advantages of minimal invasiveness, high local control rate, and few complications; it has attracted worldwide attention. With the application of 3D printing technology in medicine, individualized 3D templates are gradually applied to clinical practice. Individualized 3D templates combining with CT-guided ¹²⁵I seeds implantation are easy to operate and can not only effectively ensure the consistency and accuracy of preoperative and postoperative dose, but also minimize complications to achieve optimal efficacy. This paper reviews the application of CT-guided implantation of ¹²⁵I seeds for malignant tumors assisted by individualized 3D template, and further demonstrates the safety and effectiveness of clinical application in ¹²⁵I seeds implantation to provide a reliable basis for the standardization of ¹²⁵I seeds implantation.

Citation： LI Xingchang, LI Yixing, LIU Dehui, HU Pan, LAI Jianping. Progress in CT-guided implantation of iodine-125 seeds for malignant tumors assisted by individualized 3D template. West China Medical Journal, 2019, 34(8): 948-952. doi: 10.7507/1002-0179.201904138 Copy

1.	吴菲, 林国桢, 张晋昕. 我国恶性肿瘤发病现状及趋势. 中国肿瘤, 2012, 21(2): 81-85.
2.	Trombetta MG, Colonias A, Makishi D, et al. Tolerance of the aorta using intraoperative iodine-125 interstitial brachytherapy in cancer of the lung. Brachytherapy, 2008, 7(1): 50-54.
3.	王文俊, 陈志军, 许波, 等. 3D打印非共面模板CT引导下¹²⁵I粒子植入治疗恶性肿瘤临床应用. 实用癌症杂志, 2018, 33(9): 1557-1559.
4.	郭福新, 姜玉良, 吉喆, 等. 3D打印非共面模板辅助CT引导¹²⁵I粒子植入治疗锁骨上复发转移癌的剂量学研究. 北京大学学报(医学版), 2017, 49(3): 506-511.
5.	姜玉良. 北京大学第三医院完成首例CT引导联合3D打印模板指导放射性粒子植入治疗腹膜后复发肿瘤. 北京大学学报(医学版), 2016, 48(1): 182.
6.	Liu Q, Dai X, Zhou X, et al. Comparison of TACE combined with and without iodine-125 seeds implantation therapy for advanced stage hepatocellular carcinoma: a systematic review and meta-analysis. J BUON, 2019, 24(2): 642-649.
7.	Lu J, Huang W, Wang Z, et al. The safety and efficacy of interstitial ¹²⁵I seed implantation brachytherapy for metastatic epidural spinal cord compression. J Cancer Res Ther, 2018, 14(7): 1549-1555.
8.	Hertzanu Y, Ye X. A valuable guideline of radioactive ¹²⁵I seeds interstitial implantation brachytherapy for pancreatic cancer. J Cancer Res Ther, 2018, 14(7): 1453-1454.
9.	王俊杰, 庄永志. 放射性粒子近距离治疗肿瘤. 中国微创外科杂志, 2001, 1(3): 187-191.
10.	张开贤, 秦征东, 李苓, 等. CT引导¹²⁵I放射性粒子植入治疗复发性脑胶质瘤的研究. 中华肿瘤防治杂志, 2007, 14(22): 1714-1716.
11.	胡效坤, 乔志正, 梁克山, 等. CT引导下¹²⁵I放射粒子植入治疗脑内肿瘤的应用研究. 中华神经医学杂志, 2005, 4(7): 691-694.
12.	Ronco C, La Manna G. Current perspectives in kidney diseases. Blood Purif, 2017, 44(4): 311-313.
13.	Zhu HD, Guo JH, Zhu GY, et al. A novel biliary stent loaded with ¹²⁵I seeds in patients with malignant biliary obstruction: preliminary results versus a conventional biliary stent. J Hepatol, 2012, 56(5): 1104-1111.
14.	卓水清, 陈林, 张福君, 等. ¹²⁵I放射性粒子植入术后患者周围辐射剂量的监测. 癌症, 2007, 26(6): 666-668.
15.	Schwarz SB, Thon N, Nikolajek K, et al. Iodine-125 brachytherapy for brain tumours--a review. Radiat Oncol, 2012, 7: 30.
16.	Huang MW, Liu SM, Zheng L, et al. A digital model individual template and CT-guided ¹²⁵I seed implants for malignant tumors of the head and neck. J Radiat Res, 2012, 53(6): 973-977.
17.	Liang Y, Wang Z, Zhang H, et al. Three-dimensional-printed individual template-guided ¹²⁵I seed implantation for the cervical lymph node metastasis: a dosimetric and security study. J Cancer Res Ther, 2018, 14(1): 30-35.
18.	姜玉良, 吉喆, 田素青, 等. CT引导下¹²⁵I粒子挽救性治疗头颈部复发/转移癌的临床疗效. 中华医学杂志, 2018, 98(45): 3686-3691.
19.	胡效坤, 彭丽静, 刘士锋, 等. 靶区和剂量控制下¹²⁵I粒子治疗颅内恶性肿瘤的再评价. 中华医学杂志, 2017, 97(19): 1457-1462.
20.	Whitmore WF Jr, Hilaris B, Grabstald H. Retropubic implantation to iodine 125 in the treatment of prostatic cancer. J Urol, 1972, 108(6): 918-920.
21.	黄海锋, 汪维, 郭宏骞, 等. 125碘粒子植入术联合内分泌疗法治疗前列腺癌效果研究. 实用老年医学, 2014(10): 839-841.
22.	Qu A, Jiang P, Sun H, et al. Efficacy and dosimetry analysis of image-guided radioactive ¹²⁵I seed implantation as salvage treatment for pelvic recurrent cervical cancer after external beam radiotherapy. J Gynecol Oncol, 2019, 30(1): e9.
23.	贡桔, 王忠敏, 陈克敏, 等. CT引导下经皮穿刺¹²⁵I粒子植入治疗肺癌的临床应用. 介入放射学杂志, 2009, 18(9): 677-680.
24.	吉喆, 姜玉良, 郭福新, 等. 三维打印共面坐标模板联合CT引导¹²⁵I粒子植入治疗胸部恶性肿瘤的剂量学评价. 中华核医学与分子影像杂志, 2018, 38(1): 4-8.
25.	van Riet YE, Maaskant AJ, Creemers GJ, et al. Identification of residual breast tumour localization after neo-adjuvant chemotherapy using a radioactive 125 iodine seed. Eur J Surg Oncol, 2010, 36(2): 164-169.
26.	Yu YH, Wei CY, Qin QH, et al. Efficacy of iodine-125 seed implantation in locoregionally recurrent and unresectable breast cancer: a retrospective study. Pathol Oncol Res, 2019, 25(1): 327-332.
27.	张颖, 林琦, 袁苑, 等. 3D打印个体化模板联合CT引导¹²⁵I粒子植入治疗胸壁转移瘤1例. 山东大学学报(医学版), 2016, 54(4): 94-96.
28.	张颖, 林琦, 袁苑, 等. 3D打印个体化模板联合CT引导¹²⁵I粒子植入治疗肿瘤术前术后剂量学比较. 山东大学学报(医学版), 2017, 55(2): 45-49.
29.	张颖, 林琦, 袁苑, 等. 3D打印个体化模板联合CT引导¹²⁵I粒子植入治疗恶性肿瘤质量评价. 山东大学学报(医学版), 2016, 54(11): 44-50.
30.	Wang ZM, Liu Y, Liu FJ, et al. Clinical efficacy of CT-guided iodine-125 seed implantation therapy in patients with advanced pancreatic cancer. Eur Radiol, 2010, 20(7): 1786-1791.
31.	赵鹏, 崔红凯, 杨瑞民, 等. 放射性¹²⁵I粒子支架治疗中、晚期食管癌的疗效观察. 介入放射学杂志, 2011, 20(6): 448-451.
32.	郑家平, 邵国良, 罗君, 等. CT引导下I¹²⁵粒子组织间植入治疗难治性肝癌. 介入放射学杂志, 2015, 24(3): 260-264.
33.	王俊杰, 唐劲天, 黎功. 放射性粒子近距离治疗肿瘤. 北京: 北京医科大学出版社, 2001: 172.
34.	王俊杰. 放射性粒子治疗肿瘤临床应用规范. 北京: 北京大学医学出版社, 2011: 33.
35.	Martinez-Monge R, Nag S, Nieroda CA, et al. Iodine-125 brachytherapy in the treatment of colorectal adenocarcinoma metastatic to the liver. Cancer, 1999, 85(6): 1218-1225.
36.	Wang P, Shen LQ, Zhang H, et al. Quality of life after I-125 seed implantation using computed tomography and three-dimensional-printed template guidance in patients with advanced malignant tumor. J Cancer Res Ther, 2018, 14(7): 1492-1496.

1. 吴菲, 林国桢, 张晋昕. 我国恶性肿瘤发病现状及趋势. 中国肿瘤, 2012, 21(2): 81-85.
2. Trombetta MG, Colonias A, Makishi D, et al. Tolerance of the aorta using intraoperative iodine-125 interstitial brachytherapy in cancer of the lung. Brachytherapy, 2008, 7(1): 50-54.
3. 王文俊, 陈志军, 许波, 等. 3D打印非共面模板CT引导下¹²⁵I粒子植入治疗恶性肿瘤临床应用. 实用癌症杂志, 2018, 33(9): 1557-1559.
4. 郭福新, 姜玉良, 吉喆, 等. 3D打印非共面模板辅助CT引导¹²⁵I粒子植入治疗锁骨上复发转移癌的剂量学研究. 北京大学学报(医学版), 2017, 49(3): 506-511.
5. 姜玉良. 北京大学第三医院完成首例CT引导联合3D打印模板指导放射性粒子植入治疗腹膜后复发肿瘤. 北京大学学报(医学版), 2016, 48(1): 182.
6. Liu Q, Dai X, Zhou X, et al. Comparison of TACE combined with and without iodine-125 seeds implantation therapy for advanced stage hepatocellular carcinoma: a systematic review and meta-analysis. J BUON, 2019, 24(2): 642-649.
7. Lu J, Huang W, Wang Z, et al. The safety and efficacy of interstitial ¹²⁵I seed implantation brachytherapy for metastatic epidural spinal cord compression. J Cancer Res Ther, 2018, 14(7): 1549-1555.
8. Hertzanu Y, Ye X. A valuable guideline of radioactive ¹²⁵I seeds interstitial implantation brachytherapy for pancreatic cancer. J Cancer Res Ther, 2018, 14(7): 1453-1454.
9. 王俊杰, 庄永志. 放射性粒子近距离治疗肿瘤. 中国微创外科杂志, 2001, 1(3): 187-191.
10. 张开贤, 秦征东, 李苓, 等. CT引导¹²⁵I放射性粒子植入治疗复发性脑胶质瘤的研究. 中华肿瘤防治杂志, 2007, 14(22): 1714-1716.
11. 胡效坤, 乔志正, 梁克山, 等. CT引导下¹²⁵I放射粒子植入治疗脑内肿瘤的应用研究. 中华神经医学杂志, 2005, 4(7): 691-694.
12. Ronco C, La Manna G. Current perspectives in kidney diseases. Blood Purif, 2017, 44(4): 311-313.
13. Zhu HD, Guo JH, Zhu GY, et al. A novel biliary stent loaded with ¹²⁵I seeds in patients with malignant biliary obstruction: preliminary results versus a conventional biliary stent. J Hepatol, 2012, 56(5): 1104-1111.
14. 卓水清, 陈林, 张福君, 等. ¹²⁵I放射性粒子植入术后患者周围辐射剂量的监测. 癌症, 2007, 26(6): 666-668.
15. Schwarz SB, Thon N, Nikolajek K, et al. Iodine-125 brachytherapy for brain tumours--a review. Radiat Oncol, 2012, 7: 30.
16. Huang MW, Liu SM, Zheng L, et al. A digital model individual template and CT-guided ¹²⁵I seed implants for malignant tumors of the head and neck. J Radiat Res, 2012, 53(6): 973-977.
17. Liang Y, Wang Z, Zhang H, et al. Three-dimensional-printed individual template-guided ¹²⁵I seed implantation for the cervical lymph node metastasis: a dosimetric and security study. J Cancer Res Ther, 2018, 14(1): 30-35.
18. 姜玉良, 吉喆, 田素青, 等. CT引导下¹²⁵I粒子挽救性治疗头颈部复发/转移癌的临床疗效. 中华医学杂志, 2018, 98(45): 3686-3691.
19. 胡效坤, 彭丽静, 刘士锋, 等. 靶区和剂量控制下¹²⁵I粒子治疗颅内恶性肿瘤的再评价. 中华医学杂志, 2017, 97(19): 1457-1462.
20. Whitmore WF Jr, Hilaris B, Grabstald H. Retropubic implantation to iodine 125 in the treatment of prostatic cancer. J Urol, 1972, 108(6): 918-920.
21. 黄海锋, 汪维, 郭宏骞, 等. 125碘粒子植入术联合内分泌疗法治疗前列腺癌效果研究. 实用老年医学, 2014(10): 839-841.
22. Qu A, Jiang P, Sun H, et al. Efficacy and dosimetry analysis of image-guided radioactive ¹²⁵I seed implantation as salvage treatment for pelvic recurrent cervical cancer after external beam radiotherapy. J Gynecol Oncol, 2019, 30(1): e9.
23. 贡桔, 王忠敏, 陈克敏, 等. CT引导下经皮穿刺¹²⁵I粒子植入治疗肺癌的临床应用. 介入放射学杂志, 2009, 18(9): 677-680.
24. 吉喆, 姜玉良, 郭福新, 等. 三维打印共面坐标模板联合CT引导¹²⁵I粒子植入治疗胸部恶性肿瘤的剂量学评价. 中华核医学与分子影像杂志, 2018, 38(1): 4-8.
25. van Riet YE, Maaskant AJ, Creemers GJ, et al. Identification of residual breast tumour localization after neo-adjuvant chemotherapy using a radioactive 125 iodine seed. Eur J Surg Oncol, 2010, 36(2): 164-169.
26. Yu YH, Wei CY, Qin QH, et al. Efficacy of iodine-125 seed implantation in locoregionally recurrent and unresectable breast cancer: a retrospective study. Pathol Oncol Res, 2019, 25(1): 327-332.
27. 张颖, 林琦, 袁苑, 等. 3D打印个体化模板联合CT引导¹²⁵I粒子植入治疗胸壁转移瘤1例. 山东大学学报(医学版), 2016, 54(4): 94-96.
28. 张颖, 林琦, 袁苑, 等. 3D打印个体化模板联合CT引导¹²⁵I粒子植入治疗肿瘤术前术后剂量学比较. 山东大学学报(医学版), 2017, 55(2): 45-49.
29. 张颖, 林琦, 袁苑, 等. 3D打印个体化模板联合CT引导¹²⁵I粒子植入治疗恶性肿瘤质量评价. 山东大学学报(医学版), 2016, 54(11): 44-50.
30. Wang ZM, Liu Y, Liu FJ, et al. Clinical efficacy of CT-guided iodine-125 seed implantation therapy in patients with advanced pancreatic cancer. Eur Radiol, 2010, 20(7): 1786-1791.
31. 赵鹏, 崔红凯, 杨瑞民, 等. 放射性¹²⁵I粒子支架治疗中、晚期食管癌的疗效观察. 介入放射学杂志, 2011, 20(6): 448-451.
32. 郑家平, 邵国良, 罗君, 等. CT引导下I¹²⁵粒子组织间植入治疗难治性肝癌. 介入放射学杂志, 2015, 24(3): 260-264.
33. 王俊杰, 唐劲天, 黎功. 放射性粒子近距离治疗肿瘤. 北京: 北京医科大学出版社, 2001: 172.
34. 王俊杰. 放射性粒子治疗肿瘤临床应用规范. 北京: 北京大学医学出版社, 2011: 33.
35. Martinez-Monge R, Nag S, Nieroda CA, et al. Iodine-125 brachytherapy in the treatment of colorectal adenocarcinoma metastatic to the liver. Cancer, 1999, 85(6): 1218-1225.
36. Wang P, Shen LQ, Zhang H, et al. Quality of life after I-125 seed implantation using computed tomography and three-dimensional-printed template guidance in patients with advanced malignant tumor. J Cancer Res Ther, 2018, 14(7): 1492-1496.

West China Medical Journal

Progress in CT-guided implantation of iodine-125 seeds for malignant tumors assisted by individualized 3D template

Abstract Full text Figures/Tables Video References Cited by

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