Relationship between <i>GLUT1</i> rs3754219 single nucleotide polymorphism and genetic susceptibility to type 2 diabetes mellitus in Han population in Guangdong Province_West China Medical Journal

Authors：

YAN Yan , YANG Huihuang , HU Wei , XU Lin , WANG Shu , WANG Xingjie , XIE Yuxun , KONG Danli , PAN Haiyan , DING Yuanlin ,  YU Haibing

Department of Epidemiology and Medical Statistics, Guangdong Medical University, Dongguan, Guangdong 523808, P. R. China;

Corresponding author：

YU Haibing, Email: hby616688@gdmu.edu.cn

Keywords：

Type 2 diabetes mellitus; Single nucleotide polymorphism; GLUT1 gene

DOI：

10.7507/1002-0179.201907014

Video：

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Objective To investigate the association between single nucleotide polymorphism (SNP) rs3754219 in the glucose transporters 1 (GLUT1) gene and genetic susceptibility to type 2 diabetes mellitus (T2DM) in Han population in Guangdong Province.Methods A total of 1 092 T2DM patients (case group) and 1 092 healthy controls (control group) diagnosed or examined between November 2011 and October 2014 form 10 hospitals were enrolled in this study. SNPscan^TM SNP classification technology was used to detect the polymorphism of rs3754219 of GLUT1 genetype. Finally, 1 067 T2DM patients and 1 054 healthy controls were included, removing 37 individuals with SNP typing deletion rates >20% and 26 individucals with failed SNP site genotyping. The differences in allele frequency distribution, genotype, and genetic models between the two groups were analyzed.Results After correction for age and body mass index, there was no statistically significant difference in allele frequency or polymorphism genotype frequency of rs3754219 (P>0.05). There was no statistically significant difference between the two groups under different genetic models (P>0.05).Conclusion Genetic susceptibility to T2DM in Han population in Guangdong Province may be unrelated to the GLUT1 rs3754219 SNP.

Citation： YAN Yan, YANG Huihuang, HU Wei, XU Lin, WANG Shu, WANG Xingjie, XIE Yuxun, KONG Danli, PAN Haiyan, DING Yuanlin, YU Haibing. Relationship between GLUT1 rs3754219 single nucleotide polymorphism and genetic susceptibility to type 2 diabetes mellitus in Han population in Guangdong Province. West China Medical Journal, 2019, 34(11): 1274-1278. doi: 10.7507/1002-0179.201907014 Copy

1.	Li J, Feng JL, Wei H, et al. The aqueous extract of Gynura divaricata (L.) DC. improves glucose and lipid metabolism and ameliorates type 2 diabetes mellitus. Evid Based Complement Alternat Med, 2018, 2018(1): 1-11.
2.	Chen SC, Brooks R, Houskeeper J, et al. Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms. Mol Cell Endocrinol, 2017, 440: 57-68.
3.	Du B, Liu S, Cui C, et al. Association between glucose transporter 1 rs841853 polymorphism and type 2 diabetes mellitus risk may be population specific (1rs8418532). J Diabetes, 2013, 5(3): 291-299.
4.	Cornelis MC, Zaitlen N, Hu FB, et al. Genetic and environmental components of family history in type 2 diabetes. Hum Genet, 2015, 134(2): 259-267.
5.	Nolan CJ, Damm P, Prentki M. Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet, 2011, 378(9786): 169-181.
6.	Matsuda M, Shimomura I. Roles of adiponectin and oxidative stress in obesity-associated metabolic and cardiovascular diseases. Rev Endocr Metab Disord, 2014, 15(1): 1-10.
7.	Lian K, Guo X, Huang Q, et al. Reduction levels and the effects of high-molecular-weight adiponectin via ampk/enos in Chinese type 2 diabetes. Exp Clin Endocrinol Diabetes, 2016, 124(9): 541-547.
8.	Jaganathan R, Ravindran R, Dhanasekaran S. Emerging role of adipocytokines in type 2 diabetes as mediators of insulin resistance and cardiovascular disease. Can J Diabetes, 2018, 42(4): 446-456.e1.
9.	Su JR, Lu Zh, Su Y, et al. Relationship of serum adiponectin levels and metformin therapy in patients with type 2 diabetes. Horm Metab Res, 2016, 48(2): 92-98.
10.	Wang Y, Meng Rw, Kunutsor SK, et al. Plasma adiponectin levels and type 2 diabetes risk: a nested case-control study in a Chinese population and an updated meta-analysis. Sci Rep, 2018, 8(1): 406.
11.	徐丽英, 钟萍, 曹烨民. 脂联素与糖尿病及其并发症的关系研究. 中国医药导报, 2018, 15(28): 29-32.
12.	Mather A, Pollock C. Glucose handling by the kidney. Kidney Int, 2011, 79(120): S1-S6.
13.	Li Q, Cai Y, Huang J, et al. Resistin impairs glucose permeability in EA. hy926 cells by down-regulating GLUT1 expression. Mol Cell Endocrinol, 2016, 434: 127-134.
14.	商敏, 董旭. 胰岛素信号通路在妊娠期糖尿病患者分娩巨大儿中的作用. 临床和实验医学杂志, 2018, 17(7): 699-702.
15.	尚军洁, 董坤伦. 肥胖 2 型糖尿病患者血浆中葡萄糖转运蛋白表达及其与细胞外信号调节激酶关系的临床观察. 中国糖尿病杂志, 2015, 23(4): 323-326.
16.	李静, 张毅强, 金萨茹拉, 等. 糖尿病诊断标准再商榷. 基层医学论坛, 2018, 22(8): 1110-1111.
17.	于海兵, 闫妍, 巫舢, 等. 广东汉族人群 ADIPOQ 基因 rs266729 位点单核甘酸多态性与 2 型糖尿病遗传易感性研究. 中国糖尿病杂志, 2019, 27(7): 481-485.
18.	朱益民, 许玉洋, 凌洁. 复杂性疾病遗传研究中 Tag SNP 的筛选及其潜在功能预测. 浙江大学学报(医学版), 2011, 40(3): 237-244.
19.	Ting JC, Ye Y, Thomas GH, et al. Analysis and visualization of chromosomal abnormalities in SNP data with SNPscan. BMC bioinformatics, 2006, 7: 25.
20.	Zhang B, Zhi D, Zhang K, et al. Practical consideration of genotype imputation: sample size, window size, reference choice, and untyped rate. Stat Interface, 2011, 4(3): 339-352.
21.	Guo T, Zhu L, Tan J, et al. Promoting effect of triterpenoid compound from agrimonia pilosa ledeb on preadipocytes differentiation via up-regulation of PPARγ expression. Pharmacogn Mag, 2013, 11(41): 219-225.
22.	Hivert MF, Vassy JL, Meigs JB. Susceptibility to type 2 diabetes mellitus--from genes to prevention. Nat Rev Endocrinol, 2014, 10(4): 198-205.
23.	Varshney A, Scott LJ, Welch RP, et al. Genetic regulatory signatures underlying islet gene expression and type 2 diabetes. Proc Natl Acad Sci U S A, 2017, 114(9): 2301-2306.
24.	Lihn AS, Pedersen SB, Richelsen B. Adiponectin: action, regulation and association to insulin sensitivity. Obes Rev, 2005, 6(1): 13-21.
25.	Siokas V, Fotiadou A, Dardiotis E, et al. SLC2A1 Tag SNPs in greek patients with diabetic retinopathy and nephropathy. Ophthalmic Res, 2019, 61(1): 26-35.
26.	Stefanidis I, Kytoudis K, Papathanasiou AA, et al. XbaI GLUT1 gene polymorphism and the risk of type 2 diabetes with nephropathy. Dis Markers, 2009, 27(1): 29-35.

1. Li J, Feng JL, Wei H, et al. The aqueous extract of Gynura divaricata (L.) DC. improves glucose and lipid metabolism and ameliorates type 2 diabetes mellitus. Evid Based Complement Alternat Med, 2018, 2018(1): 1-11.
2. Chen SC, Brooks R, Houskeeper J, et al. Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms. Mol Cell Endocrinol, 2017, 440: 57-68.
3. Du B, Liu S, Cui C, et al. Association between glucose transporter 1 rs841853 polymorphism and type 2 diabetes mellitus risk may be population specific (1rs8418532). J Diabetes, 2013, 5(3): 291-299.
4. Cornelis MC, Zaitlen N, Hu FB, et al. Genetic and environmental components of family history in type 2 diabetes. Hum Genet, 2015, 134(2): 259-267.
5. Nolan CJ, Damm P, Prentki M. Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet, 2011, 378(9786): 169-181.
6. Matsuda M, Shimomura I. Roles of adiponectin and oxidative stress in obesity-associated metabolic and cardiovascular diseases. Rev Endocr Metab Disord, 2014, 15(1): 1-10.
7. Lian K, Guo X, Huang Q, et al. Reduction levels and the effects of high-molecular-weight adiponectin via ampk/enos in Chinese type 2 diabetes. Exp Clin Endocrinol Diabetes, 2016, 124(9): 541-547.
8. Jaganathan R, Ravindran R, Dhanasekaran S. Emerging role of adipocytokines in type 2 diabetes as mediators of insulin resistance and cardiovascular disease. Can J Diabetes, 2018, 42(4): 446-456.e1.
9. Su JR, Lu Zh, Su Y, et al. Relationship of serum adiponectin levels and metformin therapy in patients with type 2 diabetes. Horm Metab Res, 2016, 48(2): 92-98.
10. Wang Y, Meng Rw, Kunutsor SK, et al. Plasma adiponectin levels and type 2 diabetes risk: a nested case-control study in a Chinese population and an updated meta-analysis. Sci Rep, 2018, 8(1): 406.
11. 徐丽英, 钟萍, 曹烨民. 脂联素与糖尿病及其并发症的关系研究. 中国医药导报, 2018, 15(28): 29-32.
12. Mather A, Pollock C. Glucose handling by the kidney. Kidney Int, 2011, 79(120): S1-S6.
13. Li Q, Cai Y, Huang J, et al. Resistin impairs glucose permeability in EA. hy926 cells by down-regulating GLUT1 expression. Mol Cell Endocrinol, 2016, 434: 127-134.
14. 商敏, 董旭. 胰岛素信号通路在妊娠期糖尿病患者分娩巨大儿中的作用. 临床和实验医学杂志, 2018, 17(7): 699-702.
15. 尚军洁, 董坤伦. 肥胖 2 型糖尿病患者血浆中葡萄糖转运蛋白表达及其与细胞外信号调节激酶关系的临床观察. 中国糖尿病杂志, 2015, 23(4): 323-326.
16. 李静, 张毅强, 金萨茹拉, 等. 糖尿病诊断标准再商榷. 基层医学论坛, 2018, 22(8): 1110-1111.
17. 于海兵, 闫妍, 巫舢, 等. 广东汉族人群 ADIPOQ 基因 rs266729 位点单核甘酸多态性与 2 型糖尿病遗传易感性研究. 中国糖尿病杂志, 2019, 27(7): 481-485.
18. 朱益民, 许玉洋, 凌洁. 复杂性疾病遗传研究中 Tag SNP 的筛选及其潜在功能预测. 浙江大学学报(医学版), 2011, 40(3): 237-244.
19. Ting JC, Ye Y, Thomas GH, et al. Analysis and visualization of chromosomal abnormalities in SNP data with SNPscan. BMC bioinformatics, 2006, 7: 25.
20. Zhang B, Zhi D, Zhang K, et al. Practical consideration of genotype imputation: sample size, window size, reference choice, and untyped rate. Stat Interface, 2011, 4(3): 339-352.
21. Guo T, Zhu L, Tan J, et al. Promoting effect of triterpenoid compound from agrimonia pilosa ledeb on preadipocytes differentiation via up-regulation of PPARγ expression. Pharmacogn Mag, 2013, 11(41): 219-225.
22. Hivert MF, Vassy JL, Meigs JB. Susceptibility to type 2 diabetes mellitus--from genes to prevention. Nat Rev Endocrinol, 2014, 10(4): 198-205.
23. Varshney A, Scott LJ, Welch RP, et al. Genetic regulatory signatures underlying islet gene expression and type 2 diabetes. Proc Natl Acad Sci U S A, 2017, 114(9): 2301-2306.
24. Lihn AS, Pedersen SB, Richelsen B. Adiponectin: action, regulation and association to insulin sensitivity. Obes Rev, 2005, 6(1): 13-21.
25. Siokas V, Fotiadou A, Dardiotis E, et al. SLC2A1 Tag SNPs in greek patients with diabetic retinopathy and nephropathy. Ophthalmic Res, 2019, 61(1): 26-35.
26. Stefanidis I, Kytoudis K, Papathanasiou AA, et al. XbaI GLUT1 gene polymorphism and the risk of type 2 diabetes with nephropathy. Dis Markers, 2009, 27(1): 29-35.

West China Medical Journal

Relationship between GLUT1 rs3754219 single nucleotide polymorphism and genetic susceptibility to type 2 diabetes mellitus in Han population in Guangdong Province

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