• 1. School of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan 646000, P. R. China;
  • 2. Hyperbaric Oxygen Therapy Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, P. R. China;
  • 3. Department of Neurology, Mianyang Central Hospital, Mianyang, Sichuan 621000, P. R. China;
ZENG Xianrong, Email: 570574804@qq.com
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Objective To systematically evaluate the effect of hyperbaric oxygen therapy on delayed encephalopathy caused by carbon monoxide poisoning.Methods China National Knowledge Infrastructure, Wanfang Data, CQVIP data, China Biology Medicine Database, PubMed, Embase, and Cochrance Library were searched by computer for randomized controlled trials on hyperbaric oxygenation for delayed encephalopathy caused by carbon monoxide poisoning which were published in English or Chinese from the dates of establishment of the databases to March 31st, 2019. After literature including, excluding, and screening, RevMan 5.2 software was used to conduct a meta-analysis.Results A total of 25 studies were included, including 1 797 patients, 924 in the hyperbaric oxygen therapy group (the trial group) and 873 in the control group. The clinical effective rate [relative risk (RR)=1.24, 95% confidence interval (CI) (1.19, 1.30), P<0.000 01], the normal rate of electroencephalogram [RR=2.10, 95%CI (1.18, 3.75), P=0.01], the Mini-Mental State Examination score [standard mean difference (SMD)= 3.19, 95%CI (2.06, 4.32), P<0.000 01], and the Activities of Daily Living score [SMD=1.46, 95%CI (1.02, 1.90), P<0.000 01] were all higher in the trial group than those in the control group.Conclusion Hyperbaric oxygen therapy for delayed encephalopathy caused by carbon monoxide poisoning can improve symptoms.

Citation: WU Wei, PENG Xiaoling, YANG Bufan, ZENG Xianrong. Systematic evaluation of hyperbaric oxygen therapy for delayed encephalopathy caused by carbon monoxide poisoning. West China Medical Journal, 2019, 34(10): 1126-1133. doi: 10.7507/1002-0179.201907148 Copy

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