Influenza-associated pulmonary aspergillosis: epidemiology, diagnosis and treatment_West China Medical Journal

Authors：

TANG Jianli ^1,2 , LI Zhengtu ^1,2 ,  YE Feng ^1,2

1. Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P. R. China;
2. Guangzhou Institute of Respiratory Health, Guangzhou, Guangdong 510120, P. R. China;

Corresponding author：

YE Feng, Email: yefeng@gird.cn

Keywords：

Influenza; Pulmonary aspergillosis; Epidemiology; Diagnosis; Treatment

DOI：

10.7507/1002-0179.202001079

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Co-infection with severe influenza and bacterial is well known, but in recent years, more and more studies report that aspergillus have been identified as important pathogens, secondary only to bacteria in severe influenza. Influenza-associated aspergillus (IAA) brings a high death rate and heavy burden to our country. Therefore, early diagnosis and effective treatment are needed. In order to better understand IAA, this review summarizes the available literature on the association of IAA, including epidemiology, diagnosis and treatment.

Citation： TANG Jianli, LI Zhengtu, YE Feng. Influenza-associated pulmonary aspergillosis: epidemiology, diagnosis and treatment. West China Medical Journal, 2020, 35(1): 1-4. doi: 10.7507/1002-0179.202001079 Copy

1.	Koehler P, Bassetti M, Kochanek M, et al. Intensive care management of influenza-associated pulmonary aspergillosis. Clin Microbiol Infect, 2019, 25(12): 1501-1509.
2.	Martin-Loeches I, J Schultz M, Vincent JL, et al. Increased incidence of co-infection in critically ill patients with influenza. Intensive Care Med, 2017, 43(1): 48-58.
3.	Koch RM, Kox M, de Jonge MI, et al. Patterns in bacterial-and viral-induced immunosuppression and secondary infections in the ICU. Shock, 2017, 47(1): 5-12.
4.	Abbott JD, Fernando HV, Gurling K, et al. Pulmonary aspergillosis following post-influenzal bronchopneumonia treated with antibiotics. Br Med J, 1952, 1(4757): 523-525.
5.	Vanderbeke L, Spriet I, Breynaert C, et al. Invasive pulmonary aspergillosis complicating severe influenza: epidemiology, diagnosis and treatment. Curr Opin Infect Dis, 2018, 31(6): 471-480.
6.	Beumer MC, Koch RM, van Beuningen D, et al. Influenza virus and factors that are associated with ICU admission, pulmonary co-infections and ICU mortality. J Crit Care, 2019, 50: 59-65.
7.	Wauters J, Baar I, Meersseman P, et al. Invasive pulmonary aspergillosis is a frequent complication of critically ill H1N1 patients: a retrospective study. Intensive Care Med, 2012, 38(11): 1761-1768.
8.	Ku YH, Chan KS, Yang CC, et al. Higher mortality of severe influenza patients with probable aspergillosis than those with and without other coinfections. J Formos Med Assoc, 2017, 116(9): 660-670.
9.	Davlin SL, Blanton L, Kniss K, et al. Influenza activity-United States, 2015-16 season and composition of the 2016-17 influenza vaccine. MMWR Morb Mortal Wkly Rep, 2016, 65(22): 567-575.
10.	van de Veerdonk FL, Kolwijck E, Lestrade PP, et al. Influenza-associated aspergillosis in critically Ⅲ patients. Am J Respir Crit Care Med, 2017, 196(4): 524-527.
11.	Ullmann AJ, Aguado JM, Arikan-Akdagli S, et al. Diagnosis and management of aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline. Clin Microbiol Infect, 2018, 24(Suppl 1): e1-e38.
12.	Blot SI, Taccone FS, Van den Abeele AM, et al. A clinical algorithm to diagnose invasive pulmonary aspergillosis in critically Ⅲ patients. Am J Respir Crit Care Med, 2012, 186(1): 56-64.
13.	Lewis PA, Shope RE. Swine influenza: Ⅱ. a hemophilic bacillus from the respiratory tract of infected swine. J Exp Med, 1931, 54(3): 361-371.
14.	McCullers JA. The co-pathogenesis of influenza viruses with bacteria in the lung. Nat Rev Microbiol, 2014, 12(4): 252-262.
15.	Bermejo-Martin JF, Martin-Loeches I, Rello J, et al. Host adaptive immunity deficiency in severe pandemic influenza. Crit Care, 2010, 14(5): R167.
16.	Fox A, Le NM, Horby P, et al. Severe pandemic H1N1 2009 infection is associated with transient NK and T deficiency and aberrant CD8 responses. PLoS One, 2012, 7(2): e31535.
17.	Mauad T, Hajjar LA, Callegari GD, et al. Lung pathology in fatal novel human influenza A (H1N1) infection. Am J Respir Crit Care Med, 2010, 181(1): 72-79.
18.	Lionakis MS, Kontoyiannis DP. Glucocorticoids and invasive fungal infections. Lancet, 2003, 362(9398): 1828-1838.
19.	Walther E, Xu Z, Richter M, Kirchmair J, et al. Dual acting neuraminidase inhibitors open new opportunities to disrupt the lethal synergism between Streptococcus pneumoniae and influenza virus. Front Microbiol, 2016, 7: 357.
20.	De Pauw B, Walsh TJ, Donnelly JP, et al. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis, 2008, 46(12): 1813-1821.
21.	Cornillet A, Camus C, Nimubona S, et al. Comparison of epidemiological, clinical, and biological features of invasive aspergillosis in neutropenic and nonneutropenic patients: a 6-year survey. Clin Infect Dis, 2006, 43(5): 577-584.
22.	Vandewoude KH, Blot SI, Depuydt P, et al. Clinical relevance of Aspergillus isolation from respiratory tract samples in critically ill patients. Crit Care, 2006, 10(1): R31.
23.	国家卫生和计划生育委员会, 国家中医药管理局. 流行性感冒诊疗方案 (2018 年版). 中国感染控制杂志, 2018, 17(2): 181-184.
24.	Uyeki TM, Bernstein HH, Bradley JS, et al. Clinical practice guidelines by the infectious diseases society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenzaa. Clin Infect Dis, 2019, 68(6): e1-e47.
25.	Muthuri SG, Venkatesan S, Myles PR, et al. Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data. Lancet Respir Med, 2014, 2(5): 395-404.
26.	Duan ZP, Jia ZH, Zhang J, et al. Natural herbal medicine Lianhuaqingwen capsule anti-influenza A (H1N1) trial:a randomized, double blind, positive controlled clinical trial. Chin Med J (Engl), 2011, 124(18): 2925-2933.
27.	Rapose A. Pandemic (H1N1) 2009 virus infection: prolonged viral shedding and the role of corticosteroids. J Infect, 2012, 65(3): 281-282.
28.	刘凯雄, 瞿介明. 糖皮质激素在甲型 H1N1 流感中的应用探讨. 中国呼吸与危重监护杂志, 2010, 9(3): 226-227.
29.	Rolfes MA, Flannery B, Chung JR, et al. Effects of influenza vaccination in the United States during the 2017-2018 influenza season. Clin Infect Dis, 2019, 69(11): 1845-1853.

1. Koehler P, Bassetti M, Kochanek M, et al. Intensive care management of influenza-associated pulmonary aspergillosis. Clin Microbiol Infect, 2019, 25(12): 1501-1509.
2. Martin-Loeches I, J Schultz M, Vincent JL, et al. Increased incidence of co-infection in critically ill patients with influenza. Intensive Care Med, 2017, 43(1): 48-58.
3. Koch RM, Kox M, de Jonge MI, et al. Patterns in bacterial-and viral-induced immunosuppression and secondary infections in the ICU. Shock, 2017, 47(1): 5-12.
4. Abbott JD, Fernando HV, Gurling K, et al. Pulmonary aspergillosis following post-influenzal bronchopneumonia treated with antibiotics. Br Med J, 1952, 1(4757): 523-525.
5. Vanderbeke L, Spriet I, Breynaert C, et al. Invasive pulmonary aspergillosis complicating severe influenza: epidemiology, diagnosis and treatment. Curr Opin Infect Dis, 2018, 31(6): 471-480.
6. Beumer MC, Koch RM, van Beuningen D, et al. Influenza virus and factors that are associated with ICU admission, pulmonary co-infections and ICU mortality. J Crit Care, 2019, 50: 59-65.
7. Wauters J, Baar I, Meersseman P, et al. Invasive pulmonary aspergillosis is a frequent complication of critically ill H1N1 patients: a retrospective study. Intensive Care Med, 2012, 38(11): 1761-1768.
8. Ku YH, Chan KS, Yang CC, et al. Higher mortality of severe influenza patients with probable aspergillosis than those with and without other coinfections. J Formos Med Assoc, 2017, 116(9): 660-670.
9. Davlin SL, Blanton L, Kniss K, et al. Influenza activity-United States, 2015-16 season and composition of the 2016-17 influenza vaccine. MMWR Morb Mortal Wkly Rep, 2016, 65(22): 567-575.
10. van de Veerdonk FL, Kolwijck E, Lestrade PP, et al. Influenza-associated aspergillosis in critically Ⅲ patients. Am J Respir Crit Care Med, 2017, 196(4): 524-527.
11. Ullmann AJ, Aguado JM, Arikan-Akdagli S, et al. Diagnosis and management of aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline. Clin Microbiol Infect, 2018, 24(Suppl 1): e1-e38.
12. Blot SI, Taccone FS, Van den Abeele AM, et al. A clinical algorithm to diagnose invasive pulmonary aspergillosis in critically Ⅲ patients. Am J Respir Crit Care Med, 2012, 186(1): 56-64.
13. Lewis PA, Shope RE. Swine influenza: Ⅱ. a hemophilic bacillus from the respiratory tract of infected swine. J Exp Med, 1931, 54(3): 361-371.
14. McCullers JA. The co-pathogenesis of influenza viruses with bacteria in the lung. Nat Rev Microbiol, 2014, 12(4): 252-262.
15. Bermejo-Martin JF, Martin-Loeches I, Rello J, et al. Host adaptive immunity deficiency in severe pandemic influenza. Crit Care, 2010, 14(5): R167.
16. Fox A, Le NM, Horby P, et al. Severe pandemic H1N1 2009 infection is associated with transient NK and T deficiency and aberrant CD8 responses. PLoS One, 2012, 7(2): e31535.
17. Mauad T, Hajjar LA, Callegari GD, et al. Lung pathology in fatal novel human influenza A (H1N1) infection. Am J Respir Crit Care Med, 2010, 181(1): 72-79.
18. Lionakis MS, Kontoyiannis DP. Glucocorticoids and invasive fungal infections. Lancet, 2003, 362(9398): 1828-1838.
19. Walther E, Xu Z, Richter M, Kirchmair J, et al. Dual acting neuraminidase inhibitors open new opportunities to disrupt the lethal synergism between Streptococcus pneumoniae and influenza virus. Front Microbiol, 2016, 7: 357.
20. De Pauw B, Walsh TJ, Donnelly JP, et al. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis, 2008, 46(12): 1813-1821.
21. Cornillet A, Camus C, Nimubona S, et al. Comparison of epidemiological, clinical, and biological features of invasive aspergillosis in neutropenic and nonneutropenic patients: a 6-year survey. Clin Infect Dis, 2006, 43(5): 577-584.
22. Vandewoude KH, Blot SI, Depuydt P, et al. Clinical relevance of Aspergillus isolation from respiratory tract samples in critically ill patients. Crit Care, 2006, 10(1): R31.
23. 国家卫生和计划生育委员会, 国家中医药管理局. 流行性感冒诊疗方案 (2018 年版). 中国感染控制杂志, 2018, 17(2): 181-184.
24. Uyeki TM, Bernstein HH, Bradley JS, et al. Clinical practice guidelines by the infectious diseases society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenzaa. Clin Infect Dis, 2019, 68(6): e1-e47.
25. Muthuri SG, Venkatesan S, Myles PR, et al. Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data. Lancet Respir Med, 2014, 2(5): 395-404.
26. Duan ZP, Jia ZH, Zhang J, et al. Natural herbal medicine Lianhuaqingwen capsule anti-influenza A (H1N1) trial:a randomized, double blind, positive controlled clinical trial. Chin Med J (Engl), 2011, 124(18): 2925-2933.
27. Rapose A. Pandemic (H1N1) 2009 virus infection: prolonged viral shedding and the role of corticosteroids. J Infect, 2012, 65(3): 281-282.
28. 刘凯雄, 瞿介明. 糖皮质激素在甲型 H1N1 流感中的应用探讨. 中国呼吸与危重监护杂志, 2010, 9(3): 226-227.
29. Rolfes MA, Flannery B, Chung JR, et al. Effects of influenza vaccination in the United States during the 2017-2018 influenza season. Clin Infect Dis, 2019, 69(11): 1845-1853.

Next Article
Advances in the application of radiotherapy for bladder preservation in muscle-invasive bladder cancer

West China Medical Journal

Influenza-associated pulmonary aspergillosis: epidemiology, diagnosis and treatment

Abstract Full text Figures/Tables Video References Cited by

Next Article

Format

Content