Advance in rehabilitation of motor dysfunction in individuals with stroke_West China Medical Journal

Authors：

CHEN Yi ^1,2 ,  GAO Qiang ^1,2

1. Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

GAO Qiang, Email: gaoqiang_hxkf@163.com

Keywords：

Stroke; rehabilitation; motor dysfunction; research progress

DOI：

10.7507/1002-0179.202002352

Video：

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Abstract Full text Figures/Tables Video References Cited by

Serious motor dysfunction is the leading cause of disability in individuals with stroke. Rehabilitation is the most effective intervention. Taking “stroke” “cerebrovascular accident” “rehabilitation” “motor dysfunction” and other key words, the relevant studies published from January 2015 to January 2020 were searched in Web of Science database to explore the advance in rehabilitation of motor dysfunction in individuals with stroke based on basic and clinical researches. Basic researches mainly focused on the mechanism of neural plasticity, neural loop and various intervention measures, and clinical researches mainly focused on novel rehabilitation intervention technologies for motor dysfunction in individuals with stroke. In addition, mechanism and rehabilitation are still two hotpots in the field of the disease. This paper reviews the search results in order to provide reference for subsequent relevant clinical work and scientific research.

Citation： CHEN Yi, GAO Qiang. Advance in rehabilitation of motor dysfunction in individuals with stroke. West China Medical Journal, 2022, 37(5): 757-764. doi: 10.7507/1002-0179.202002352 Copy

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1. Powers WJ, Rabinstein AA, Ackerson T, et al. 2018 guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 2018, 49(3): e46-e110.
2. Winstein CJ, Stein J, Arena R, et al. Guidelines for adult stroke rehabilitation and recovery: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 2016, 47(6): e98-e169.
3. Feigin VL, Norrving B, Mensah GA. Global burden of stroke. Circ Res, 2017, 120(3): 439-448.
4. GBD 2017 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2018, 392(10159): 1859-1922.
5. Krishnamurthi RV, Feigin VL, Forouzanfar MH, et al. Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990-2010: findings from the global burden of disease study 2010. Lancet Global health, 2013, 1(5): e259-e281.
6. Wang W, Jiang B, Sun H, et al. Prevalence, incidence, and mortality of stroke in china: results from a nationwide population-based survey of 480 687 adults. Circulation, 2017, 135(8): 759-771.
7. Esquiva G, Grayston A, Rosell A. Revascularization and endothelial progenitor cells in stroke. Am J Physiol Cell Physiol, 2018, 315(5): C664-C674.
8. Gouveia A, Seegobin M, Kannangara TS, et al. The aPKC-CBP pathway regulates post-stroke neurovascular remodeling and functional recovery. Stem Cell Reports, 2017, 9(6): 1735-1744.
9. Cai H, Ma Y, Jiang L, et al. Hypoxia response element-regulated MMP-9 promotes neurological recovery via glial scar degradation and angiogenesis in delayed stroke. Mol Ther, 2017, 25(6): 1448-1459.
10. Shen SW, Duan CL, Chen XH, et al. Neurogenic effect of VEGF is related to increase of astrocytes transdifferentiation into new mature neurons in rat brains after stroke. Neuropharmacology, 2016, 108: 451-461.
11. Kim SY, Hsu JE, Husbands LC, et al. Coordinated plasticity of synapses and astrocytes underlies practice-driven functional vicariation in peri-infarct motor cortex. J Neurosci, 2018, 38(1): 93-107.
12. Kim SY, Allred RP, Adkins DL, et al. Experience with the “good” limb induces aberrant synaptic plasticity in the perilesion cortex after stroke. J Neurosci, 2015, 35(22): 8604-8610.
13. Blanco W, Bertram R, Tabak J. The effects of GABAergic polarity changes on episodic neural network activity in developing neural systems. Front Comput Neurosci, 2017, 11: 88.
14. Silva A, Vaughan-Graham J, Silva C, et al. Stroke rehabilitation and research: consideration of the role of the cortico-reticulospinal system. Somatosens Mot Res, 2018, 35(2): 148-152.
15. Okabe N, Himi N, Maruyama-Nakamura E, et al. Rehabilitative skilled forelimb training enhances axonal remodeling in the corticospinal pathway but not the brainstem-spinal pathways after photothrombotic stroke in the primary motor cortex. PLoS One, 2017, 12(11): e0187413.
16. Li S, Chen YT, Francisco GE, et al. A unifying pathophysiological account for post-stroke spasticity and disordered motor control. Front Neurol, 2019, 10: 468.
17. Tian R, Wang S. Electroacupuncture reduced apoptosis of hippocampal neurons in mice with cerebral infarction by regulating the Notch3 signaling pathway. J Mol Neurosci, 2019, 67(3): 456-466.
18. Xing Y, Yang SD, Wang MM, et al. Electroacupuncture alleviated neuronal apoptosis following ischemic stroke in rats via midkine and ERK/JNK/p38 signaling pathway. J Mol Neurosci, 2018, 66(1): 26-36.
19. Xing Y, Wang MM, Feng YS, et al. Possible involvement of PTEN signaling pathway in the anti-apoptotic effect of electroacupuncture following ischemic stroke in rats. Cell Mol Neurobiol, 2018, 38(8): 1453-1463.
20. Liu J, Wang Q, Yang S, et al. Electroacupuncture inhibits apoptosis of peri-ischemic regions via modulating p38, extracellular signal-regulated kinase (ERK1/2), and c-Jun N terminal kinases (JNK) in cerebral ischemia-reperfusion-injured rats. Med Sci Monit, 2018, 24: 4395-4404.
21. 印婷, 陈海萍, 汪文, 等. 电针预处理对急性脑梗死大鼠神经功能损伤及大脑皮层 Cx 43 蛋白表达的影响. 针刺研究, 2019, 44(7): 497-500.
22. Xie G, Song C, Lin X, et al. Electroacupuncture regulates hippocampal synaptic plasticity via inhibiting Janus-activated kinase 2/signal transducer and activator of transcription 3 signaling in cerebral ischemic rats. J Stroke Cerebrovasc Dis, 2019, 28(3): 792-799.
23. Ahn SM, Kim YR, Shin YI, et al. Therapeutic potential of a combination of electroacupuncture and TrkB-expressing mesenchymal stem cells for ischemic stroke. Mol Neurobiol, 2019, 56(1): 157-173.
24. Kim YR, Ahn SM, Pak ME, et al. Potential benefits of mesenchymal stem cells and electroacupuncture on the trophic factors associated with neurogenesis in mice with ischemic stroke. Sci Rep, 2018, 8(1): 2044.
25. Yu Q, Li XH, Jiang W, et al. Combined effects of electroacupuncture and behavioral training on learning-memory ability and event-related potential P300 in rats with mid/advanced cerebral infarction. Chin Med J (Engl), 2018, 131(18): 2172-2178.
26. Zhang Y, Mao X, Lin R, et al. Electroacupuncture ameliorates cognitive impairment through inhibition of Ca²⁺-mediated neurotoxicity in a rat model of cerebral ischaemia-reperfusion injury. Acupunct Med, 2018, 36(6): 401-407.
27. Chi L, Du K, Liu D, et al. Electroacupuncture brain protection during ischemic stroke: a role for the parasympathetic nervous system. J Cereb Blood Flow Metab, 2018, 38(3): 479-491.
28. El Amki M, Baumgartner P, Bracko O, et al. Task-specific motor rehabilitation therapy after stroke improves performance in a different motor task: translational evidence. Transl Stroke Res, 2017, 8(4): 347-350.
29. Tennant KA, Kerr AL, Adkins DL, et al. Age-dependent reorganization of peri-infarct “premotor” cortex with task-specific rehabilitative training in mice. Neurorehabil Neural Repair, 2015, 29(2): 193-202.
30. Choi IA, Lee CS, Kim HY, et al. Effect of inhibition of dna methylation combined with task-specific training on chronic stroke recovery. Int J Mol Sci, 2018, 19(7): 2019.
31. Nesin SM, Sabitha KR, Gupta A, et al. Constraint induced movement therapy as a rehabilitative strategy for ischemic stroke-linking neural plasticity with restoration of skilled movements. J Stroke Cerebrovasc Dis, 2019, 28(6): 1640-1653.
32. Okabe N, Himi N, Nakamura-Maruyama E, et al. Constraint-induced movement therapy improves efficacy of task-specific training after severe cortical stroke depending on the ipsilesional corticospinal projections. Exp Neurol, 2018, 305: 108-120.
33. Nie J, Yang X, Tang Q, et al. Willed-movement training reduces brain damage and enhances synaptic plasticity related proteins synthesis after focal ischemia. Brain Res Bull, 2016, 120: 90-96.
34. Nishioka R, Sugimoto K, Aono H, et al. Treadmill exercise ameliorates ischemia-induced brain edema while suppressing Na⁺/H⁺ exchanger 1 expression. Exp Neurol, 2016, 277: 150-161.
35. Li C, Wen H, Wang Q, et al. Exercise training inhibits the Nogo-A/NgR1/Rho-A signals in the cortical peri-infarct area in hypertensive stroke rats. Am J Phys Med Rehabil, 2015, 94(12): 1083-1094.
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West China Medical Journal

Advance in rehabilitation of motor dysfunction in individuals with stroke

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