Analysis of current status of immunonutrition research in China based on Chinese databases_West China Medical Journal

Authors：

ZHANG Xingxia ¹ , CHEN Xinrong ² , HU Yanjie ² ,  LI Ka ²

1. Organization Department, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. West China School of Nursing, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

LI Ka, Email: lika127@126.com

Keywords：

Immunonutrition; bibliometrics; Chinese databases

DOI：

10.7507/1002-0179.202006122

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Objective To analyze the research status of immunonutrition in China based on Chinese databases, and to provide a reference for clinical practice and future research. Methods Literatures about the application of immunonutrition in nutrition support were searched in China National Knowledge Infrastructure, SinoMed, Chongqing VIP and Wanfang databases using bibliometrics methods. The retrieval time was up to August 2022, and the document characteristics such as the number of publications, the institutions and the citation frequency and other features were analyzed. Results A total of 725 literatures were included, with the highest number of literatures issued in 2015 and 2020, both 62. The areas with the most published literatures were Jiangsu (10.6%) and Guangdong (8.4%). The institutions with the most published literatures were General Hospital of Eastern Theater Command (4.8%) and West China Hospital of Sichuan University (3.9%). There were 78 dissertations and 647 journal articles in total. The most published journal was Parenteral & Enteral Nutrition (6.5%). The top three citations were all reviews. The degree of cooperation was 2.7, and the co-authorship rate was 70.1%. A total of 121 articles reported the supporting funds and projects. The research types included 499 original studies (68.8%) and 226 secondary studies (31.2%). The analysis of the subjects showed that immunonutrition was mostly applied to gastrointestinal diseases, especially gastrointestinal cancer patients, accounting for 42.5%. Nutritional support was divided into enteral nutrition and parenteral nutrition. Enteral nutrition was adopted in most literatures, accounting for 88.4%. Conclusions The research content of immunonutrition in Chinese database in China is relatively simple. Most of them focus on the comparison between immunonutrition and general nutrition support. The selection of immune nutrients and the application of immunonutrition in critically ill patients such as sepsis need further research.

Citation： ZHANG Xingxia, CHEN Xinrong, HU Yanjie, LI Ka. Analysis of current status of immunonutrition research in China based on Chinese databases. West China Medical Journal, 2023, 38(1): 65-71. doi: 10.7507/1002-0179.202006122 Copy

1.	Calder PC. Immunonutrition in surgical and critically ill patients. Br J Nutr, 2007, 98(Suppl 1): S133-S139.
2.	崔久嵬, 卓文磊, 黄岚, 等. 肿瘤免疫营养治疗指南. 肿瘤代谢与营养电子杂志, 2020, 7(2): 160-168.
3.	Cheng Y, Zhang J, Zhang L, et al. Enteral immunonutrition versus enteral nutrition for gastric cancer patients undergoing a total gastrectomy: a systematic review and meta-analysis. BMC Gastroenterol, 2018, 18(1): 11.
4.	Daly JM, Lieberman MD, Goldfine J, et al. Enteral nutrition with supplemental arginine, RNA, and omega-3 fatty acids in patients after operation: immunologic, metabolic, and clinical outcome. Surgery, 1992, 112(1): 56-67.
5.	Pilotto S, Agustoni F, Morelli AM, et al. Nutritional support in lung cancer: time to combine immunonutrition with immunotherapy?. Nutrition, 2022, 98: 111637.
6.	Probst P, Ohmann S, Klaiber U, et al. Meta-analysis of immunonutrition in major abdominal surgery. Br J Surg, 2017, 104(12): 1594-1608.
7.	Heyland DK, Novak F, Drover JW, et al. Should immunonutrition become routine in critically ill patients? A systematic review of the evidence. JAMA, 2001, 286(8): 944-953.
8.	彭俊生, 王吉甫, 王颀. 精氨酸强化全肠外营养的免疫恢复作用研究. 中国临床营养杂志, 1997(3): 112-115.
9.	黎介寿. 临床营养支持的发展趋势. 肠外与肠内营养, 2010, 17(1): 1-4.
10.	黎介寿. 危重病人与免疫营养. 肠外与肠内营养, 2001(3): 127-128.
11.	李宁, 黎介寿. 外科营养近 20 年的进展与展望. 中国实用外科杂志, 2002, 22(1): 6-8.
12.	江志伟, 李宁, 刘福坤, 等. 肠内免疫营养对胃癌手术病人免疫功能和急性炎性反应的调理作用. 肠外与肠内营养, 2000, 7(4): 200-203.
13.	李宁. 临床营养的新概念: 免疫营养. 中国实用外科杂志, 2001, 21(1): 7-9.
14.	李小好, 尚桂莲, 周志斌, 等. 早期免疫肠内营养支持对重症脑卒中患者营养状况和免疫功能以及预后的影响. 中国全科医学, 2012, 15(26): 3006-3008.
15.	李幼生, 黎介寿. 围手术期肠内营养支持. 实用临床医药杂志, 2004, 8(5): 1-5.
16.	陈亚军, 齐玉梅. 精氨酸免疫营养作用的研究进展. 中国临床营养杂志, 2007, 15(5): 310-314.
17.	许剑民, 何连齐, 吴新华, 等. 胃肠道肿瘤患者术前肠内免疫营养支持. 中华消化杂志, 2005, 25(1): 19-22.
18.	蒋小华, 李宁, 朱维铭, 等. 肠内免疫营养对手术创伤后机体免疫、炎症反应及预后的影响. 中国实用外科杂志, 2004, 24(1): 43-46.
19.	崔久嵬, 卓文磊, 黄岚, 等. 肿瘤免疫营养治疗指南. 肿瘤代谢与营养电子杂志, 2016, 3(4): 224-228.
20.	Fan M, Wang Q, Fang W, et al. Early enteral combined with parenteral nutrition treatment for severe traumatic brain injury: effects on immune function, nutritional status and outcomes. Chin Med Sci J, 2016, 31(4): 213-220.
21.	Kaźmierczak-Siedlecka K, Daca A, Folwarski M, et al. Immunonutritional support as an important part of multidisciplinary anti-cancer therapy. Cent Eur J Immunol, 2020, 45(4): 454-460.
22.	庞增粉, 刘玉萍, 李灵娟. 肠内免疫营养与全素营养疗法在胃肠道肿瘤患者术后护理中的应用. 齐鲁护理杂志, 2019, 25(2): 58-60.
23.	熊睿, 汪晓泊, 殷生芝, 等. 免疫营养素强化的肠内营养治疗对创伤危重患者免疫功能及临床结局的影响. 中国医药, 2018, 13(1): 99-103.
24.	马春剑. 早期免疫肠内营养对重症急性胰腺炎患者免疫功能及炎性反应的影响. 中国医学前沿杂志(电子版), 2018, 10(6): 151-155.
25.	范士元. 肠内免疫营养与全素营养疗法在胃肠道肿瘤患者术后护理中的应用效果对比. 中国当代医药, 2016, 23(33): 174-176.
26.	Slim K, Badon F, Vacheron CH, et al. Umbrella review of the efficacy of perioperative immunonutrition in visceral surgery. Clin Nutr ESPEN, 2022, 48: 99-108.
27.	王蕾, 张颖, 王立彬, 等. 肠内免疫营养在胃肠道肿瘤围手术期的临床应用. 中华临床医师杂志(电子版), 2020, 14(6): 465-468.
28.	林勇军, 熊滨, 林忠文. 免疫营养支持治疗对早期脓毒症患者的作用研究. 广西医学, 2017, 39(8): 1242-1245.
29.	Arends J, Bachmann P, Baracos V, et al. ESPEN guidelines on nutrition in cancer patients. Clin Nutr, 2017, 36(1): 11-48.
30.	Weimann A, Braga M, Carli F, et al. ESPEN guideline: clinical nutrition in surgery. Clin Nutr, 2017, 36(3): 623-650.
31.	郭志学, 葛长青, 刘博, 等. 肝癌术后早期不同免疫增强型营养支持方式的治疗效果比较. 河北医药, 2017, 39(17): 2589-2592, 2596.
32.	谢琦, 金慧成, 贾忠, 等. 胃癌全胃切除患者围术期两种免疫营养支持治疗的临床比较. 浙江医学, 2015, 34(6): 484-487.
33.	邱小文. 肠内免疫增强型营养对肺癌化疗患者的影响及护理. 解放军护理杂志, 2004, 21(3): 14-16.
34.	Yang J, Zhang X, Li K, et al. Effects of EN combined with PN enriched with n-3 polyunsaturated fatty acids on immune related indicators and early rehabilitation of patients with gastric cancer: a randomized controlled trial. Clin Nutr, 2022, 41(6): 1163-1170.
35.	刘邦伦, 田旭, 陈伟庆. 不同肠内免疫营养方案对胃癌术后患者临床结局影响的网状 Meta 分析. 临床与病理杂志, 2018, 38(9): 1921-1934.
36.	Prieto I, Montemuiño S, Luna J, et al. The role of immunonutritional support in cancer treatment: Current evidence. Clin Nutr, 2017, 36(6): 1457-1464.
37.	Belsky JB, Wira CR, Jacob V, et al. A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D. Nutr Res Rev, 2018, 31(2): 281-290.
38.	Boisramé-Helms J, Meyer G, Degirmenci SE, et al. “Immunonutrition” has failed to improve peritonitis-induced septic shock in rodents. PLoS One, 2016, 11(1): e0147644.

1. Calder PC. Immunonutrition in surgical and critically ill patients. Br J Nutr, 2007, 98(Suppl 1): S133-S139.
2. 崔久嵬, 卓文磊, 黄岚, 等. 肿瘤免疫营养治疗指南. 肿瘤代谢与营养电子杂志, 2020, 7(2): 160-168.
3. Cheng Y, Zhang J, Zhang L, et al. Enteral immunonutrition versus enteral nutrition for gastric cancer patients undergoing a total gastrectomy: a systematic review and meta-analysis. BMC Gastroenterol, 2018, 18(1): 11.
4. Daly JM, Lieberman MD, Goldfine J, et al. Enteral nutrition with supplemental arginine, RNA, and omega-3 fatty acids in patients after operation: immunologic, metabolic, and clinical outcome. Surgery, 1992, 112(1): 56-67.
5. Pilotto S, Agustoni F, Morelli AM, et al. Nutritional support in lung cancer: time to combine immunonutrition with immunotherapy?. Nutrition, 2022, 98: 111637.
6. Probst P, Ohmann S, Klaiber U, et al. Meta-analysis of immunonutrition in major abdominal surgery. Br J Surg, 2017, 104(12): 1594-1608.
7. Heyland DK, Novak F, Drover JW, et al. Should immunonutrition become routine in critically ill patients? A systematic review of the evidence. JAMA, 2001, 286(8): 944-953.
8. 彭俊生, 王吉甫, 王颀. 精氨酸强化全肠外营养的免疫恢复作用研究. 中国临床营养杂志, 1997(3): 112-115.
9. 黎介寿. 临床营养支持的发展趋势. 肠外与肠内营养, 2010, 17(1): 1-4.
10. 黎介寿. 危重病人与免疫营养. 肠外与肠内营养, 2001(3): 127-128.
11. 李宁, 黎介寿. 外科营养近 20 年的进展与展望. 中国实用外科杂志, 2002, 22(1): 6-8.
12. 江志伟, 李宁, 刘福坤, 等. 肠内免疫营养对胃癌手术病人免疫功能和急性炎性反应的调理作用. 肠外与肠内营养, 2000, 7(4): 200-203.
13. 李宁. 临床营养的新概念: 免疫营养. 中国实用外科杂志, 2001, 21(1): 7-9.
14. 李小好, 尚桂莲, 周志斌, 等. 早期免疫肠内营养支持对重症脑卒中患者营养状况和免疫功能以及预后的影响. 中国全科医学, 2012, 15(26): 3006-3008.
15. 李幼生, 黎介寿. 围手术期肠内营养支持. 实用临床医药杂志, 2004, 8(5): 1-5.
16. 陈亚军, 齐玉梅. 精氨酸免疫营养作用的研究进展. 中国临床营养杂志, 2007, 15(5): 310-314.
17. 许剑民, 何连齐, 吴新华, 等. 胃肠道肿瘤患者术前肠内免疫营养支持. 中华消化杂志, 2005, 25(1): 19-22.
18. 蒋小华, 李宁, 朱维铭, 等. 肠内免疫营养对手术创伤后机体免疫、炎症反应及预后的影响. 中国实用外科杂志, 2004, 24(1): 43-46.
19. 崔久嵬, 卓文磊, 黄岚, 等. 肿瘤免疫营养治疗指南. 肿瘤代谢与营养电子杂志, 2016, 3(4): 224-228.
20. Fan M, Wang Q, Fang W, et al. Early enteral combined with parenteral nutrition treatment for severe traumatic brain injury: effects on immune function, nutritional status and outcomes. Chin Med Sci J, 2016, 31(4): 213-220.
21. Kaźmierczak-Siedlecka K, Daca A, Folwarski M, et al. Immunonutritional support as an important part of multidisciplinary anti-cancer therapy. Cent Eur J Immunol, 2020, 45(4): 454-460.
22. 庞增粉, 刘玉萍, 李灵娟. 肠内免疫营养与全素营养疗法在胃肠道肿瘤患者术后护理中的应用. 齐鲁护理杂志, 2019, 25(2): 58-60.
23. 熊睿, 汪晓泊, 殷生芝, 等. 免疫营养素强化的肠内营养治疗对创伤危重患者免疫功能及临床结局的影响. 中国医药, 2018, 13(1): 99-103.
24. 马春剑. 早期免疫肠内营养对重症急性胰腺炎患者免疫功能及炎性反应的影响. 中国医学前沿杂志(电子版), 2018, 10(6): 151-155.
25. 范士元. 肠内免疫营养与全素营养疗法在胃肠道肿瘤患者术后护理中的应用效果对比. 中国当代医药, 2016, 23(33): 174-176.
26. Slim K, Badon F, Vacheron CH, et al. Umbrella review of the efficacy of perioperative immunonutrition in visceral surgery. Clin Nutr ESPEN, 2022, 48: 99-108.
27. 王蕾, 张颖, 王立彬, 等. 肠内免疫营养在胃肠道肿瘤围手术期的临床应用. 中华临床医师杂志(电子版), 2020, 14(6): 465-468.
28. 林勇军, 熊滨, 林忠文. 免疫营养支持治疗对早期脓毒症患者的作用研究. 广西医学, 2017, 39(8): 1242-1245.
29. Arends J, Bachmann P, Baracos V, et al. ESPEN guidelines on nutrition in cancer patients. Clin Nutr, 2017, 36(1): 11-48.
30. Weimann A, Braga M, Carli F, et al. ESPEN guideline: clinical nutrition in surgery. Clin Nutr, 2017, 36(3): 623-650.
31. 郭志学, 葛长青, 刘博, 等. 肝癌术后早期不同免疫增强型营养支持方式的治疗效果比较. 河北医药, 2017, 39(17): 2589-2592, 2596.
32. 谢琦, 金慧成, 贾忠, 等. 胃癌全胃切除患者围术期两种免疫营养支持治疗的临床比较. 浙江医学, 2015, 34(6): 484-487.
33. 邱小文. 肠内免疫增强型营养对肺癌化疗患者的影响及护理. 解放军护理杂志, 2004, 21(3): 14-16.
34. Yang J, Zhang X, Li K, et al. Effects of EN combined with PN enriched with n-3 polyunsaturated fatty acids on immune related indicators and early rehabilitation of patients with gastric cancer: a randomized controlled trial. Clin Nutr, 2022, 41(6): 1163-1170.
35. 刘邦伦, 田旭, 陈伟庆. 不同肠内免疫营养方案对胃癌术后患者临床结局影响的网状 Meta 分析. 临床与病理杂志, 2018, 38(9): 1921-1934.
36. Prieto I, Montemuiño S, Luna J, et al. The role of immunonutritional support in cancer treatment: Current evidence. Clin Nutr, 2017, 36(6): 1457-1464.
37. Belsky JB, Wira CR, Jacob V, et al. A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D. Nutr Res Rev, 2018, 31(2): 281-290.
38. Boisramé-Helms J, Meyer G, Degirmenci SE, et al. “Immunonutrition” has failed to improve peritonitis-induced septic shock in rodents. PLoS One, 2016, 11(1): e0147644.

West China Medical Journal

Analysis of current status of immunonutrition research in China based on Chinese databases

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