Correlation analysis between platelet-related parameters and inflammatory indicators in patients with acute pancreatitis_West China Medical Journal

Authors：

FU Yang , ZHANG Qi , LI Mengyu , MIAO Qiang , WEI Bin , JIANG Hong ,  NIU Qian

Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

NIU Qian, Email: niuqian991@126.com

Keywords：

Acute pancreatitis; Platelet-related parameters; Immature platelet fraction; Inflammatory indicators

DOI：

10.7507/1002-0179.202006249

Video：

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Objective To find out the diagnostic power and correlation between platelet-related parameters and inflammatory indicators in acute pancreatitis patients with different severity.Methods A total of 88 patients with acute pancreatitis diagnosed in West China Hospital of Sichuan University from January 2019 to August 2019 were enrolled in the retrospective study, including 58 mild acute pancreatitis patients and 30 severe acute pancreatitis patients. The patients’ platelet-related parameters and inflammatory indicators were collected. The platelet parameters and inflammatory indicators in different severity acute pancreatitis groups were compared and the diagnostic power and correlation were analyzed.Results The platelet count and plateletcrit of the severe group were lower than those of the mild group, the difference was statistically significant (Z=–5.502, –3.673; P<0.001). The immature platelet fraction, platelet distribution width, mean platelet volume and platelet-large cell ratio levels of the severe group were higher than those of the mild group (Z=–4.217, –2.998, –3.754, –3.816; P<0.05). Platelet-related parameters platelet count, immature platelet fraction, platelet distribution width, mean platelet volume, platelet-large cell ratio, plateletcrit and inflammatory indicators procalcitonin, interleukin-6 showed good diagnostic power with areas under under receiver operating characteristic curves greater than 0.75 in differentiating the severity of acute pancreatitis. Correlation analysis showed that immature platelet fraction was positively correlated with procalcitonin and interleukin-6 levels in patients with acute pancreatitis (r_s=0.457, 0.385; P<0.05).Conclusions Immature platelet fraction is correlated with the severity of acute pancreatitis, and positively correlated with the levels of inflammatory indicators procalcitonin and interleukin-6.

Citation： FU Yang, ZHANG Qi, LI Mengyu, MIAO Qiang, WEI Bin, JIANG Hong, NIU Qian. Correlation analysis between platelet-related parameters and inflammatory indicators in patients with acute pancreatitis. West China Medical Journal, 2020, 35(8): 943-947. doi: 10.7507/1002-0179.202006249 Copy

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11.	金爽, 许智利, 陈建时. 急性胰腺炎患者早期凝血功能及血管内皮功能检测及临床意义. 中国中西医结合消化杂志, 2019, 27(3): 215-218, 223.
12.	周仁伟, 刘鹏军. PDW、PLT、MPV 及 BISAP 评分对急性胰腺炎病情程度的预测价值. 热带医学杂志, 2017, 17(11): 1490-1493.
13.	陈国胜, 薛绮萍, 许海尘, 等. 乌司他丁对老年中重度急性胰腺炎患者血小板参数的影响. 胃肠病学, 2014, 19(11): 678-681.
14.	戴庆忠, 覃瑜. 急性胰腺炎患者凝血指标变化的临床研究. 国际检验医学杂志, 2014, 35(18): 2563-2564.
15.	Kaur M, Nibhoria S, Tiwana K, <italic>et al</italic>. Rapid transformation of chronic lymphocytic leukemia to acute lymphoblastic leukemia: a rare case report. J Basic Clin Pharm, 2016, 7(2): 60-63.
16.	张红松, 冯芳, 付丽彬, 等. 不同炎性因子对重症急性胰腺炎的预测价值研究. 中国全科医学, 2017, 20(25): 3127-3131.
17.	Liang Y, Zhao X, Meng F. Procalcitonin, C-reactive protein, and neutrophil ratio contribute to the diagnosis and prognosis of severe acute pancreatitis. Iran J Public Health, 2019, 48(12): 2177-2186.

1. 殷跃文, 袁诚. 急性胰腺炎患者凝血功能指标改变的临床意义. 实用临床医药杂志, 2014, 18(15): 150-152.
2. 尹连杰, 徐英军, 王乃存. 急性胰腺炎血清降钙素原与血小板平均体积检测临床价值探讨. 国际检验医学杂志, 2018, 39(2): 240-243.
3. Yadav J, Yadav SK, Kumar S, <italic>et al</italic>. Predicting morbidity and mortality in acute pancreatitis in an Indian population: a comparative study of the BISAP score, Ranson’s score and CT severity index. Gastroenterol Rep (Oxf), 2016, 4(3): 216-220.
4. 常建同, 纪宗正, 白郑海, 等. 急性胰腺炎血浆 D-二聚体和纤维蛋白(原)降解产物的动态变化及意义. 临床外科杂志, 2014, 22(2): 108-110.
5. van der Linden N, Klinkenberg LJ, Meex SJ, <italic>et al</italic>. Immature platelet fraction measured on the Sysmex XN hemocytometer predicts thrombopoietic recovery after autologous stem cell transplantation. Eur J Haematol, 2014, 93(2): 150-156.
6. 罗媛. 急性胰腺炎与凝血功能及全身炎症反应综合征发生的相关性. 血栓与止血学, 2016, 22(4): 376-378.
7. 中华医学会外科学分会胰腺外科学组. 急性胰腺炎诊治指南(2014). 中国实用外科杂志, 2015, 35(1): 4-7.
8. 冀亮, 孙备, 程春东, 等. 创伤递升式分阶段治疗重症急性胰腺炎局部并发症的临床经验总结. 中华外科杂志, 2016, 54(11): 839-843.
9. Huang L, Chen C, Yang L, <italic>et al</italic>. Neutrophil-to-lymphocyte ratio can specifically predict the severity of hypertriglyceridemia-induced acute pancreatitis compared with white blood cell. J Clin Lab Anal, 2019, 33(4): e22839.
10. Manohar M, Verma AK, Venkateshaiah SU, <italic>et al</italic>. Pathogenic mechanisms of pancreatitis. World J Gastrointest Pharmacol Ther, 2017, 8(1): 10-25.
11. 金爽, 许智利, 陈建时. 急性胰腺炎患者早期凝血功能及血管内皮功能检测及临床意义. 中国中西医结合消化杂志, 2019, 27(3): 215-218, 223.
12. 周仁伟, 刘鹏军. PDW、PLT、MPV 及 BISAP 评分对急性胰腺炎病情程度的预测价值. 热带医学杂志, 2017, 17(11): 1490-1493.
13. 陈国胜, 薛绮萍, 许海尘, 等. 乌司他丁对老年中重度急性胰腺炎患者血小板参数的影响. 胃肠病学, 2014, 19(11): 678-681.
14. 戴庆忠, 覃瑜. 急性胰腺炎患者凝血指标变化的临床研究. 国际检验医学杂志, 2014, 35(18): 2563-2564.
15. Kaur M, Nibhoria S, Tiwana K, <italic>et al</italic>. Rapid transformation of chronic lymphocytic leukemia to acute lymphoblastic leukemia: a rare case report. J Basic Clin Pharm, 2016, 7(2): 60-63.
16. 张红松, 冯芳, 付丽彬, 等. 不同炎性因子对重症急性胰腺炎的预测价值研究. 中国全科医学, 2017, 20(25): 3127-3131.
17. Liang Y, Zhao X, Meng F. Procalcitonin, C-reactive protein, and neutrophil ratio contribute to the diagnosis and prognosis of severe acute pancreatitis. Iran J Public Health, 2019, 48(12): 2177-2186.

West China Medical Journal

Correlation analysis between platelet-related parameters and inflammatory indicators in patients with acute pancreatitis

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