• Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
FAN Hong, Email: fanhongfan@qq.com
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Pulmonary fibrosis is a kind of chronic and fibrotic lung disease caused by a variety of reasons, and its main pathological characteristic is excessive scar formation after the destruction of normal lung tissue structure, which eventually leads to respiratory insufficiency. Although the research on the pathophysiological mechanism of pulmonary fibrosis has made great progress, its pathogenesis has not been fully elucidated, and it is still clinically incurable. In recent years, studies have shown that non-coding RNAs are involved in the pathogenesis of pulmonary fibrosis, therefore, this article summarizes the related research progress of non-coding RNA in regulation of pulmonary fibrosis by affecting epithelial-mesenchymal transition, fibroblast activation and function of macrophages, in order to provide new ideas for the treatment of pulmonary fibrosis.

Citation: ZHANG Shijie, ZHANG Tianli, TONG Xiang, HUANG Jizhen, FAN Hong. Research progress on the mechanism of non-coding RNA in pulmonary fibrosis. West China Medical Journal, 2021, 36(1): 91-96. doi: 10.7507/1002-0179.202012309 Copy

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