库欣综合征伴足溃疡两例_West China Medical Journal

Authors：

崔利娜 ^1,2 , 蔡传元 ^1,3 , 周婷婷 ^1,4 , 周培志 ⁵ , 姜曙 ⁵ , 陈大伟 ¹ , 黄慧 ¹ , 王椿 ¹ ,  冉兴无 ¹

1. ;
2. ;
3. ;
4. ;
5. ;

Corresponding author：

冉兴无, Email: ranxingwu@163.com

Keywords：

库欣综合征; 足溃疡; 垂体瘤; 地塞米松抑制试验; 岩下窦采血

DOI：

10.7507/1002-0179.202103138

Video：

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Citation： 崔利娜, 蔡传元, 周婷婷, 周培志, 姜曙, 陈大伟, 黄慧, 王椿, 冉兴无. 库欣综合征伴足溃疡两例. West China Medical Journal, 2021, 36(12): 1796-1800. doi: 10.7507/1002-0179.202103138 Copy

1.	Nikolakis G, Zouboulis CC. Skin and glucocorticoids: effects of local skin glucocorticoid impairment on skin homeostasis. Exp Dermatol, 2014, 23(11): 807-808.
2.	Nuutinen P, Autio P, Hurskainen T, et al. Glucocorticoid action on skin collagen: overview on clinical significance and consequences. J Eur Acad Dermatol venereol, 2001, 15(4): 361-362.
3.	Stojadinovic O, Lee B, Vouthounis C, et al. Novel genomic effects of glucocorticoids in epidermal keratinocytes: inhibition of apoptosis, interferon-gamma pathway, and wound healing along with promotion of terminal differentiation. J Biol Chem, 2007, 282(6): 4021-4034.
4.	Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev, 2003, 83(3): 835-870.
5.	Pastar I, Stojadinovic O, Yin NC, et al. Epithelialization in wound healing: a comprehensive review. Adv Wound Care (New Rochelle), 2014, 3(7): 445-464.
6.	Vukelic S, Stojadinovic O, Pastar I, et al. Cortisol synthesis in epidermis is induced by IL-1 and tissue injury. J Biol Chem, 2011, 286(12): 10265-10275.
7.	Youm JK, Park K, Uchida Y, et al. Local blockade of glucocorticoid activation reverses stress- and glucocorticoid-induced delays in cutaneous wound healing. Wound Repair Regen, 2013, 21(5): 715-722.
8.	Tiganescu A, Tahrani AA, Morgan SA, et al. 11β-hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects. J Clin Invest, 2013, 123(7): 3051-3060.
9.	Sarlis NJ, Chanock SJ, Nieman LK. Cortisolemic indices predict severe infections in Cushing syndrome due to ectopic production of adrenocorticotropin. J Clin Endocrinol Metab, 2000, 85(1): 42-47.
10.	Ilias I, Torpy DJ, Pacak K, et al. Cushing’s syndrome due to ectopic corticotrop insecretion: twenty years’ experience at the National Institutes of Health. J Clin Endocrinol Metab, 2005, 90(8): 4955-4962.
11.	Ejaz S, Vassilopoulou-Sellin R, Busaidy NL, et al. Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion: the University of Texas MD Anderson Cancer Center Experience. Cancer, 2011, 117(19): 4381-4389.
12.	Aucott JN. Glucocorticoids and infection. Endocrinol Metab Clin North Am, 1994, 23(3): 655-670.
13.	Uva L, Freitas J, Soares de Almeida L, et al. Squamous cell carcinoma arising in ulcerated necrobiosis lipoidica diabeticorum. Int Wound J, 2015, 12(6): 741-743.
14.	王维萍, 袁南兵, 王椿, 等. 一例糖尿病性类脂质渐进性坏死左小腿皮肤溃疡患者的循证治疗. 中国循证医学杂志, 2007, 7(11): 830-835.
15.	Nishioka H, Yamada S. Cushing’s disease. J Clin Med, 2019, 8(11): 1951.
16.	中国垂体腺瘤协作组. 中国库欣病诊治专家共识(2015). 中华医学杂志, 2016, 96(11): 835-840.
17.	冉兴无, 赵纪春. 加强多学科协作团队建设, 提高糖尿病周围血管病变与足病的诊治水平. 四川大学学报(医学版), 2012, 43(5): 728-733.

1. Nikolakis G, Zouboulis CC. Skin and glucocorticoids: effects of local skin glucocorticoid impairment on skin homeostasis. Exp Dermatol, 2014, 23(11): 807-808.
2. Nuutinen P, Autio P, Hurskainen T, et al. Glucocorticoid action on skin collagen: overview on clinical significance and consequences. J Eur Acad Dermatol venereol, 2001, 15(4): 361-362.
3. Stojadinovic O, Lee B, Vouthounis C, et al. Novel genomic effects of glucocorticoids in epidermal keratinocytes: inhibition of apoptosis, interferon-gamma pathway, and wound healing along with promotion of terminal differentiation. J Biol Chem, 2007, 282(6): 4021-4034.
4. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev, 2003, 83(3): 835-870.
5. Pastar I, Stojadinovic O, Yin NC, et al. Epithelialization in wound healing: a comprehensive review. Adv Wound Care (New Rochelle), 2014, 3(7): 445-464.
6. Vukelic S, Stojadinovic O, Pastar I, et al. Cortisol synthesis in epidermis is induced by IL-1 and tissue injury. J Biol Chem, 2011, 286(12): 10265-10275.
7. Youm JK, Park K, Uchida Y, et al. Local blockade of glucocorticoid activation reverses stress- and glucocorticoid-induced delays in cutaneous wound healing. Wound Repair Regen, 2013, 21(5): 715-722.
8. Tiganescu A, Tahrani AA, Morgan SA, et al. 11β-hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects. J Clin Invest, 2013, 123(7): 3051-3060.
9. Sarlis NJ, Chanock SJ, Nieman LK. Cortisolemic indices predict severe infections in Cushing syndrome due to ectopic production of adrenocorticotropin. J Clin Endocrinol Metab, 2000, 85(1): 42-47.
10. Ilias I, Torpy DJ, Pacak K, et al. Cushing’s syndrome due to ectopic corticotrop insecretion: twenty years’ experience at the National Institutes of Health. J Clin Endocrinol Metab, 2005, 90(8): 4955-4962.
11. Ejaz S, Vassilopoulou-Sellin R, Busaidy NL, et al. Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion: the University of Texas MD Anderson Cancer Center Experience. Cancer, 2011, 117(19): 4381-4389.
12. Aucott JN. Glucocorticoids and infection. Endocrinol Metab Clin North Am, 1994, 23(3): 655-670.
13. Uva L, Freitas J, Soares de Almeida L, et al. Squamous cell carcinoma arising in ulcerated necrobiosis lipoidica diabeticorum. Int Wound J, 2015, 12(6): 741-743.
14. 王维萍, 袁南兵, 王椿, 等. 一例糖尿病性类脂质渐进性坏死左小腿皮肤溃疡患者的循证治疗. 中国循证医学杂志, 2007, 7(11): 830-835.
15. Nishioka H, Yamada S. Cushing’s disease. J Clin Med, 2019, 8(11): 1951.
16. 中国垂体腺瘤协作组. 中国库欣病诊治专家共识(2015). 中华医学杂志, 2016, 96(11): 835-840.
17. 冉兴无, 赵纪春. 加强多学科协作团队建设, 提高糖尿病周围血管病变与足病的诊治水平. 四川大学学报(医学版), 2012, 43(5): 728-733.

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West China Medical Journal

库欣综合征伴足溃疡两例

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