Research progress on the relationship between polycystic ovarian syndrome and periodontitis_West China Medical Journal

Authors：

GUO Weixia ^1,2 ,  WANG Yan ^1,2 ,  FAN Wei ^1,2

1. Center for Reproductive Medicine, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

WANG Yan, Email: wangyy1210@163.com; FAN Wei, Email: fw215@163.com

Keywords：

Polycystic ovarian syndrome; periodontitis; correlation

DOI：

10.7507/1002-0179.202105266

Video：

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Polycystic ovary syndrome (PCOS) is a complex and heterogeneous common endocrine disease, and periodontitis is a chronic infectious immune inflammatory disease caused by dental plaque. In recent years, a large number of studies have shown that PCOS and periodontitis may be related, but the pathological mechanism is still unclear. Therefore, this article reviews the correlation between PCOS and periodontitis and the possible biological mechanisms of their mutual influence, in order to provide a theoretical basis for the prevention and treatment of periodontal disease in patients with PCOS.

Citation： GUO Weixia, WANG Yan, FAN Wei. Research progress on the relationship between polycystic ovarian syndrome and periodontitis. West China Medical Journal, 2022, 37(9): 1424-1427. doi: 10.7507/1002-0179.202105266 Copy

1.	张益倬, 张跃辉, 韩延华, 等. 多囊卵巢综合征中抗米勒管激素的作用. 华西医学, 2020, 35(11): 1399-1403.
2.	Young HE, Ward WE. The relationship between polycystic ovarian syndrome, periodontal disease, and osteoporosis. Reprod Sci, 2021, 28(4): 950-962.
3.	Zeng X, Xie YJ, Liu YT, et al. Polycystic ovarian syndrome: correlation between hyperandrogenism, insulin resistance and obesity. Clin Chim Acta, 2020, 502: 214-221.
4.	Kakoly NS, Moran LJ, Teede HJ, et al. Cardiometabolic risks in PCOS: a review of the current state of knowledge. Expert Rev Endocrinol Metab, 2019, 14(1): 23-33.
5.	Zhu T, Cui J, Goodarzi MO. Polycystic ovary syndrome and risk of type 2 diabetes, coronary heart disease, and stroke. Diabetes, 2021, 70(2): 627-637.
6.	Xing C, Li C, He B. Insulin sensitizers for improving the endocrine and metabolic profile in overweight women with PCOS. J Clin Endocrinol Metab, 2020, 105(9): 2950-2963.
7.	Codner E. Type 1 diabetes, obesity and PCOS: is type 1 stepping into the shoes of type 2 diabetes?. Clin Endocrinol (Oxf), 2021, 95(2): 265-266.
8.	Tefiku U, Popovska M, Cana A, et al. Determination of the role of fusobacterium nucleatum in the pathogenesis in and out the mouth. Pril (Makedon Akad Nauk Umet Odd Med Nauki), 2020, 41(1): 87-99.
9.	Tsai CY, Tang CY, Tan TS, et al. Subgingival microbiota in individuals with severe chronic periodontitis. J Microbiol Immunol Infect, 2018, 51(2): 226-234.
10.	Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet, 2005, 366(9499): 1809-1820.
11.	Muñoz Aguilera E, Leira Y, Miró Catalina Q, et al. Is systemic inflammation a missing link between periodontitis and hypertension? Results from two large population-based surveys. J Intern Med, 2021, 289(4): 532-546.
12.	Wu CZ, Yuan YH, Liu HH, et al. Epidemiologic relationship between periodontitis and type 2 diabetes mellitus. BMC Oral Health, 2020, 20(1): 204.
13.	Wadia R. Polycystic ovarian syndrome & periodontitis. Br Dent J, 2020, 229(2): 125.
14.	Márquez-Arrico CF, Silvestre-Rangil J, Gutiérrez-Castillo L, et al. Association between periodontal diseases and polycystic ovary syndrome: a systematic review. J Clin Med, 2020, 9(5): 1586.
15.	Machado V, Escalda C, Proença L, et al. Is there a bidirectional association between polycystic ovarian syndrome and periodontitis? A systematic review and meta-analysis. J Clin Med, 2020, 9(6): 1961.
16.	Saljoughi F, Nasri K, Bayani M. Gingival crevicular fluid levels of visfatin in patients with chronic periodontitis and polycystic ovary syndrome. Obstet Gynecol Sci, 2020, 63(1): 87-93.
17.	Porwal S, Tewari S, Sharma RK, et al. Periodontal status and high-sensitivity C-reactive protein levels in polycystic ovary syndrome with and without medical treatment. J Periodontol, 2014, 85(10): 1380-1389.
18.	Tong C, Wang YH, Yu HC, et al. Increased risk of polycystic ovary syndrome in taiwanese women with chronic periodontitis: a nationwide population-based retrospective cohort study. J Womens Health (Larchmt), 2019, 28(10): 1436-1441.
19.	Dursun E, Akalın FA, Güncü GN, et al. Periodontal disease in polycystic ovary syndrome. Fertil Steril, 2011, 95(1): 320-323.
20.	Zia A, Hakim S, Khan AU, et al. Bone markers and bone mineral density associates with periodontitis in females with poly-cystic ovarian syndrome. J Bone Miner Metab, 2022, 40(3): 487-497.
21.	Özçaka Ö, Ceyhan BÖ, Akcali A, et al. Is there an interaction between polycystic ovary syndrome and gingival inflammation?. J Periodontol, 2012, 83(12): 1529-1537.
22.	Rahiminejad ME, Moaddab A, Zaryoun H, et al. Comparison of prevalence of periodontal disease in women with polycystic ovary syndrome and healthy controls. Dent Res J (Isfahan), 2015, 12(6): 507-512.
23.	Varadan M, Gopalkrishna P, Bhat PV, et al. Influence of polycystic ovary syndrome on the periodontal health of Indian women visiting a secondary health care centre. Clin Oral Investig, 2019, 23(8): 3249-3255.
24.	Işık Y, Telatar GY, Neşelioğlu S, et al. Evaluation of periodontal status in different phenotypes of polycystic ovary syndrome in untreated patients of early reproductive age: a case-control study. J Obstet Gynaecol Res, 2020, 46(3): 459-465.
25.	Saglam E, Canakci CF, Sebin SO, et al. Evaluation of oxidative status in patients with chronic periodontitis and polycystic ovary syndrome: a cross-sectional study. J Periodontol, 2018, 89(1): 76-84.
26.	Deepti, Tewari S, Narula SC, et al. Effect of non-surgical periodontal therapy along with myo-inositol on high-sensitivity C-reactive protein and insulin resistance in women with polycystic ovary syndrome and chronic periodontitis: a randomized controlled trial. J Periodontol, 2017, 88(10): 999-1011.
27.	Moghetti P, Tosi F. Insulin resistance and PCOS: chicken or egg?. J Endocrinol Invest, 2021, 44(2): 233-244.
28.	Osibogun O, Ogunmoroti O, Michos ED. Polycystic ovary syndrome and cardiometabolic risk: opportunities for cardiovascular disease prevention. Trends Cardiovasc Med, 2020, 30(7): 399-404.
29.	Li Y, Chen C, Ma Y, et al. Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS). Life Sci, 2019, 228: 167-175.
30.	梅忆媛, 谢青贞. 多囊卵巢综合征合并代谢紊乱的炎症机制. 中国计划生育和妇产科, 2021, 13(4): 20-23.
31.	Patel S. Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy. J Steroid Biochem Mol Biol, 2018, 182: 27-36.
32.	姜梅, 徐俊仙, 翁庭静. 血清脂联素、超敏 C-反应蛋白、白细胞介素 6、肿瘤坏死因子-α联合检测在慢性牙周炎患者早期诊断中的应用价值. 中国卫生检验杂志, 2020, 30(18): 2248-2251.
33.	Varghese A, Balu P, R S, et al. Salivary interleukin-6 levels among polycystic ovary syndrome patients with and without chronic periodontitis - a comparative study. Contemp Clin Dent, 2019, 10(3): 498-501.
34.	Özçaka Ö, Buduneli N, Ceyhan BO, et al. Is interleukin-17 involved in the interaction between polycystic ovary syndrome and gingival inflammation?. J Periodontol, 2013, 84(12): 1827-1837.
35.	Akcalı A, Bostanci N, Özçaka Ö, et al. Association between polycystic ovary syndrome, oral microbiota and systemic antibody responses. PLoS One, 2014, 9(9): e108074.
36.	Hong CE, Lee JY, Choi J, et al. Prediction of the alveolar bone level after the extraction of maxillary anterior teeth with severe periodontitis. J Periodontal Implant Sci, 2015, 45(6): 216-222.

1. 张益倬, 张跃辉, 韩延华, 等. 多囊卵巢综合征中抗米勒管激素的作用. 华西医学, 2020, 35(11): 1399-1403.
2. Young HE, Ward WE. The relationship between polycystic ovarian syndrome, periodontal disease, and osteoporosis. Reprod Sci, 2021, 28(4): 950-962.
3. Zeng X, Xie YJ, Liu YT, et al. Polycystic ovarian syndrome: correlation between hyperandrogenism, insulin resistance and obesity. Clin Chim Acta, 2020, 502: 214-221.
4. Kakoly NS, Moran LJ, Teede HJ, et al. Cardiometabolic risks in PCOS: a review of the current state of knowledge. Expert Rev Endocrinol Metab, 2019, 14(1): 23-33.
5. Zhu T, Cui J, Goodarzi MO. Polycystic ovary syndrome and risk of type 2 diabetes, coronary heart disease, and stroke. Diabetes, 2021, 70(2): 627-637.
6. Xing C, Li C, He B. Insulin sensitizers for improving the endocrine and metabolic profile in overweight women with PCOS. J Clin Endocrinol Metab, 2020, 105(9): 2950-2963.
7. Codner E. Type 1 diabetes, obesity and PCOS: is type 1 stepping into the shoes of type 2 diabetes?. Clin Endocrinol (Oxf), 2021, 95(2): 265-266.
8. Tefiku U, Popovska M, Cana A, et al. Determination of the role of fusobacterium nucleatum in the pathogenesis in and out the mouth. Pril (Makedon Akad Nauk Umet Odd Med Nauki), 2020, 41(1): 87-99.
9. Tsai CY, Tang CY, Tan TS, et al. Subgingival microbiota in individuals with severe chronic periodontitis. J Microbiol Immunol Infect, 2018, 51(2): 226-234.
10. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet, 2005, 366(9499): 1809-1820.
11. Muñoz Aguilera E, Leira Y, Miró Catalina Q, et al. Is systemic inflammation a missing link between periodontitis and hypertension? Results from two large population-based surveys. J Intern Med, 2021, 289(4): 532-546.
12. Wu CZ, Yuan YH, Liu HH, et al. Epidemiologic relationship between periodontitis and type 2 diabetes mellitus. BMC Oral Health, 2020, 20(1): 204.
13. Wadia R. Polycystic ovarian syndrome & periodontitis. Br Dent J, 2020, 229(2): 125.
14. Márquez-Arrico CF, Silvestre-Rangil J, Gutiérrez-Castillo L, et al. Association between periodontal diseases and polycystic ovary syndrome: a systematic review. J Clin Med, 2020, 9(5): 1586.
15. Machado V, Escalda C, Proença L, et al. Is there a bidirectional association between polycystic ovarian syndrome and periodontitis? A systematic review and meta-analysis. J Clin Med, 2020, 9(6): 1961.
16. Saljoughi F, Nasri K, Bayani M. Gingival crevicular fluid levels of visfatin in patients with chronic periodontitis and polycystic ovary syndrome. Obstet Gynecol Sci, 2020, 63(1): 87-93.
17. Porwal S, Tewari S, Sharma RK, et al. Periodontal status and high-sensitivity C-reactive protein levels in polycystic ovary syndrome with and without medical treatment. J Periodontol, 2014, 85(10): 1380-1389.
18. Tong C, Wang YH, Yu HC, et al. Increased risk of polycystic ovary syndrome in taiwanese women with chronic periodontitis: a nationwide population-based retrospective cohort study. J Womens Health (Larchmt), 2019, 28(10): 1436-1441.
19. Dursun E, Akalın FA, Güncü GN, et al. Periodontal disease in polycystic ovary syndrome. Fertil Steril, 2011, 95(1): 320-323.
20. Zia A, Hakim S, Khan AU, et al. Bone markers and bone mineral density associates with periodontitis in females with poly-cystic ovarian syndrome. J Bone Miner Metab, 2022, 40(3): 487-497.
21. Özçaka Ö, Ceyhan BÖ, Akcali A, et al. Is there an interaction between polycystic ovary syndrome and gingival inflammation?. J Periodontol, 2012, 83(12): 1529-1537.
22. Rahiminejad ME, Moaddab A, Zaryoun H, et al. Comparison of prevalence of periodontal disease in women with polycystic ovary syndrome and healthy controls. Dent Res J (Isfahan), 2015, 12(6): 507-512.
23. Varadan M, Gopalkrishna P, Bhat PV, et al. Influence of polycystic ovary syndrome on the periodontal health of Indian women visiting a secondary health care centre. Clin Oral Investig, 2019, 23(8): 3249-3255.
24. Işık Y, Telatar GY, Neşelioğlu S, et al. Evaluation of periodontal status in different phenotypes of polycystic ovary syndrome in untreated patients of early reproductive age: a case-control study. J Obstet Gynaecol Res, 2020, 46(3): 459-465.
25. Saglam E, Canakci CF, Sebin SO, et al. Evaluation of oxidative status in patients with chronic periodontitis and polycystic ovary syndrome: a cross-sectional study. J Periodontol, 2018, 89(1): 76-84.
26. Deepti, Tewari S, Narula SC, et al. Effect of non-surgical periodontal therapy along with myo-inositol on high-sensitivity C-reactive protein and insulin resistance in women with polycystic ovary syndrome and chronic periodontitis: a randomized controlled trial. J Periodontol, 2017, 88(10): 999-1011.
27. Moghetti P, Tosi F. Insulin resistance and PCOS: chicken or egg?. J Endocrinol Invest, 2021, 44(2): 233-244.
28. Osibogun O, Ogunmoroti O, Michos ED. Polycystic ovary syndrome and cardiometabolic risk: opportunities for cardiovascular disease prevention. Trends Cardiovasc Med, 2020, 30(7): 399-404.
29. Li Y, Chen C, Ma Y, et al. Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS). Life Sci, 2019, 228: 167-175.
30. 梅忆媛, 谢青贞. 多囊卵巢综合征合并代谢紊乱的炎症机制. 中国计划生育和妇产科, 2021, 13(4): 20-23.
31. Patel S. Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy. J Steroid Biochem Mol Biol, 2018, 182: 27-36.
32. 姜梅, 徐俊仙, 翁庭静. 血清脂联素、超敏 C-反应蛋白、白细胞介素 6、肿瘤坏死因子-α联合检测在慢性牙周炎患者早期诊断中的应用价值. 中国卫生检验杂志, 2020, 30(18): 2248-2251.
33. Varghese A, Balu P, R S, et al. Salivary interleukin-6 levels among polycystic ovary syndrome patients with and without chronic periodontitis - a comparative study. Contemp Clin Dent, 2019, 10(3): 498-501.
34. Özçaka Ö, Buduneli N, Ceyhan BO, et al. Is interleukin-17 involved in the interaction between polycystic ovary syndrome and gingival inflammation?. J Periodontol, 2013, 84(12): 1827-1837.
35. Akcalı A, Bostanci N, Özçaka Ö, et al. Association between polycystic ovary syndrome, oral microbiota and systemic antibody responses. PLoS One, 2014, 9(9): e108074.
36. Hong CE, Lee JY, Choi J, et al. Prediction of the alveolar bone level after the extraction of maxillary anterior teeth with severe periodontitis. J Periodontal Implant Sci, 2015, 45(6): 216-222.

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Research progress on the relationship between polycystic ovarian syndrome and periodontitis

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