Research progress on the efficacy of platelet-rich plasma with different properties on rotator cuff injury_West China Medical Journal

Authors：

PENG Yundong ¹ , WANG Guanglan ² ,  ZHENG Cheng ³

1. School of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, P. R. China;
2. College of Sport Medicine, Wuhan Sports University, Wuhan, Hubei 430079, P. R. China;
3. Department of Sports Medicine, Affiliated Hospital of Wuhan Sports University, Wuhan, Hubei 430079, P. R. China;

Corresponding author：

ZHENG Cheng, Email: zchmily5460@126.com

Keywords：

Platelet-rich plasma; platelet-rich fibrin; biological enhancement; rotator cuff injury

DOI：

10.7507/1002-0179.202107191

Video：

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Abstract Full text Figures/Tables Video References Cited by

Arthroscopic rotator cuff repair is widely used clinically, but the phenomenon of re-tear after repair is still common. Due to the special structure of the tendon-bone junction, the promotion of tissue regeneration from the perspective of biological enhancement has attracted attention. Platelet-rich plasma (PRP) is a supraphysiological concentration of autologous platelets, which can promote the healing of rotator cuff injury after repair. However, due to the lack of clinical use standards, not all PRPs are the same, there are clear differences between liquid PRP and solid platelet-rich fibrin, and many studies have not differentiated their properties. This article reviews the research progress of different types of PRP in the repair of rotator cuff injury, aiming to provide some reference for clinical treatment selection.

Citation： PENG Yundong, WANG Guanglan, ZHENG Cheng. Research progress on the efficacy of platelet-rich plasma with different properties on rotator cuff injury. West China Medical Journal, 2022, 37(10): 1582-1587. doi: 10.7507/1002-0179.202107191 Copy

1.	Greenspoon JA, Moulton SG, Millett PJ, et al. The role of platelet rich plasma (PRP) and other biologics for rotator cuff repair. Open Orthop J, 2016, 10: 309-314.
2.	Veronesi F, Borsari V, Contartese D, et al. The clinical strategies for tendon repair with biomaterials: a review on rotator cuff and achilles tendons. J Biomed Mater Res B Appl Biomater, 2020, 108(5): 1826-1843.
3.	Schmidt CC, Jarrett CD, Brown BT. Management of rotator cuff tears. J Hand Surg Am, 2015, 40(2): 399-408.
4.	Boileau P, Brassart N, Watkinson DJ, et al. Arthroscopic repair of full-thickness tears of the supraspinatus: does the tendon really heal?. J Bone Joint Surg Am, 2005, 87(6): 1229-1240.
5.	Burkhart SS, Hartzler RU. Arthroscopic rotator cuff repair: how to avoid retear. Arthroscopy, 2019, 35(1): 12-13.
6.	Schneider A, Burr R, Garbis N, et al. Platelet-rich plasma and the shoulder: clinical indications and outcomes. Curr Rev Musculoskelet Med, 2018, 11(4): 593-597.
7.	de Oliveira BGRB, de Oliveira FP, Teixeira LA, et al. Epidermal growth factor vs platelet-rich plasma: activity against chronic wound microbiota. Int Wound J, 2019, 16(6): 1408-1415.
8.	Alves R, Grimalt R. A review of platelet-rich plasma: history, biology, mechanism of action, and classification. Skin Appendage Disord, 2018, 4(1): 18-24.
9.	Mlynarek RA, Kuhn AW, Bedi A. Platelet-rich plasma (PRP) in orthopedic sports medicine. Am J Orthop (Belle Mead NJ), 2016, 45(5): 290-326.
10.	Everts P, Onishi K, Jayaram P, et al. Platelet-rich plasma: new performance understandings and therapeutic considerations in 2020. Int J Mol Sci, 2020, 21(20): 7794.
11.	Lin MT, Wei KC, Wu CH. Effectiveness of platelet-rich plasma injection in rotator cuff tendinopathy: a systematic review and meta-analysis of randomized controlled trials. Diagnostics (Basel), 2020, 10(4): 189.
12.	Dohan Ehrenfest DM, Andia I, Zumstein MA, et al. Classification of platelet concentrates (Platelet-rich plasma-PRP, Platelet-rich fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J, 2014, 4(1): 3-9.
13.	Kim JI, Bae HC, Park HJ, et al. Effect of storage conditions and activation on growth factor concentration in platelet-rich plasma. J Orthop Res, 2020, 38(4): 777-784.
14.	Oudelaar BW, Peerbooms JC, Huis In’t Veld R, et al. Concentrations of blood components in commercial platelet-rich plasma separation systems: a review of the literature. Am J Sports Med, 2019, 47(2): 479-487.
15.	Le ADK, Enweze L, DeBaun MR, et al. Current clinical recommendations for use of platelet-rich plasma. Curr Rev Musculoskelet Med, 2018, 11(4): 624-634.
16.	Kennedy MI, Whitney K, Evans T, et al. Platelet-rich plasma and cartilage repair. Curr Rev Musculoskelet Med, 2018, 11(4): 573-582.
17.	Etulain J. Platelets in wound healing and regenerative medicine. Platelets, 2018, 29(6): 556-568.
18.	Kim SJ, Kim EK, Kim SJ, et al. Effects of bone marrow aspirate concentrate and platelet-rich plasma on patients with partial tear of the rotator cuff tendon. J Orthop Surg Res, 2018, 13(1): 1.
19.	Pauly S, Klatte-Schulz F, Stahnke K, et al. The effect of autologous platelet rich plasma on tenocytes of the human rotator cuff. BMC Musculoskelet Disord, 2018, 19(1): 422.
20.	Varela HA, Souza JCM, Nascimento RM, et al. Injectable platelet rich fibrin: cell content, morphological, and protein characterization. Clin Oral Investig, 2019, 23(3): 1309-1318.
21.	Lopez-Vidriero E, Goulding KA, Simon DA, et al. The use of platelet-rich plasma in arthroscopy and sports medicine: optimizing the healing environment. Arthroscopy, 2010, 26(2): 269-278.
22.	López-Nájera D, Rubio-Zaragoza M, Sopena-Juncosa JJ, et al. Effects of plasma rich in growth factors (PRGF) on biomechanical properties of achilles tendon repair. Knee Surg Sports Traumatol Arthrosc, 2016, 24(12): 3997-4004.
23.	Yin W, Xu H, Sheng J, et al. Optimization of pure platelet-rich plasma preparation: a comparative study of pure platelet-rich plasma obtained using different centrifugal conditions in a single-donor model. Exp Ther Med, 2017, 14(3): 2060-2070.
24.	Zhou Y, Zhang J, Wu H, et al. The differential effects of leukocyte-containing and pure platelet-rich plasma (PRP) on tendon stem/progenitor cells - implications of PRP application for the clinical treatment of tendon injuries. Stem Cell Res Ther, 2015, 6(1): 173.
25.	Xu Z, Yin W, Zhang Y, et al. Comparative evaluation of leukocyte- and platelet-rich plasma and pure platelet-rich plasma for cartilage regeneration. Sci Rep, 2017, 7: 43301.
26.	Muto T, Kokubu T, Mifune Y, et al. Effects of platelet-rich plasma and triamcinolone acetonide on interleukin-1β-stimulated human rotator cuff-derived cells. Bone Joint Res, 2016, 5(12): 602-609.
27.	Papait A, Cancedda R, Mastrogiacomo M, et al. Allogeneic platelet-rich plasma affects monocyte differentiation to dendritic cells causing an anti-inflammatory microenvironment, putatively fostering wound healing. J Tissue Eng Regen Med, 2018, 12(1): 30-43.
28.	Shimizu M, Natori T, Tsuda K, et al. Thrombin-induced platelet aggregation -effect of dabigatran using automated platelet aggregometry. Platelets, 2020, 31(3): 360-364.
29.	Fu CJ, Sun JB, Bi ZG, et al. Evaluation of platelet-rich plasma and fibrin matrix to assist in healing and repair of rotator cuff injuries: a systematic review and meta-analysis. Clin Rehabil, 2017, 31(2): 158-172.
30.	Walsh MR, Nelson BJ, Braman JP, et al. Platelet-rich plasma in fibrin matrix to augment rotator cuff repair: a prospective, single-blinded, randomized study with 2-year follow-up. J Shoulder Elbow Surg, 2018, 27(9): 1553-1563.
31.	Zafarani Z, Mirzaee F, Guity M, et al. Clinical results of platelet-rich plasma for partial thickness rotator cuff tears: a case series. Arch Bone Jt Surg, 2017, 5(5): 328-331.
32.	Malavolta EA, Gracitelli MEC, Assunção JH, et al. Clinical and structural evaluations of rotator cuff repair with and without added platelet-rich plasma at 5-year follow-up: a prospective randomized study. Am J Sports Med, 2018, 46(13): 3134-3141.
33.	Pandey V, Bandi A, Madi S, et al. Does application of moderately concentrated platelet-rich plasma improve clinical and structural outcome after arthroscopic repair of medium-sized to large rotator cuff tear? A randomized controlled trial. J Shoulder Elbow Surg, 2016, 25(8): 1312-1322.
34.	Lee KW, Yang DS, Chun TJ, et al. A comparison of conventional ultrasonography and arthrosonography in the assessment of cuff integrity after rotator cuff repair. Clin Orthop Surg, 2014, 6(3): 336-342.
35.	Holtby R, Christakis M, Maman E, et al. Impact of platelet-rich plasma on arthroscopic repair of small- to medium-sized rotator cuff tears: a randomized controlled trial. Orthop J Sports Med, 2016, 4(9): 2325967116665595.
36.	Zhang Z, Wang Y, Sun J. The effect of platelet-rich plasma on arthroscopic double-row rotator cuff repair: a clinical study with 12-month follow-up. Acta Orthop Traumatol Turc, 2016, 50(2): 191-197.
37.	Ruiz-Moneo P, Molano-Muñoz J, Prieto E, et al. Plasma rich in growth factors in arthroscopic rotator cuff repair: a randomized, double-blind, controlled clinical trial. Arthroscopy, 2013, 29(1): 2-9.
38.	Rha DW, Park GY, Kim YK, et al. Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease: a randomized controlled trial. Clin Rehabil, 2013, 27(2): 113-122.
39.	Schwitzguebel AJ, Kolo FC, Tirefort J, et al. Efficacy of platelet-rich plasma for the treatment of interstitial supraspinatus tears: a double-blinded, randomized controlled trial. Am J Sports Med, 2019, 47(8): 1885-1892.
40.	Gwinner C, Gerhardt C, Haneveld H, et al. Two-staged application of PRP in arthroscopic rotator cuff repair: a matched-pair analysis. Arch Orthop Trauma Surg, 2016, 136(8): 1165-1171.
41.	Ebert JR, Wang A, Smith A, et al. A midterm evaluation of postoperative platelet-rich plasma injections on arthroscopic supraspinatus repair: a randomized controlled trial. Am J Sports Med, 2017, 45(13): 2965-2974.
42.	Gumina S, Campagna V, Ferrazza G, et al. Use of platelet-leukocyte membrane in arthroscopic repair of large rotator cuff tears: a prospective randomized study. J Bone Joint Surg Am, 2012, 94(15): 1345-1352.
43.	Castricini R, Longo UG, De Benedetto M, et al. Platelet-rich plasma augmentation for arthroscopic rotator cuff repair: a randomized controlled trial. Am J Sports Med, 2011, 39(2): 258-265.
44.	Jo CH, Kim JE, Yoon KS, et al. Does platelet-rich plasma accelerate recovery after rotator cuff repair? A prospective cohort study. Am J Sports Med, 2011, 39(10): 2082-2090.
45.	Jo CH, Shin JS, Lee YG, et al. Platelet-rich plasma for arthroscopic repair of large to massive rotator cuff tears: a randomized, single-blind, parallel-group trial. Am J Sports Med, 2013, 41(10): 2240-2248.
46.	Jo CH, Shin JS, Shin WH, et al. Platelet-rich plasma for arthroscopic repair of medium to large rotator cuff tears: a randomized controlled trial. Am J Sports Med, 2015, 43(9): 2102-2110.
47.	Dukan R, Bommier A, Rousseau MA, et al. Arthroscopic knotless tape bridging with autologous platelet-rich fibrin gel augmentation: functional and structural results. Phys Sportsmed, 2019, 47(4): 455-462.
48.	von Wehren L, Blanke F, Todorov A, et al. The effect of subacromial injections of autologous conditioned plasma versus cortisone for the treatment of symptomatic partial rotator cuff tears. Knee Surg Sports Traumatol Arthrosc, 2016, 24(12): 3787-3792.
49.	Barber FA, Hrnack SA, Snyder SJ, et al. Rotator cuff repair healing influenced by platelet-rich plasma construct augmentation. Arthroscopy, 2011, 27(8): 1029-1035.
50.	Zumstein MA, Rumian A, Lesbats V, et al. Increased vascularization during early healing after biologic augmentation in repair of chronic rotator cuff tears using autologous leukocyte- and platelet-rich fibrin (L-PRF): a prospective randomized controlled pilot trial. J Shoulder Elbow Surg, 2014, 23(1): 3-12.
51.	Zhang Q, Ge H, Zhou J, et al. Are platelet-rich products necessary during the arthroscopic repair of full-thickness rotator cuff tears: a meta-analysis. PLoS One, 2013, 8(7): e69731.
52.	Visser LC, Arnoczky SP, Caballero O, et al. Platelet-rich fibrin constructs elute higher concentrations of transforming growth factor-β1 and increase tendon cell proliferation over time when compared to blood clots: a comparative in vitro analysis. Vet Surg, 2010, 39(7): 811-817.
53.	Warth RJ, Dornan GJ, James EW, et al. Clinical and structural outcomes after arthroscopic repair of full-thickness rotator cuff tears with and without platelet-rich product supplementation: a meta-analysis and meta-regression. Arthroscopy, 2015, 31(2): 306-320.
54.	Chahal J, Van Thiel GS, Mall N, et al. The role of platelet-rich plasma in arthroscopic rotator cuff repair: a systematic review with quantitative synthesis. Arthroscopy, 2012, 28(11): 1718-1727.
55.	Saltzman BM, Jain A, Campbell KA, et al. Does the use of platelet-rich plasma at the time of surgery improve clinical outcomes in arthroscopic rotator cuff repair when compared with control cohorts? A systematic review of meta-analyses. Arthroscopy, 2016, 32(5): 906-918.
56.	Jo CH, Lee SY, Yoon KS, et al. Allogenic pure platelet-rich plasma therapy for rotator cuff disease: a bench and bed study. Am J Sports Med, 2018, 46(13): 3142-3154.
57.	Goldenberg BT, Lacheta L, Dekker TJ, et al. Biologics to improve healing in large and massive rotator cuff tears: a critical review. Orthop Res Rev, 2020, 12: 151-160.
58.	Periayah MH, Halim AS, Mat Saad AZ. Mechanism action of platelets and crucial blood coagulation pathways in hemostasis. Int J Hematol Oncol Stem Cell Res, 2017, 11(4): 319-327.

1. Greenspoon JA, Moulton SG, Millett PJ, et al. The role of platelet rich plasma (PRP) and other biologics for rotator cuff repair. Open Orthop J, 2016, 10: 309-314.
2. Veronesi F, Borsari V, Contartese D, et al. The clinical strategies for tendon repair with biomaterials: a review on rotator cuff and achilles tendons. J Biomed Mater Res B Appl Biomater, 2020, 108(5): 1826-1843.
3. Schmidt CC, Jarrett CD, Brown BT. Management of rotator cuff tears. J Hand Surg Am, 2015, 40(2): 399-408.
4. Boileau P, Brassart N, Watkinson DJ, et al. Arthroscopic repair of full-thickness tears of the supraspinatus: does the tendon really heal?. J Bone Joint Surg Am, 2005, 87(6): 1229-1240.
5. Burkhart SS, Hartzler RU. Arthroscopic rotator cuff repair: how to avoid retear. Arthroscopy, 2019, 35(1): 12-13.
6. Schneider A, Burr R, Garbis N, et al. Platelet-rich plasma and the shoulder: clinical indications and outcomes. Curr Rev Musculoskelet Med, 2018, 11(4): 593-597.
7. de Oliveira BGRB, de Oliveira FP, Teixeira LA, et al. Epidermal growth factor vs platelet-rich plasma: activity against chronic wound microbiota. Int Wound J, 2019, 16(6): 1408-1415.
8. Alves R, Grimalt R. A review of platelet-rich plasma: history, biology, mechanism of action, and classification. Skin Appendage Disord, 2018, 4(1): 18-24.
9. Mlynarek RA, Kuhn AW, Bedi A. Platelet-rich plasma (PRP) in orthopedic sports medicine. Am J Orthop (Belle Mead NJ), 2016, 45(5): 290-326.
10. Everts P, Onishi K, Jayaram P, et al. Platelet-rich plasma: new performance understandings and therapeutic considerations in 2020. Int J Mol Sci, 2020, 21(20): 7794.
11. Lin MT, Wei KC, Wu CH. Effectiveness of platelet-rich plasma injection in rotator cuff tendinopathy: a systematic review and meta-analysis of randomized controlled trials. Diagnostics (Basel), 2020, 10(4): 189.
12. Dohan Ehrenfest DM, Andia I, Zumstein MA, et al. Classification of platelet concentrates (Platelet-rich plasma-PRP, Platelet-rich fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J, 2014, 4(1): 3-9.
13. Kim JI, Bae HC, Park HJ, et al. Effect of storage conditions and activation on growth factor concentration in platelet-rich plasma. J Orthop Res, 2020, 38(4): 777-784.
14. Oudelaar BW, Peerbooms JC, Huis In’t Veld R, et al. Concentrations of blood components in commercial platelet-rich plasma separation systems: a review of the literature. Am J Sports Med, 2019, 47(2): 479-487.
15. Le ADK, Enweze L, DeBaun MR, et al. Current clinical recommendations for use of platelet-rich plasma. Curr Rev Musculoskelet Med, 2018, 11(4): 624-634.
16. Kennedy MI, Whitney K, Evans T, et al. Platelet-rich plasma and cartilage repair. Curr Rev Musculoskelet Med, 2018, 11(4): 573-582.
17. Etulain J. Platelets in wound healing and regenerative medicine. Platelets, 2018, 29(6): 556-568.
18. Kim SJ, Kim EK, Kim SJ, et al. Effects of bone marrow aspirate concentrate and platelet-rich plasma on patients with partial tear of the rotator cuff tendon. J Orthop Surg Res, 2018, 13(1): 1.
19. Pauly S, Klatte-Schulz F, Stahnke K, et al. The effect of autologous platelet rich plasma on tenocytes of the human rotator cuff. BMC Musculoskelet Disord, 2018, 19(1): 422.
20. Varela HA, Souza JCM, Nascimento RM, et al. Injectable platelet rich fibrin: cell content, morphological, and protein characterization. Clin Oral Investig, 2019, 23(3): 1309-1318.
21. Lopez-Vidriero E, Goulding KA, Simon DA, et al. The use of platelet-rich plasma in arthroscopy and sports medicine: optimizing the healing environment. Arthroscopy, 2010, 26(2): 269-278.
22. López-Nájera D, Rubio-Zaragoza M, Sopena-Juncosa JJ, et al. Effects of plasma rich in growth factors (PRGF) on biomechanical properties of achilles tendon repair. Knee Surg Sports Traumatol Arthrosc, 2016, 24(12): 3997-4004.
23. Yin W, Xu H, Sheng J, et al. Optimization of pure platelet-rich plasma preparation: a comparative study of pure platelet-rich plasma obtained using different centrifugal conditions in a single-donor model. Exp Ther Med, 2017, 14(3): 2060-2070.
24. Zhou Y, Zhang J, Wu H, et al. The differential effects of leukocyte-containing and pure platelet-rich plasma (PRP) on tendon stem/progenitor cells - implications of PRP application for the clinical treatment of tendon injuries. Stem Cell Res Ther, 2015, 6(1): 173.
25. Xu Z, Yin W, Zhang Y, et al. Comparative evaluation of leukocyte- and platelet-rich plasma and pure platelet-rich plasma for cartilage regeneration. Sci Rep, 2017, 7: 43301.
26. Muto T, Kokubu T, Mifune Y, et al. Effects of platelet-rich plasma and triamcinolone acetonide on interleukin-1β-stimulated human rotator cuff-derived cells. Bone Joint Res, 2016, 5(12): 602-609.
27. Papait A, Cancedda R, Mastrogiacomo M, et al. Allogeneic platelet-rich plasma affects monocyte differentiation to dendritic cells causing an anti-inflammatory microenvironment, putatively fostering wound healing. J Tissue Eng Regen Med, 2018, 12(1): 30-43.
28. Shimizu M, Natori T, Tsuda K, et al. Thrombin-induced platelet aggregation -effect of dabigatran using automated platelet aggregometry. Platelets, 2020, 31(3): 360-364.
29. Fu CJ, Sun JB, Bi ZG, et al. Evaluation of platelet-rich plasma and fibrin matrix to assist in healing and repair of rotator cuff injuries: a systematic review and meta-analysis. Clin Rehabil, 2017, 31(2): 158-172.
30. Walsh MR, Nelson BJ, Braman JP, et al. Platelet-rich plasma in fibrin matrix to augment rotator cuff repair: a prospective, single-blinded, randomized study with 2-year follow-up. J Shoulder Elbow Surg, 2018, 27(9): 1553-1563.
31. Zafarani Z, Mirzaee F, Guity M, et al. Clinical results of platelet-rich plasma for partial thickness rotator cuff tears: a case series. Arch Bone Jt Surg, 2017, 5(5): 328-331.
32. Malavolta EA, Gracitelli MEC, Assunção JH, et al. Clinical and structural evaluations of rotator cuff repair with and without added platelet-rich plasma at 5-year follow-up: a prospective randomized study. Am J Sports Med, 2018, 46(13): 3134-3141.
33. Pandey V, Bandi A, Madi S, et al. Does application of moderately concentrated platelet-rich plasma improve clinical and structural outcome after arthroscopic repair of medium-sized to large rotator cuff tear? A randomized controlled trial. J Shoulder Elbow Surg, 2016, 25(8): 1312-1322.
34. Lee KW, Yang DS, Chun TJ, et al. A comparison of conventional ultrasonography and arthrosonography in the assessment of cuff integrity after rotator cuff repair. Clin Orthop Surg, 2014, 6(3): 336-342.
35. Holtby R, Christakis M, Maman E, et al. Impact of platelet-rich plasma on arthroscopic repair of small- to medium-sized rotator cuff tears: a randomized controlled trial. Orthop J Sports Med, 2016, 4(9): 2325967116665595.
36. Zhang Z, Wang Y, Sun J. The effect of platelet-rich plasma on arthroscopic double-row rotator cuff repair: a clinical study with 12-month follow-up. Acta Orthop Traumatol Turc, 2016, 50(2): 191-197.
37. Ruiz-Moneo P, Molano-Muñoz J, Prieto E, et al. Plasma rich in growth factors in arthroscopic rotator cuff repair: a randomized, double-blind, controlled clinical trial. Arthroscopy, 2013, 29(1): 2-9.
38. Rha DW, Park GY, Kim YK, et al. Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease: a randomized controlled trial. Clin Rehabil, 2013, 27(2): 113-122.
39. Schwitzguebel AJ, Kolo FC, Tirefort J, et al. Efficacy of platelet-rich plasma for the treatment of interstitial supraspinatus tears: a double-blinded, randomized controlled trial. Am J Sports Med, 2019, 47(8): 1885-1892.
40. Gwinner C, Gerhardt C, Haneveld H, et al. Two-staged application of PRP in arthroscopic rotator cuff repair: a matched-pair analysis. Arch Orthop Trauma Surg, 2016, 136(8): 1165-1171.
41. Ebert JR, Wang A, Smith A, et al. A midterm evaluation of postoperative platelet-rich plasma injections on arthroscopic supraspinatus repair: a randomized controlled trial. Am J Sports Med, 2017, 45(13): 2965-2974.
42. Gumina S, Campagna V, Ferrazza G, et al. Use of platelet-leukocyte membrane in arthroscopic repair of large rotator cuff tears: a prospective randomized study. J Bone Joint Surg Am, 2012, 94(15): 1345-1352.
43. Castricini R, Longo UG, De Benedetto M, et al. Platelet-rich plasma augmentation for arthroscopic rotator cuff repair: a randomized controlled trial. Am J Sports Med, 2011, 39(2): 258-265.
44. Jo CH, Kim JE, Yoon KS, et al. Does platelet-rich plasma accelerate recovery after rotator cuff repair? A prospective cohort study. Am J Sports Med, 2011, 39(10): 2082-2090.
45. Jo CH, Shin JS, Lee YG, et al. Platelet-rich plasma for arthroscopic repair of large to massive rotator cuff tears: a randomized, single-blind, parallel-group trial. Am J Sports Med, 2013, 41(10): 2240-2248.
46. Jo CH, Shin JS, Shin WH, et al. Platelet-rich plasma for arthroscopic repair of medium to large rotator cuff tears: a randomized controlled trial. Am J Sports Med, 2015, 43(9): 2102-2110.
47. Dukan R, Bommier A, Rousseau MA, et al. Arthroscopic knotless tape bridging with autologous platelet-rich fibrin gel augmentation: functional and structural results. Phys Sportsmed, 2019, 47(4): 455-462.
48. von Wehren L, Blanke F, Todorov A, et al. The effect of subacromial injections of autologous conditioned plasma versus cortisone for the treatment of symptomatic partial rotator cuff tears. Knee Surg Sports Traumatol Arthrosc, 2016, 24(12): 3787-3792.
49. Barber FA, Hrnack SA, Snyder SJ, et al. Rotator cuff repair healing influenced by platelet-rich plasma construct augmentation. Arthroscopy, 2011, 27(8): 1029-1035.
50. Zumstein MA, Rumian A, Lesbats V, et al. Increased vascularization during early healing after biologic augmentation in repair of chronic rotator cuff tears using autologous leukocyte- and platelet-rich fibrin (L-PRF): a prospective randomized controlled pilot trial. J Shoulder Elbow Surg, 2014, 23(1): 3-12.
51. Zhang Q, Ge H, Zhou J, et al. Are platelet-rich products necessary during the arthroscopic repair of full-thickness rotator cuff tears: a meta-analysis. PLoS One, 2013, 8(7): e69731.
52. Visser LC, Arnoczky SP, Caballero O, et al. Platelet-rich fibrin constructs elute higher concentrations of transforming growth factor-β1 and increase tendon cell proliferation over time when compared to blood clots: a comparative in vitro analysis. Vet Surg, 2010, 39(7): 811-817.
53. Warth RJ, Dornan GJ, James EW, et al. Clinical and structural outcomes after arthroscopic repair of full-thickness rotator cuff tears with and without platelet-rich product supplementation: a meta-analysis and meta-regression. Arthroscopy, 2015, 31(2): 306-320.
54. Chahal J, Van Thiel GS, Mall N, et al. The role of platelet-rich plasma in arthroscopic rotator cuff repair: a systematic review with quantitative synthesis. Arthroscopy, 2012, 28(11): 1718-1727.
55. Saltzman BM, Jain A, Campbell KA, et al. Does the use of platelet-rich plasma at the time of surgery improve clinical outcomes in arthroscopic rotator cuff repair when compared with control cohorts? A systematic review of meta-analyses. Arthroscopy, 2016, 32(5): 906-918.
56. Jo CH, Lee SY, Yoon KS, et al. Allogenic pure platelet-rich plasma therapy for rotator cuff disease: a bench and bed study. Am J Sports Med, 2018, 46(13): 3142-3154.
57. Goldenberg BT, Lacheta L, Dekker TJ, et al. Biologics to improve healing in large and massive rotator cuff tears: a critical review. Orthop Res Rev, 2020, 12: 151-160.
58. Periayah MH, Halim AS, Mat Saad AZ. Mechanism action of platelets and crucial blood coagulation pathways in hemostasis. Int J Hematol Oncol Stem Cell Res, 2017, 11(4): 319-327.

West China Medical Journal

Research progress on the efficacy of platelet-rich plasma with different properties on rotator cuff injury

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