Research progress of adenosine activated protein kinase α1 in tumor_West China Medical Journal

Authors：

HUANG Xiaoqin , JIA Yufang ,  ZHANG Haitao

Department of Biochemistry, Guangdong Medical University, Zhanjiang, Guangdong 524023, P. R. China;

Corresponding author：

ZHANG Haitao, Email: taohaizhang33@163.com

Keywords：

Adenosine activated protein kinase α1; tumor; treatment

DOI：

10.7507/1002-0179.202108252

Video：

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Abstract Full text Figures/Tables Video References Cited by

Adenosine activated protein kinase (AMPK) is a serine/threonine protein kinase that can sense the change of intracellular energy. AMPK plays a critical part in the occurrence and development of tumors. According to the difference of AMPK catalytic subunits, it is divided into AMPKα1 and AMPKα2. The AMPKα1 subunit is the catalytic subunit of AMPK and is extensively distributed in the various tissues and organs. This review focuses on the structural, activated and functional aspects of AMPKα1 and the involvement of AMPKα1 in the regulation of intracellular substance metabolism, and summarizes the respective performances of AMPKα1 in different cancers and the corresponding potential applications of AMPKα1 as a drug target in the relevant cancers. AMPKα1 can be used as a diagnostic marker or drug target for cancer diagnosis and therapy, providing an idea for cancer treatment, which has importance clinical significance.

Citation： HUANG Xiaoqin, JIA Yufang, ZHANG Haitao. Research progress of adenosine activated protein kinase α1 in tumor. West China Medical Journal, 2022, 37(3): 460-467. doi: 10.7507/1002-0179.202108252 Copy

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2.	Kemp BE, Mitchelhill KI, Stapleton D, et al. Dealing with energy demand: the AMP-activated protein kinase. Trends Biochem Sci, 1999, 24(1): 22-25.
3.	Guo Y, Meng J, Tang Y, et al. AMP-activated kinase α2 deficiency protects mice from denervation-induced skeletal muscle atrophy. Arch Biochem Biophys, 2016, 600: 56-60.
4.	Hardie DG, Ross FA, Hawley SA, et al. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol, 2012, 13(4): 251-262.
5.	Vara-Ciruelos D, Dandapani M, Gray A, et al. Genotoxic damage activates the AMPK-α1 isoform in the nucleus via Ca²⁺/CaMKK2 signaling to enhance tumor cell survival. Mol Cancer Res, 2018, 16(2): 345-357.
6.	Sanli T, Rashid A, Liu C, et al. Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells. Int J Radiat Oncol Biol Phys, 2010, 78(1): 221-229.
7.	Narbonne P, Roy R. Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival. Nature, 2009, 457(7226): 210-214.
8.	Al-Khalili L, Krook A, Zierath JR, et al. Prior serum- and AICAR-induced AMPK activation in primary human myocytes does not lead to subsequent increase in insulin-stimulated glucose uptake. Am J Physiol Endocrinol Metab, 2004, 287(3): E553-E557.
9.	Hu R, Yan H, Fei X, et al. Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase. Sci Rep, 2017, 7(1): 778.
10.	Yang Q, Xu J, Ma Q, et al. PRKAA1/AMPK α1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis. Nat Commun, 2018, 9(1): 4667.
11.	Yang Q, Ma Q, Xu J, et al. Prkaa1 metabolically regulates onocyte/macrophage recruitment and viability in diet-induced murine metabolic disorders. Front Cell Dev Biol, 2020, 8: 611354.
12.	Carling D, Zammit VA, Hardie DG. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett, 1987, 223(2): 217-222.
13.	Sato R, Goldstein JL, Brown MS. Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion. Proc Natl Acad Sci U S A, 1993, 90(20): 9261-9265.
14.	Habets DD, Coumans WA, El Hasnaoui M, et al. Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes. Biochim Biophys Acta, 2009, 1791(3): 212-219.
15.	Fang K, Wu F, Chen G, et al. Diosgenin ameliorates palmitic acid-induced lipid accumulation via AMPK/ACC/CPT-1A and SREBP-1c/FAS signaling pathways in LO2 cells. BMC Complement Altern Med, 2019, 19(1): 255.
16.	Daval M, Foufelle F, Ferré P. Functions of AMP-activated protein kinase in adipose tissue. J Physiol, 2006, 574(Pt-1): 55-62.
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19.	Kim I, He YY. Targeting the AMP-activated protein kinase for cancer prevention and therapy. Front Oncol, 2013, 3: 175.
20.	Gao XY, Deng BH, Li XR, et al. Melatonin regulates differentiation of sheep brown adipocyte precursor cells via AMP-activated protein kinase. Front Vet Sci, 2021, 8: 661773.
21.	Zhao J, Yang Q, Zhang L, et al. AMPKα1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development. Biochem Biophys Res Commun, 2017, 491(2): 508-514.
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24.	Spengler K, Kryeziu N, Große S, et al. VEGF triggers transient induction of autophagy in endothelial cells via AMPKα1. Cells, 2020, 9(3): 687.
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31.	Böttcher K, Longato L, Marrone G, et al. AICAR and compound C negatively modulate HCC-induced primary human hepatic stellate cell activation in vitro. Am J Physiol Gastrointest Liver Physiol, 2021, 320(4): G543-G556.
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33.	Qiu S, Liu T, Piao C, et al. AMPKα2 knockout enhances tumour inflammation through exacerbated liver injury and energy deprivation-associated AMPKα1 activation. J Cell Mol Med, 2019, 23(3): 1687-1697.
34.	Wang Y, Xu B, Zhou J, et al. Propofol activates AMPK to inhibit the growth of HepG2 cells in vitro and hepatocarcinogenesis in xenograft mouse tumor models by inducing autophagy. J Gastrointest Oncol, 2020, 11(6): 1322-1332.
35.	Qiu SL, Xiao ZC, Piao CM, et al. AMP-activated protein kinaseα2 protects against liver injury from metastasized tumors via reduced glucose deprivation‐induced oxidative stress. J Biol Chem, 2014, 289(13): 9449‐9459.
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38.	Zhang C, Zhang Q, Huang Z, et al. Adropin inhibited tilapia hepatic glucose output and triglyceride accumulation via AMPK activation. J Endocrinol, 2020, 246(2): 109-122.
39.	Chen M, Jiang B, He B, et al. Genetic variations in PRKAA1 predict the risk and progression of gastric cancer. BMC Cancer, 2018, 18(1): 923.
40.	Jeon SM, Hay N. The dark face of AMPK as an essential tumor promoter. Cell Logist, 2012, 2(4): 197-202.
41.	Eom SY, Hong SM, Yim DH, et al. Additive interactions between PRKAA1 polymorphisms and Helicobacter pylori CagA infection associated with gastric cancer risk in Koreans. Cancer Med, 2016, 5(11): 3236-3335.
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51.	Han X, Ren C, Yang T, et al. Negative regulation of AMPK α1 by PIM2 promotes aerobic glycolysis and tumorigenesis in endometrial cancer. Oncogene, 2019, 38(38): 6537-6549.
52.	Huang FY, Chiu PM, Tam KF, et al. Semi-quantitative fluorescent PCR analysis identifies PRKAA1 on chromosome 5 as a potential candidate cancer gene of cervical cancer. Gynecol Oncol, 2006, 103(1): 219-225.
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54.	Yi Y, Chen D, Ao J, et al. Transcriptional suppression of AMPKα1 promotes breast cancer metastasis upon oncogene activation. Proc Natl Acad Sci USA, 2020, 117(14): 8013-8021.
55.	Johnson J, how Z, Lee E, et al. Role of AMPK and Akt in triple negative breast cancer lung colonization. Neoplasia, 2021, 23(4): 429-438.
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57.	Pan SJ, Ren J, Jiang H, et al. MAGEA6 promotes human glioma cell survival via targeting AMPK α1. Cancer Lett, 2018, 412: 21-29.
58.	Zhao K, Wang L, Li T, et al. The role of miR-451 in the switching between proliferation and migration in malignant glioma cells: AMPK signaling, mTOR modulation and Rac1 activation required. Int J Oncol, 2017, 50(6): 1989-1999.
59.	Sun B, He S, Liu B, et al. Stanniocalcin-1 protected astrocytes from hypoxic damage through the AMPK pathway. Neurochem Res, 2021, 46(11): 2948-2957.
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1. Carling D. AMPK signalling in health and disease. Curr Opin Cell Biol, 2017, 45: 31-37.
2. Kemp BE, Mitchelhill KI, Stapleton D, et al. Dealing with energy demand: the AMP-activated protein kinase. Trends Biochem Sci, 1999, 24(1): 22-25.
3. Guo Y, Meng J, Tang Y, et al. AMP-activated kinase α2 deficiency protects mice from denervation-induced skeletal muscle atrophy. Arch Biochem Biophys, 2016, 600: 56-60.
4. Hardie DG, Ross FA, Hawley SA, et al. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol, 2012, 13(4): 251-262.
5. Vara-Ciruelos D, Dandapani M, Gray A, et al. Genotoxic damage activates the AMPK-α1 isoform in the nucleus via Ca²⁺/CaMKK2 signaling to enhance tumor cell survival. Mol Cancer Res, 2018, 16(2): 345-357.
6. Sanli T, Rashid A, Liu C, et al. Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells. Int J Radiat Oncol Biol Phys, 2010, 78(1): 221-229.
7. Narbonne P, Roy R. Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival. Nature, 2009, 457(7226): 210-214.
8. Al-Khalili L, Krook A, Zierath JR, et al. Prior serum- and AICAR-induced AMPK activation in primary human myocytes does not lead to subsequent increase in insulin-stimulated glucose uptake. Am J Physiol Endocrinol Metab, 2004, 287(3): E553-E557.
9. Hu R, Yan H, Fei X, et al. Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase. Sci Rep, 2017, 7(1): 778.
10. Yang Q, Xu J, Ma Q, et al. PRKAA1/AMPK α1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis. Nat Commun, 2018, 9(1): 4667.
11. Yang Q, Ma Q, Xu J, et al. Prkaa1 metabolically regulates onocyte/macrophage recruitment and viability in diet-induced murine metabolic disorders. Front Cell Dev Biol, 2020, 8: 611354.
12. Carling D, Zammit VA, Hardie DG. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett, 1987, 223(2): 217-222.
13. Sato R, Goldstein JL, Brown MS. Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion. Proc Natl Acad Sci U S A, 1993, 90(20): 9261-9265.
14. Habets DD, Coumans WA, El Hasnaoui M, et al. Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes. Biochim Biophys Acta, 2009, 1791(3): 212-219.
15. Fang K, Wu F, Chen G, et al. Diosgenin ameliorates palmitic acid-induced lipid accumulation via AMPK/ACC/CPT-1A and SREBP-1c/FAS signaling pathways in LO2 cells. BMC Complement Altern Med, 2019, 19(1): 255.
16. Daval M, Foufelle F, Ferré P. Functions of AMP-activated protein kinase in adipose tissue. J Physiol, 2006, 574(Pt-1): 55-62.
17. Jiang Y, Li W, Lu J, et al. Association between PRKAA1 rs13361707 T>C polymorphism and gastric cancer risk: evidence based on a meta-analysis. Medicine (Baltimore), 2018, 97(14): e0302.
18. Tosello V, Bongiovanni D, Di Martino L, et al. Responsiveness to hedgehog pathway inhibitors in T-cell acute lymphoblastic leukemia cells is highly dependent on 5’AMP-activated kinase inactivation. Int J Mol Sci, 2021, 22(12): 6384.
19. Kim I, He YY. Targeting the AMP-activated protein kinase for cancer prevention and therapy. Front Oncol, 2013, 3: 175.
20. Gao XY, Deng BH, Li XR, et al. Melatonin regulates differentiation of sheep brown adipocyte precursor cells via AMP-activated protein kinase. Front Vet Sci, 2021, 8: 661773.
21. Zhao J, Yang Q, Zhang L, et al. AMPKα1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development. Biochem Biophys Res Commun, 2017, 491(2): 508-514.
22. Daurio NA, Tuttle SW, Worth AJ, et al. AMPK activation and metabolic reprogramming by tamoxifen through estrogen receptor-independent mechanisms suggests new uses for this therapeutic modality in cancer treatment. Cancer Res, 2016, 76(11): 3295-3306.
23. Jang M, Park R, Kim H, et al. AMPK contributes to autophagosome maturation and lysosomal fusion. Sci Rep, 2018, 8(1): 12637.
24. Spengler K, Kryeziu N, Große S, et al. VEGF triggers transient induction of autophagy in endothelial cells via AMPKα1. Cells, 2020, 9(3): 687.
25. Kim J, Kundu M, Viollet B, et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol, 2011, 13(2): 132-141.
26. Gao J, Aksoy BA, Dogrusoz U, et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal, 2013, 6(269): pl1.
27. Russell FM, Hardie DG. AMP-activated protein kinase: do we need activators or inhibitors to treat or prevent cancer. Int J Mol Sci, 2020, 22(1): 186.
28. Monteverde T, Muthalagu N, Port J, et al. Evidence of cancer- promoting roles for AMPK and related kinases. FEBS J, 2015, 282(24): 4658-4671.
29. Jeon SM, Chandel NS, Hay N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature, 2012, 485(7400): 661-665.
30. Jeon SM, Hay N. The double- edged sword of AMPK signaling in cancer and its therapeutic implications. Arch Pharm Res, 2015, 38(3): 346-357.
31. Böttcher K, Longato L, Marrone G, et al. AICAR and compound C negatively modulate HCC-induced primary human hepatic stellate cell activation in vitro. Am J Physiol Gastrointest Liver Physiol, 2021, 320(4): G543-G556.
32. Kikuchi S, Piraino G, O’Connor M, et al. Hepatocyte-specific deletion of AMPKα1 results in worse outcomes in mice subjected to sepsis in a sex-specific manner. Front Immunol, 2020, 11: 210.
33. Qiu S, Liu T, Piao C, et al. AMPKα2 knockout enhances tumour inflammation through exacerbated liver injury and energy deprivation-associated AMPKα1 activation. J Cell Mol Med, 2019, 23(3): 1687-1697.
34. Wang Y, Xu B, Zhou J, et al. Propofol activates AMPK to inhibit the growth of HepG2 cells in vitro and hepatocarcinogenesis in xenograft mouse tumor models by inducing autophagy. J Gastrointest Oncol, 2020, 11(6): 1322-1332.
35. Qiu SL, Xiao ZC, Piao CM, et al. AMP-activated protein kinaseα2 protects against liver injury from metastasized tumors via reduced glucose deprivation‐induced oxidative stress. J Biol Chem, 2014, 289(13): 9449‐9459.
36. Yang Z, Kahn BB, Shi H, et al. Macrophage alpha1 AMP‐activated protein kinase (alpha1AMPK) antagonizes fatty acid‐induced inflammation through SIRT1. J Biol Chem, 2010, 285(25): 19051-19059.
37. Ren G, Guo JH, Qian YZ, et al. Berberine improves glucose and lipid metabolism in HepG2 cells through AMPKα1 activation. Front Pharmacol, 2020, 11: 647.
38. Zhang C, Zhang Q, Huang Z, et al. Adropin inhibited tilapia hepatic glucose output and triglyceride accumulation via AMPK activation. J Endocrinol, 2020, 246(2): 109-122.
39. Chen M, Jiang B, He B, et al. Genetic variations in PRKAA1 predict the risk and progression of gastric cancer. BMC Cancer, 2018, 18(1): 923.
40. Jeon SM, Hay N. The dark face of AMPK as an essential tumor promoter. Cell Logist, 2012, 2(4): 197-202.
41. Eom SY, Hong SM, Yim DH, et al. Additive interactions between PRKAA1 polymorphisms and Helicobacter pylori CagA infection associated with gastric cancer risk in Koreans. Cancer Med, 2016, 5(11): 3236-3335.
42. Zhang Y, Zhou X, Cheng L, et al. PRKAA1 promotes proliferation and inhibits apoptosis of gastric cancer cells through activating JNK1 and Akt pathways. Oncol Res, 2020, 28(3): 213-223.
43. Chen W, Zheng R, Zuo T, et al. National cancer incidence and mortality in China 2012. Chin J Cancer Res, 2016, 28(1): 1-11.
44. Ross FA, MacKintosh C, Hardie DG. AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours. FEBS J, 2016, 283(16): 2987-3001.
45. Hui GD, Xiu WY, Yong C, et al. AMP-activated protein kinase α1 serves a carcinogenic role via regulation of vascular endothelial growth factor expression in patients with non-small cell lung cancer. Oncol Lett, 2019, 17(5): 4329-4334.
46. Eichner LJ, Brun SN, Herzig S, et al. Genetic analysis reveals AMPK is required to support tumor growth in murine Kras-dependent lung cancer models. Cell Metab, 2019, 29(2): 285-302.e7.
47. Gong D, Li Y, Wang Y, et al. AMPKα1 downregulates ROS levels through regulating Trx leading to dysfunction of apoptosis in non-small cell lung cancer. Onco Targets Ther, 2020, 13: 5967-5977.
48. Kim MJ, Min Y, Son J, et al. AMPKα1 regulates lung and breast cancer progression by regulating TLR4-mediated TRAF6-BECN1 signaling axis. Cancers (Basel), 2020, 12(11): 3289.
49. Faubert B, Boily G, Izreig S, et al. AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab, 2013, l.17(1): 113-124.
50. Wang YN, Lu YX, Liu J, et al. AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation. Oncogene, 2020, 39(3): 637-650.
51. Han X, Ren C, Yang T, et al. Negative regulation of AMPK α1 by PIM2 promotes aerobic glycolysis and tumorigenesis in endometrial cancer. Oncogene, 2019, 38(38): 6537-6549.
52. Huang FY, Chiu PM, Tam KF, et al. Semi-quantitative fluorescent PCR analysis identifies PRKAA1 on chromosome 5 as a potential candidate cancer gene of cervical cancer. Gynecol Oncol, 2006, 103(1): 219-225.
53. Choi CH, Chung JY, Cho H, et al. Prognostic significance of AMP-dependent kinase alpha expression in cervical cancer. Pathobiology, 2015, 82(5): 203-211.
54. Yi Y, Chen D, Ao J, et al. Transcriptional suppression of AMPKα1 promotes breast cancer metastasis upon oncogene activation. Proc Natl Acad Sci USA, 2020, 117(14): 8013-8021.
55. Johnson J, how Z, Lee E, et al. Role of AMPK and Akt in triple negative breast cancer lung colonization. Neoplasia, 2021, 23(4): 429-438.
56. He Z. LINC00473/miR-497-5p regulates esophageal squamous cell carcinoma progression through targeting PRKAA1. Cancer Biother Radio pharm, 2019, 34(10): 650-659.
57. Pan SJ, Ren J, Jiang H, et al. MAGEA6 promotes human glioma cell survival via targeting AMPK α1. Cancer Lett, 2018, 412: 21-29.
58. Zhao K, Wang L, Li T, et al. The role of miR-451 in the switching between proliferation and migration in malignant glioma cells: AMPK signaling, mTOR modulation and Rac1 activation required. Int J Oncol, 2017, 50(6): 1989-1999.
59. Sun B, He S, Liu B, et al. Stanniocalcin-1 protected astrocytes from hypoxic damage through the AMPK pathway. Neurochem Res, 2021, 46(11): 2948-2957.
60. De Veirman K, Menu E, Maes K, et al. Myeloid-derived suppressor cells induce multiple myeloma cell survival by activating the AMPK pathway. Cancer Lett, 2019, 442: 233-241.
61. Obba S, Hizir Z, Boyer L, et al. The PRKAA1/AMPK α1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML. Autophagy, 2015, 11(7): 1114-1129.
62. Kopsiaftis S, Hegde P, Taylor JA 3rd, et al. AMPKα is suppressed in bladder cancer through macrophage-mediated mechanisms. Transl Oncol, 2016, 9(6): 606-616.
63. Park SJ, Lee TJ, Chang IH. Role of the mTOR pathway in the progression and recurrence of bladder cancer: an immunohistochemical tissue microarray study. Korean J Urol, 2011, 52(7): 466-473.
64. Sun CH, Chang YH, Pan CC. Activation of the PI3K/Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladder. Histopathology, 2011, 58(7): 1054-1063.
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66. Kwon HY, Kim JH, Kim B, et al. Regulation of SIRT1/AMPK axis is critically involved in gallotannin-induced senescence and impaired autophagy leading to cell death in hepatocellular carcinoma cells. Arch Toxicol, 2018, 92(1): 241-257.
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