Correlation of <i>OPRM</i><i>1</i> A118G gene polymorphism with Eysenck personality type and pain sensitivity_West China Medical Journal

Authors：

YUAN Ling ¹ , DENG Xiaoli ² , ZHONG Jingyi ³ , HE Yunan ¹ ,  ZHONG Wu ¹

1. Department of Emergency Medicine, Luzhou People’s Hospital, Luzhou, Sichuan 646000, P. R. China;
2. Department of Pharmacy, Luzhou People’s Hospital, Luzhou, Sichuan 646000, P. R. China;
3. Medical Records and Statistics Department, Luzhou People’s Hospital, Luzhou, Sichuan 646000, P. R. China;

Corresponding author：

ZHONG Wu, Email: zhongwu2876@sina.com

Keywords：

OPRM1 A118G gene; gene polymorphism; Eysenck personality type; pain sensitivity

DOI：

10.7507/1002-0179.202110118

Video：

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Objective To investigate the correlation between OPRM1 A118G gene polymorphism and Eysenck personality type and pain sensitivity. Methods The surgical patients who were transferred from Department of Emergency Medicine to Department of General Surgery of Luzhou People’s Hospital between January 2018 and December 2020 were selected. Before surgery, Eysenck Personality Questionnai (EPQ) was used to investigate the patient’s personality type, and the pain threshold and pain tolerance threshold were determined by electric stimulation instrument. The OPRM1 A118G genotype of peripheral venous blood was detected by polymerase chain reaction-restriction fragment length polymorphism analysis technique. Patients were divided into wild homozygous (A/A) group, mutant heterozygous (A/G) group and mutant homozygous (G/G) group according to the typing results. The general condition, pain sensitivity, EPQ score, difference of Eysenck personality type and correlation between Eysenck personality type and pain sensitivity were analyzed. Results A total of 356 patients were enrolled, including 174 in A/A group, 136 in A/G group and 46 in G/G group. The mutation rate of OPRM1 A118G gene was 32.00%. There were statistically significant differences in pain sensitivity (pain threshold, pain tolerance threshold) and scores of introverted and extraverted, neurotic and dissemble personality types among three groups (P<0.05). There were significant differences in introverted and extraverted and psychotic personality types among the three groups (P<0.05). There were significant differences in pain threshold and pain tolerance threshold among different introverted, extraverted and psychotropic personality types (P<0.05). Conclusion Both OPRM1 A118G gene polymorphism and Eysenck personality type have influence on pain sensitivity, and there is a correlation between them.

Citation： YUAN Ling, DENG Xiaoli, ZHONG Jingyi, HE Yunan, ZHONG Wu. Correlation of OPRM1 A118G gene polymorphism with Eysenck personality type and pain sensitivity. West China Medical Journal, 2022, 37(2): 237-241. doi: 10.7507/1002-0179.202110118 Copy

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2.	Matic M, Simons SH, van Lingen RA, et al. Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype. Pharmacogenomics, 2014, 15(10): 1287-1295.
3.	徐静, 冯黎阳, 邱英, 等. 直肠癌患者人格特征、应对方式与术前焦虑状况的相关性研究. 解放军预防医学杂志, 2019, 37(5): 161-162, 165.
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5.	胡慧君, 常志明, 李晓蕾, 等. 下颌第三磨牙拔除患者疼痛、焦虑情况与人格特点的相关性分析. 中国口腔颌面外科杂志, 2020, 18(6): 508-511.
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7.	陈思, 刘瞾宇, 曾毅, 等. OPRM1 A118G 多态性对喉癌患者术后舒芬太尼静脉自控镇痛效果的影响. 西部医学, 2018, 30(11): 1589-1592.
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10.	伍小英, 鲁婧婧, 张晋昕, 等. 两两比较的 Bonferroni 法. 循证医学, 2006, 6(6): 361-363, 374.
11.	Zhang W, Yuan JJ, Kan QC, et al. Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting induced by fentanal intravenous analgesia. Minerva Anestesiol, 2011, 77(1): 33-39.
12.	Shi CM, Wang DX, Chen KS, et al. Incidence and risk factors of delirium in critically ill patients after non-cardiac surgery. Chin Med J (Engl), 2010, 123(8): 993-999.
13.	Van Rompaey B, Elseviers MM, Schuurmans MJ, et al. Risk factors for delirium in intensive care patients: a prospective cohort study. Crit Care, 2009, 13(3): R77.
14.	Inouye SK. Delirium in older persons. N Engl J Med, 2006, 354(11): 1157-1165.
15.	Gallinat J, Möller H, Moser RL, et al. Postoperative delirium: risk factors, prophylaxis and treatment. Anaesthesist, 1999, 48(8): 507-518.
16.	钱铭怡, 武国城, 朱荣春, 等. 艾森克人格问卷简式量表中国版(EPQ-RSC)的修订. 心理学报, 2000, 32(3): 317-323.
17.	郑丽, 陈铭晟, 王璐, 等. 艾森克人格因素对颌骨囊肿开窗减压术后应用塞制器患者牙科焦虑症和疼痛的影响研究. 口腔医学研究, 2017, 33(9): 978-981.
18.	谭灵, 黄学平, 付禹尧, 等. OPRM1 A118G 基因多态性对创伤患者疼痛治疗效果的影响. 中国医学前沿杂志(电子版), 2020, 12(12): 72-75.
19.	王伟, 黄文锋, 栗村瑞. OPRM1 118G 基因多态性对剖宫产鞘内注射吗啡术后镇痛的影响. 西部医学, 2020, 32(12): 1841-1844.
20.	林涛, 李祥奎, 宋俊梅, 等. OPRM1 118A/G 基因多态性与癌痛患者羟考酮剂量相关性. 中华医学遗传学杂志, 2018, 35(6): 887-890.
21.	陆彦霓, 汤晓青, 沈丽达. OPRM1 (A118G) 基因多态性对阿片类药物镇痛效应影响的研究进展. 现代肿瘤医学, 2018, 26(9): 1477-1480.
22.	Stamer UM, Stüber F. Genetic factors in pain and its treatment. Curr Opin Anaesthesiol, 2007, 20(5): 478-484.

1. Victoria G. Pain care. Nurs Care North Am, 1994, 29(3): 534-544.
2. Matic M, Simons SH, van Lingen RA, et al. Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype. Pharmacogenomics, 2014, 15(10): 1287-1295.
3. 徐静, 冯黎阳, 邱英, 等. 直肠癌患者人格特征、应对方式与术前焦虑状况的相关性研究. 解放军预防医学杂志, 2019, 37(5): 161-162, 165.
4. 张庆, 陈文静, 马龙, 等. 艾森克人格因素对正畸中植入微种植体支抗患者焦虑症和疼痛的影响研究. 口腔医学, 2015, 35(8): 644-648.
5. 胡慧君, 常志明, 李晓蕾, 等. 下颌第三磨牙拔除患者疼痛、焦虑情况与人格特点的相关性分析. 中国口腔颌面外科杂志, 2020, 18(6): 508-511.
6. 李琳. 腹腔镜子宫切除术患者术前焦虑对术后疼痛的影响. 太原: 山西医科大学, 2020.
7. 陈思, 刘瞾宇, 曾毅, 等. OPRM1 A118G 多态性对喉癌患者术后舒芬太尼静脉自控镇痛效果的影响. 西部医学, 2018, 30(11): 1589-1592.
8. 龚耀先. 修订艾森克个性问卷手册. 长沙: 湖南医学院, 1986.
9. 王中玉. COMTvall58 met 和 OPRM1 A118G 基因多态性对国人电刺激疼痛敏感性和术前焦虑的影响. 郑州: 郑州大学, 2012.
10. 伍小英, 鲁婧婧, 张晋昕, 等. 两两比较的 Bonferroni 法. 循证医学, 2006, 6(6): 361-363, 374.
11. Zhang W, Yuan JJ, Kan QC, et al. Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting induced by fentanal intravenous analgesia. Minerva Anestesiol, 2011, 77(1): 33-39.
12. Shi CM, Wang DX, Chen KS, et al. Incidence and risk factors of delirium in critically ill patients after non-cardiac surgery. Chin Med J (Engl), 2010, 123(8): 993-999.
13. Van Rompaey B, Elseviers MM, Schuurmans MJ, et al. Risk factors for delirium in intensive care patients: a prospective cohort study. Crit Care, 2009, 13(3): R77.
14. Inouye SK. Delirium in older persons. N Engl J Med, 2006, 354(11): 1157-1165.
15. Gallinat J, Möller H, Moser RL, et al. Postoperative delirium: risk factors, prophylaxis and treatment. Anaesthesist, 1999, 48(8): 507-518.
16. 钱铭怡, 武国城, 朱荣春, 等. 艾森克人格问卷简式量表中国版(EPQ-RSC)的修订. 心理学报, 2000, 32(3): 317-323.
17. 郑丽, 陈铭晟, 王璐, 等. 艾森克人格因素对颌骨囊肿开窗减压术后应用塞制器患者牙科焦虑症和疼痛的影响研究. 口腔医学研究, 2017, 33(9): 978-981.
18. 谭灵, 黄学平, 付禹尧, 等. OPRM1 A118G 基因多态性对创伤患者疼痛治疗效果的影响. 中国医学前沿杂志(电子版), 2020, 12(12): 72-75.
19. 王伟, 黄文锋, 栗村瑞. OPRM1 118G 基因多态性对剖宫产鞘内注射吗啡术后镇痛的影响. 西部医学, 2020, 32(12): 1841-1844.
20. 林涛, 李祥奎, 宋俊梅, 等. OPRM1 118A/G 基因多态性与癌痛患者羟考酮剂量相关性. 中华医学遗传学杂志, 2018, 35(6): 887-890.
21. 陆彦霓, 汤晓青, 沈丽达. OPRM1 (A118G) 基因多态性对阿片类药物镇痛效应影响的研究进展. 现代肿瘤医学, 2018, 26(9): 1477-1480.
22. Stamer UM, Stüber F. Genetic factors in pain and its treatment. Curr Opin Anaesthesiol, 2007, 20(5): 478-484.

West China Medical Journal

Correlation of OPRM1 A118G gene polymorphism with Eysenck personality type and pain sensitivity

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